2型免疫的新范式。

IF 26.9 1区医学 Q1 IMMUNOLOGY

Annual review of immunology Pub Date : 2022-04-26 DOI:10.1146/annurev-immunol-101320-030339

H. Hammad, Nincy Debeuf, H. Aegerter, A. Brown, B. Lambrecht

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引用次数: 12

摘要

2型免疫的一个主要目的被认为是防御大型寄生虫，但它也在恢复体内平衡中起作用，例如在蛇咬伤后清除毒素。在其他情况下，如过敏，2型T辅助(Th2)细胞因子和存在于环境中的细胞是有害的，导致疾病。近年来，对th2相关细胞群内细胞异质性的认识揭示了具有特定表型或基因特征的细胞的特定功能。此外，我们还讨论了最近关于2型免疫相关细胞异质性的数据，以及它们在各种过程中的新发现作用，从参与呼吸道病毒感染(特别是在最近的COVID-19(冠状病毒病2019)大流行的背景下)到控制癌症发展或代谢稳态。

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Emerging Paradigms in Type 2 Immunity.

A principal purpose of type 2 immunity was thought to be defense against large parasites, but it also functions in the restoration of homeostasis, such as toxin clearance following snake bites. In other cases, like allergy, the type 2 T helper (Th2) cytokines and cells present in the environment are detrimental and cause diseases. In recent years, the recognition of cell heterogeneity within Th2-associated cell populations has revealed specific functions of cells with a particular phenotype or gene signature. In addition, here we discuss the recent data regarding heterogeneity of type 2 immunity-related cells, as well as their newly identified role in a variety of processes ranging from involvement in respiratory viral infections [especially in the context of the recent COVID-19 (coronavirus disease 2019) pandemic] to control of cancer development or of metabolic homeostasis.

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来源期刊

Annual review of immunology 医学-免疫学

CiteScore

57.20

自引率

0.70%

发文量

期刊介绍： The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.