{"title":"Incidentally Diagnosed Very Well-Differentiated Gastric Adenocarcinoma at Intraoperative Frozen Section.","authors":"Takuya Nagasaka, Hirofumi Rokutan, Akiko Komatsu, Nobuo Kanazawa, Tomio Arai","doi":"10.14309/crj.0000000000002308","DOIUrl":"10.14309/crj.0000000000002308","url":null,"abstract":"<p><p>Very well-differentiated gastric adenocarcinoma is a rare subtype that is often overlooked because of minimal cytological atypia and ill-defined gross findings. We report an 82-year-old man who was incidentally diagnosed with this entity in an intraoperative cut-end frozen section during gastrectomy for another adenocarcinoma. The frozen specimen showed irregularly fused glands with characteristic architecture, prompting additional resection to secure negative margins. Immunohistochemistry revealed loss of AT-rich interaction domain 1A expression exclusively in the neoplastic glands. This case highlights the importance of recognizing subtle architectural abnormalities in frozen sections to avoid overlooking clinically undetected gastric neoplasms.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02308"},"PeriodicalIF":0.6,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13561248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Probable Isolated Rectal Tuberculosis Presenting as Mild Chronic Proctitis in an Immunocompetent Adolescent: A Diagnostic Pitfall and Mini-Review of the Literature.","authors":"Gourab Bhaduri, Bijan Basak, Bijit Saha, Asif Ali Ahmed, Brindaa Bandopadhyay","doi":"10.14309/crj.0000000000002297","DOIUrl":"10.14309/crj.0000000000002297","url":null,"abstract":"<p><p>Rectal involvement in gastrointestinal tuberculosis (TB) is uncommon and may mimic inflammatory bowel disease or nonspecific proctitis, leading to diagnostic uncertainty. We report the case of an 18-year-old immunocompetent man presenting with chronic increased stool frequency and mucus passage, occasionally blood-streaked, without constitutional symptoms. Colonoscopy revealed nonspecific proctitis. Histopathological examination demonstrated confluent granulomas with Langhans giant cells. Microbiological confirmation including GeneXpert was negative. In view of the strongly suggestive histopathological findings and the endemic setting, a diagnosis of probable isolated TB was made, and anti-tubercular therapy was initiated. Probable rectal TB should be considered in the differential diagnosis of chronic proctitis, even in the absence of systemic features. Histopathology remains crucial, particularly in endemic regions where microbiological tests may be negative.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02297"},"PeriodicalIF":0.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2026-09-02eCollection Date: 2026-09-01DOI: 10.14309/crj.0000000000002292
Breanna Dobberpuhl, Falak Hamo, Salih Samo
{"title":"The Tissue Systems Pathology Test Enabled Detection of Missed Prevalent High-Grade Dysplasia in a Presumed Clinically Low-Risk Patient With Nondysplastic Barrett's Esophagus.","authors":"Breanna Dobberpuhl, Falak Hamo, Salih Samo","doi":"10.14309/crj.0000000000002292","DOIUrl":"10.14309/crj.0000000000002292","url":null,"abstract":"<p><p>Clinical guidelines recommend the use of histopathology and segment length to risk stratify patients with Barrett's esophagus (BE), the only known precursor of esophageal adenocarcinoma (EAC). However, these clinicopathologic factors have limited ability to accurately identify patients with nondysplastic BE (NDBE) who may be at high risk of progression. The tissue systems pathology-9 (TSP-9) test (TissueCypher) is clinically validated to predict the risk of progression of BE to high-grade dysplasia (HGD) or EAC within 5 years. This case report highlights the clinical utility of TSP-9 test to identify high-risk patients with NDBE and inform shared decision making to prevent progression to HGD/EAC.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02292"},"PeriodicalIF":0.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2026-09-02eCollection Date: 2026-09-01DOI: 10.14309/crj.0000000000002293
Muhammad Nouman Aslam, Maddison Weber, Ahmed Al-Hindawi, Sarah Park, Gautam Maddineni, Anjana Pillai
{"title":"Recurrent Sickle Cell Hepatopathy After Liver Transplantation Despite Guideline-Directed Red Blood Cell Exchange.","authors":"Muhammad Nouman Aslam, Maddison Weber, Ahmed Al-Hindawi, Sarah Park, Gautam Maddineni, Anjana Pillai","doi":"10.14309/crj.0000000000002293","DOIUrl":"10.14309/crj.0000000000002293","url":null,"abstract":"<p><p>Sickle cell hepatopathy is an uncommon but severe cause of liver dysfunction after transplantation. We present a case of a 37-year-old man who developed recurrent sickle cell hepatopathy 12 months postliver transplant despite maintaining hemoglobin S (HbS) levels below 30% per American Society of Hematology recommendations. Liver biopsy demonstrated sinusoidal sickling without rejection. Liver tests improved after intensifying red cell exchange to achieve HbS below 20%. This case illustrates that standard posttransplant HbS targets may be insufficient in high-risk patients and highlights the need for individualized HbS goals.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02293"},"PeriodicalIF":0.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2026-09-02eCollection Date: 2026-09-01DOI: 10.14309/crj.0000000000002294
Toufic Dabit, Kobina Essilfie-Quaye, Farah Haneyah, Mohammad Abuassi, Yaseen Perbtani, Tony Brar
{"title":"Catastrophic Gastroduodenal Artery Pseudoaneurysm Rupture During Endoscopic Necrosectomy in Severe Necrotizing Pancreatitis: A Rare Life-Threatening Complication.","authors":"Toufic Dabit, Kobina Essilfie-Quaye, Farah Haneyah, Mohammad Abuassi, Yaseen Perbtani, Tony Brar","doi":"10.14309/crj.0000000000002294","DOIUrl":"10.14309/crj.0000000000002294","url":null,"abstract":"<p><p>Pseudoaneurysm formation is a rare but potentially fatal complication of necrotizing pancreatitis due to the risk of rupture. We report a 28-year-old man with walled-off pancreatic necrosis who developed catastrophic hemorrhage from a ruptured pseudoaneurysm during endoscopic ultrasound-guided necrosectomy, resulting in intraprocedural cardiac arrest. The patient required immediate cardiopulmonary resuscitation and emergent angiography, which identified the bleeding source and achieved hemostasis via coil embolization. He survived following prompt multidisciplinary intervention. This case highlights the unpredictable nature of vascular complications in necrotizing pancreatitis and the critical role of rapid multidisciplinary response in managing life-threatening hemorrhage.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02294"},"PeriodicalIF":0.6,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pancytopenia as the Initial Presentation of Celiac Disease.","authors":"Ponn Karthikeyan Saravanamuthu, Anup Kumar Das","doi":"10.14309/crj.0000000000002289","DOIUrl":"10.14309/crj.0000000000002289","url":null,"abstract":"<p><p>Celiac disease is an immune-mediated enteropathy precipitated by gluten in genetically susceptible individuals. Although diarrhea, weight loss, and malabsorption are classical features, extraintestinal presentations are increasingly recognized. Pancytopenia as the initial manifestation of adult celiac disease is rare and often delays diagnosis. We report a 39-year-old woman from Assam, Northeast India, who presented with chronic diarrhea, weight loss, and progressive weakness, and was found to have severe pancytopenia (hemoglobin 3.9 g/dL, leukocytes 1,200/mm<sup>3</sup>, and platelets 23,000/mm<sup>3</sup>). Iron studies suggested iron deficiency. Despite a normal serum vitamin B12 level (874 pg/mL), markedly elevated methylmalonic acid (1,600 nmol/L) and homocysteine (56.8 μmol/L) confirmed functional B12 deficiency. Anti-tissue transglutaminase immunoglobulin A was equivocal, but duodenal biopsy demonstrated partial villous atrophy, crypt hyperplasia, and increased intraepithelial lymphocytes (Marsh 3A). Peripheral blood flow cytometry was notable for lymphopenia with elevated T-cell receptor αβ<sup>+</sup> double-negative T cells (2.59%), a finding of immunological interest. A gluten-free diet with iron, folate, and parenteral B12 supplementation produced rapid clinical and hematological recovery within 3 weeks. At 3-week follow-up, all 3 lineages had improved (hemoglobin 10.4 g/dL, total leukocyte count 3,800/mm<sup>3</sup>, and platelets 170,000/mm<sup>3</sup> by manual count; the platelet count had normalized while hemoglobin and leukocytes were improving but not yet fully normalized). This case underscores celiac disease as a reversible cause of unexplained pancytopenia, highlights the limitations of serum B12 and serology in equivocal presentations, and adds to the limited literature on celiac disease from Northeast India-a region where the condition remains substantially underdiagnosed.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02289"},"PeriodicalIF":0.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Srikaran Bojja, Michael Bebawy, Sameer Kandhi, Danial Shaikh, Ahmed Al-Khazraji, Harish K Patel
{"title":"Large Colonic Perineurioma Presenting During Evaluation of Chronic Abdominal Pain and Constipation.","authors":"Srikaran Bojja, Michael Bebawy, Sameer Kandhi, Danial Shaikh, Ahmed Al-Khazraji, Harish K Patel","doi":"10.14309/crj.0000000000002291","DOIUrl":"10.14309/crj.0000000000002291","url":null,"abstract":"<p><p>Colonic perineuriomas (PNs), also known as fibroblastic polyps, are rare benign mesenchymal lesions. They are typically found in the distal colon, particularly in the rectosigmoid region. These lesions are usually asymptomatic and incidentally detected during routine screening colonoscopy. We present a 44-year-old woman with long-standing lower abdominal pain and constipation. Colonoscopy revealed a large (5 cm), multilobulated polyp, diagnosed as a colonic PN based on histopathologic and immunohistochemical findings.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02291"},"PeriodicalIF":0.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deep Durable Response in Metastatic Hepatocellular Carcinoma After Early Discontinuation of Atezolizumab-Bevacizumab.","authors":"Rónán O'Connor, Dominic Coates, Hirannya Karunadasa, Robbie Chan, Manfred Spanger, Amanda Nicoll, Rohit Sawhney","doi":"10.14309/crj.0000000000002244","DOIUrl":"10.14309/crj.0000000000002244","url":null,"abstract":"<p><p>Advanced stage hepatocellular carcinoma with metastatic disease is typically managed with combination systemic therapy. Objective responses generally require several months of treatment. We present a patient with metastatic hepatocellular carcinoma who received 4 cycles of atezolizumab and bevacizumab before treatment cessation due to grade 2 immune-related adverse events. Despite early discontinuation, the patient demonstrated progressive reduction in intrahepatic and extrahepatic tumor burden with normalization of alpha-fetoprotein and durable disease control for 19 months off therapy. This case highlights the potential for sustained antitumor activity following brief exposure to immunotherapy.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02244"},"PeriodicalIF":0.6,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13506229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2026-08-25eCollection Date: 2026-08-01DOI: 10.14309/crj.0000000000002295
Joanna Yuen, Patt Panuncillon, Ruona Ebiai, Adil Memon
{"title":"Severe Cholestatic Liver Injury Associated With Clopidogrel: A Rare Case of Drug-Induced Liver Injury.","authors":"Joanna Yuen, Patt Panuncillon, Ruona Ebiai, Adil Memon","doi":"10.14309/crj.0000000000002295","DOIUrl":"10.14309/crj.0000000000002295","url":null,"abstract":"<p><p>Drug-induced liver injury remains a diagnostic challenge. Clopidogrel, a widely prescribed antiplatelet agent, is rarely associated with hepatotoxicity. We present a case of severe cholestatic liver injury temporally related to clopidogrel use. Extensive evaluation excluded other etiologies, including biliary obstruction, autoimmune hepatitis, primary biliary cholangitis, and viral hepatitis. Liver biopsy demonstrated cholestasis with ductular reaction, and serial liver function tests showed a reproducible pattern of alkaline phosphatase elevation and decline corresponding to clopidogrel administration and withdrawal. This case highlights the importance of considering clopidogrel-induced cholestatic drug-induced liver injury in patients on the medication who develop unexplained cholestasis.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02295"},"PeriodicalIF":0.6,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13506230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2026-08-21eCollection Date: 2026-08-01DOI: 10.14309/crj.0000000000002256
Ouwais Alkhateb, Don C Rockey, Kassem Barada
{"title":"A Novel Homozygous <i>ATP7B</i> Splice-Site Variant Causes Late-Onset Hepatic Wilson Disease.","authors":"Ouwais Alkhateb, Don C Rockey, Kassem Barada","doi":"10.14309/crj.0000000000002256","DOIUrl":"10.14309/crj.0000000000002256","url":null,"abstract":"<p><p>Wilson disease (WD) is a rare disorder that may be missed because of atypical presentations. We present a 47-year-old asymptomatic man who was incidentally discovered to have hepatic steatosis and cirrhosis without features of the metabolic syndrome and with normal physical examination and liver function tests. Very low ceruloplasmin and high urine copper prompted evaluation for WD. He had no Kayser-Fleischer rings. Genetic testing revealed a novel homozygous splice-site <i>ATP7B</i> variant (NM_000053.2:c.1707+2dupT p.(?)), the first reported case of homozygosity for this mutation. This case highlights the importance of considering WD in patients with unexplained hepatic steatosis and cryptogenic cirrhosis.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 8","pages":"e02256"},"PeriodicalIF":0.6,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}