Kidney-Specific Interleukin-17 Responses During Infection and Injury.

IF 26.9 1区 医学 Q1 IMMUNOLOGY
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI:10.1146/annurev-immunol-052523-015141
Doureradjou Peroumal, Partha S Biswas
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引用次数: 0

Abstract

The kidneys are life-sustaining organs that are vital to removing waste from our bodies. Because of their anatomic position and high blood flow, the kidneys are vulnerable to damage due to infections and autoinflammatory conditions. Even now, our knowledge of immune responses in the kidney is surprisingly rudimentary. Studying kidney-specific immune events is challenging because of the poor regenerative capacity of the nephrons, accumulation of uremic toxins, and hypoxia- and arterial blood pressure-mediated changes, all of which have unexpected positive or negative impacts on the immune response in the kidney. Kidney-specific defense confers protection against pathogens. On the other hand, unresolved inflammation leads to kidney damage and fibrosis. Interleukin-17 is a proinflammatory cytokine that has been linked to immunity against pathogens and pathogenesis of autoinflammatory diseases. In this review, we discuss current knowledge of IL-17 activities in the kidney in the context of infections, autoinflammatory diseases, and renal fibrosis.

感染和损伤过程中肾脏特异性白细胞介素17的反应。
肾脏是维持生命的器官,对清除体内废物至关重要。由于其解剖位置和高血流量,肾脏很容易因感染和自身炎症而受损。即使是现在,我们对肾脏免疫反应的了解也出奇地初级。研究肾脏特异性免疫事件具有挑战性,因为肾单位的再生能力差、尿毒症毒素的积累以及缺氧和动脉血压介导的变化,所有这些都会对肾脏的免疫反应产生意想不到的积极或消极影响。肾脏特异性防御可以抵御病原体。另一方面,未解决的炎症会导致肾脏损伤和纤维化。白细胞介素-17是一种促炎细胞因子,与对病原体的免疫和自身炎症性疾病的发病机制有关。在这篇综述中,我们讨论了在感染、自身炎症性疾病和肾纤维化的背景下,IL-17在肾脏中活性的最新知识。《免疫学年度评论》第42卷预计最终在线出版日期为2024年4月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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