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Goltz Syndrome With Large Esophageal Squamous Papillomas-A Unique Cause of Dysphagia Amenable to Endoscopic Treatment. 戈尔茨综合征伴大食管鳞状乳头状瘤-吞咽困难的独特原因，可经内镜治疗。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-09-18 eCollection Date: 2026-09-01 DOI: 10.14309/crj.0000000000002332
Pius Ehiremen Ojemolon, Hayalneh Gessessew, Bereket Abraha Molla, Juwairiya Arshi, Raymond Kim, Sonali Sakaria
{"title":"Goltz Syndrome With Large Esophageal Squamous Papillomas-A Unique Cause of Dysphagia Amenable to Endoscopic Treatment.","authors":"Pius Ehiremen Ojemolon, Hayalneh Gessessew, Bereket Abraha Molla, Juwairiya Arshi, Raymond Kim, Sonali Sakaria","doi":"10.14309/crj.0000000000002332","DOIUrl":"10.14309/crj.0000000000002332","url":null,"abstract":"<p><p>Focal dermal hypoplasia, also referred to as Goltz syndrome, is a rare X-linked dominant multisystem disorder primarily affecting women, with an estimated prevalence of roughly 1 per 1 million individuals. The condition arises from pathogenic variants in the <i>PORCN</i> gene, resulting in disrupted Wnt signaling and subsequent developmental abnormalities involving the skin, skeletal system, and various other tissues. While mucocutaneous papillomas commonly affect the oral cavity and pharynx, distal gastrointestinal manifestations are infrequent. This report describes an exceptionally unusual case of focal dermal hypoplasia with multiple esophageal squamous papillomas causing symptomatic obstruction, which was effectively managed by endoscopic mucosal resection.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02332"},"PeriodicalIF":0.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13593067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrent Intestinal Tuberculosis and Colon Cancer in a Young Patient: A Diagnostic Challenge. 一名年轻患者并发肠结核和结肠癌：诊断挑战。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-09-18 eCollection Date: 2026-09-01 DOI: 10.14309/crj.0000000000002299
Anusha A, Ratnakar Kini, Prem Kumar Karunakaran
{"title":"Concurrent Intestinal Tuberculosis and Colon Cancer in a Young Patient: A Diagnostic Challenge.","authors":"Anusha A, Ratnakar Kini, Prem Kumar Karunakaran","doi":"10.14309/crj.0000000000002299","DOIUrl":"10.14309/crj.0000000000002299","url":null,"abstract":"<p><p>Concurrent intestinal tuberculosis and colonic adenocarcinoma are rare and pose significant diagnostic challenges due to overlapping clinical and endoscopic features. We report a 25-year-old woman presenting with right iliac fossa pain, anorexia, and 10-kg weight loss. Colonoscopy showed a proliferative ascending colon growth with adjacent cecal ulcers. Histopathology confirmed adenocarcinoma from the growth, while catridge-based nucleic acid amplification test from the ulcers detected <i>Mycobacterium tuberculosis</i>. The patient received antitubercular therapy, followed by right hemicolectomy and adjuvant folinic acid, 5-fluorouracil, and oxaliplatin chemotherapy. This case emphasizes the importance of obtaining separate biopsies from multiple lesions to identify dual pathology and ensure appropriate sequential management in tuberculosis-endemic regions.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02299"},"PeriodicalIF":0.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13593144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mediastinal Pancreatic Pseudocyst With Esophageal Compression Presenting as Acute Chest Pain. 纵隔胰腺假性囊肿伴食管压迫，表现为急性胸痛。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-09-17 eCollection Date: 2026-09-01 DOI: 10.14309/crj.0000000000002302
Bibek Saha, Savan Kothadia, Kirsten Losclazo, Sarah Dwyer Holland, Kena P Vyas, Banreet Dhindsa
{"title":"Mediastinal Pancreatic Pseudocyst With Esophageal Compression Presenting as Acute Chest Pain.","authors":"Bibek Saha, Savan Kothadia, Kirsten Losclazo, Sarah Dwyer Holland, Kena P Vyas, Banreet Dhindsa","doi":"10.14309/crj.0000000000002302","DOIUrl":"10.14309/crj.0000000000002302","url":null,"abstract":"<p><p>Acute pancreatitis is a major cause of inpatient morbidity and mortality. Pancreatitis can be complicated by the formation of pseudocysts, which develop after 4 weeks in the peripancreatic space. Most pseudocysts resolve spontaneously but indications for drainage include superimposed infection or organ compression. We present a rare case of a young male cocaine user who presented with acute chest pain found to have esophageal compression from a large mediastinal pseudocyst. The etiology of the chest pain was misdiagnosed on multiple occasions and attributed to a cardiopulmonary or musculoskeletal source, or esophagitis. He underwent endoscopic ultrasound-guided cystogastrostomy with symptom resolution.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02302"},"PeriodicalIF":0.6,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent Jejunal Melanoma Presenting as Obscure Gastrointestinal Bleeding: A Diagnostic Challenge. 复发性空肠黑色素瘤表现为消化道出血：诊断上的挑战。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-09-17 eCollection Date: 2026-09-01 DOI: 10.14309/crj.0000000000002296
Hamza Almusabeh, Daniel Teran, Dayyan Adoor, Ayowumi A Adekolu, Abdullahi Adedotun Sulaiman, Shyam Thakkar
{"title":"Recurrent Jejunal Melanoma Presenting as Obscure Gastrointestinal Bleeding: A Diagnostic Challenge.","authors":"Hamza Almusabeh, Daniel Teran, Dayyan Adoor, Ayowumi A Adekolu, Abdullahi Adedotun Sulaiman, Shyam Thakkar","doi":"10.14309/crj.0000000000002296","DOIUrl":"10.14309/crj.0000000000002296","url":null,"abstract":"<p><p>Melanoma commonly metastasizes to the gastrointestinal tract but is often asymptomatic. Symptomatic small intestinal metastatic melanoma presenting with overt gastrointestinal bleeding is uncommon and may be difficult to diagnose when the initial radiographic and endoscopic workup is unrevealing. We report a 47-year-old patient with prior stage III cutaneous melanoma status post wide local excision and sentinel lymph node biopsy, who declined adjuvant immunotherapy and surveillance, presenting with acute blood loss anemia occurring 3 years after definitive treatment. After nondiagnostic radiographic evaluation, esophagogastroduodenoscopy, colonoscopy, and push enteroscopy, anterograde double-balloon enteroscopy revealed an actively bleeding ulcerated midjejunal mass, later measuring 6 cm on surgical pathology, with pathology confirming the diagnosis of metastatic melanoma.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02296"},"PeriodicalIF":0.6,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guselkumab as a Treatment Adjunct for Pyoderma Gangrenosum While Maintaining Clinical Remission of Ulcerative Colitis. Guselkumab作为坏疽性脓皮病的辅助治疗，同时维持溃疡性结肠炎的临床缓解。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-09-16 eCollection Date: 2026-09-01 DOI: 10.14309/crj.0000000000002290
Rohan Moghe, Alex J Mathew, David Choi, David T Rubin
{"title":"Guselkumab as a Treatment Adjunct for Pyoderma Gangrenosum While Maintaining Clinical Remission of Ulcerative Colitis.","authors":"Rohan Moghe, Alex J Mathew, David Choi, David T Rubin","doi":"10.14309/crj.0000000000002290","DOIUrl":"10.14309/crj.0000000000002290","url":null,"abstract":"<p><p>Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis which can present as an extraintestinal manifestation of ulcerative colitis (UC). There is significant overlap in the pathophysiology of both diseases, including interleukin (IL)-23 overexpression. Guselkumab, a selective IL-23 inhibitor, has been shown to be an effective treatment option in UC and has successfully treated PG in case reports. However, there is limited literature on concomitantly treating PG and UC. We present a case in which guselkumab contributed to the treatment of PG in a patient with UC, while also maintaining clinical remission of UC.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02290"},"PeriodicalIF":0.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dumping Syndrome Following Endoscopic Sleeve Gastroplasty. 内镜下套管胃成形术后倾倒综合征。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-09-16 eCollection Date: 2026-09-01 DOI: 10.14309/crj.0000000000002305
Muhab Saadeh, Zain Albdour, Anas Zaher, Bashar Qumseya
{"title":"Dumping Syndrome Following Endoscopic Sleeve Gastroplasty.","authors":"Muhab Saadeh, Zain Albdour, Anas Zaher, Bashar Qumseya","doi":"10.14309/crj.0000000000002305","DOIUrl":"10.14309/crj.0000000000002305","url":null,"abstract":"<p><p>Dumping syndrome is a recognized complication of bariatric surgery but has not been previously reported following endoscopic sleeve gastroplasty (ESG). We present a woman in her mid-30s who underwent ESG in 2022, achieving a body mass index reduction from 35.4 to 26.7 kg/m<sup>2</sup>. Following subsequent laparoscopic cholecystectomy for cholelithiasis, she developed stereotyped postprandial episodes of diaphoresis, palpitations, lightheadedness, nausea, diarrhea, and bloating, with a Sigstad score of 12 confirming dumping syndrome. Dietary modification and acarbose provided meaningful relief. This case raises the possibility that ESG-related changes in gastric physiology may predispose to dumping syndrome, particularly after subsequent abdominal surgery.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02305"},"PeriodicalIF":0.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Cause of Life-Threatening Rectal Bleeding in Acute Pancreatitis. 急性胰腺炎中危及生命的直肠出血的罕见原因。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-09-16 eCollection Date: 2026-09-01 DOI: 10.14309/crj.0000000000002303
Aditya Patil, Nirbaanjot Walia, Lucy Corlette, Simon Hew
{"title":"A Rare Cause of Life-Threatening Rectal Bleeding in Acute Pancreatitis.","authors":"Aditya Patil, Nirbaanjot Walia, Lucy Corlette, Simon Hew","doi":"10.14309/crj.0000000000002303","DOIUrl":"10.14309/crj.0000000000002303","url":null,"abstract":"","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02303"},"PeriodicalIF":0.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare Delayed Complications of Laparoscopic Adjustable Gastric Band Erosion: Contained Gastric Perforation and Bleeding Pseudoaneurysm. 腹腔镜可调节胃带糜烂的罕见延迟并发症：包含胃穿孔和出血假性动脉瘤。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-09-16 eCollection Date: 2026-09-01 DOI: 10.14309/crj.0000000000002309
Oscar Noble, Ana Paola Islas-Guerra, Jesus Paez-Mayorga, Emiliano Garza-Frias, Davood Abdollahian, Maya Pimentel, Thomas McCarty, Neha Mathur
{"title":"Rare Delayed Complications of Laparoscopic Adjustable Gastric Band Erosion: Contained Gastric Perforation and Bleeding Pseudoaneurysm.","authors":"Oscar Noble, Ana Paola Islas-Guerra, Jesus Paez-Mayorga, Emiliano Garza-Frias, Davood Abdollahian, Maya Pimentel, Thomas McCarty, Neha Mathur","doi":"10.14309/crj.0000000000002309","DOIUrl":"10.14309/crj.0000000000002309","url":null,"abstract":"<p><p>Laparoscopic adjustable gastric banding (LAGB) has declined in use due to long-term complications such as erosions. We report a 65-year-old man who presented with melena 15 years after LAGB placement and ultimately found to have complete intragastric LAGB erosion. His clinical course was complicated by recurrent gastrointestinal bleeding, a contained gastric perforation, intra-abdominal infection, and a right gastric artery pseudoaneurysm. Management required laparoscopic band removal, advanced endoscopic procedures, and arterial embolization. This case highlights a rare but serious late complication of LAGB and emphasizes the need for continued vigilance in patients with legacy bariatric devices.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02309"},"PeriodicalIF":0.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13577434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Not All Pancreatic Masses are Cancer: Pancreatic Tuberculosis Masquerading as Malignancy. 并非所有胰腺肿块都是癌症：伪装成恶性肿瘤的胰腺结核。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-09-15 eCollection Date: 2026-09-01 DOI: 10.14309/crj.0000000000002300
Ronald Blanco Montecino, Alvaro Cadillo Arbaiza, James Cutrell, Puneet Bajaj, Patricio Polanco, Anna Tavakkoli
{"title":"Not All Pancreatic Masses are Cancer: Pancreatic Tuberculosis Masquerading as Malignancy.","authors":"Ronald Blanco Montecino, Alvaro Cadillo Arbaiza, James Cutrell, Puneet Bajaj, Patricio Polanco, Anna Tavakkoli","doi":"10.14309/crj.0000000000002300","DOIUrl":"10.14309/crj.0000000000002300","url":null,"abstract":"<p><p>Pancreatic tuberculosis (TB) is a rare extrapulmonary manifestation that can mimic pancreatic cancer. We report a 61-year-old man presenting with epigastric discomfort, weight loss, elevated liver enzymes, elevated carbohydrate antigen 19-9, and a pancreatic mass causing biliary obstruction. Endoscopic ultrasound-guided biopsies revealed granulomatous inflammation and necrosis. Autoimmune and fungal etiologies were excluded, and acid-fast stains were negative. Definitive diagnosis was achieved through 16S ribosomal RNA sequencing followed by detection of the <i>Mycobacterium tuberculosis</i> <i>hsp65</i> gene. This case highlights the diagnostic challenge of pancreatic TB and the importance of reconsidering the differential diagnosis when histopathological findings do not align with clinical suspicion.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02300"},"PeriodicalIF":0.6,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustained Remission Following Limited Dupilumab Exposure in Refractory Eosinophilic Esophagitis. 难治性嗜酸性食管炎有限Dupilumab暴露后持续缓解。
IF 0.6
ACG Case Reports Journal Pub Date : 2026-09-11 eCollection Date: 2026-09-01 DOI: 10.14309/crj.0000000000002314
Dain Raina Kim, Adam Bubelenyi, Milli Gupta
{"title":"Sustained Remission Following Limited Dupilumab Exposure in Refractory Eosinophilic Esophagitis.","authors":"Dain Raina Kim, Adam Bubelenyi, Milli Gupta","doi":"10.14309/crj.0000000000002314","DOIUrl":"10.14309/crj.0000000000002314","url":null,"abstract":"<p><p>Eosinophilic esophagitis (EoE) is a type 2 immune-mediated esophageal disorder that can be refractory to standard therapy. We present a case of a 49-year-old woman with asthma, chronic sinusitis, and nasal polyposis diagnosed with EoE refractory to proton pump inhibitors, dietary modification, and swallowed topical corticosteroids. She was treated with dupilumab in 2023 but discontinued it after 3 months due to side effects. Subsequent esophagogastroduodenoscopies demonstrated sustained histologic and endoscopic remission up to October 2025 (26 months later), after which recurrence of disease was confirmed. This case highlights 2-year sustained remission following limited exposure to dupilumab in refractory EoE.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 9","pages":"e02314"},"PeriodicalIF":0.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13568291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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