Systemic Immune Modulation by Gastrointestinal Nematodes.

IF 26.9 1区 医学 Q1 IMMUNOLOGY
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI:10.1146/annurev-immunol-090222-101331
Darshan N Kasal, Lindsey M Warner, Astra S Bryant, Elia Tait Wojno, Jakob von Moltke
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引用次数: 0

Abstract

Gastrointestinal nematode (GIN) infection has applied significant evolutionary pressure to the mammalian immune system and remains a global economic and human health burden. Upon infection, type 2 immune sentinels activate a common antihelminth response that mobilizes and remodels the intestinal tissue for effector function; however, there is growing appreciation of the impact GIN infection also has on the distal tissue immune state. Indeed, this effect is observed even in tissues through which GINs never transit. This review highlights how GIN infection modulates systemic immunity through (a) induction of host resistance and tolerance responses, (b) secretion of immunomodulatory products, and (c) interaction with the intestinal microbiome. It also discusses the direct consequences that changes to distal tissue immunity can have for concurrent and subsequent infection, chronic noncommunicable diseases, and vaccination efficacy.

肠道线虫对全身免疫的调节作用
胃肠道线虫(GIN)感染对哺乳动物免疫系统造成了巨大的进化压力,并一直是全球经济和人类健康的负担。感染后,2 型免疫哨兵会激活共同的抗蠕虫反应,调动和重塑肠道组织的效应功能;然而,人们越来越认识到 GIN 感染对远端组织免疫状态的影响。事实上,即使在 GIN 从未过境的组织中也能观察到这种影响。本综述强调了 GIN 感染如何通过(a)诱导宿主抵抗和耐受反应,(b)分泌免疫调节产物,以及(c)与肠道微生物组相互作用来调节全身免疫。报告还讨论了远端组织免疫力的变化可能对并发和继发感染、慢性非传染性疾病和疫苗接种效果产生的直接影响。免疫学年刊》第 42 卷的最终在线出版日期预计为 2024 年 4 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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