ACG Case Reports JournalPub Date : 2026-05-06eCollection Date: 2026-05-01DOI: 10.14309/crj.0000000000002100
Pranav Patel, Aaron Rampersad, Jay Alden, Anjani Jammula, Prerana Roth
{"title":"HIV and Hickam's Dictum: Multiple Opportunistic Infections.","authors":"Pranav Patel, Aaron Rampersad, Jay Alden, Anjani Jammula, Prerana Roth","doi":"10.14309/crj.0000000000002100","DOIUrl":"https://doi.org/10.14309/crj.0000000000002100","url":null,"abstract":"<p><p>Opportunistic infections are common in patients with acquired immunodeficiency syndrome (AIDS) or advanced human immunodeficiency virus infection when adherence to anti-retroviral is poor. We present a case report of multiple opportunistic infections simultaneously present in a patient with AIDS who presented with fevers, abdominal pain, and diarrhea. He was ultimately diagnosed with <i>Streptococcus pneumoniae</i> pneumonia, oral thrush, esophageal histoplasmosis, cytomegalovirus esophagitis and herpes simplex esophagitis. This case is a reminder of the severity of illness in AIDS and the need for thorough workups to address all disease processes.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 5","pages":"e02100"},"PeriodicalIF":0.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2026-04-29eCollection Date: 2026-05-01DOI: 10.14309/crj.0000000000002112
Sofi Damjanovska, Brendan Andres, Stanley M Cohen
{"title":"Acute Liver Failure Revealing Disseminated Ocular Melanoma With Hepatic and Duodenal Metastases.","authors":"Sofi Damjanovska, Brendan Andres, Stanley M Cohen","doi":"10.14309/crj.0000000000002112","DOIUrl":"https://doi.org/10.14309/crj.0000000000002112","url":null,"abstract":"","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 5","pages":"e02112"},"PeriodicalIF":0.5,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2026-04-28eCollection Date: 2026-05-01DOI: 10.14309/crj.0000000000002102
Minmin Hu, Tong Lin, Xiaodong Chen
{"title":"Gastric and Pan-Colonic Cement Bezoars Secondary to Pica in an Elderly Man.","authors":"Minmin Hu, Tong Lin, Xiaodong Chen","doi":"10.14309/crj.0000000000002102","DOIUrl":"https://doi.org/10.14309/crj.0000000000002102","url":null,"abstract":"","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 5","pages":"e02102"},"PeriodicalIF":0.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2026-04-28eCollection Date: 2026-05-01DOI: 10.14309/crj.0000000000002103
Adlin Lawrence, Ingrid Villanueva, Jignesh Parikh, Amar Mandalia
{"title":"Pancreatic Adenocarcinoma Associated With a Germline RAD51C Mutation.","authors":"Adlin Lawrence, Ingrid Villanueva, Jignesh Parikh, Amar Mandalia","doi":"10.14309/crj.0000000000002103","DOIUrl":"https://doi.org/10.14309/crj.0000000000002103","url":null,"abstract":"<p><p>Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality in the United States, with a 5-year survival of ∼10%-13%. Although 5%-10% of PDAC cases arise from pathogenic germline variants in cancer-predisposition genes, association with <i>RAD51C</i> remains exceedingly rare, with only one prior case reported. We describe a 64-year-old woman who presented with progressive epigastric pain and was found to have a hypermetabolic pancreatic head mass with markedly elevated CA 19-9. Endoscopic biopsy confirmed pancreatic adenocarcinoma (MSI-stable, HER2-negative), staged as cT2N0M0. Comprehensive germline testing identified a pathogenic <i>RAD51C</i> mutation. The patient declined treatment and genetic counseling, electing for palliative care. <i>RAD51C</i> plays a critical role in homologous recombination DNA repair, and its loss may confer sensitivity to platinum-based chemotherapy and poly (ADP-ribose) polymerase inhibitors. This case represents only the second reported RAD51C-associated PDAC and reinforces the importance of universal germline testing to identify hereditary risk and guide therapeutic strategies.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 5","pages":"e02103"},"PeriodicalIF":0.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2026-04-28eCollection Date: 2026-05-01DOI: 10.14309/crj.0000000000002111
Mischelle Lopez Quinteros, Marisa S Zayat, Jessica C Petrov, Frank J Lukens, Mihir S Wagh, Jana G Hashash, Timothy A Woodward, Osayande Osagiede
{"title":"Endoscopic Management of Variceal Band Ligation Leading to Acute Esophageal Obstruction.","authors":"Mischelle Lopez Quinteros, Marisa S Zayat, Jessica C Petrov, Frank J Lukens, Mihir S Wagh, Jana G Hashash, Timothy A Woodward, Osayande Osagiede","doi":"10.14309/crj.0000000000002111","DOIUrl":"https://doi.org/10.14309/crj.0000000000002111","url":null,"abstract":"<p><p>Complete esophageal obstruction is a rare but serious complication of endoscopic variceal band ligation (EVBL). We present the case of a 75-year-old man with cirrhosis and esophageal varices who developed acute esophageal obstruction following EVBL, which was successfully managed with a combination of endoscopic scissors to cut the band and through-the-scope balloon dilation, restoring luminal patency and recanalization of the esophagus. This case highlights the importance of prevention, early recognition, and timely management of this rare but important complication of EVBL. Key management options addressed include preventive, conservative, and interventional strategies to improve patient outcomes.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 5","pages":"e02111"},"PeriodicalIF":0.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Visceral Muscle Dysmotility Syndrome With Esophageal Aperistalsis (VMDS Tetrad): A Rare Initial Manifestation of Systemic Lupus Erythematosus.","authors":"Shubham Kashyap, Chhagan Lal Birda, Ankit Agarwal, Ayushi Agarwal, Vivek Chowdary Gogineni, Ashish Agarwal","doi":"10.14309/crj.0000000000002110","DOIUrl":"https://doi.org/10.14309/crj.0000000000002110","url":null,"abstract":"<p><p>Visceral muscle dysmotility syndrome (VMDS) is a rare manifestation of systemic lupus erythematosus. VMDS with esophageal aperistalsis (VMDS tetrad) as the initial presentation of systemic lupus erythematosus has not been previously reported. We describe a case of 35-year-old woman with recurrent intestinal pseudo-obstruction associated with pyeloureterectasis, nonobstructive biliary dilatation, and esophageal aperistalsis, constituting a VMDS tetrad. The diagnosis was established based on clinical features, radiologic findings, and serologic evaluation. The patient responded promptly to immunosuppressive therapy, with complete clinical and radiologic resolution, highlighting the importance of early recognition and timely treatment.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 5","pages":"e02110"},"PeriodicalIF":0.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Virtual Reality in the Field of Gastroenterology: Entering a New Era.","authors":"Hema Sameera Pinnam, Bhanu Siva Mohan Pinnam, Harshita Malik, Hareesha Rishab Bharadwaj, Hassam Ali, Dushyant Singh Dahiya","doi":"10.14309/crj.0000000000002109","DOIUrl":"https://doi.org/10.14309/crj.0000000000002109","url":null,"abstract":"","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 5","pages":"e02109"},"PeriodicalIF":0.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACG Case Reports JournalPub Date : 2026-04-24eCollection Date: 2026-05-01DOI: 10.14309/crj.0000000000002104
Alessandra Saraga, Rachel Bocchino, Ajay Gade, Michelle J Wang, Melissa Spiel, Adam S Cheifetz, Loren G Rabinowitz
{"title":"Sertraline-Associated Microscopic Colitis Flare in Pregnancy.","authors":"Alessandra Saraga, Rachel Bocchino, Ajay Gade, Michelle J Wang, Melissa Spiel, Adam S Cheifetz, Loren G Rabinowitz","doi":"10.14309/crj.0000000000002104","DOIUrl":"https://doi.org/10.14309/crj.0000000000002104","url":null,"abstract":"<p><p>Microscopic colitis (MC) is a histologically confirmed cause of chronic diarrhea with normal endoscopy, and limited data complicate diagnosis and management during pregnancy. We report a 31-year-old woman with lymphocytic colitis, initially misdiagnosed as irritable bowel syndrome, who experienced an MC flare at 15 weeks' gestation after starting sertraline. Symptoms resolved with sertraline discontinuation and budesonide, with remission maintained postpartum. This case underscores the importance of medication review, early recognition, and multidisciplinary care in pregnant patients with persistent diarrhea, particularly when coordinating gastrointestinal and psychiatric management.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 5","pages":"e02104"},"PeriodicalIF":0.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dual Ampullary Orifices: A Forgotten Embryologic Anomaly in Modern ERCP.","authors":"Pankaj Gupta, Pankaj Singh, Vikas Singla, Muzzaffar Rashid Shawl, Akash Goel","doi":"10.14309/crj.0000000000002062","DOIUrl":"https://doi.org/10.14309/crj.0000000000002062","url":null,"abstract":"<p><p>Bile duct and pancreatic duct join as a single orifice at ampulla of Vater. Anomalous rotation or recanalization of hepatopancreatic ducts during embryogenesis can lead to anatomical variations of ampulla of Vater. One such anatomical variation is double major papilla with dual ampullary orifices for bile and pancreatic duct, the incidence of which is exceedingly rare. Identification and early recognition of such variations before initiating cannulation can prevent inadvertent pancreatic duct cannulation. We report a case of 78-year-old man with chronic calcific pancreatitis with choledocholithiasis, found to have dual ampullary orifices. Selective cannulation was performed for each duct followed by stenting without any complications. This case emphasizes that knowledge and awareness of such rare ampullary variations can prevent inadvertent pancreatic duct cannulation.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"13 5","pages":"e02062"},"PeriodicalIF":0.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}