Neuroimmunology of the Lung.

IF 26.9 1区 医学 Q1 IMMUNOLOGY
Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI:10.1146/annurev-immunol-083122-042512
Rossana Azzoni, Olaf Perdijk, Nicola L Harris, Benjamin J Marsland
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引用次数: 0

Abstract

Barrier tissues are highly innervated by sensory and autonomic nerves that are positioned in close proximity to both stromal and immune cell populations. Together with a growing awareness of the far-reaching consequences of neuroimmune interactions, recent studies have uncovered key mechanisms through which they contribute to organ homeostasis and immunity. It has also become clear that dysregulation of such interactions is implicated in the development of chronic lung diseases. This review describes the characteristics of the lung nervous system and discusses the molecular mechanisms that underlie lung neuroimmune interactions in infection and disease. We have contextualized the current literature and identified opportune areas for further investigation. Indeed, both the lung-brain axis and local neuroimmune interactions hold enormous potential for the exploration and development of novel therapeutic strategies targeting lung diseases.

肺中的神经免疫相互作用。
屏障组织由感觉神经和自主神经高度支配,这些神经位于基质细胞和免疫细胞群附近。随着人们越来越意识到神经免疫相互作用的深远影响,最近的研究揭示了它们有助于器官稳态和免疫的关键机制。同样清楚的是,这种相互作用的失调与慢性肺部疾病的发展有关。本文综述了肺神经系统的特点,并讨论了感染和疾病中肺神经免疫相互作用的分子机制。我们对当前文献进行了背景分析,并确定了进一步调查的合适领域。事实上,肺脑轴和局部神经免疫相互作用对于探索和开发针对肺部疾病的新治疗策略具有巨大的潜力。预计免疫学年度评论第42卷的最终在线出版日期为2024年4月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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