ACG Case Reports JournalPub Date : 2025-05-22eCollection Date: 2025-05-01DOI: 10.14309/crj.0000000000001688
Taimur Khan, Safia Afaq, Nadia Mishal, Chuan Loong Miao
{"title":"Unmasking Gastrointestinal Stromal Tumor: Gastrointestinal Stromal Tumor Presenting With Recurrent Gastrointestinal Bleeding.","authors":"Taimur Khan, Safia Afaq, Nadia Mishal, Chuan Loong Miao","doi":"10.14309/crj.0000000000001688","DOIUrl":"10.14309/crj.0000000000001688","url":null,"abstract":"<p><p>A jejunal gastrointestinal stromal tumor (GIST) is a rare malignant mesenchymal neoplasm of the gastrointestinal tract that arises from the interstitial cells of Cajal. Massive and recurrent bleeding due to jejunal GIST is a diagnostic challenge which may lead to delays in treatment. GISTs as the source of bleeding are already rare. This case is further characterized by endoscopic visualization and clipping of a site of bleeding before eventual surgical resection for recurrent bleeding.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 5","pages":"e01688"},"PeriodicalIF":0.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2025-05-21eCollection Date: 2025-05-01DOI: 10.14309/crj.0000000000001711
Kenan Sinan, Serina Beydoun, Tony Lulgjuraj
{"title":"The Clinical Conundrum of Cyclic Vomiting in the Cannabinoid User: Simply Cannabinoid Hyperemesis or Could It Be More?","authors":"Kenan Sinan, Serina Beydoun, Tony Lulgjuraj","doi":"10.14309/crj.0000000000001711","DOIUrl":"10.14309/crj.0000000000001711","url":null,"abstract":"<p><p>Distinguishing between cannabinoid hyperemesis syndrome and cyclic vomiting syndrome (CVS) in patients with cyclical vomiting and heavy cannabinoid use is a significant diagnostic challenge. A critical consideration is catamenial CVS, a subtype of CVS in which vomiting episodes are closely linked to the menstrual cycle. This pattern is frequently overlooked in cannabinoid users due to the overlapping symptomatology of both conditions. However, identifying a menstrual association with vomiting episodes is crucial for diagnosing catamenial CVS because hormonal contraceptive therapy is an effective treatment. We present 2 adolescent cases of cyclical vomiting with cannabis use, where further clinical investigation revealed the menstrual cycle as a key trigger for vomiting, ultimately leading to successful treatment with hormonal contraception despite continued cannabis use. Clinicians should always consider menstrual history in patients with cyclical vomiting to facilitate early and accurate diagnosis and timely treatment of catamenial CVS.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 5","pages":"e01711"},"PeriodicalIF":0.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2025-05-21eCollection Date: 2025-05-01DOI: 10.14309/crj.0000000000001708
Abdulmalik Saleem, Taher Jamali, Iana Gueorguieva
{"title":"Mucosal Schwann Cell Hamartoma of the Appendix: Expanding the Differential for Gastrointestinal Bleeding.","authors":"Abdulmalik Saleem, Taher Jamali, Iana Gueorguieva","doi":"10.14309/crj.0000000000001708","DOIUrl":"10.14309/crj.0000000000001708","url":null,"abstract":"<p><p>Mucosal Schwann cell hamartomas (MSCH) are rare benign tumors typically found in the colorectal region. We present the case of an 87-year-old man with a history of mucosa-associated lymphoid tissue lymphoma who developed symptomatic gastrointestinal bleeding due to an appendiceal MSCH. The patient's ongoing melena and anemia led to further evaluation. Subsequent colonoscopy revealed active bleeding from the appendiceal orifice with hemostasis achieved using epinephrine injection. A laparoscopic appendectomy confirmed MSCH through histopathology and immunohistochemical staining. Given its rarity, this case underscores the importance of considering MSCH in unexplained gastrointestinal bleeding and demonstrates its potential to be a symptomatically significant entity.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 5","pages":"e01708"},"PeriodicalIF":0.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2025-05-19eCollection Date: 2025-05-01DOI: 10.14309/crj.0000000000001712
Hala Alrasheed, Oray Kahraman, Eva Markert, Olaf Chan-Hi Kim, Christin Pelzer, Katia Boggian, Stephan Brand, Samuel Truniger
{"title":"First Description of Simultaneous Sweet Syndrome and Tracheal Stenosis as Extraintestinal Manifestations in a Patient With Highly Active Ulcerative Colitis.","authors":"Hala Alrasheed, Oray Kahraman, Eva Markert, Olaf Chan-Hi Kim, Christin Pelzer, Katia Boggian, Stephan Brand, Samuel Truniger","doi":"10.14309/crj.0000000000001712","DOIUrl":"10.14309/crj.0000000000001712","url":null,"abstract":"<p><p>Sweet syndrome and tracheal stenosis are very rare extraintestinal manifestations of inflammatory bowel diseases. In this study, we present a patient with ulcerative colitis, who developed Sweet syndrome in combination with an acute tracheal stenosis causing a life-threatening situation requiring admission to the intensive care unit. The patient had an excellent response to intravenous corticosteroids and intravenous infliximab, which had to be switched to vedolizumab after an allergic reaction to infliximab. The patient remained in stable remission with vedolizumab. This is, to our knowledge, the first case reported, in which these very rare extraintestinal manifestations occurred simultaneously.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 5","pages":"e01712"},"PeriodicalIF":0.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2025-05-17eCollection Date: 2025-05-01DOI: 10.14309/crj.0000000000001705
Salim C Lutfallah, John F G Bobo, Rachna Jetly-Shridhar, Nisha Loganantharaj
{"title":"The Persistent Wound: Plasmablastic Lymphoma in a Perianal Fistula.","authors":"Salim C Lutfallah, John F G Bobo, Rachna Jetly-Shridhar, Nisha Loganantharaj","doi":"10.14309/crj.0000000000001705","DOIUrl":"10.14309/crj.0000000000001705","url":null,"abstract":"<p><p>Plasmablastic lymphoma is an aggressive subtype of diffuse large B-cell lymphoma associated with immunosuppression, particularly in HIV-positive patients. Although rare in HIV-negative individuals, patients with Crohn's disease experience immune dysregulation due to chronic immunosuppression that can predispose them to plasmablastic lymphoma. We present a case of a 54-year-old man with ileocolonic and perianal fistulizing Crohn's disease who developed plasmablastic lymphoma. This case emphasizes the importance of early recognition of plasmablastic lymphoma in patients undergoing chronic immunosuppressive treatment of Crohn's disease, as early diagnosis and timely intervention are crucial for improving outcomes.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 5","pages":"e01705"},"PeriodicalIF":0.6,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antitumor Necrosis Factor-Refractory Esophageal Lesions in Crohn's Disease Successfully Treated With Upadacitinib.","authors":"Naohiro Nakamura, Yusuke Honzawa, Yuka Ito, Yasuki Sano, Naoto Yagi, Eiko Saito, Norimasa Fukata, Makoto Naganuma","doi":"10.14309/crj.0000000000001713","DOIUrl":"10.14309/crj.0000000000001713","url":null,"abstract":"<p><p>A 39-year-old man with a 5-year history of ileocolonic Crohn's disease received treatment with 6-mercaptopurine and adalimumab. A computed tomography scan was performed due to a persistent cough, revealing esophageal wall thickening. Esophagogastroduodenoscopy identified multiple longitudinal ulcers throughout the esophagus. Despite infliximab treatment, the esophageal lesions deteriorated, leading to the initiation of upadacitinib for antitumor necrosis factor-refractory esophageal lesions. Consequently, all esophageal lesions were healed, and serum biomarkers returned negative results. Although upadacitinib is effective for patients with ileocolonic Crohn's disease, this is the first case demonstrating its efficacy for refractory esophageal lesions.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 5","pages":"e01713"},"PeriodicalIF":0.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2025-05-16eCollection Date: 2025-05-01DOI: 10.14309/crj.0000000000001704
Kevan Josloff, Benjamin Young, Marc Hersh, Alekya Bheemreddy, Sherry Lee, Dina Halegoua-Demarzio
{"title":"De novo Hepatitis B Virus Infection in a Post-transplant Patient Causing Stage 4 Cirrhosis Necessitating Retransplant.","authors":"Kevan Josloff, Benjamin Young, Marc Hersh, Alekya Bheemreddy, Sherry Lee, Dina Halegoua-Demarzio","doi":"10.14309/crj.0000000000001704","DOIUrl":"10.14309/crj.0000000000001704","url":null,"abstract":"<p><p>Hepatitis B virus (HBV) is a common cause of liver cirrhosis worldwide, almost always as a result of HBV infection at birth or a very young age. HBV very rarely causes cirrhosis when contracted as an adult. Notably, the risk of HBV progression to cirrhosis is higher in immunocompromised patients, such as liver transplant patients, although it is still quite rare. We present a liver-transplant patient who acquired a de novo HBV infection and developed HBV-associated cirrhosis requiring retransplantation.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 5","pages":"e01704"},"PeriodicalIF":0.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2025-05-16eCollection Date: 2025-05-01DOI: 10.14309/crj.0000000000001706
Kashif Ali, Samra Sohail, Grecia Dominguez Rivera, Valeska Balderas
{"title":"Rectosigmoid Intussusception Due to a Nonmalignant Etiology: An Extremely Rare Cause of Acute Lower Gastrointestinal Bleeding in an Elderly Patient.","authors":"Kashif Ali, Samra Sohail, Grecia Dominguez Rivera, Valeska Balderas","doi":"10.14309/crj.0000000000001706","DOIUrl":"10.14309/crj.0000000000001706","url":null,"abstract":"<p><p>An intussusception at the rectosigmoid junction with acute gastrointestinal bleeding is exceedingly rare. We present a case of an 88-year-old man who presented in the emergency department with bilateral lower quadrant abdominal pain and frank rectal bleeding for 2 days. A computed tomography abdomen pelvis angiogram with contrast showed a target sign, and a flexible sigmoidoscopy showed congested bowel, ischemia, frank blood, and intussusception at the rectosigmoid junction. He underwent an exploratory laparotomy with the removal of the affected part. The pathology and the peritoneal fluid cytology results came out negative for dysplasia and malignancy.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 5","pages":"e01706"},"PeriodicalIF":0.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2025-05-16eCollection Date: 2025-05-01DOI: 10.14309/crj.0000000000001710
Clive Jude Miranda, Marcellus Anthony Singh, Fnu Monika, Ahmed Al-Chalabi
{"title":"Duodenogastric Prolapse as a Rare Cause of Gastrointestinal Bleeding.","authors":"Clive Jude Miranda, Marcellus Anthony Singh, Fnu Monika, Ahmed Al-Chalabi","doi":"10.14309/crj.0000000000001710","DOIUrl":"10.14309/crj.0000000000001710","url":null,"abstract":"","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 5","pages":"e01710"},"PeriodicalIF":0.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Achalasia or Pseudoachalasia: Incidental Esophagogastric Junction Submucosal Leiomyoma During Peroral Endoscopic Myotomy.","authors":"Kenan Rahima, Mohamad Hijazi, Mhd Kutaiba Albuni, Sogand Taheri, Venkata Muddana","doi":"10.14309/crj.0000000000001709","DOIUrl":"10.14309/crj.0000000000001709","url":null,"abstract":"<p><p>The concomitant presence of esophageal achalasia and esophagogastric junction submucosal leiomyoma is extremely rare. Peroral endoscopic myotomy has been endorsed as one of the primary interventions to manage esophageal achalasia. We present a 49-year-old woman who had initial endoscopic evaluation and diagnosis of achalasia type II then underwent peroral endoscopic myotomy and found to have incidental submucosal leiomyoma at 1 cm distal to esophagogastric junction. It was removed successfully by submucosal tunneling endoscopic resection. This poses the question of whether this is a case of achalasia or pseudoachalasia caused by leiomyoma.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 5","pages":"e01709"},"PeriodicalIF":0.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}