The Multifaceted Role of Tissue-Resident Memory T Cells.

IF 26.9 1区 医学 Q1 IMMUNOLOGY
Susan N Christo, Simone L Park, Scott N Mueller, Laura K Mackay
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引用次数: 0

Abstract

Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in barrier tissues, where they enable efficient frontline defense against infections and cancer. However, the long-term persistence of these cells has been implicated in a variety of immune-mediated pathologies. Consequently, modulating TRM cell populations represents an attractive strategy for novel vaccination and therapeutic interventions against tissue-based diseases. Here, we provide an updated overview of TRM cell heterogeneity and function across tissues and disease states. We discuss mechanisms of TRM cell-mediated immune protection and their potential contributions to autoimmune disorders. Finally, we examine how TRM cell responses might be durably boosted or dampened for therapeutic gain.

组织驻留记忆 T 细胞的多重作用
区域化免疫监视依赖于各种记忆 T 细胞群的协同努力。其中,组织驻留记忆 T 细胞(TRM)被战略性地安置在屏障组织中,在那里它们能对感染和癌症进行有效的前线防御。然而,这些细胞的长期存在与多种免疫介导的病症有关。因此,调节 TRM 细胞群是针对基于组织的疾病进行新型疫苗接种和治疗干预的一种有吸引力的策略。在此,我们将对TRM细胞在不同组织和疾病状态下的异质性和功能进行最新概述。我们讨论了 TRM 细胞介导的免疫保护机制及其对自身免疫性疾病的潜在贡献。最后,我们探讨了如何持久增强或抑制 TRM 细胞的反应以获得治疗效果。
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来源期刊
Annual review of immunology
Annual review of immunology 医学-免疫学
CiteScore
57.20
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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