{"title":"黄体生成素释放激素(LRH)在大鼠体内的局部抗生育作用:作用机制。","authors":"R C Jones","doi":"10.1080/07435808009065964","DOIUrl":null,"url":null,"abstract":"<p><p>The administration of luteinizing hormone-releasing hormone (LRH) into one horn of the uterus at 0900 h on D5 of pregnancy produces a 96% reduction in the number of zona-encased blastocysts recovered between 0915 and 1300 h on D5. The number of blastocysts recovered within this time period also decreased; only one blastocyst was recovered from the LRH-treated horn at 1300 h while 26 were flushed from the horns injected with saline. The results of this study suggest that LRH causes a premature disassociation of the zona from the blasocyst allowing early adherence to the uterine wall. This asynchronous attachment results in disruption of the ensuing pregnancy.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 2","pages":"107-12"},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435808009065964","citationCount":"5","resultStr":"{\"title\":\"Local antifertility effect of luteinizing hormone-releasing hormone (LRH) in the rat: mechanism of action.\",\"authors\":\"R C Jones\",\"doi\":\"10.1080/07435808009065964\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The administration of luteinizing hormone-releasing hormone (LRH) into one horn of the uterus at 0900 h on D5 of pregnancy produces a 96% reduction in the number of zona-encased blastocysts recovered between 0915 and 1300 h on D5. The number of blastocysts recovered within this time period also decreased; only one blastocyst was recovered from the LRH-treated horn at 1300 h while 26 were flushed from the horns injected with saline. The results of this study suggest that LRH causes a premature disassociation of the zona from the blasocyst allowing early adherence to the uterine wall. This asynchronous attachment results in disruption of the ensuing pregnancy.</p>\",\"PeriodicalId\":75821,\"journal\":{\"name\":\"Endocrine research communications\",\"volume\":\"7 2\",\"pages\":\"107-12\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1980-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/07435808009065964\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/07435808009065964\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/07435808009065964","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Local antifertility effect of luteinizing hormone-releasing hormone (LRH) in the rat: mechanism of action.
The administration of luteinizing hormone-releasing hormone (LRH) into one horn of the uterus at 0900 h on D5 of pregnancy produces a 96% reduction in the number of zona-encased blastocysts recovered between 0915 and 1300 h on D5. The number of blastocysts recovered within this time period also decreased; only one blastocyst was recovered from the LRH-treated horn at 1300 h while 26 were flushed from the horns injected with saline. The results of this study suggest that LRH causes a premature disassociation of the zona from the blasocyst allowing early adherence to the uterine wall. This asynchronous attachment results in disruption of the ensuing pregnancy.
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