Endocrine research communications最新文献

Evidence for cellular mediated immunity in an animal model of autoimmune pituitary disease. 自身免疫性垂体疾病动物模型中细胞介导免疫的证据

Endocrine research communications Pub Date : 1982-01-01 DOI: 10.1080/07435808209045760

I Klein, K E Kraus, A J Martines, S Weber

引用次数: 23

Activation and transport of fatty acids in ovarian mitochondria: effect of Lh. 脂肪酸在卵巢线粒体中的活化和转运:Lh的作用。

Endocrine research communications Pub Date : 1982-01-01 DOI: 10.1080/07435808209045748

C H Tan, J Robinson

{"title":"Activation and transport of fatty acids in ovarian mitochondria: effect of Lh.","authors":"C H Tan, J Robinson","doi":"10.1080/07435808209045748","DOIUrl":"https://doi.org/10.1080/07435808209045748","url":null,"abstract":"Enzymes of fatty acid activation and transport were studied in luteinized rat ovaries. Luteal mitochondria were found to contain high levels of palmitoyl-CoA synthetase and carnitine palmitoyl-transferase activities. In addition, studies on the effect of palmitate concentration on palmitoyl-CoA synthetase activity revealed the possible existence of two forms of the enzyme: Km values of 0.34 mM and 21.33 mM, with Vmax of 3.64 and 66.67 nmoles/min/mg mitochondrial protein respectively, were obtained for the two activities. Similar kinetic data for carnitine palmitoyl-transferase activity in intact mitochondria are a Km of 21 microM and a Vmax of 18.2 nmoles/min/mg mitochondrial protein. Only one activity of this enzyme could be detected in luteal mitochondria. It appears that the activities of both enzymes were not affected by prior administration of LH in vivo. The possibility that this negative finding was due to the experimental procedures employed, rather than a reflection of the situation in vivo, could not be discounted, although its more likely that these two enzymes are probably not locus of LH stimulation. The results indicate that fatty acid oxidation is an important metabolic capability of luteal mitochondria, and support the view regarding the lipid nature of the respiratory fuel of ovarian tissue.","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"9 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435808209045748","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17276599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Stimulation by calcium and other cations of the cholesterol binding to steroid-free cytochrome P-450scc purified from bovine adrenocortical mitochondria: the implication of ACTH-mediated calcium homeostasis on the cholesterol availability. 钙和其他阳离子刺激胆固醇与从牛肾上腺皮质线粒体纯化的无类固醇细胞色素P-450scc结合:acth介导的钙稳态对胆固醇可用性的影响

Endocrine research communications Pub Date : 1982-01-01 DOI: 10.1080/07435808209045749

T Kido, T Kimura

引用次数: 7

The effect of prolactin on the Dunning R3327H rat prostatic adenocarcinoma. 催乳素对Dunning R3327H大鼠前列腺癌的影响。

Endocrine research communications Pub Date : 1982-01-01 DOI: 10.3109/07435808209045766

A Kharroubi, W R Slaunwhite

引用次数: 3

Relationship of phosphate administration to serum and red cell phosphate concentration, erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and blood P50 in the hyperglycemic dog. 磷酸给药对高血糖犬血清和红细胞磷酸浓度、红细胞2,3-二磷酸甘油酸(2,3- dpg)和血P50的关系。

Endocrine research communications Pub Date : 1982-01-01 DOI: 10.3109/07435808209045765

K M Mylotte, N H Otten, P J Davis, L Edwards

{"title":"Relationship of phosphate administration to serum and red cell phosphate concentration, erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and blood P50 in the hyperglycemic dog.","authors":"K M Mylotte, N H Otten, P J Davis, L Edwards","doi":"10.3109/07435808209045765","DOIUrl":"https://doi.org/10.3109/07435808209045765","url":null,"abstract":"In vitro studies indicate that acute increases in intracellular phosphate concentration decrease red blood cell 2,3-diphosphoglycerate levels (G. Momsen, B. Vestergaard-Bogind, Arch Biochem Biophys 190:67, 1978). We have examined the relationship in vivo of serum phosphate concentration, red cell phosphate, 2,3-DPG and blood P50 in hyperglycemic dogs infused alternately with phosphate or chloride (control) solutions. During the 8-hr insulin infusion, serum phosphate (Pi) fell 40% in the chloride-treated animals and rose 71% in the phosphate-treated dogs (P less than 0.001, phosphate vs. control). RBC Pi concentration declined in the controls and rose significantly in the phosphate-infused dogs (P less than 0.02). Serum Pi and RBC Pi were correlated in the phosphate-managed animals (r = 0.76, P less than 0.02), but not in the controls. RBC 2,3-DPG failed to rise in either group during insulin infusion and regression analysis showed a negative correlation between serum Pi and 2,3-DPG (r = -0.90, P less than 0.005) and between RBC Pi concentration and 2,3-DPG (r = -0.84, P less than 0.02). P50 failed to change in either group during insulin treatment and for up to 24 hr after initiation of the 8-hr infusion of insulin.","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"9 3-4","pages":"195-216"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808209045765","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17817079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Conformational effects of ether bridge substitution in thyroid hormone analogues. 乙醚桥取代对甲状腺激素类似物构象的影响。

Endocrine research communications Pub Date : 1982-01-01 DOI: 10.1080/07435808209045753

V Cody

引用次数: 1

The biological half-life of human growth hormone and a biologically active 20,000-dalton variant in mouse blood. 人类生长激素的生物半衰期和小鼠血液中具有20,000道尔顿生物活性的变体。

Endocrine research communications Pub Date : 1982-01-01 DOI: 10.1080/07435808209045754

M B Sigel, W P VanderLaan, M S Kobrin, E F VanderLaan, N A Thorpe

引用次数: 10

Red blood cell insulin binding studies in Reye's syndrome survivors and families. 雷氏综合症幸存者及其家属的红细胞胰岛素结合研究。

Endocrine research communications Pub Date : 1982-01-01 DOI: 10.1080/07435808209045758

E S Kang, S S Solomon, R E Gates, S J Schaeffer

{"title":"Red blood cell insulin binding studies in Reye's syndrome survivors and families.","authors":"E S Kang, S S Solomon, R E Gates, S J Schaeffer","doi":"10.1080/07435808209045758","DOIUrl":"https://doi.org/10.1080/07435808209045758","url":null,"abstract":"RBC insulin binding was examined in Reye's survivors and families of affected patients to determine whether their previously reported hyperinsulinemic responses to oral glucose are accompanied by alterations in insulin binding and could contribute to the hypercatabolism seen in this disorder. The mean (125I)-insulin binding to 3 X 10(9) RBC's was 5.7 +/- SEM 0.4 percent in survivors compared to 6.6 +/- 0.3 in siblings (p less than .05) and 6.6 +/- 0.4 in control children (p = .05). Sex and maturity differences were found with higher binding values in men than women as well as higher values in men than boys. Receptor numbers in survivors were comparable to control values. Average affinities varied widely. Plasma insulin levels were low in the fathers (9 +/- SEM 1.4 uU/ml compared to 18.3 +/- 1.8 for control men and 20 +/- 4.5 for mothers of affected patients). The acute syndrome is accompanied by hypercatabolism in the presence of increased plasma insulin levels and familial clustering of cases and recurrences are known to occur. Reduction in insulin binding may play a role in the acute disease if such is shared by more traditionally hormone-responsive cells.","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"9 2","pages":"121-33"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435808209045758","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17813963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Acute effects of a "physiological" dose of 1,25-dihydroxy vitamin D3 on renal phosphate transport. “生理”剂量的1,25-二羟基维生素D3对肾磷酸盐运输的急性影响。

Endocrine research communications Pub Date : 1982-01-01 DOI: 10.1080/07435808209045759

H Georgaki, J B Puschett

引用次数: 20

Renin-angiotensin-aldosterone system in hyper- and hypothyroid rats during sodium depletion. 钠耗竭时甲状腺功能亢进和减退大鼠肾素-血管紧张素-醛固酮系统的变化。

Endocrine research communications Pub Date : 1982-01-01 DOI: 10.3109/07435808209045768

M Montiel, E Jiménez, J A Narváez, M Morell

{"title":"Renin-angiotensin-aldosterone system in hyper- and hypothyroid rats during sodium depletion.","authors":"M Montiel, E Jiménez, J A Narváez, M Morell","doi":"10.3109/07435808209045768","DOIUrl":"https://doi.org/10.3109/07435808209045768","url":null,"abstract":"A study was made of the responses of the renin-angiotensin-aldosterone system (RAAS) produced in hyper- and hypothyroid rats maintained in a state of sodium depletion, as part of a wider study to effect a comparison with results previously obtained for the same parameters in rats maintained on a normal sodium diet and during experimental alterations of thyroid function. In hyperthyroid rats maintained on sodium deficient and normal sodium diet, and in euthyroid animals on a sodium deficient regimen, elevations of both plasma renin concentration (PRC) and serum aldosterone concentration (AC) were observed, while the plasma renin substrate (PRS) was decreased. In hypothyroid rats with normal sodium intake, PRC and AC were observed to be decreased relative to similar sodium-deficient animals. Relationships were observed between PRC and AC, and between AC and urinary sodium excretion. These results suggest that: i) Sodium depletion is a more effective stimulus than the thyroid hormones on the RAAS. ii) Aldosterone changes in sodium depletion are mediated by the RAS. iii) Sodium depletion appeared to induce a decrease in the hepatic synthesis of angiotensinogen.","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"9 3-4","pages":"249-60"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808209045768","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18202560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5