Annual review of immunology最新文献

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The Immunobiology and Treatment of Food Allergy. 食物过敏的免疫生物学和治疗。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-090122-043501
Suzanne Barshow, Jyothi Tirumalasetty, Vanitha Sampath, Xiaoying Zhou, Hana Seastedt, Jackson Schuetz, Kari Nadeau
{"title":"The Immunobiology and Treatment of Food Allergy.","authors":"Suzanne Barshow, Jyothi Tirumalasetty, Vanitha Sampath, Xiaoying Zhou, Hana Seastedt, Jackson Schuetz, Kari Nadeau","doi":"10.1146/annurev-immunol-090122-043501","DOIUrl":"10.1146/annurev-immunol-090122-043501","url":null,"abstract":"<p><p>IgE-mediated food allergy (IgE-FA) occurs due to a breakdown in immune tolerance that leads to a detrimental type 2 helper T cell (T<sub>H</sub>2) adaptive immune response. While the processes governing this loss of tolerance are incompletely understood, several host-related and environmental factors impacting the risk of IgE-FA development have been identified. Mounting evidence supports the role of an impaired epithelial barrier in the development of IgE-FA, with exposure of allergens through damaged skin and gut epithelium leading to the aberrant production of alarmins and activation of T<sub>H</sub>2-type allergic inflammation. The treatment of IgE-FA has historically been avoidance with acute management of allergic reactions, but advances in allergen-specific immunotherapy and the development of biologics and other novel therapeutics are rapidly changing the landscape of food allergy treatment. Here, we discuss the pathogenesis and immunobiology of IgE-FA in addition to its diagnosis, prognosis, and treatment.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimmune Interactions in the Intestine. 肠道中的神经免疫相互作用
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 DOI: 10.1146/annurev-immunol-101921-042929
Antonia Wallrapp, Isaac M Chiu
{"title":"Neuroimmune Interactions in the Intestine.","authors":"Antonia Wallrapp, Isaac M Chiu","doi":"10.1146/annurev-immunol-101921-042929","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101921-042929","url":null,"abstract":"<p><p>Recent advances have contributed to a mechanistic understanding of neuroimmune interactions in the intestine and revealed an essential role of this cross talk for gut homeostasis and modulation of inflammatory and infectious intestinal diseases. In this review, we describe the innervation of the intestine by intrinsic and extrinsic neurons and then focus on the bidirectional communication between neurons and immune cells. First, we highlight the contribution of neuronal subtypes to the development of colitis and discuss the different immune and epithelial cell types that are regulated by neurons via the release of neuropeptides and neurotransmitters. Next, we review the role of intestinal inflammation in the development of visceral hypersensitivity and summarize how inflammatory mediators induce peripheral and central sensitization of gut-innervating sensory neurons. Finally, we outline the importance of immune cells and gut microbiota for the survival and function of different neuronal populations at homeostasis and during bacterial and helminth infection.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The CD4 Versus CD8 T Cell Fate Decision: A Multiomics-Informed Perspective. CD4 与 CD8 T 细胞命运的决定:从多组学的角度看问题。
IF 26.9 1区 医学
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI: 10.1146/annurev-immunol-083122-040929
Zoë Steier, Esther Jeong Yoon Kim, Dominik A Aylard, Ellen A Robey
{"title":"The CD4 Versus CD8 T Cell Fate Decision: A Multiomics-Informed Perspective.","authors":"Zoë Steier, Esther Jeong Yoon Kim, Dominik A Aylard, Ellen A Robey","doi":"10.1146/annurev-immunol-083122-040929","DOIUrl":"10.1146/annurev-immunol-083122-040929","url":null,"abstract":"<p><p>The choice of developing thymocytes to become CD8+ cytotoxic or CD4+ helper T cells has been intensely studied, but many of the underlying mechanisms remain to be elucidated. Recent multiomics approaches have provided much higher resolution analysis of gene expression in developing thymocytes than was previously achievable, thereby offering a fresh perspective on this question. Focusing on our recent studies using CITE-seq (cellular indexing of transcriptomes and epitopes) analyses of mouse thymocytes, we present a detailed timeline of RNA and protein expression changes during CD8 versus CD4 T cell differentiation. We also revisit our current understanding of the links between T cell receptor signaling and expression of the lineage-defining transcription factors ThPOK and RUNX3. Finally, we propose a sequential selection model to explain the tight linkage between MHC-I versus MHC-II recognition and T cell lineage choice. This model incorporates key aspects of previously proposed kinetic signaling, instructive, and stochastic/selection models.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":26.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging Implementation Science to Advance Environmental Justice Research and Achieve Health Equity through Neighborhood and Policy Interventions. 利用实施科学推进环境正义研究,通过邻里和政策干预实现健康公平。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2024-05-01 Epub Date: 2024-04-03 DOI: 10.1146/annurev-publhealth-060222-033003
Laura Ellen Ashcraft, Keven I Cabrera, Meghan B Lane-Fall, Eugenia C South
{"title":"Leveraging Implementation Science to Advance Environmental Justice Research and Achieve Health Equity through Neighborhood and Policy Interventions.","authors":"Laura Ellen Ashcraft, Keven I Cabrera, Meghan B Lane-Fall, Eugenia C South","doi":"10.1146/annurev-publhealth-060222-033003","DOIUrl":"10.1146/annurev-publhealth-060222-033003","url":null,"abstract":"<p><p>Environmental justice research is increasingly focused on community-engaged, participatory investigations that test interventions to improve health. Such research is primed for the use of implementation science-informed approaches to optimize the uptake and use of interventions proven to be effective. This review identifies synergies between implementation science and environmental justice with the goal of advancing both disciplines. Specifically, the article synthesizes the literature on neighborhood-, community-, and policy-level interventions in environmental health that address underlying structural determinants (e.g., structural racism) and social determinants of health. Opportunities to facilitate and scale the equitable implementation of evidence-based environmental health interventions are highlighted, using urban greening as an illustrative example. An environmental justice-focused version of the implementation science subway is provided, which highlights these principles: Remember and Reflect, Restore and Reclaim, and Reinvest. The review concludes with existing gaps and future directions to advance the science of implementation to promote environmental justice.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence for Policies and Practices to Address Global Food Insecurity. 解决全球粮食不安全问题的政策和实践证据。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2024-05-01 Epub Date: 2024-04-03 DOI: 10.1146/annurev-publhealth-060922-041451
Lora Iannotti, Eliza Kleban, Patrizia Fracassi, Stineke Oenema, Chessa Lutter
{"title":"Evidence for Policies and Practices to Address Global Food Insecurity.","authors":"Lora Iannotti, Eliza Kleban, Patrizia Fracassi, Stineke Oenema, Chessa Lutter","doi":"10.1146/annurev-publhealth-060922-041451","DOIUrl":"10.1146/annurev-publhealth-060922-041451","url":null,"abstract":"<p><p>Food insecurity affects an estimated 691-783 million people globally and is disproportionately high in Africa and Asia. It arises from poverty, armed conflict, and climate change, among other demographic and globalization forces. This review summarizes evidence for policies and practices across five elements of the agrifood system framework and identifies gaps that inform an agenda for future research. Under availability<i>,</i> imbalanced agriculture policies protect primarily staple food producers, and there is limited evidence on food security impacts for smallholder and women food producers. Evidence supports the use of cash transfers and food aid for affordability and school feeding for multiple benefits. Food-based dietary guidelines can improve the nutritional quality of dietary patterns, yet they may not reflect the latest evidence or food supplies. Evidence from the newer food environment elements, promotion and sustainability, while relatively minimal, provides insight into achieving long-term impacts. To eliminate hunger, our global community should embrace integrated approaches and bring evidence-based policies and practices to scale.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extreme Heat and Occupational Health Risks. 酷热与职业健康风险。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2024-05-01 Epub Date: 2024-04-03 DOI: 10.1146/annurev-publhealth-060222-034715
Kathryn Gibb, Stella Beckman, Ximena P Vergara, Amy Heinzerling, Robert Harrison
{"title":"Extreme Heat and Occupational Health Risks.","authors":"Kathryn Gibb, Stella Beckman, Ximena P Vergara, Amy Heinzerling, Robert Harrison","doi":"10.1146/annurev-publhealth-060222-034715","DOIUrl":"10.1146/annurev-publhealth-060222-034715","url":null,"abstract":"<p><p>Climate change poses a significant occupational health hazard. Rising temperatures and more frequent heat waves are expected to cause increasing heat-related morbidity and mortality for workers across the globe. Agricultural, construction, military, firefighting, mining, and manufacturing workers are at particularly high risk for heat-related illness (HRI). Various factors, including ambient temperatures, personal protective equipment, work arrangements, physical exertion, and work with heavy equipment may put workers at higher risk for HRI. While extreme heat will impact workers across the world, workers in low- and middle-income countries will be disproportionately affected. Tracking occupational HRI will be critical to informing prevention and mitigation strategies. Renewed investment in these strategies, including workplace heat prevention programs and regulatory standards for indoor and outdoor workers, will be needed. Additional research is needed to evaluate the effectiveness of interventions in order to successfully reduce the risk of HRI in the workplace.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and Opportunities for Paving the Road to Global Health Equity Through Implementation Science. 通过实施科学为实现全球健康公平铺平道路的挑战与机遇。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2024-05-01 Epub Date: 2024-04-03 DOI: 10.1146/annurev-publhealth-060922-034822
Prajakta Adsul, Rachel C Shelton, April Oh, Nathalie Moise, Juliet Iwelunmor, Derek M Griffith
{"title":"Challenges and Opportunities for Paving the Road to Global Health Equity Through Implementation Science.","authors":"Prajakta Adsul, Rachel C Shelton, April Oh, Nathalie Moise, Juliet Iwelunmor, Derek M Griffith","doi":"10.1146/annurev-publhealth-060922-034822","DOIUrl":"10.1146/annurev-publhealth-060922-034822","url":null,"abstract":"<p><p>Implementation science focuses on enhancing the widespread uptake of evidence-based interventions into routine practice to improve population health. However, optimizing implementation science to promote health equity in domestic and global resource-limited settings requires considering historical and sociopolitical processes (e.g., colonization, structural racism) and centering in local sociocultural and indigenous cultures and values. This review weaves together principles of decolonization and antiracism to inform critical and reflexive perspectives on partnerships that incorporate a focus on implementation science, with the goal of making progress toward global health equity. From an implementation science perspective, wesynthesize examples of public health evidence-based interventions, strategies, and outcomes applied in global settings that are promising for health equity, alongside a critical examination of partnerships, context, and frameworks operationalized in these studies. We conclude with key future directions to optimize the application of implementation science with a justice orientation to promote global health equity.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Warning Labels as a Public Health Intervention: Effects and Challenges for Tobacco, Cannabis, and Opioid Medications. 警示标签作为一种公共卫生干预措施:烟草、大麻和阿片类药物的效果与挑战。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2024-05-01 Epub Date: 2024-04-03 DOI: 10.1146/annurev-publhealth-060922-042254
Lucy Popova, Zachary B Massey, Nicholas A Giordano
{"title":"Warning Labels as a Public Health Intervention: Effects and Challenges for Tobacco, Cannabis, and Opioid Medications.","authors":"Lucy Popova, Zachary B Massey, Nicholas A Giordano","doi":"10.1146/annurev-publhealth-060922-042254","DOIUrl":"10.1146/annurev-publhealth-060922-042254","url":null,"abstract":"<p><p>Warning labels help consumers understand product risks, enabling informed decisions. Since the 1966 introduction of cigarette warning labels in the United States, research has determined the most effective message content (health effects information) and format (brand-free packaging with pictures). However, new challenges have emerged. This article reviews the current state of tobacco warning labels in the United States, where legal battles have stalled pictorial cigarette warnings and new products such as electronic cigarettes and synthetic nicotine products pose unknown health risks. This article describes the emerging research on cannabis warnings; as more places legalize recreational cannabis, they are adopting lessons from tobacco warnings. However, its uncertain legal status and widespread underestimation of harms impede strict warning standards. The article also reviews opioid medication warning labels, suggesting that lessons from tobacco could help in the development of effective and culturally appropriate FDA-compliant opioid warning labels that promote safe medication use and increased co-dispensing of naloxone.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Climate Change, Landscape Fires, and Human Health: A Global Perspective. 气候变化、景观火灾与人类健康:全球视角。
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2024-05-01 Epub Date: 2024-04-03 DOI: 10.1146/annurev-publhealth-060222-034131
Fay H Johnston, Grant Williamson, Nicolas Borchers-Arriagada, Sarah B Henderson, David M J S Bowman
{"title":"Climate Change, Landscape Fires, and Human Health: A Global Perspective.","authors":"Fay H Johnston, Grant Williamson, Nicolas Borchers-Arriagada, Sarah B Henderson, David M J S Bowman","doi":"10.1146/annurev-publhealth-060222-034131","DOIUrl":"10.1146/annurev-publhealth-060222-034131","url":null,"abstract":"<p><p>Landscape fires are an integral component of the Earth system and a feature of prehistoric, subsistence, and industrial economies. Specific spatiotemporal patterns of landscape fire occur in different locations around the world, shaped by the interactions between environmental and human drivers of fire activity. Seven distinct types of landscape fire emerge from these interactions: remote area fires, wildfire disasters, savanna fires, Indigenous burning, prescribed burning, agricultural burning, and deforestation fires. All can have substantial impacts on human health and well-being directly and indirectly through (<i>a</i>) exposure to heat flux (e.g., injuries and destructive impacts), (<i>b</i>) emissions (e.g., smoke-related health impacts), and (<i>c</i>) altered ecosystem functioning (e.g., biodiversity, amenity, water quality, and climate impacts). Minimizing the adverse effects of landscape fires on population health requires understanding how human and environmental influences on fire impacts can be modified through interventions targeted at individual, community, and regional levels.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the Barrier: Unraveling the Mechanisms of Immunotherapy Resistance 超越障碍:揭示免疫疗法的抗药性机制
IF 29.7 1区 医学
Annual review of immunology Pub Date : 2024-02-21 DOI: 10.1146/annurev-immunol-101819-024752
Hannah N. Bell, Weiping Zou
{"title":"Beyond the Barrier: Unraveling the Mechanisms of Immunotherapy Resistance","authors":"Hannah N. Bell, Weiping Zou","doi":"10.1146/annurev-immunol-101819-024752","DOIUrl":"https://doi.org/10.1146/annurev-immunol-101819-024752","url":null,"abstract":"Immune checkpoint blockade (ICB) induces a remarkable and durable response in a subset of cancer patients. However, most patients exhibit either primary or acquired resistance to ICB. This resistance arises from a complex interplay of diverse dynamic mechanisms within the tumor microenvironment (TME). These mechanisms include genetic, epigenetic, and metabolic alterations that prevent T cell trafficking to the tumor site, induce immune cell dysfunction, interfere with antigen presentation, drive heightened expression of coinhibitory molecules, and promote tumor survival after immune attack. The TME worsens ICB resistance through the formation of immunosuppressive networks via immune inhibition, regulatory metabolites, and abnormal resource consumption. Finally, patient lifestyle factors, including obesity and microbiome composition, influence ICB resistance. Understanding the heterogeneity of cellular, molecular, and environmental factors contributing to ICB resistance is crucial to develop targeted therapeutic interventions that enhance the clinical response. This comprehensive overview highlights key mechanisms of ICB resistance that may be clinically translatable.Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":null,"pages":null},"PeriodicalIF":29.7,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139922780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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