亮氨酸和异丙肾上腺素对自发性糖尿病新西兰大白兔胰岛素分泌的抑制作用。

R L Taylor, H H Conaway, S I Roth
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引用次数: 4

摘要

研究对象是一个封闭的NZW兔群,自发性糖尿病发生率为19%。对6只糖尿病家兔和8只葡萄糖处理正常的家兔进行静脉葡萄糖灌胃(500 mg/kg)、l -亮氨酸灌胃(125 mg/kg)和异丙肾上腺素(10微克/kg/min)输注30分钟的试验。与在正常葡萄糖处理的兔群中观察到的高度显著的IRI反应相比,这些药物在明显的糖尿病组中被证明是无效的胰岛素分泌剂。这些数据表明,自发性糖尿病NZW家兔IRI分泌缺陷并不局限于葡萄糖刺激,而是一种异常的IRI释放机制,似乎缺乏促分泌特异性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Depression of leucine and isoproterenol induced insulin secretions in the spontaneously diabetic New Zealand white rabbit.

Rabbits were studied from a closed colony of NZW rabbits which exhibits a 19% occurrance of spontaneous diabetes mellitus. Six overtly diabetic rabbits and eight rabbits with normal glucose disposal were tested with intravenous glucose challenge (500 mg/kg), L-leucine administration (125 mg/kg), and 30 minute infusions with isoproterenol (10 microgram/kg/min.). These agents were shown to be ineffective insulin secretogogues in the overtly diabetic group when compared to the highly significant IRI response observed in colony rabbits with normal glucose disposal. The data indicate that the defect in IRI secretion observed in the spontaneously diabetic NZW rabbits is not confined to stimulation by glucose, but represents an abnormal IRI release mechanism which appears to lack secretogogue specificity.

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