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Impact of GLP-1 Receptor Agonists on Whole-Gut Gastrointestinal Motility Using Wireless Motility Capsule: A Descriptive Single-Center Case Series. 使用无线运动胶囊GLP-1受体激动剂对全肠胃肠运动的影响：描述性单中心病例系列。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-04 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001789
Michael Cymbal, Zehra Naseem, Din Hoxha, Samita Garg
{"title":"Impact of GLP-1 Receptor Agonists on Whole-Gut Gastrointestinal Motility Using Wireless Motility Capsule: A Descriptive Single-Center Case Series.","authors":"Michael Cymbal, Zehra Naseem, Din Hoxha, Samita Garg","doi":"10.14309/crj.0000000000001789","DOIUrl":"10.14309/crj.0000000000001789","url":null,"abstract":"<p><p>This retrospective case series investigates the impact of GLP-1 receptor agonists (GLP-1RAs) on whole-gut gastrointestinal motility using wireless motility capsule testing. We analyzed 10 patients on GLP-1RAs who underwent wireless motility capsule testing for constipation or gastroparesis to assess gastric, small bowel, and colonic transit times. Delayed gastric emptying time was observed in 80% of patients, whereas delayed whole-gut transit time was noted in 44% of patients. The 3 patients on semaglutide (1 mg) had the longest gastric emptying time, delayed whole-gut transit time, and were the only patients with delayed small bowel transit time. Although limited by retrospective observation, our findings are consistent with the effects of GLP-1RAs on gastric motility delay and suggest an impact on whole-gut motility. With the expanding use of GLP-1RAs, these findings underscore the need for prospective studies using emerging motility technologies to further characterize the motility effects both during treatment and after cessation, thereby guiding evidence-based clinical decision-making.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01789"},"PeriodicalIF":0.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resistant Hilar Stricture Following Transarterial Bleomycin-Lipiodol Embolization for a Large Hepatic Hemangioma. 经动脉博莱霉素-脂醇栓塞治疗大肝血管瘤后出现顽固性肝门狭窄。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-04 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001793
Man Ting Kristina Yau, Cynthuja Thilakanathan, Hyun Jae Kim, Stephen G F Ho, Roberto P Trasolini, S Ian Gan, Maja Segedi
{"title":"Resistant Hilar Stricture Following Transarterial Bleomycin-Lipiodol Embolization for a Large Hepatic Hemangioma.","authors":"Man Ting Kristina Yau, Cynthuja Thilakanathan, Hyun Jae Kim, Stephen G F Ho, Roberto P Trasolini, S Ian Gan, Maja Segedi","doi":"10.14309/crj.0000000000001793","DOIUrl":"10.14309/crj.0000000000001793","url":null,"abstract":"<p><p>Symptomatic hepatic hemangiomas are commonly treated by transcatheter arterial embolization as an alternative to surgical resection. Bile duct complications are rare. An 80-year-old woman had a progressive refractory stricture postbleomycin transcatheter arterial chemoembolization. Magnetic resonance cholangiopancreatography showed that the hemangioma reduced in size, but there was a new 2 cm hilar stricture on cholangiopancreatography. Digital cholangioscopy and biopsy showed benign changes. Despite repeat dilations and stent treatments, she had persistent stricture and recurrent cholangitis. The stricture was not operable. The stricture was likely from angiosclerotic effects of bleomycin. The bile duct is prone to ischemic injury as it lacks dual blood supply.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01793"},"PeriodicalIF":0.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Extremely Rare Cause of Protein-Losing Enteropathy: Waldenström Macroglobulinemia. 一种极为罕见的蛋白质丢失性肠病的病因：Waldenström巨球蛋白血症。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-04 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001800
Omar Saab, Marwah Algodi, Hasan Al-Obaidi, Alhareth Al-Sagban, Sebouh Setrakian, Alberto Rubio-Tapia
{"title":"An Extremely Rare Cause of Protein-Losing Enteropathy: Waldenström Macroglobulinemia.","authors":"Omar Saab, Marwah Algodi, Hasan Al-Obaidi, Alhareth Al-Sagban, Sebouh Setrakian, Alberto Rubio-Tapia","doi":"10.14309/crj.0000000000001800","DOIUrl":"10.14309/crj.0000000000001800","url":null,"abstract":"<p><p>Protein-losing enteropathy (PLE) results in the abnormal loss of proteins through the gastrointestinal tract, leading to malabsorption and hypoalbuminemia. A rare etiology of PLE is Waldenström macroglobulinemia (WM), a hematological malignancy characterized by immunoglobulin M (IgM) monoclonal gammopathy. We present a case of a 66-year-old man with a history of small bowel bacterial overgrowth and lactose intolerance, admitted for worsening gastrointestinal symptoms, including abdominal discomfort, bloating, and watery diarrhea. He had experienced significant weight loss and anasarca over 6 months. Laboratory tests indicated hypoproteinemia, hypoalbuminemia, and elevated IgM levels, accompanied by abnormal stool studies. Imaging showed no significant findings, while endoscopic evaluation revealed lymphangiectasia-like changes in the small bowel. Biopsy results demonstrated proteinaceous material in dilated villi and IgM deposition. The diagnosis of WM was confirmed by bone marrow biopsy. Thus, WM should be considered when evaluating unexplained PLE, particularly with associated gastrointestinal symptoms and elevated IgM levels.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01800"},"PeriodicalIF":0.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholestatic Drug-Induced Liver Injury From Rad-140 Successfully Treated With Corticosteroids. 用皮质类固醇成功治疗Rad-140致胆汁淤积性药物性肝损伤。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-04 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001803
Bilal Niazi, Bill Quach, Kurt Fisher, Thoetchai Peeraphatdit
{"title":"Cholestatic Drug-Induced Liver Injury From Rad-140 Successfully Treated With Corticosteroids.","authors":"Bilal Niazi, Bill Quach, Kurt Fisher, Thoetchai Peeraphatdit","doi":"10.14309/crj.0000000000001803","DOIUrl":"10.14309/crj.0000000000001803","url":null,"abstract":"<p><p>Selective androgen receptor modulators (SARMs) are anabolic compounds that modulate androgen activity. They have been increasingly used in supplements to enhance performance and muscle growth despite not being Food and Drug Administration approved. Their use has been associated with a cholestatic pattern of liver injury similar to that seen by anabolic androgens. Treatment is primarily supportive with drug cessation and cholestasis can take weeks to months to normalize. We present an atypical case of prolonged cholestasis caused by the readily available selective androgen receptor modulator called RAD-140 that was successfully managed with corticosteroids.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01803"},"PeriodicalIF":0.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pyogenic Granuloma at the Ileocecal Junction: Unusual Culprit of Chronic Anemia and Intussusception. 回盲交界处的化脓性肉芽肿：慢性贫血和肠套叠的罕见罪魁祸首。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-01 DOI: 10.14309/crj.0000000000001783
Xavia Taylor, Kelly Fuller, Gregory K Patterson, Hima Chakka
{"title":"Pyogenic Granuloma at the Ileocecal Junction: Unusual Culprit of Chronic Anemia and Intussusception.","authors":"Xavia Taylor, Kelly Fuller, Gregory K Patterson, Hima Chakka","doi":"10.14309/crj.0000000000001783","DOIUrl":"10.14309/crj.0000000000001783","url":null,"abstract":"<p><p>Pyogenic granulomas (PGs) are benign vascular lesions usually found in the skin and mucous membranes but rarely in the gastrointestinal tract. This case highlights a large PG in the small intestine, causing chronic anemia and serving as a lead point for intussusception. We discuss its diagnostic challenges, potential for misdiagnosis, and treatment options. This case underscores the need for awareness among clinicians regarding atypical presentations of PGs. It also highlights the importance of thorough evaluation in patients with unexplained anemia and intermittent obstruction, ensuring timely diagnosis and appropriate management of this rare gastrointestinal condition.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01783"},"PeriodicalIF":0.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Unexpected Culprit: Fatal Gastrointestinal Hemorrhage due to Duodenal Histoplasmosis in a Patient With End-Stage Renal Disease. 一个意想不到的罪魁祸首：终末期肾病患者十二指肠组织胞浆菌病引起的致命胃肠道出血。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-01 DOI: 10.14309/crj.0000000000001781
Vanya Rai, Rohit Goyal, Aditya Vyas, Karan Sachdeva, Kshitij Arora, Hassan Zia
{"title":"An Unexpected Culprit: Fatal Gastrointestinal Hemorrhage due to Duodenal Histoplasmosis in a Patient With End-Stage Renal Disease.","authors":"Vanya Rai, Rohit Goyal, Aditya Vyas, Karan Sachdeva, Kshitij Arora, Hassan Zia","doi":"10.14309/crj.0000000000001781","DOIUrl":"10.14309/crj.0000000000001781","url":null,"abstract":"<p><p>Histoplasmosis has a wide spectrum of presentations ranging from mild pulmonary disease to a more widespread infection leading to disseminated histoplasmosis. Gastrointestinal histoplasmosis is a rare form of disseminated histoplasmosis that most commonly causes nonspecific symptoms and rarely presents with serious symptoms. Duodenal involvement is further rare but can cause ulcerated lesions leading to upper gastrointestinal bleed. The potential for a nonspecific initial presentation quickly progressing to a fatal upper gastrointestinal bleed makes it important to keep Gastrointestinal histoplasmosis in our list of differentials, as timely initiation of appropriate antifungal therapy can significantly reduce the risk of severe complications and mortality.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01781"},"PeriodicalIF":0.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paraneoplastic Effects of Lung Adenocarcinoma Causing Persistently Elevated Lipase, Amylase, and CA 19-9. 肺腺癌引起脂肪酶、淀粉酶和ca19 -9持续升高的副肿瘤效应。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-01 DOI: 10.14309/crj.0000000000001792
Lily Lucerne, Saurabh Chawla
{"title":"Paraneoplastic Effects of Lung Adenocarcinoma Causing Persistently Elevated Lipase, Amylase, and CA 19-9.","authors":"Lily Lucerne, Saurabh Chawla","doi":"10.14309/crj.0000000000001792","DOIUrl":"10.14309/crj.0000000000001792","url":null,"abstract":"<p><p>Lipase, amylase, and carbohydrate antigen 19-9 are associated with pancreatic pathology. We report a rare case of a patient with persistent elevation of these markers due to paraneoplastic effects of lung adenocarcinoma. The patient presented with right upper quadrant pain and had elevated lipase, amylase, and carbohydrate antigen 19-9. Workup was unrevealing for pancreatic pathology but found a lung nodule, later confirmed as adenocarcinoma. The patient underwent chemotherapy, radiation, and immunotherapy. All levels subsequently normalized. This case underscores the importance of considering malignancy in patients with unexplained, persistent elevation of pancreatic enzymes or tumor markers in the absence of clear pancreatic pathology.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01792"},"PeriodicalIF":0.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Bleeding due to Idiopathic Colonic Varices. 特发性结肠静脉曲张出血的处理。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-01 DOI: 10.14309/crj.0000000000001791
Abhimati Ravikulan, Richard Gearry, Jan Kubovy
{"title":"Management of Bleeding due to Idiopathic Colonic Varices.","authors":"Abhimati Ravikulan, Richard Gearry, Jan Kubovy","doi":"10.14309/crj.0000000000001791","DOIUrl":"10.14309/crj.0000000000001791","url":null,"abstract":"<p><p>Lower gastrointestinal bleeding due to idiopathic colonic varices (ICV) is very rare. We present a 66-year-old man with recurrent hematochezia but without history of liver disease or portal hypertension. Colonoscopy revealed extensive varices throughout the colon. There was no biochemical or radiological evidence of cirrhosis or portal hypertension. The underlying etiology of ICV is unknown, and management of this condition is challenging without standardized treatment protocols. Nonselective beta-blockers could be considered despite the unknown ICV pathophysiology and their effect in this clinical entity. The successful management in our case included immediate endoscopic treatment and secondary prophylaxis with carvedilol.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01791"},"PeriodicalIF":0.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multifocal Superficial Squamous Cell Carcinoma Arising in the Setting of Esophageal Intramural Pseudodiverticulosis. 食管壁内假性憩室病并发多灶性浅表鳞状细胞癌。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-01 DOI: 10.14309/crj.0000000000001786
Matthew J Custodio, Premsai Nagabhyrava, Grace Zhao, Zhichun Lu, Christopher Digesu, Christopher Huang
{"title":"Multifocal Superficial Squamous Cell Carcinoma Arising in the Setting of Esophageal Intramural Pseudodiverticulosis.","authors":"Matthew J Custodio, Premsai Nagabhyrava, Grace Zhao, Zhichun Lu, Christopher Digesu, Christopher Huang","doi":"10.14309/crj.0000000000001786","DOIUrl":"10.14309/crj.0000000000001786","url":null,"abstract":"<p><p>Esophageal intramural pseudodiverticulosis (EIPD) is a rare disease characterized endoscopically by numerous small outpouchings within the esophageal wall. While typically associated with benign symptoms such as dysphagia, EIPD has been linked to esophageal malignancy, both as a predisposing condition and associated coexisting diagnosis. However, the association is not clear. This case report details a patient with a history of EIPD who developed multifocal superficial squamous cell carcinoma in the context of high-grade dysplasia throughout the esophagus.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01786"},"PeriodicalIF":0.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemorrhagic Gastropathy From Paclitaxel-Carboplatin Combination Chemotherapy. 紫杉醇-卡铂联合化疗引起出血性胃病。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-01 DOI: 10.14309/crj.0000000000001780
Kristeen Onyirioha, Maya Balakrishnan
{"title":"Hemorrhagic Gastropathy From Paclitaxel-Carboplatin Combination Chemotherapy.","authors":"Kristeen Onyirioha, Maya Balakrishnan","doi":"10.14309/crj.0000000000001780","DOIUrl":"10.14309/crj.0000000000001780","url":null,"abstract":"<p><p>A 58-year-old woman with endometrial cancer started on paclitaxel in combination with carboplatin chemotherapy, presented to the hospital with severe anemia and melena. An esophagogastroduodenoscopy with biopsies revealed diffuse gastric antrum hemorrhagic gastropathy without inflammatory changes. She had recurrent admissions with similar presentations during her chemotherapy. Her management included frequent blood transfusions, endoscopic Argon plasma coagulation to hemorrhagic lesions, and a prolonged course of proton pump inhibition to facilitate post-Argon plasma coagulation mucosal healing. Weeks after completing chemotherapy, her hemoglobin improved and recurrent upper gastrointestinal bleeding resolved. In this case, we identify a rare paclitaxel, in combination with carboplatin, associated hemorrhagic gastropathy with symptomatic, clinical, and endoscopic resolution seen only after completing chemotherapy.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01780"},"PeriodicalIF":0.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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