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First Reported Successful Use of Infliximab Maintenance Therapy for Dual Treatment of Crohn Disease and Idiopathic Retroperitoneal Fibrosis. 首次报道成功使用英夫利昔单抗维持治疗克罗恩病和特发性腹膜后纤维化的双重治疗。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-11 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001795
Giovannie Isaac-Coss, Zoë Post, Megahna Kakarla, Lily Johnsky, Atsushi Sakuraba, Ira Miller, Jakate M Shriram, Joseph Frasca
{"title":"First Reported Successful Use of Infliximab Maintenance Therapy for Dual Treatment of Crohn Disease and Idiopathic Retroperitoneal Fibrosis.","authors":"Giovannie Isaac-Coss, Zoë Post, Megahna Kakarla, Lily Johnsky, Atsushi Sakuraba, Ira Miller, Jakate M Shriram, Joseph Frasca","doi":"10.14309/crj.0000000000001795","DOIUrl":"10.14309/crj.0000000000001795","url":null,"abstract":"<p><p>This case report describes the novel use of infliximab as maintenance therapy for both Crohn disease and idiopathic retroperitoneal fibrosis in a patient with concurrent disease. A 34-year-old man with Crohn disease developed a pelvic mass and hydroureteronephrosis, leading to an idiopathic retroperitoneal fibrosis diagnosis. Given shared inflammatory pathways, he was treated with prednisone followed by infliximab. Post-treatment imaging showed mass reduction and hydronephrosis improvement. After 1 year, he remains stable. This case highlights infliximab's potential in managing both conditions, presenting a unique therapeutic approach. Further studies are needed to evaluate its broader application in dual pathology.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01795"},"PeriodicalIF":0.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12338202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pancreatic Doppelgängers: A Case of Misdiagnosed Identity. 胰腺Doppelgängers：一例误诊诊断。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-11 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001796
Aditya Kler, Nirjhar Dutta, Jake Theis, Daniela Guerrero Vinsard
{"title":"Pancreatic Doppelgängers: A Case of Misdiagnosed Identity.","authors":"Aditya Kler, Nirjhar Dutta, Jake Theis, Daniela Guerrero Vinsard","doi":"10.14309/crj.0000000000001796","DOIUrl":"10.14309/crj.0000000000001796","url":null,"abstract":"<p><p>IgG-4 related disease (IgG4-RD) is an autoimmune disease that can affect multiple organs and mimic adenocarcinoma of the pancreas. We describe the case of a 74-year-old man who presented with pancreatic mass and biliary obstruction. He was initially diagnosed with pancreatic adenocarcinoma and was started on chemotherapy. Eventually, he was diagnosed with IgG-4 related disease with autoimmune pancreatitis type 1 and IgG-4 sclerosing cholangitis with rapid improvement of symptoms and clinical findings after receiving steroid therapy.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01796"},"PeriodicalIF":0.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12338298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Candida glabrata Acalculous Cholecystitis in an Immunocompetent Host. 免疫活性宿主的光念珠菌无结石性胆囊炎。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-11 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001802
Abdulazeez Swaiti, Jinye Liu, Hassam Ali, Zarak Khan, Rahul Pamarthy, Khaled Elhusseiny, Danielle Hoo-Fatt
{"title":"<i>Candida glabrata</i> Acalculous Cholecystitis in an Immunocompetent Host.","authors":"Abdulazeez Swaiti, Jinye Liu, Hassam Ali, Zarak Khan, Rahul Pamarthy, Khaled Elhusseiny, Danielle Hoo-Fatt","doi":"10.14309/crj.0000000000001802","DOIUrl":"10.14309/crj.0000000000001802","url":null,"abstract":"<p><p>Acalculous cholecystitis (AC) is an inflammatory condition of the gallbladder without the presence of gallstones. Although far less common than calculus cholecystitis, AC is associated with a mortality rate 10 times higher than that of calculus cholecystitis. While normally due to bacterial pathogens, opportunistic ones such as the fungi <i>Candida</i> species (spp) can be rare causative agents of AC, typically observed in those with underlying malignancy or immunosuppression. In this study, we present an unusual case of an immunocompetent patient who was afflicted by fluconazole-resistant <i>Candida glabrata</i> AC. Our case highlights the complexity of this diagnosis and the challenges providers may encounter while treating the underlying infection.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01802"},"PeriodicalIF":0.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12338181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nivolumab-Induced Refractory Hemorrhagic Gastritis and Duodenitis Requiring Multimodal Biologic Therapy. 尼伏单抗引起的难治性出血性胃炎和十二指肠炎需要多模式生物治疗。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-07 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001782
Roney Shibu, Kayla Scully, Waled Mohsen, Robert Mason, Sooraj Rajendran Pillai
{"title":"Nivolumab-Induced Refractory Hemorrhagic Gastritis and Duodenitis Requiring Multimodal Biologic Therapy.","authors":"Roney Shibu, Kayla Scully, Waled Mohsen, Robert Mason, Sooraj Rajendran Pillai","doi":"10.14309/crj.0000000000001782","DOIUrl":"10.14309/crj.0000000000001782","url":null,"abstract":"<p><p>Rising immune checkpoint inhibitor use in modern cancer therapy has increased the incidence of immune-related adverse events. Although isolated upper gastrointestinal immune-related adverse events including gastritis and duodenitis are uncommon, they may be severe and potentially life-threatening. The heterogeneous presentation of immune-related gastritis and duodenitis causes diagnostic and therapeutic challenges. We present a rare case of severe hemorrhagic gastritis and duodenitis occurring 2 months after completion of nivolumab therapy for stage III melanoma. The disease proved refractory to intravenous pantoprazole, steroids, and infliximab alone, ultimately requiring the addition of vedolizumab in the short term. Complete clinical and biochemical remission was achieved after 12 months of infliximab, which was ceased a month later. Following cessation of immunomodulatory therapy, there was no recurrence of disease at 12-month follow-up.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01782"},"PeriodicalIF":0.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating Complications: A Case of Hemostatic Clip-Induced Biliary Obstruction Leading to Acute Cholangitis. 导航并发症：止血夹致胆道梗阻致急性胆管炎1例。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-07 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001805
Boniface Mensah, Farhan Ali, Abdulhameed M Al-Sabban
{"title":"Navigating Complications: A Case of Hemostatic Clip-Induced Biliary Obstruction Leading to Acute Cholangitis.","authors":"Boniface Mensah, Farhan Ali, Abdulhameed M Al-Sabban","doi":"10.14309/crj.0000000000001805","DOIUrl":"10.14309/crj.0000000000001805","url":null,"abstract":"<p><p>A 67-year-old man presented with signs and symptoms of acute cholangitis following recent endoscopic evaluation at an outside facility for upper gastrointestinal bleed requiring hemostatic clip placement in the duodenum. Endoscopic retrograde cholangiopancreatography showed a hemostatic clip placed at the major papillary orifice, resulting in mechanical obstruction. The hemostatic clip was removed, and a biliary sphincterotomy was performed with subsequent biliary stent placement with successful alleviation of the patient's biliary obstruction.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01805"},"PeriodicalIF":0.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Semaglutide-Induced Liver Injury. semaglutide诱导的肝损伤。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-04 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001776
Harsimran Kalsi, Samneet Singh Arora, Kobina Essilfie-Quaye, Raghav Bassi, Neeka Akhavan, Yaseen Perbtani, Tony S Brar
{"title":"Semaglutide-Induced Liver Injury.","authors":"Harsimran Kalsi, Samneet Singh Arora, Kobina Essilfie-Quaye, Raghav Bassi, Neeka Akhavan, Yaseen Perbtani, Tony S Brar","doi":"10.14309/crj.0000000000001776","DOIUrl":"10.14309/crj.0000000000001776","url":null,"abstract":"<p><p>Semaglutide, a glucagon-like peptide-1 receptor agonist widely used for managing type 2 diabetes mellitus and obesity. Reports of semaglutide-associated hepatotoxicity are exceedingly rare. We detail a case of a 44-year-old woman who developed liver injury with elevated liver enzymes after semaglutide initiation for weight management. Liver enzyme levels normalized after discontinuing the drug and worsened upon rechallenge, confirming semaglutide's potential to cause liver injury. In addition, our case study encompasses a literature review of all reported semaglutide-related drug-induced liver injury cases, highlighting the need for diligent liver function monitoring in patients on semaglutide and offering valuable insights into its hepatotoxic potential.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01776"},"PeriodicalIF":0.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dapagliflozin-Associated Hepatotoxicity With a Positive Rechallenge. 达格列净相关的肝毒性与阳性再挑战。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-04 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001799
Yusuf Alawadhi, Ali Abdolall, Christopher Cunningham, Megan Valente, Robert J Fontana, Kathir Balakumaran
{"title":"Dapagliflozin-Associated Hepatotoxicity With a Positive Rechallenge.","authors":"Yusuf Alawadhi, Ali Abdolall, Christopher Cunningham, Megan Valente, Robert J Fontana, Kathir Balakumaran","doi":"10.14309/crj.0000000000001799","DOIUrl":"10.14309/crj.0000000000001799","url":null,"abstract":"<p><p>Sodium glucose cotransporter 2 inhibitors are generally safe medications, with labelled indications for diabetes mellites, heart failure, and chronic kidney disease. We present a case of suspected dapagliflozin-induced liver injury in a 68-year-old man who presented with 2 weeks of upper abdominal pain, myalgias, and transaminitis following a prior episode of unexplained hepatitis. It was determined that the patient's liver injury with jaundice was likely due to dapagliflozin with a Revised Electronic Causality Assessment Method (RECAM) score of 9 (Highly likely). Laboratory findings and clinical symptoms resolved after discontinuing dapagliflozin during follow up.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01799"},"PeriodicalIF":0.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Empagliflozin-Induced Nondiabetic Ketoacidosis in Advanced Alcoholic Liver Disease. 恩格列净诱导的晚期酒精性肝病非糖尿病酮症酸中毒
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-04 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001787
Sudheer Dhoop, Mohammed Shehada, Ahmad Abdelrahman, Abdel-Rhman Mohamed, Thomas Sodeman
{"title":"Empagliflozin-Induced Nondiabetic Ketoacidosis in Advanced Alcoholic Liver Disease.","authors":"Sudheer Dhoop, Mohammed Shehada, Ahmad Abdelrahman, Abdel-Rhman Mohamed, Thomas Sodeman","doi":"10.14309/crj.0000000000001787","DOIUrl":"10.14309/crj.0000000000001787","url":null,"abstract":"<p><p>A 67-year-old man with advanced alcoholic-associated liver disease developed nondiabetic ketoacidosis shortly after starting empagliflozin for congestive heart failure. He presented with high anion-gap metabolic acidosis, elevated beta-hydroxybutyrate levels, and hypoglycemia. The condition resolved promptly after empagliflozin discontinuation and initiation of intravenous fluids, thiamine, and dextrose therapy. This case highlights the risk of early-onset ketoacidosis in patients with cirrhosis and alcohol use treated with sodium-glucose cotransporter-2 inhibitors, emphasizing careful patient selection and vigilant early monitoring of electrolytes and renal function. As the application of sodium-glucose cotransporter-2 inhibitors expands into managing refractory ascites in cirrhotic patients, further studies are required to confirm their safety.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01787"},"PeriodicalIF":0.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Jaundice in an Adult Female Patient With Photosensitivity. 成年女性光敏性黄疸1例。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-04 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001797
Orlando Emmanuel Falcón-Antonio, David Aguirre-Villarreal, Froylan David Martínez-Sánchez, Ignacio García-Juárez
{"title":"Jaundice in an Adult Female Patient With Photosensitivity.","authors":"Orlando Emmanuel Falcón-Antonio, David Aguirre-Villarreal, Froylan David Martínez-Sánchez, Ignacio García-Juárez","doi":"10.14309/crj.0000000000001797","DOIUrl":"10.14309/crj.0000000000001797","url":null,"abstract":"<p><p>This was the case of a 21-year-old woman with longstanding photosensitivity who developed progressive jaundice and liver dysfunction. The initial workup excluded common hepatobiliary and autoimmune causes. Skin and liver biopsies revealed characteristic histological features, including hyaline dermal deposits and birefringent pigments in the hepatic canaliculi. Elevated erythrocyte protoporphyrin levels and genetic testing confirmed erythropoietic protoporphyria with hepatic involvement. Despite supportive care, she required liver transplantation and later died of infectious complications. This case underscores the importance of considering porphyria in patients with combined cutaneous and hepatic manifestations and highlights the diagnostic value of clinicopathological correlations.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01797"},"PeriodicalIF":0.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiation-Associated Vascular Ectasias in the Esophagus: A Rare Cause of Recurrent Upper Gastrointestinal Bleeding. 食道放射相关血管扩张：复发性上消化道出血的罕见原因。
IF 0.5
ACG Case Reports Journal Pub Date : 2025-08-04 eCollection Date: 2025-08-01 DOI: 10.14309/crj.0000000000001804
Seyedbabak Mirminachi, Tehseen Raza, Steven Bollipo, Sultan Mahmood
{"title":"Radiation-Associated Vascular Ectasias in the Esophagus: A Rare Cause of Recurrent Upper Gastrointestinal Bleeding.","authors":"Seyedbabak Mirminachi, Tehseen Raza, Steven Bollipo, Sultan Mahmood","doi":"10.14309/crj.0000000000001804","DOIUrl":"10.14309/crj.0000000000001804","url":null,"abstract":"","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01804"},"PeriodicalIF":0.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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