窥探T细胞受体信号传导的黑匣子。

IF 26.9 1区医学 Q1 IMMUNOLOGY

Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI:10.1146/annurev-immunol-090222-112028

Arthur Weiss

{"title":"窥探T细胞受体信号传导的黑匣子。","authors":"Arthur Weiss","doi":"10.1146/annurev-immunol-090222-112028","DOIUrl":null,"url":null,"abstract":"I have spent more than the last 40 years at the University of California, San Francisco (UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an exceptionally talented group of trainees, and wonderful collaborators and colleagues during my journey who have enabled me to make significant contributions to our understanding of how the TCR initiates signaling. TCR signaling events contribute to T cell development as well as to mature T cell activation and differentiation.","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"1-20"},"PeriodicalIF":26.9000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Peeking Into the Black Box of T Cell Receptor Signaling.\",\"authors\":\"Arthur Weiss\",\"doi\":\"10.1146/annurev-immunol-090222-112028\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"I have spent more than the last 40 years at the University of California, San Francisco (UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an exceptionally talented group of trainees, and wonderful collaborators and colleagues during my journey who have enabled me to make significant contributions to our understanding of how the TCR initiates signaling. TCR signaling events contribute to T cell development as well as to mature T cell activation and differentiation.\",\"PeriodicalId\":8271,\"journal\":{\"name\":\"Annual review of immunology\",\"volume\":\" \",\"pages\":\"1-20\"},\"PeriodicalIF\":26.9000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annual review of immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1146/annurev-immunol-090222-112028\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1146/annurev-immunol-090222-112028","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/14 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

在过去的40多年里，我一直在加州大学旧金山分校（UCSF）研究T细胞受体（TCR）信号传导。在我的旅程中，我有幸得到了支持我的导师、一群才华横溢的受训人员以及出色的合作者和同事，他们使我能够为我们理解TCR如何启动信号做出重大贡献。TCR信号传导事件有助于T细胞的发育以及成熟T细胞的活化和分化。《免疫学年度评论》第42卷预计最终在线出版日期为2024年4月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Peeking Into the Black Box of T Cell Receptor Signaling.

I have spent more than the last 40 years at the University of California, San Francisco (UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an exceptionally talented group of trainees, and wonderful collaborators and colleagues during my journey who have enabled me to make significant contributions to our understanding of how the TCR initiates signaling. TCR signaling events contribute to T cell development as well as to mature T cell activation and differentiation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Annual review of immunology 医学-免疫学

CiteScore

57.20

自引率

0.70%

发文量

期刊介绍： The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.