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Annual review of immunology最新文献

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Microbial Metabolites and Gut Immunology. 微生物代谢物与肠道免疫学
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 DOI: 10.1146/annurev-immunol-090222-102035
Tadashi Takeuchi, Yumiko Nakanishi, Hiroshi Ohno
{"title":"Microbial Metabolites and Gut Immunology.","authors":"Tadashi Takeuchi, Yumiko Nakanishi, Hiroshi Ohno","doi":"10.1146/annurev-immunol-090222-102035","DOIUrl":"https://doi.org/10.1146/annurev-immunol-090222-102035","url":null,"abstract":"<p><p>The intestine is the largest peripheral lymphoid organ in animals, including humans, and interacts with a vast array of microorganisms called the gut microbiota. Comprehending the symbiotic relationship between the gut microbiota and our immune system is essential not only for the field of immunology but also for understanding the pathogenesis of various systemic diseases, including cancer, cardiometabolic disorders, and extraintestinal autoimmune conditions. Whereas microbe-derived antigens are crucial for activating the intestinal immune system, particularly T and B cells, as environmental cues, microbes and their metabolites play a critical role in directing the differentiation of these immune cells. Microbial metabolites are regarded as messengers from the gut microbiota, since bacteria have the ability to produce unique molecules that humans cannot, and many immune cells in the intestine express receptors for these molecules. This review highlights the distinct relationships between microbial metabolites and the differentiation and function of the immune system.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"42 1","pages":"153-178"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunology of Kidney Disease. 肾脏疾病免疫学。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-090122-045843
Orestes Foresto-Neto, Luísa Menezes-Silva, Jefferson Antônio Leite, Magaiver Andrade-Silva, Niels Olsen Saraiva Câmara
{"title":"Immunology of Kidney Disease.","authors":"Orestes Foresto-Neto, Luísa Menezes-Silva, Jefferson Antônio Leite, Magaiver Andrade-Silva, Niels Olsen Saraiva Câmara","doi":"10.1146/annurev-immunol-090122-045843","DOIUrl":"10.1146/annurev-immunol-090122-045843","url":null,"abstract":"<p><p>The immune system and the kidneys are closely related. Immune components mediate acute kidney disease and are crucial to the progression of chronic kidney disease. Beyond its pathogenic functions, the immune system supports immunological homeostasis in healthy kidneys. The kidneys help maintain immune equilibrium by removing metabolic waste products and toxins, thereby limiting local and systemic inflammation. In this review, we describe the close relationship between the immune system and the kidneys. We discuss how the imbalance in the immune response can be deleterious to the kidneys and how immunomodulation can be important in preventing end-stage renal disease. In addition, recent tools such as in silico platforms and kidney organoids can help unveil the relationship between immune cells and kidney homeostasis.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"207-233"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139428774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
B Cell-Directed Therapy in Autoimmunity. 自身免疫的B细胞定向治疗。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-083122-044829
Ilana Abeles, Chris Palma, Nida Meednu, Aimee S Payne, R John Looney, Jennifer H Anolik
{"title":"B Cell-Directed Therapy in Autoimmunity.","authors":"Ilana Abeles, Chris Palma, Nida Meednu, Aimee S Payne, R John Looney, Jennifer H Anolik","doi":"10.1146/annurev-immunol-083122-044829","DOIUrl":"10.1146/annurev-immunol-083122-044829","url":null,"abstract":"<p><p>Autoimmune diseases with B cell-directed therapeutics approved by the US Food and Drug Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this review, we focus on recent clinical and mechanistic insights into the efficacy of B cell depletion in these diverse autoimmune disorders, the rapidly expanding armamentarium of approved agents, and future approaches. The pathogenic roles for B cells include direct functions such as production of autoantibodies and proinflammatory cytokines and indirect functions via antigen presentation to T cells. The efficacy of B cell-depleting strategies varies across diseases and likely reflects the complexity of disease pathogenesis and relative contribution of B cell roles. Additionally, B cell-depleting therapies do not equally target all B cell subsets in all patients, and this likely explains some of the variability in responses. Recent reports of B cell depletion with novel chimeric antigen receptor (CAR) T cell approaches in an expanding number of autoimmune diseases highlight the potential role of B cell depletion in resetting immune tolerance. The relative importance of eliminating autoreactive B cells and plasma cells and approaches to doing so will also be discussed.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"103-126"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138443661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Multifaceted Role of Tissue-Resident Memory T Cells. 组织驻留记忆 T 细胞的多重作用
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 DOI: 10.1146/annurev-immunol-101320-020220
Susan N Christo, Simone L Park, Scott N Mueller, Laura K Mackay
{"title":"The Multifaceted Role of Tissue-Resident Memory T Cells.","authors":"Susan N Christo, Simone L Park, Scott N Mueller, Laura K Mackay","doi":"10.1146/annurev-immunol-101320-020220","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101320-020220","url":null,"abstract":"<p><p>Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell populations. Of these, tissue-resident memory T (T<sub>RM</sub>) cells are strategically positioned in barrier tissues, where they enable efficient frontline defense against infections and cancer. However, the long-term persistence of these cells has been implicated in a variety of immune-mediated pathologies. Consequently, modulating T<sub>RM</sub> cell populations represents an attractive strategy for novel vaccination and therapeutic interventions against tissue-based diseases. Here, we provide an updated overview of T<sub>RM</sub> cell heterogeneity and function across tissues and disease states. We discuss mechanisms of T<sub>RM</sub> cell-mediated immune protection and their potential contributions to autoimmune disorders. Finally, we examine how T<sub>RM</sub> cell responses might be durably boosted or dampened for therapeutic gain.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"42 1","pages":"317-345"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Priming and Maintenance of Adaptive Immunity in the Liver. 肝脏适应性免疫的启动和维持
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-090122-041354
Keigo Kawashima, Francesco Andreata, Cristian Gabriel Beccaria, Matteo Iannacone
{"title":"Priming and Maintenance of Adaptive Immunity in the Liver.","authors":"Keigo Kawashima, Francesco Andreata, Cristian Gabriel Beccaria, Matteo Iannacone","doi":"10.1146/annurev-immunol-090122-041354","DOIUrl":"10.1146/annurev-immunol-090122-041354","url":null,"abstract":"<p><p>The liver's unique characteristics have a profound impact on the priming and maintenance of adaptive immunity. This review delves into the cellular circuits that regulate adaptive immune responses in the liver, with a specific focus on hepatitis B virus infection as an illustrative example. A key aspect highlighted is the liver's specialized role in priming CD8+ T cells, leading to a distinct state of immune hyporesponsiveness. Additionally, the influence of the liver's hemodynamics and anatomical features, particularly during liver fibrosis and cirrhosis, on the differentiation and function of adaptive immune cells is discussed. While the primary emphasis is on CD8+ T cells, recent findings regarding the involvement of B cells and CD4+ T cells in hepatic immunity are also reviewed. Furthermore, we address the challenges ahead and propose integrating cutting-edge techniques, such as spatial biology, and combining mouse models with human sample analyses to gain comprehensive insights into the liver's adaptive immunity. This understanding could pave the way for novel therapeutic strategies targeting infectious diseases, malignancies, and inflammatory liver conditions like metabolic dysfunction-associated steatohepatitis and autoimmune hepatitis.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"375-399"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multilayered Immunity by Tissue-Resident Lymphocytes in Cancer. 癌症中组织驻留淋巴细胞的多层免疫作用
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-083122-043836
Ming O Li, Jing Zhang, Zijian Xu, Xian Zhang, Peng Li, Andrew E Cornish
{"title":"Multilayered Immunity by Tissue-Resident Lymphocytes in Cancer.","authors":"Ming O Li, Jing Zhang, Zijian Xu, Xian Zhang, Peng Li, Andrew E Cornish","doi":"10.1146/annurev-immunol-083122-043836","DOIUrl":"10.1146/annurev-immunol-083122-043836","url":null,"abstract":"<p><p>Lymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and constitute an integral component of the local defense network against immunological challenges. In tight interactions with the epithelium and endothelium, tissue-resident lymphocytes sense antigens and alarmins elicited by infectious microbes and abiotic stresses at barrier sites and mount effector responses to restore tissue homeostasis. Of note, such a host cell-directed immune defense system has been recently demonstrated to surveil epithelial cell transformation and carcinoma development, as well as cancer cell metastasis at selected distant organs, and thus represents a primordial cancer immune defense module. Here we review how distinct lineages of tissue-resident innate lymphoid cells, innate-like T cells, and adaptive T cells participate in a form of multilayered cancer immunity in murine models and patients, and how their convergent effector programs may be targeted through both shared and private regulatory pathways for cancer immunotherapy.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"647-677"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune Responses in Controllers of HIV Infection. HIV感染控制者的免疫反应。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-083122-035233
Abena K Kwaa, Joel N Blankson
{"title":"Immune Responses in Controllers of HIV Infection.","authors":"Abena K Kwaa, Joel N Blankson","doi":"10.1146/annurev-immunol-083122-035233","DOIUrl":"10.1146/annurev-immunol-083122-035233","url":null,"abstract":"<p><p>Elite controllers are a heterogeneous group of people living with HIV who control viral replication without antiretroviral therapy. There is substantial evidence that at least some elite controllers are infected with replication-competent virus, thus they may serve as a model of a functional cure of HIV. The mechanisms responsible for virologic control have been actively studied. The most objective data support CD8+ T cell-based mechanisms of control, but other immune responses, mediated by antibodies and natural killer cells, may also play a role in controlling viral replication. In this article, we review the evidence for different mechanisms of immune control in these remarkable individuals.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"21-33"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41189502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poxvirus Immune Evasion. 痘病毒的免疫逃避
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 DOI: 10.1146/annurev-immunol-090222-110227
Bruno Hernaez, Antonio Alcamí
{"title":"Poxvirus Immune Evasion.","authors":"Bruno Hernaez, Antonio Alcamí","doi":"10.1146/annurev-immunol-090222-110227","DOIUrl":"https://doi.org/10.1146/annurev-immunol-090222-110227","url":null,"abstract":"<p><p>Poxviruses have evolved a wide array of mechanisms to evade the immune response, and we provide an overview of the different immunomodulatory strategies. Poxviruses prevent the recognition of viral DNA that triggers the immune responses and inhibit signaling pathways within the infected cell. A unique feature of poxviruses is the production of secreted proteins that mimic cytokines and cytokine receptors, acting as decoy receptors to neutralize the activity of cytokines and chemokines. The capacity of these proteins to evade cellular immune responses by inhibiting cytokine activation is complemented by poxviruses' strategies to block natural killer cells and cytotoxic T cells, often through interfering with antigen presentation pathways. Mechanisms that target complement activation are also encoded by poxviruses. Virus-encoded proteins that target immune molecules and pathways play a major role in immune modulation, and their contribution to viral pathogenesis, facilitating virus replication or preventing immunopathology, is discussed.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":"42 1","pages":"551-584"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aire in Autoimmunity. 自身免疫中的空气
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-090222-101050
Corey N Miller, Michael R Waterfield, James M Gardner, Mark S Anderson
{"title":"Aire in Autoimmunity.","authors":"Corey N Miller, Michael R Waterfield, James M Gardner, Mark S Anderson","doi":"10.1146/annurev-immunol-090222-101050","DOIUrl":"10.1146/annurev-immunol-090222-101050","url":null,"abstract":"<p><p>The role of the autoimmune regulator (Aire) in central immune tolerance and thymic self-representation was first described more than 20 years ago, but fascinating new insights into its biology continue to emerge, particularly in the era of advanced single-cell genomics. We briefly describe the role of human genetics in the discovery of Aire, as well as insights into its function gained from genotype-phenotype correlations and the spectrum of Aire-associated autoimmunity-including insights from patients with Aire mutations with broad and diverse implications for human health. We then highlight emerging trends in Aire biology, focusing on three topic areas. First, we discuss medullary thymic epithelial diversity and the role of Aire in thymic epithelial development. Second, we highlight recent developments regarding the molecular mechanisms of Aire and its binding partners. Finally, we describe the rapidly evolving biology of the identity and function of extrathymic Aire-expressing cells (eTACs), and a novel eTAC subset called Janus cells, as well as their potential roles in immune homeostasis.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"427-53"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kidney-Specific Interleukin-17 Responses During Infection and Injury. 感染和损伤过程中肾脏特异性白细胞介素17的反应。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-052523-015141
Doureradjou Peroumal, Partha S Biswas
{"title":"Kidney-Specific Interleukin-17 Responses During Infection and Injury.","authors":"Doureradjou Peroumal, Partha S Biswas","doi":"10.1146/annurev-immunol-052523-015141","DOIUrl":"10.1146/annurev-immunol-052523-015141","url":null,"abstract":"<p><p>The kidneys are life-sustaining organs that are vital to removing waste from our bodies. Because of their anatomic position and high blood flow, the kidneys are vulnerable to damage due to infections and autoinflammatory conditions. Even now, our knowledge of immune responses in the kidney is surprisingly rudimentary. Studying kidney-specific immune events is challenging because of the poor regenerative capacity of the nephrons, accumulation of uremic toxins, and hypoxia- and arterial blood pressure-mediated changes, all of which have unexpected positive or negative impacts on the immune response in the kidney. Kidney-specific defense confers protection against pathogens. On the other hand, unresolved inflammation leads to kidney damage and fibrosis. Interleukin-17 is a proinflammatory cytokine that has been linked to immunity against pathogens and pathogenesis of autoinflammatory diseases. In this review, we discuss current knowledge of IL-17 activities in the kidney in the context of infections, autoinflammatory diseases, and renal fibrosis.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"35-55"},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71420222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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