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引用次数: 0
摘要
免疫系统与肾脏密切相关。免疫成分介导急性肾脏疾病，对慢性肾脏疾病的进展至关重要。除了致病功能外，免疫系统还支持健康肾脏的免疫平衡。肾脏通过清除代谢废物和毒素来帮助维持免疫平衡，从而限制局部和全身炎症。在这篇综述中，我们将描述免疫系统与肾脏之间的密切关系。我们将讨论免疫反应失衡如何对肾脏造成损害，以及免疫调节如何在预防终末期肾病方面发挥重要作用。此外，硅学平台和肾脏有机体等最新工具有助于揭示免疫细胞与肾脏稳态之间的关系。免疫学年刊》（Annual Review of Immunology）第42卷的最终在线出版日期预计为2024年4月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
The immune system and the kidneys are closely related. Immune components mediate acute kidney disease and are crucial to the progression of chronic kidney disease. Beyond its pathogenic functions, the immune system supports immunological homeostasis in healthy kidneys. The kidneys help maintain immune equilibrium by removing metabolic waste products and toxins, thereby limiting local and systemic inflammation. In this review, we describe the close relationship between the immune system and the kidneys. We discuss how the imbalance in the immune response can be deleterious to the kidneys and how immunomodulation can be important in preventing end-stage renal disease. In addition, recent tools such as in silico platforms and kidney organoids can help unveil the relationship between immune cells and kidney homeostasis.
期刊介绍：
The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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