尿中褪黑素产生率的测量作为人类松果体功能的指标。

A J Fellenberg, G Phillipou, R F Seamark
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引用次数: 38

摘要

通过测量氘标记的褪黑素作为同位素示踪剂加入6-羟基硫酸褪黑素后,两名男性受试者的尿褪黑素产生率约为每24小时30微克。由于示踪剂对内源性褪黑激素分泌没有明显的药理作用,计算的生成速率不受剂量或给药时间的影响。因此,我们得出结论,使用氘标记的褪黑激素与定量气相色谱-质谱联用提供了一种实用的程序,可以提供人体褪黑激素生产的临床有用指数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Measurement of urinary production rates of melatonin as an index of human pineal function.

The urinary production rate of melatonin has been estimated for two male subjects at approximately 30 micrograms per 24 h by measurement of the specific incorporation of deuterium label into 6-hydroxy melatonin sulphate following administration of deuterium-labelled melatonin as an isotopic tracer. No pharmacological effect due to the tracer was apparent on endogenous melatonin secretion and the production rates calculated were unaffected by either dosage or time of administration. It is, therefore, concluded that the use of deuterium-labelled melatonin coupled with quantitative gas chromatography-mass spectrometry offers a practical procedure for providing a clinically useful index of melatonin production in man.

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