大鼠给予对氯苯丙胺后血清催乳素的急剧升高。

Endocrine research communications Pub Date : 1980-01-01 DOI:10.1080/07435808009065961

R W Fuller, H D Snoddy, J A Clemens

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引用次数: 6

摘要

对氯苯丙胺(0.5-10 mg/kg, 1次)使雄性大鼠血清催乳素浓度迅速(30分钟内)呈剂量相关性升高。对氯苯丙氨酸(5 -羟色胺合成抑制剂)或美高林(5 -羟色胺受体拮抗剂)预处理可拮抗该效应。血清催乳素的急性升高可能是由对氯苯丙胺释放血清素介导的。

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Elevation of serum prolactin acutely after administration of p-chloroamphetamine in rats.

p-Chloroamphetamine hydrochloride (0.5-10 mg/kg, i.p.) caused a rapid (within 30 minutes), dose-related increase in serum prolactin concentration in male rats. The effect was antagonized by pretreatment with p-chlorophenylalanine, an inhibitor of serotonin synethesis, or by metergoline, a serotonin receptor antagonist. The acute elevation of serum prolactin may have been mediated by the release of serotonin by p-chloroamphetamine.

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Endocrine research communications

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