The biological half-life of human growth hormone and a biologically active 20,000-dalton variant in mouse blood.

M B Sigel, W P VanderLaan, M S Kobrin, E F VanderLaan, N A Thorpe
{"title":"The biological half-life of human growth hormone and a biologically active 20,000-dalton variant in mouse blood.","authors":"M B Sigel,&nbsp;W P VanderLaan,&nbsp;M S Kobrin,&nbsp;E F VanderLaan,&nbsp;N A Thorpe","doi":"10.1080/07435808209045754","DOIUrl":null,"url":null,"abstract":"<p><p>We compared the disappearance rate of hGH and hGH20K injected into groups of mice. Radioactivity measurements and RIA were used to determine the amount of hormone in blood collected at various times after injection. The results indicate that the T1/2 value for hGH and hGH20K are equal. We conclude that there is no apparent relationship between the equal rates of disappearance, the dissimilar binding characteristics that have been shown for the hormones and their equipotent growth promoting activities.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":" ","pages":"67-77"},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435808209045754","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/07435808209045754","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10

Abstract

We compared the disappearance rate of hGH and hGH20K injected into groups of mice. Radioactivity measurements and RIA were used to determine the amount of hormone in blood collected at various times after injection. The results indicate that the T1/2 value for hGH and hGH20K are equal. We conclude that there is no apparent relationship between the equal rates of disappearance, the dissimilar binding characteristics that have been shown for the hormones and their equipotent growth promoting activities.

人类生长激素的生物半衰期和小鼠血液中具有20,000道尔顿生物活性的变体。
比较各组小鼠注射hGH和hGH20K的消失率。使用放射性测量和RIA测定注射后不同时间采集的血液中激素的量。结果表明,hGH和hGH20K的T1/2值相等。我们得出的结论是,在相同的消失率之间没有明显的关系,不同的结合特征已经显示出激素和它们的等效生长促进活动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信