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Diffuse Large B-Cell Lymphoma Masquerading as Cholangiocarcinoma in a Young Adult. 青年人弥漫性大b细胞淋巴瘤伪装成胆管癌。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-08-20 eCollection Date: 2026-08-01 DOI: 10.14309/crj.0000000000002271
Fernando Gil-Lopez, Frank J Lukens, Ricardo Paz-Fumagalli, Muhamad Alhaj Moustafa, Umair Majeed, Ruifeng Guo, Miguel Cadenas Morales, Guillermo Riley, Omar Y Mousa
{"title":"Diffuse Large B-Cell Lymphoma Masquerading as Cholangiocarcinoma in a Young Adult.","authors":"Fernando Gil-Lopez, Frank J Lukens, Ricardo Paz-Fumagalli, Muhamad Alhaj Moustafa, Umair Majeed, Ruifeng Guo, Miguel Cadenas Morales, Guillermo Riley, Omar Y Mousa","doi":"10.14309/crj.0000000000002271","DOIUrl":"https://doi.org/10.14309/crj.0000000000002271","url":null,"abstract":"<p><p>A previously healthy 29-year-old man presented with abdominal pain and was found to have a liver mass with periductal infiltration and a stricture of the common bile duct, concerning for cholangiocarcinoma. Hepatic function panel disclosed alanine transaminase 293 U/L, aspartate aminotransferase 122 U/L, γ-glutamyl transferase 2019 U/L, normal total bilirubin, carcinoembryonic antigen, and carbohydrate antigen 19-9. Biopsy established the diagnosis of diffuse large B-cell lymphoma, with no underlying hepatic disease. He was started on polatuzumab-rituximab-cyclophosphamide-doxorubicin-prednisone chemotherapy and achieved complete tumor response. This case highlights the importance of a thorough evaluation of liver tumors and the critical role of tissue diagnosis.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02271"},"PeriodicalIF":0.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic Purse-String Loop Suturing of a Forrest IIc Deep Duodenal Ulcer in a Case of Decompensated HBV Cirrhosis. 内窥镜荷包环缝合1例失代偿期乙型肝炎肝硬化深十二指肠溃疡。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-08-20 eCollection Date: 2026-08-01 DOI: 10.14309/crj.0000000000002285
Suhas D Wagle, Sahil D Rasane, Akshay R Kale, Durga Borkar
{"title":"Endoscopic Purse-String Loop Suturing of a Forrest IIc Deep Duodenal Ulcer in a Case of Decompensated HBV Cirrhosis.","authors":"Suhas D Wagle, Sahil D Rasane, Akshay R Kale, Durga Borkar","doi":"10.14309/crj.0000000000002285","DOIUrl":"https://doi.org/10.14309/crj.0000000000002285","url":null,"abstract":"","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02285"},"PeriodicalIF":0.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant Mature Cystic Perihepatic Teratoma in an Adult Woman. 成年女性巨大成熟囊性肝周畸胎瘤一例。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-08-20 eCollection Date: 2026-08-01 DOI: 10.14309/crj.0000000000002286
Bisher Sawaf, Nwal Hadaki, Mohammed Abu-Rumaileh, Akram Alnounou, Ajay Katwala, Sejal Gunaratnam, Umer A Bhatti, Mohammad Al-Haddad
{"title":"Giant Mature Cystic Perihepatic Teratoma in an Adult Woman.","authors":"Bisher Sawaf, Nwal Hadaki, Mohammed Abu-Rumaileh, Akram Alnounou, Ajay Katwala, Sejal Gunaratnam, Umer A Bhatti, Mohammad Al-Haddad","doi":"10.14309/crj.0000000000002286","DOIUrl":"https://doi.org/10.14309/crj.0000000000002286","url":null,"abstract":"<p><p>Perihepatic teratomas are exceedingly rare extragonadal germ cell tumors that may mimic more common hepatic cystic lesions on imaging. We report a 38-year-old woman with several months of abdominal bloating and early satiety. Laboratory studies and tumor markers (α-fetoprotein and carcinoembryonic antigen) were unremarkable. Magnetic resonance imaging demonstrated a 17.7 cm complex cystic lesion adjacent to the left hepatic lobe with fatty components and a mural nodule. Elective laparotomy revealed a well-encapsulated mass arising from the lesser omentum, excised intact. Histopathology confirmed a mature cystic teratoma with elements from all 3 germ layers. The postoperative course was uneventful.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02286"},"PeriodicalIF":0.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoimmune Hepatitis/Primary Sclerosing Cholangitis Overlap Syndrome Associated With Minimal Change Disease and Tubulointerstitial Nephritis. 自身免疫性肝炎/原发性硬化性胆管炎重叠综合征与微小改变病和小管间质性肾炎相关。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-08-18 eCollection Date: 2026-08-01 DOI: 10.14309/crj.0000000000002273
Michael S Metry, Syed Ali
{"title":"Autoimmune Hepatitis/Primary Sclerosing Cholangitis Overlap Syndrome Associated With Minimal Change Disease and Tubulointerstitial Nephritis.","authors":"Michael S Metry, Syed Ali","doi":"10.14309/crj.0000000000002273","DOIUrl":"https://doi.org/10.14309/crj.0000000000002273","url":null,"abstract":"<p><p>Autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome is rare and incompletely defined. Its association with renal disease is less frequently reported. Systemic disorders such as systemic lupus erythematosus, immunoglobulin G4-related disease, light chain disorders, amyloidosis, and pediatric autoimmune polyendocrine syndromes may cause concurrent hepatic and renal involvement; however, renal disease with liver pathology in the absence of systemic illness is exceedingly uncommon. We describe a case of autoimmune hepatitis/primary sclerosing cholangitis overlap complicated by nephrotic syndrome due to minimal change disease with tubulointerstitial involvement. No systemic disease or drug-induced cause was identified. Renal function fully recovered with treatment while liver disease persisted.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02273"},"PeriodicalIF":0.6,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13485841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GALT/Dome Adenocarcinoma in a Patient With MLH1-Deficient Lynch Syndrome: Navigating a Clinical and Management Dilemma. mlh1缺陷Lynch综合征患者的GALT/Dome腺癌：导航临床和管理困境
IF 0.6
ACG Case Reports Journal Pub Date : 2026-08-14 eCollection Date: 2026-08-01 DOI: 10.14309/crj.0000000000002262
Vishal Deshpande, Ashish Sharma, Angad Tiwari, Jaya Sai Mupparaju, Tej Bodla, Dushyant Singh Dahiya
{"title":"GALT/Dome Adenocarcinoma in a Patient With MLH1-Deficient Lynch Syndrome: Navigating a Clinical and Management Dilemma.","authors":"Vishal Deshpande, Ashish Sharma, Angad Tiwari, Jaya Sai Mupparaju, Tej Bodla, Dushyant Singh Dahiya","doi":"10.14309/crj.0000000000002262","DOIUrl":"https://doi.org/10.14309/crj.0000000000002262","url":null,"abstract":"<p><p>A woman in her early 40s with MLH1-deficient Lynch syndrome was incidentally found to have a cecal gut-associated lymphoid tissue (GALT)/dome carcinoma during routine surveillance colonoscopy. This case highlights the co-occurrence of 2 rare entities: a germline <i>MLH1</i> pathogenic variant and a GALT/dome carcinoma, now recognized within the lymphoglandular complex-like carcinoma spectrum, which carries potential for nodal metastasis. The intersection of mismatch repair deficiency and GALT/dome carcinoma raises a management dilemma: prophylactic colectomy vs endoscopic surveillance in the absence of high-risk histologic features. We review the literature to guide management in this rare scenario.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02262"},"PeriodicalIF":0.6,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13475921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148766515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Refractory Esophageal Varices Requiring Transjugular Intrahepatic Portosystemic Shunt Placement in Oxaliplatin-Induced Portosinusoidal Vascular Disorder. 奥沙利铂诱发的门窦血管病变中需要经颈静脉肝内门静脉系统分流的难治性食管静脉曲张。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-08-13 eCollection Date: 2026-08-01 DOI: 10.14309/crj.0000000000002280
James Vu, Ashna Aggarwal, Maud Morshedi, Valentina Medici
{"title":"Refractory Esophageal Varices Requiring Transjugular Intrahepatic Portosystemic Shunt Placement in Oxaliplatin-Induced Portosinusoidal Vascular Disorder.","authors":"James Vu, Ashna Aggarwal, Maud Morshedi, Valentina Medici","doi":"10.14309/crj.0000000000002280","DOIUrl":"https://doi.org/10.14309/crj.0000000000002280","url":null,"abstract":"<p><p>Colorectal carcinoma is a leading cause of cancer-related mortality in the United States. Capecitabine and oxaliplatin, a standard first-line chemotherapy regimen contains oxaliplatin, which rarely causes sinusoidal injury leading to portosinusoidal vascular disorder (PSVD). We report a rare case of oxaliplatin-associated PSVD presenting with esophageal varices refractory to banding, ultimately requiring transjugular intrahepatic portosystemic shunt placement with variceal embolization. With few similar cases reported in the literature and in the absence of guidelines on managing refractory esophageal varices in PSVD, this case demonstrates a successful outcome with transjugular intrahepatic portosystemic shunt placement.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02280"},"PeriodicalIF":0.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Pancreas Out of Place: Acute Interstitial Pancreatitis Caused by Pancreatic Herniation in a Type IV Paraesophageal Hernia. 胰腺错位：IV型食管旁疝胰疝引起的急性间质性胰腺炎。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-08-13 eCollection Date: 2026-08-01 DOI: 10.14309/crj.0000000000002274
Arman Manjikian, Victoria Diaz, Mark Hsu, Christian Stone
{"title":"A Pancreas Out of Place: Acute Interstitial Pancreatitis Caused by Pancreatic Herniation in a Type IV Paraesophageal Hernia.","authors":"Arman Manjikian, Victoria Diaz, Mark Hsu, Christian Stone","doi":"10.14309/crj.0000000000002274","DOIUrl":"https://doi.org/10.14309/crj.0000000000002274","url":null,"abstract":"<p><p>Pancreatic involvement in paraesophageal hernias is rare and can precipitate acute pancreatitis through mechanical compression or ischemia. We report an 82-year-old woman who presented with epigastric pain and an elevated lipase level. Imaging demonstrated a large type IV paraesophageal hernia containing the stomach, transverse colon, and pancreatic body and tail, with inflammatory changes localized to the pancreatic tail. Common causes of pancreatitis were excluded. The patient improved with conservative management and was referred for elective hernia repair after resolution of pancreatitis. This case highlights an uncommon mechanical cause of acute pancreatitis and the importance of anatomic evaluation in atypical presentations.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02274"},"PeriodicalIF":0.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Not Your Typical Vaginal Bleed: Inflammatory Bowel Disease in a Sigmoid Neovagina. 不是典型的阴道出血：乙状结肠新阴道的炎症性肠病。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-08-13 eCollection Date: 2026-08-01 DOI: 10.14309/crj.0000000000002284
Duha Zaffar, Michael J McCabe, Dhruvkumar M Patel, Daniel K Daniels
{"title":"Not Your Typical Vaginal Bleed: Inflammatory Bowel Disease in a Sigmoid Neovagina.","authors":"Duha Zaffar, Michael J McCabe, Dhruvkumar M Patel, Daniel K Daniels","doi":"10.14309/crj.0000000000002284","DOIUrl":"https://doi.org/10.14309/crj.0000000000002284","url":null,"abstract":"<p><p>A 31-year-old woman with mullerian agenesis and a neovagina derived from the sigmoid colon presented with bleeding per vaginum along with luminal gastrointestinal symptoms. Diagnostic evaluation revealed ulcerative colitis (UC) involving the native colon and neo vagina. Both her gastrointestinal and vaginal symptoms responded very well to conventional UC treatment. This case highlights a rare complication of UC in patients with Mullerian agenesis who have undergone sigmoid colon vaginoplasty. The association between UC and neovaginal bleeding underscores the need for careful monitoring and early intervention in such complex cases to prevent further morbidity and improve patient outcomes.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02284"},"PeriodicalIF":0.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small Intestinal Extranodal Marginal Zone Lymphoma Mimicking Crohn's Disease. 模拟克罗恩病的小肠结外边缘区淋巴瘤。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-08-13 eCollection Date: 2026-08-01 DOI: 10.14309/crj.0000000000002276
Annavaram Jeswanth Reddy, Deepak Chellan, Sithara Kodapally Balagopal, George Sarin Zacharia, Sandesh Kolassery
{"title":"Small Intestinal Extranodal Marginal Zone Lymphoma Mimicking Crohn's Disease.","authors":"Annavaram Jeswanth Reddy, Deepak Chellan, Sithara Kodapally Balagopal, George Sarin Zacharia, Sandesh Kolassery","doi":"10.14309/crj.0000000000002276","DOIUrl":"https://doi.org/10.14309/crj.0000000000002276","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) mimics pose a significant diagnostic challenge, particularly in patients with atypical features or refractory disease. Intestinal lymphomas, especially extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma, can closely resemble Crohn's disease clinically, endoscopically, and histologically. We report a 23-year-old woman with a 2-year history of chronic, large-volume diarrhea, weight loss, and malabsorption, initially diagnosed and treated as Crohn's disease. Despite corticosteroids, azathioprine, and biologic therapy, she demonstrated only a partial response. Further evaluation revealed hypoalbuminemia, elevated inflammatory markers, and monoclonal gammopathy on serum protein electrophoresis. Endoscopic and radiological findings showed ileal and jejunal involvement. Histopathological examination demonstrated a dense lymphoplasmacytic infiltrate, and immunohistochemistry revealed CD20 and CD138 positivity with light chain restriction. A final diagnosis of small intestinal extranodal marginal zone lymphoma was established. The patient was treated with combined chemotherapy, with plans to escalate to rituximab-based therapy due to a suboptimal response. This case highlights the importance of reconsidering the diagnosis in patients with presumed IBD who exhibit atypical features, such as severe malabsorption, proximal small bowel involvement, monoclonal gammopathy, or refractory disease. Early recognition of IBD mimics, particularly intestinal lymphomas, is critical to ensure appropriate management and improve outcomes.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02276"},"PeriodicalIF":0.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autologous Stromal Vascular Fraction Achieves Closure of Biologic-Refractory Crohn's Enterocutaneous Fistula. 自体间质血管碎片实现生物难治性克罗恩病肠皮瘘的闭合。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-08-13 eCollection Date: 2026-08-01 DOI: 10.14309/crj.0000000000002277
Goutham Reddy Katukuri, Rajendra Patel, Swaapnika Vemulapalli, Ravikiran Naalla, Sowmya Kasulanati, Rupa Banerjee, Rakesh Kalapala, Nageshwar Reddy
{"title":"Autologous Stromal Vascular Fraction Achieves Closure of Biologic-Refractory Crohn's Enterocutaneous Fistula.","authors":"Goutham Reddy Katukuri, Rajendra Patel, Swaapnika Vemulapalli, Ravikiran Naalla, Sowmya Kasulanati, Rupa Banerjee, Rakesh Kalapala, Nageshwar Reddy","doi":"10.14309/crj.0000000000002277","DOIUrl":"https://doi.org/10.14309/crj.0000000000002277","url":null,"abstract":"","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02277"},"PeriodicalIF":0.6,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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