Ontogeny and Function of Plasmacytoid Dendritic Cells.

IF 26.9 1区 医学 Q1 IMMUNOLOGY
Nicholas M Adams, Annesa Das, Tae Jin Yun, Boris Reizis
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引用次数: 0

Abstract

Plasmacytoid dendritic cells (pDCs) represent a unique cell type within the innate immune system. Their defining property is the recognition of pathogen-derived nucleic acids through endosomal Toll-like receptors and the ensuing production of type I interferon and other soluble mediators, which orchestrate innate and adaptive responses. We review several aspects of pDC biology that have recently come to the fore. We discuss emerging questions regarding the lineage affiliation and origin of pDCs and argue that these cells constitute an integral part of the dendritic cell lineage. We emphasize the specific function of pDCs as innate sentinels of virus infection, particularly their recognition of and distinct response to virus-infected cells. This essential evolutionary role of pDCs has been particularly important for the control of coronaviruses, as demonstrated by the recent COVID-19 pandemic. Finally, we highlight the key contribution of pDCs to systemic lupus erythematosus, in which therapeutic targeting of pDCs is currently underway.

质体树突状细胞的本体和功能
类质体树突状细胞(pDCs)是先天性免疫系统中一种独特的细胞类型。它们的主要特性是通过内质体 Toll 样受体识别病原体衍生的核酸,并随之产生 I 型干扰素和其他可溶性介质,从而协调先天性和适应性反应。我们回顾了最近引人注目的 pDC 生物学的几个方面。我们讨论了有关 pDC 的系属和起源的新问题,并认为这些细胞构成了树突状细胞系的一个组成部分。我们强调了 pDCs 作为病毒感染先天哨兵的特殊功能,尤其是它们对病毒感染细胞的识别和独特反应。正如最近的 COVID-19 大流行所证明的那样,pDCs 的这种重要进化作用对于冠状病毒的控制尤为重要。最后,我们强调了 pDCs 对系统性红斑狼疮的关键贡献,目前针对 pDCs 的治疗正在进行中。
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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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