Ming O Li, Jing Zhang, Zijian Xu, Xian Zhang, Peng Li, Andrew E Cornish
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引用次数: 0
Abstract
Lymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and constitute an integral component of the local defense network against immunological challenges. In tight interactions with the epithelium and endothelium, tissue-resident lymphocytes sense antigens and alarmins elicited by infectious microbes and abiotic stresses at barrier sites and mount effector responses to restore tissue homeostasis. Of note, such a host cell-directed immune defense system has been recently demonstrated to surveil epithelial cell transformation and carcinoma development, as well as cancer cell metastasis at selected distant organs, and thus represents a primordial cancer immune defense module. Here we review how distinct lineages of tissue-resident innate lymphoid cells, innate-like T cells, and adaptive T cells participate in a form of multilayered cancer immunity in murine models and patients, and how their convergent effector programs may be targeted through both shared and private regulatory pathways for cancer immunotherapy.
跨越整个先天适应谱系的淋巴细胞可以稳定地驻留在组织中,并构成局部防御网络的一个组成部分,抵御免疫挑战。在与上皮细胞和内皮细胞的紧密互动中,组织驻留的淋巴细胞能感知屏障部位由传染性微生物和非生物压力引起的抗原和警报素,并启动效应反应以恢复组织的平衡。值得注意的是,这种由宿主细胞引导的免疫防御系统最近已被证实能监测上皮细胞转化和癌变发展,以及癌细胞在选定远处器官的转移,因此代表了一种原始的癌症免疫防御模块。在这里,我们回顾了组织驻留型先天性淋巴细胞、先天性类 T 细胞和适应性 T 细胞的不同品系是如何参与小鼠模型和患者的多层癌症免疫的,以及它们趋同的效应程序是如何通过共享和私有的调控途径成为癌症免疫疗法的靶点的。免疫学年刊》(Annual Review of Immunology)第 42 卷的最终在线出版日期预计为 2024 年 4 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
期刊介绍:
The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.