{"title":"尿中褪黑素产生率的测量作为人类松果体功能的指标。","authors":"A J Fellenberg, G Phillipou, R F Seamark","doi":"10.3109/07435808009065970","DOIUrl":null,"url":null,"abstract":"<p><p>The urinary production rate of melatonin has been estimated for two male subjects at approximately 30 micrograms per 24 h by measurement of the specific incorporation of deuterium label into 6-hydroxy melatonin sulphate following administration of deuterium-labelled melatonin as an isotopic tracer. No pharmacological effect due to the tracer was apparent on endogenous melatonin secretion and the production rates calculated were unaffected by either dosage or time of administration. It is, therefore, concluded that the use of deuterium-labelled melatonin coupled with quantitative gas chromatography-mass spectrometry offers a practical procedure for providing a clinically useful index of melatonin production in man.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 3","pages":"167-75"},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808009065970","citationCount":"38","resultStr":"{\"title\":\"Measurement of urinary production rates of melatonin as an index of human pineal function.\",\"authors\":\"A J Fellenberg, G Phillipou, R F Seamark\",\"doi\":\"10.3109/07435808009065970\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The urinary production rate of melatonin has been estimated for two male subjects at approximately 30 micrograms per 24 h by measurement of the specific incorporation of deuterium label into 6-hydroxy melatonin sulphate following administration of deuterium-labelled melatonin as an isotopic tracer. No pharmacological effect due to the tracer was apparent on endogenous melatonin secretion and the production rates calculated were unaffected by either dosage or time of administration. It is, therefore, concluded that the use of deuterium-labelled melatonin coupled with quantitative gas chromatography-mass spectrometry offers a practical procedure for providing a clinically useful index of melatonin production in man.</p>\",\"PeriodicalId\":75821,\"journal\":{\"name\":\"Endocrine research communications\",\"volume\":\"7 3\",\"pages\":\"167-75\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1980-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/07435808009065970\",\"citationCount\":\"38\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3109/07435808009065970\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/07435808009065970","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Measurement of urinary production rates of melatonin as an index of human pineal function.
The urinary production rate of melatonin has been estimated for two male subjects at approximately 30 micrograms per 24 h by measurement of the specific incorporation of deuterium label into 6-hydroxy melatonin sulphate following administration of deuterium-labelled melatonin as an isotopic tracer. No pharmacological effect due to the tracer was apparent on endogenous melatonin secretion and the production rates calculated were unaffected by either dosage or time of administration. It is, therefore, concluded that the use of deuterium-labelled melatonin coupled with quantitative gas chromatography-mass spectrometry offers a practical procedure for providing a clinically useful index of melatonin production in man.