{"title":"钙和其他阳离子刺激胆固醇与从牛肾上腺皮质线粒体纯化的无类固醇细胞色素P-450scc结合:acth介导的钙稳态对胆固醇可用性的影响","authors":"T Kido, T Kimura","doi":"10.1080/07435808209045749","DOIUrl":null,"url":null,"abstract":"<p><p>By utilizing purified cytochrome P-450scc from bovine adrenocortical mitochondria and cholesterol-containing dioleoylglycerophosphocholine liposomes, we have demonstrated a dramatic stimulation (2-3 fold) of cholesterol binding to the steroid-free cytochrome by Ca++. We theorize that ACTH modulates the increase of intracellular Ca++ concentration resulting in the increase of the cholesterol availability to the mitochondrial cytochrome.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"9 1","pages":"9-24"},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435808209045749","citationCount":"7","resultStr":"{\"title\":\"Stimulation by calcium and other cations of the cholesterol binding to steroid-free cytochrome P-450scc purified from bovine adrenocortical mitochondria: the implication of ACTH-mediated calcium homeostasis on the cholesterol availability.\",\"authors\":\"T Kido, T Kimura\",\"doi\":\"10.1080/07435808209045749\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>By utilizing purified cytochrome P-450scc from bovine adrenocortical mitochondria and cholesterol-containing dioleoylglycerophosphocholine liposomes, we have demonstrated a dramatic stimulation (2-3 fold) of cholesterol binding to the steroid-free cytochrome by Ca++. We theorize that ACTH modulates the increase of intracellular Ca++ concentration resulting in the increase of the cholesterol availability to the mitochondrial cytochrome.</p>\",\"PeriodicalId\":75821,\"journal\":{\"name\":\"Endocrine research communications\",\"volume\":\"9 1\",\"pages\":\"9-24\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/07435808209045749\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/07435808209045749\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/07435808209045749","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Stimulation by calcium and other cations of the cholesterol binding to steroid-free cytochrome P-450scc purified from bovine adrenocortical mitochondria: the implication of ACTH-mediated calcium homeostasis on the cholesterol availability.
By utilizing purified cytochrome P-450scc from bovine adrenocortical mitochondria and cholesterol-containing dioleoylglycerophosphocholine liposomes, we have demonstrated a dramatic stimulation (2-3 fold) of cholesterol binding to the steroid-free cytochrome by Ca++. We theorize that ACTH modulates the increase of intracellular Ca++ concentration resulting in the increase of the cholesterol availability to the mitochondrial cytochrome.
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