{"title":"Local antifertility effect of luteinizing hormone-releasing hormone (LRH) in the rat: mechanism of action.","authors":"R C Jones","doi":"10.1080/07435808009065964","DOIUrl":null,"url":null,"abstract":"<p><p>The administration of luteinizing hormone-releasing hormone (LRH) into one horn of the uterus at 0900 h on D5 of pregnancy produces a 96% reduction in the number of zona-encased blastocysts recovered between 0915 and 1300 h on D5. The number of blastocysts recovered within this time period also decreased; only one blastocyst was recovered from the LRH-treated horn at 1300 h while 26 were flushed from the horns injected with saline. The results of this study suggest that LRH causes a premature disassociation of the zona from the blasocyst allowing early adherence to the uterine wall. This asynchronous attachment results in disruption of the ensuing pregnancy.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 2","pages":"107-12"},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435808009065964","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/07435808009065964","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
The administration of luteinizing hormone-releasing hormone (LRH) into one horn of the uterus at 0900 h on D5 of pregnancy produces a 96% reduction in the number of zona-encased blastocysts recovered between 0915 and 1300 h on D5. The number of blastocysts recovered within this time period also decreased; only one blastocyst was recovered from the LRH-treated horn at 1300 h while 26 were flushed from the horns injected with saline. The results of this study suggest that LRH causes a premature disassociation of the zona from the blasocyst allowing early adherence to the uterine wall. This asynchronous attachment results in disruption of the ensuing pregnancy.
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