HIV感染控制者的免疫反应。

IF 26.9 1区医学 Q1 IMMUNOLOGY

Annual review of immunology Pub Date : 2024-06-01 Epub Date: 2024-06-14 DOI:10.1146/annurev-immunol-083122-035233

Abena K Kwaa, Joel N Blankson

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引用次数: 0

摘要

精英控制者是一组异质性的艾滋病毒感染者，他们在没有抗逆转录病毒治疗的情况下控制病毒复制。有大量证据表明，至少有一些精英控制者感染了具有复制能力的病毒，因此他们可能成为功能性治愈艾滋病毒的典范。负责病毒学控制的机制已得到积极研究。最客观的数据支持基于CD8+T细胞的控制机制，但由抗体和自然杀伤细胞介导的其他免疫反应也可能在控制病毒复制中发挥作用。在这篇文章中，我们回顾了这些杰出个体的不同免疫控制机制的证据。《免疫学年度评论》第42卷预计最终在线出版日期为2024年4月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Immune Responses in Controllers of HIV Infection.

Elite controllers are a heterogeneous group of people living with HIV who control viral replication without antiretroviral therapy. There is substantial evidence that at least some elite controllers are infected with replication-competent virus, thus they may serve as a model of a functional cure of HIV. The mechanisms responsible for virologic control have been actively studied. The most objective data support CD8+ T cell-based mechanisms of control, but other immune responses, mediated by antibodies and natural killer cells, may also play a role in controlling viral replication. In this article, we review the evidence for different mechanisms of immune control in these remarkable individuals.

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来源期刊

Annual review of immunology 医学-免疫学

CiteScore

57.20

自引率

0.70%

发文量

期刊介绍： The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.