{"title":"三碘甲状腺原氨酸诱导大鼠肝染色质蛋白甲基化增强。","authors":"J Short, L Kibert","doi":"10.1080/07435808009065965","DOIUrl":null,"url":null,"abstract":"<p><p>A pharmacological dose of 3,3',5-triiodo-L-thryonine (200 microgram/100g) that induce marked DNA replication in rat liver cells, also is shown to cause a significant increase in the methylation of chromatin proteins in these cells. This increase in the methylation apppears to correlate with the increase in DNA replication. Specificity of this phenomenon is suggested by its absence in kidney and spleen of the hormone-treated animals, two tissues that also fails to respond proliferatively to the iodothyronine.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"7 2","pages":"113-9"},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435808009065965","citationCount":"2","resultStr":"{\"title\":\"Enhanced hepatic chromatin protein methylation induced by triiodothyronine treatment of the rat.\",\"authors\":\"J Short, L Kibert\",\"doi\":\"10.1080/07435808009065965\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A pharmacological dose of 3,3',5-triiodo-L-thryonine (200 microgram/100g) that induce marked DNA replication in rat liver cells, also is shown to cause a significant increase in the methylation of chromatin proteins in these cells. This increase in the methylation apppears to correlate with the increase in DNA replication. Specificity of this phenomenon is suggested by its absence in kidney and spleen of the hormone-treated animals, two tissues that also fails to respond proliferatively to the iodothyronine.</p>\",\"PeriodicalId\":75821,\"journal\":{\"name\":\"Endocrine research communications\",\"volume\":\"7 2\",\"pages\":\"113-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1980-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/07435808009065965\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine research communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/07435808009065965\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/07435808009065965","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
摘要
药理剂量的3,3'，5-三碘- l -酪氨酸(200微克/100克)在大鼠肝细胞中诱导显著的DNA复制，也被证明会导致这些细胞中染色质蛋白甲基化的显著增加。甲基化的增加似乎与DNA复制的增加有关。这种现象的特异性表明，在激素治疗的动物的肾脏和脾脏中不存在这种现象，这两个组织也不能对碘甲状腺原氨酸产生增殖反应。
Enhanced hepatic chromatin protein methylation induced by triiodothyronine treatment of the rat.
A pharmacological dose of 3,3',5-triiodo-L-thryonine (200 microgram/100g) that induce marked DNA replication in rat liver cells, also is shown to cause a significant increase in the methylation of chromatin proteins in these cells. This increase in the methylation apppears to correlate with the increase in DNA replication. Specificity of this phenomenon is suggested by its absence in kidney and spleen of the hormone-treated animals, two tissues that also fails to respond proliferatively to the iodothyronine.
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