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引用次数: 4
摘要
测定了三种四氢- β -碳水化合物(TH β C)对雄性大鼠血浆催乳素的影响。腹腔内给药后，6-甲氧基- th β C (6-MeO-TH β C;80 mg/kg)显著提高催乳素水平6分钟。通过颈静脉留置套管静脉给药后，6- meo - th β C (20 mg/kg，而不是2.0 mg/kg)，TH β C (20 mg/kg)和6-OH-TH β C (20 mg/kg)均能在30分钟内显著提高血浆催乳素水平，后者的有效时间为60分钟。先前的证据表明，TH β C相对选择性地与血清素能神经递质系统相互作用，以增加血清素能功能。因此，目前的数据与先前的研究一致，表明血清素能活性的增加导致催乳素分泌的增加。
Tetrahydro-beta-carbolines elevate plasma prolactin in male rats.
The effects of systemic administration of three tetrahydro-beta-carbolines (TH beta C's) on plasma prolactin were determined in male rats. After intraperitoneal administration, 6-methoxy-TH beta C (6-MeO-TH beta C; 80 mg/kg) significantly elevated prolactin levels for 6 min. After intravenous administration via an indwelling jugular cannula, 6-MeO-TH beta C (20 mg/kg but not 2.0 mg/kg), TH beta C (20 mg/kg) and 6-OH-TH beta C (20 mg/kg) all produced a significant elevation in plasma prolactin for 30 min. with the latter compound effective for 60 min. Previous evidence indicated that the TH beta C's interact relatively selectively with the serotonergic neurotransmitter system to increase serotonergic function. Thus, the present data are consistent with previous studies which indicated that increased serotonergic activity resulted in enhanced prolactin secretion.
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