Endocrine research communications最新文献_第7页

Tetrahydro-beta-carbolines elevate plasma prolactin in male rats. 四氢- β -碳水化合物提高雄性大鼠血浆催乳素。

Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065974

N S Buckholtz, J G Ondo

引用次数: 4

Epididymal androgen binding protein in protein-calorie malnourished rats. 蛋白质热量营养不良大鼠附睾雄激素结合蛋白的研究。

Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065959

D C Herbert, D J Tindall

引用次数: 4

Effects of estrogen on luteinizing hormone releasing hormone in a hypothalamic synaptosomal fraction from the ovariectomized rat. 雌激素对去卵巢大鼠下丘脑突触体中促黄体生成素释放激素的影响。

Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065957

M Tytell, J H Clark, E J Peck

{"title":"Effects of estrogen on luteinizing hormone releasing hormone in a hypothalamic synaptosomal fraction from the ovariectomized rat.","authors":"M Tytell, J H Clark, E J Peck","doi":"10.3109/07435808009065957","DOIUrl":"https://doi.org/10.3109/07435808009065957","url":null,"abstract":"Previous investigations have shown that hypothalamic luteinizing hormone releasing hormone (LHRH) is localized within a subcellular fraction eqivalent or similar to the synaptosome or nerve ending particle. In the present study, the ovariectomized adult rat was employed to investigate the effects of estrogen on the distribution of LHRH among various subcellular fractions of the hypothalamus. In addition, the liberation of LHRH from a synaptosomal fraction by repeated freeze-thaw cycles was examined before and after in vivo estrogen treatment. Following a single injection of 5 micrograms of estradiol benzoate (EB), the LHRH concentration of the synaptosomal fraction rose as much as 100% in 27 h. Increasing the dose of EB to 50 micrograms shortened the latency of the rise and prolonged its duration, but did not alter its magnitude compared to the lower dose. Furthermore, the LHRH in that synaptosomal fraction was significantly more resistant to solubilization by repetitive freezing and thawing than the LHRH in a synaptosomal fraction from rats which had not received EB. These observations led us to conclude that estrogens can alter the physical properties of the hypothalamic LHRH-containing particles or the storage form of the peptide within those particles so that it is less easily released. This phenomenon may represent one aspect of the regulatory effects of estrogens on hypothalamic LHRH secretion.","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 1","pages":"27-44"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808009065957","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18037684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Elevation of serum prolactin acutely after administration of p-chloroamphetamine in rats. 大鼠给予对氯苯丙胺后血清催乳素的急剧升高。

Endocrine research communications Pub Date : 1980-01-01 DOI: 10.1080/07435808009065961

R W Fuller, H D Snoddy, J A Clemens

引用次数: 6

Activation of bovine renal cortex membrane adenylyl cyclase by low concentrations of parathyroid hormone. 低浓度甲状旁腺激素对牛肾皮质膜腺苷酸环化酶的激活作用。

Endocrine research communications Pub Date : 1980-01-01 DOI: 10.1080/07435808009065962

E B Heath, J E Zull

引用次数: 7

Effect of endogenous TSH on the in vitro responsiveness and binding of TSH in rat thyroid tissue. 内源性TSH对大鼠甲状腺组织体外反应性和TSH结合的影响。

Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065973

S D Holmes, J B Field

{"title":"Effect of endogenous TSH on the in vitro responsiveness and binding of TSH in rat thyroid tissue.","authors":"S D Holmes, J B Field","doi":"10.3109/07435808009065973","DOIUrl":"https://doi.org/10.3109/07435808009065973","url":null,"abstract":"These studies examined the effect of deficient endogenous TSH (hypophysectomy) on in vitro TSH responsiveness and binding in rat thyroid tissue. The results showed that thyroid from hypophysectomized rats were hyper-responsive to stimulation of cyclic AMP by TSH while PGE1 stimulation of cyclic AMP was similar in hypophysectomized rats compared to controls. When iodide organification was measured, the TSH and dibutyryl cyclic AMP stimulation in hypophysectomized rats was equivalent to the response of control animals. Binding studies demonstrated there was an increased number of TSH receptors in the thyroid from hypophysectomized rats compared to the control group. The affinity constant was unchanged. The results demonstrate that endogenous TSH appears to inversely regulate the responsiveness and number of TSH receptors in thyroid tissue. The effect of an i.v. injection of TSH on the levels of cyclic AMP and binding characteristics of TSH was also examined. Although cyclic AMP levels were significantly increased after a 10 min in vitro incubation of the lobes from TSH-injected rats as an indication of persistently bound TSH, the number of TSH binding sites was the same in the saline the TSH-injected animals.","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 4","pages":"205-19"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808009065973","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17322234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

CAMP-dissociation kinetics in hormone-dependent and -independent rat mammary tumor cytosols. 激素依赖性和非依赖性大鼠乳腺肿瘤细胞质中camp解离动力学。

Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065977

F Y Tang, K Skerrett, D Heiman, N Ballatori

{"title":"CAMP-dissociation kinetics in hormone-dependent and -independent rat mammary tumor cytosols.","authors":"F Y Tang, K Skerrett, D Heiman, N Ballatori","doi":"10.3109/07435808009065977","DOIUrl":"https://doi.org/10.3109/07435808009065977","url":null,"abstract":"Cytosols from 7, 12-dimethylbenz (alpha) anthracene-induced rat mammary tumors which exhibit different hormone-responsiveness were compared with respect to their cAMP-dissociation kinetics. At 22 degree C, pH 4.5, 1 micrometer cAMP, hormone-dependent mammary tumors exhibited monophasic dissociation rates with a rate constant of k-1 = 0.06 min-1. In contrast, hormone-independent mammary tumors exhibited biphasic dissociation curves with rate constants of k-1 = 0.47 and k-2 = 0.06 min-1. The binding of cAMP was completely reversible; radio-labeled ligand was completely dissociated by 1mM nonradioactive cAMP; the binding protein could be reassociated to its original binding level after dextran-coated charcoal adsorption. The mammary cytosols exhibited specific binding for cAMP which could be displaced partially by cGMP but not by ATP, ADP, AMP, or adenosine. Receptor inactivation during the course of incubation was negligible. Both mammary tissue cytosols exhibited similar association rates at 22 degree C, pH 4.5, 1 micrometer cAMP (k+1 = 5-7 x 10(5)M-1 min-1). These data indicate that mammary tissues exhibit 2 cAMP dissociation rates. Hormone-dependent mammary tumors exhibit a dissociation constant of a high affinity binding site (k-1/k+1 = 0.07 micrometer) whereas hormone-independent mammary tumors exhibit dissociation constants of one high affinity (k-1/k+1 = 0.07 micrometer) and a second low affinity site (k-1/k+1 = 0.05 micrometer).","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 4","pages":"253-67"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808009065977","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17322235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Depression of leucine and isoproterenol induced insulin secretions in the spontaneously diabetic New Zealand white rabbit. 亮氨酸和异丙肾上腺素对自发性糖尿病新西兰大白兔胰岛素分泌的抑制作用。

Endocrine research communications Pub Date : 1980-01-01 DOI: 10.1080/07435808009065966

R L Taylor, H H Conaway, S I Roth

引用次数: 4

Enhanced hepatic chromatin protein methylation induced by triiodothyronine treatment of the rat. 三碘甲状腺原氨酸诱导大鼠肝染色质蛋白甲基化增强。

Endocrine research communications Pub Date : 1980-01-01 DOI: 10.1080/07435808009065965

J Short, L Kibert

引用次数: 2

Measurement of urinary production rates of melatonin as an index of human pineal function. 尿中褪黑素产生率的测量作为人类松果体功能的指标。

Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065970

A J Fellenberg, G Phillipou, R F Seamark

引用次数: 38