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Endocrine research communications最新文献

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Hypothalamic amenorrhea in runners of normal body composition. 身体成分正常的跑步者的下丘脑闭经。
Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065956
J W McArthur, B A Bullen, I Z Beitins, M Pagano, T M Badger, A Klibanski
{"title":"Hypothalamic amenorrhea in runners of normal body composition.","authors":"J W McArthur,&nbsp;B A Bullen,&nbsp;I Z Beitins,&nbsp;M Pagano,&nbsp;T M Badger,&nbsp;A Klibanski","doi":"10.3109/07435808009065956","DOIUrl":"https://doi.org/10.3109/07435808009065956","url":null,"abstract":"<p><p>Three amenorrheic runners of normal body weight, in whom organic disease had been excluded, were found to exhibit: (1) normal body composition, (2) low baseline concentrations of serum LH and normal concentrations of FSH, (3) normal to hyper-responsiveness of LH and FSH to GnRH testing, and (4) normal and possibly increased frequency of LH pulsations. In one of the 3 runners, the administration of naloxone was followed by a pronounced increase in the amplitude of the LH pulsations.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 1","pages":"13-25"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808009065956","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17820173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 93
Nerve growth factor and pancreatic APUD cells. 神经生长因子与胰腺APUD细胞。
Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065960
G C Weir, S Bonner-Weir, D C Edwards
{"title":"Nerve growth factor and pancreatic APUD cells.","authors":"G C Weir,&nbsp;S Bonner-Weir,&nbsp;D C Edwards","doi":"10.3109/07435808009065960","DOIUrl":"https://doi.org/10.3109/07435808009065960","url":null,"abstract":"<p><p>Pancreatic endocrine cells have been considered APUD cells and been thought to be of neural crest origin. Neonatal rats were passively immunized with nerve growth factor antiserum and the development of neural crest derived superior cervical ganglia was markedly inhibited. The pancreatic content of glucagon, insulin, and somatostatin was unaffected, suggesting that pancreatic A,B, and D cells are under different developmental control than are cells of known neural crest origin.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 1","pages":"71-5"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808009065960","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17170143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence for central nervous system (CNS) involvement in inhibition of luteinizing hormone (LH) release by dopamine receptor stimulation. 中枢神经系统(CNS)参与多巴胺受体刺激抑制黄体生成素(LH)释放的证据。
Endocrine research communications Pub Date : 1980-01-01 DOI: 10.1080/07435808009065963
R E Owens, J L Fleeger, P G Harms
{"title":"Evidence for central nervous system (CNS) involvement in inhibition of luteinizing hormone (LH) release by dopamine receptor stimulation.","authors":"R E Owens,&nbsp;J L Fleeger,&nbsp;P G Harms","doi":"10.1080/07435808009065963","DOIUrl":"https://doi.org/10.1080/07435808009065963","url":null,"abstract":"<p><p>A pharmacologic study using 2-Br-alpha-ergocryptine (CB-154), a dopamine (DA) receptor agonist, the pimozide, a specific DA receptor antagonist, was undertaken to evaluate effects of manipulation of the DA system on plasma LH levels and on the ability of the pituitary to release LH following LHRH stimulation. Intraveneous administration of CB-154 lowered plasma LH levels in ovariectomized rats. Prior treatment with pimozide blocked the effect of CB-154, supporting dopaminergic system mediation in the observed response. Inhibition of LH release by pharmacologic stimulation of DA receptors did not appear to occur at the level of the pituitary, as pituitary release of LH following LHRH was not altered in CB-154 treated rats.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 2","pages":"99-105"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435808009065963","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18045848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Local antifertility effect of luteinizing hormone-releasing hormone (LRH) in the rat: mechanism of action. 黄体生成素释放激素(LRH)在大鼠体内的局部抗生育作用:作用机制。
Endocrine research communications Pub Date : 1980-01-01 DOI: 10.1080/07435808009065964
R C Jones
{"title":"Local antifertility effect of luteinizing hormone-releasing hormone (LRH) in the rat: mechanism of action.","authors":"R C Jones","doi":"10.1080/07435808009065964","DOIUrl":"https://doi.org/10.1080/07435808009065964","url":null,"abstract":"<p><p>The administration of luteinizing hormone-releasing hormone (LRH) into one horn of the uterus at 0900 h on D5 of pregnancy produces a 96% reduction in the number of zona-encased blastocysts recovered between 0915 and 1300 h on D5. The number of blastocysts recovered within this time period also decreased; only one blastocyst was recovered from the LRH-treated horn at 1300 h while 26 were flushed from the horns injected with saline. The results of this study suggest that LRH causes a premature disassociation of the zona from the blasocyst allowing early adherence to the uterine wall. This asynchronous attachment results in disruption of the ensuing pregnancy.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 2","pages":"107-12"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435808009065964","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18045993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Effect of testosterone on the androgen receptor in the liver cytosol and nuclei of castrated male rats. 睾酮对去势雄性大鼠肝细胞质及细胞核雄激素受体的影响。
Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065976
N Sato, S Takahashi, M Ota
{"title":"Effect of testosterone on the androgen receptor in the liver cytosol and nuclei of castrated male rats.","authors":"N Sato,&nbsp;S Takahashi,&nbsp;M Ota","doi":"10.3109/07435808009065976","DOIUrl":"https://doi.org/10.3109/07435808009065976","url":null,"abstract":"<p><p>The androgen-binding sites in the cytosol and nuclei were decreased 1 week following castration and this reduced level was sustained for 2 weeks. A maximal increase of the androgen-binding sites in the cytosol was induced by a single injection of testosterone, while the sites in the nuclei were increased gradually with the duration of testosterone injection. These findings suggest that testosterone was able to induce the binding sites in the liver cytosol and nuclei which had been reduced after castration.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 4","pages":"241-52"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808009065976","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18479168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Evidence for proteolysis during purification of relaxin from pregnant sow ovaries. 妊娠母猪卵巢松弛素纯化过程中蛋白水解的证据。
Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065955
S C Kwok, G D Bryant-Greenwood, H D Niall
{"title":"Evidence for proteolysis during purification of relaxin from pregnant sow ovaries.","authors":"S C Kwok,&nbsp;G D Bryant-Greenwood,&nbsp;H D Niall","doi":"10.3109/07435808009065955","DOIUrl":"https://doi.org/10.3109/07435808009065955","url":null,"abstract":"<p><p>The proteolytic degradation of relaxin during its isolation from pregnant sow ovaries has been examined. Ovaries from pregnant sows were selected and divided into three groups according to the stages of pregnancy. Each group was extracted with and without protease inhibitors. It was found that protease(s) were present in all groups of ovaries and that a 2-4 fold increase in yield of total relaxin was obtained when isolation and purification was carried out in the presence of protease inhibitors. However the ratio of the three forms of relaxin remain unchanged.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808009065955","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18037683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Kinetics of insulin clearance by the liver in perfused liver-pancreas. 灌注肝-胰中肝脏清除胰岛素的动力学。
Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065975
J S Striffler, D L Curry
{"title":"Kinetics of insulin clearance by the liver in perfused liver-pancreas.","authors":"J S Striffler,&nbsp;D L Curry","doi":"10.3109/07435808009065975","DOIUrl":"https://doi.org/10.3109/07435808009065975","url":null,"abstract":"<p><p>The relationship between hepatic insulin extraction velocity and portal plasma insulin concentration was assessed using in situ perfused liver-pancreas preparations from rats fasted 24 or 48 hours. During hepatic transit of the first phase of glucose-stimulated insulin secretion, hepatic extraction velocities followed first order kinetics for all insulin concentrations observed (less than 1 to 17 ng/ml). During the second phase of insulin release, saturation of the insulin removal process occurred at insulin concentrations between 12 and 14 ng/ml. At non-saturating insulin levels, livers from rats fasted 24 hours clear insulin at about 4.0 ml/min corresponding to an extraction ratio of 52%. In contrast, livers of liver-pancreases from 48 hour fasted rats clear insulin at 2.4 ml/min with an extraction ratio of 31%.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 4","pages":"231-9"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808009065975","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18056716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The lactogenic response of mouse mammary explants to mose prolactin and growth hormone. 小鼠乳腺外植体对泌乳素和生长激素的产乳反应。
Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065978
E Markoff, F Talamantes
{"title":"The lactogenic response of mouse mammary explants to mose prolactin and growth hormone.","authors":"E Markoff,&nbsp;F Talamantes","doi":"10.3109/07435808009065978","DOIUrl":"https://doi.org/10.3109/07435808009065978","url":null,"abstract":"<p><p>The lactogenic response of mouse mammary explants to mouse prolactin (mPRL) and mouse growth hormone (mGH) was studied. Mouse mammary explants were cultured, in a defined medium, in the presence of varying concentrations of either mPRL or mGH and the rate of 3H amino acid incorporation into casein was measured. The lactogenic activity of mPRL was compared with that of ovine prolactin (oPRL) and found to be directly comparable. MGH, when compared to oPRL, was found to be less active in stimulating casein synthesis.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 4","pages":"269-78"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808009065978","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18208031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Direct detection of the vasopressin precursor. 直接检测抗利尿激素前体。
Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065958
K A Gruber, M Morris
{"title":"Direct detection of the vasopressin precursor.","authors":"K A Gruber,&nbsp;M Morris","doi":"10.3109/07435808009065958","DOIUrl":"https://doi.org/10.3109/07435808009065958","url":null,"abstract":"<p><p>Cysteine-rich proteins were isolated from the hypothalamo-neurohypophyseal tract of dogs by high performance molecular weight chromatography. Trypsin digestion of these proteins produced a low molecular weight (LMW) peptide which was identified, by chemical and immunological assays, as (Arg8) vasopressin. There appear to be two forms of the precursor protein, one which has vasopressin immunoreactivity, and one which does not. Trypsin digestion of this latter protein produces high as well as LMW immunoreactivity. This suggests that the non-immunoreactive protein may be the precursor to the immunoreactive protein.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 1","pages":"45-59"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808009065958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18373721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Long-term effects of neonatal DES treatment on plasma prolactin in female mice. 新生儿DES治疗对雌性小鼠血浆催乳素的长期影响。
Endocrine research communications Pub Date : 1980-01-01 DOI: 10.3109/07435808009065969
T Kalland, J G Forsberg, Y N Sinha
{"title":"Long-term effects of neonatal DES treatment on plasma prolactin in female mice.","authors":"T Kalland,&nbsp;J G Forsberg,&nbsp;Y N Sinha","doi":"10.3109/07435808009065969","DOIUrl":"https://doi.org/10.3109/07435808009065969","url":null,"abstract":"<p><p>Prolactin was measured with a homologous radioimmunoassay in plasma samples from adult female NMRI mice injected with 5 micrograms diethylstilbestrol (DES females) or olive oil for the first five days after birth. Estradiol treatment of 6-month-old ovariectomized DES females resulted in markedly higher plasma prolactin concentration compared with the conditions in similarly treated but neonatally olive oil injected females; for both groups the concentrations decreased to the same and very low level after treatment with bromocriptine. The results suggest that DES treatment of neonatal mice enhances the capacity of the pituitary to release prolactin in response to estrogen in later life.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 3","pages":"157-66"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/07435808009065969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18429083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
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