T Follicular Helper Cell Heterogeneity

IF 26.9 1区 医学 Q1 IMMUNOLOGY
Wenzhi Song, Joe Craft
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引用次数: 0

Abstract

T follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which they emerge. We review recent advances in understanding the heterogeneity within Tfh cell subsets along with their differentiation and migratory trajectory, the phenotype they adopt, their ontological relationships with one another, and their function in their respective environments.Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
T 滤泡辅助细胞的异质性
T 滤泡辅助细胞(Tfh)专门帮助 B 细胞,因此是产生体液免疫的关键因素。Tfh细胞帮助免疫球蛋白类开关重组,支持生殖中心反应,从而促进免疫球蛋白亲和力成熟和体液免疫记忆的产生。尽管Tfh细胞的主要功能是促进B细胞反应,但它们也表现出表型和功能的多样性,这取决于它们产生的免疫学和空间环境。我们回顾了最近在理解 Tfh 细胞亚群内部的异质性、它们的分化和迁移轨迹、它们采用的表型、它们之间的本体论关系以及它们在各自环境中的功能方面取得的进展。《免疫学年刊》(第 42 卷)的最终在线出版日期预计为 2024 年 4 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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