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Atorvastatin-Induced Liver Injury With Concurrent Rhabdomyolysis After a Positive Rechallenge.
IF 0.6
ACG Case Reports Journal Pub Date : 2024-12-30 eCollection Date: 2025-01-01 DOI: 10.14309/crj.0000000000001570
Harjit Singh, Adam Khalaf, Bryce F Kunkle, Sherry Gholami, James H Lewis, Amol S Rangnekar
{"title":"Atorvastatin-Induced Liver Injury With Concurrent Rhabdomyolysis After a Positive Rechallenge.","authors":"Harjit Singh, Adam Khalaf, Bryce F Kunkle, Sherry Gholami, James H Lewis, Amol S Rangnekar","doi":"10.14309/crj.0000000000001570","DOIUrl":"10.14309/crj.0000000000001570","url":null,"abstract":"<p><p>Statin-induced liver injury has been widely described. However, cases of clinically significant liver injury are rare. We present a 56-year-old woman who developed atorvastatin-induced grade III acute liver injury with concurrent rhabdomyolysis that worsened after rechallenging, which highlighted the need for pharmacovigilance with statins. The Roussel Uclaf Causality Assessment Method and Revised Electronic Causality Assessment Method both showed that atorvastatin was highly probable in causing hepatotoxicity. To our knowledge, this is the first reported case of concurrent drug-induced liver injury and rhabdomyolysis after a positive rechallenge with atorvastatin.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 1","pages":"e01570"},"PeriodicalIF":0.6,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11688008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Diffuse Ulcerative Esophagitis Caused by Epstein-Barr Virus/Cytomegalovirus Coinfection in an Immunocompetent Individual.
IF 0.6
ACG Case Reports Journal Pub Date : 2024-12-27 eCollection Date: 2025-01-01 DOI: 10.14309/crj.0000000000001578
Kartikeya Mathur, Chhagan Lal Birda, Satyam Kumar Singh, Vvienodd Uppuv, Shubham Kashyap, Ashish Agarwal
{"title":"Severe Diffuse Ulcerative Esophagitis Caused by Epstein-Barr Virus/Cytomegalovirus Coinfection in an Immunocompetent Individual.","authors":"Kartikeya Mathur, Chhagan Lal Birda, Satyam Kumar Singh, Vvienodd Uppuv, Shubham Kashyap, Ashish Agarwal","doi":"10.14309/crj.0000000000001578","DOIUrl":"10.14309/crj.0000000000001578","url":null,"abstract":"<p><p>Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) are important causes of viral esophagitis mainly in immunocompromised individuals. Both viruses lead to development of focal ulcerations in the esophagus. While there have been rare case reports of esophagitis in immunocompetent individuals, there has not been a single reported case of coinfection with both CMV and EBV in an immunocompetent individual and presenting with diffuse esophageal ulceration. We report a case of severe diffuse ulcerative esophagitis caused by EBV/CMV coinfection in an immunocompetent individual.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 1","pages":"e01578"},"PeriodicalIF":0.6,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Semaglutide-Associated Gastric Pneumatosis.
IF 0.6
ACG Case Reports Journal Pub Date : 2024-12-27 eCollection Date: 2025-01-01 DOI: 10.14309/crj.0000000000001579
Andrew M Turunen, Reilly A Coombs, Sushil Kumar Garg
{"title":"Semaglutide-Associated Gastric Pneumatosis.","authors":"Andrew M Turunen, Reilly A Coombs, Sushil Kumar Garg","doi":"10.14309/crj.0000000000001579","DOIUrl":"10.14309/crj.0000000000001579","url":null,"abstract":"<p><p>Semaglutide, a glucagon-like peptide-1 receptor agonist, used for Type 2 diabetes mellitus and more recently for weight loss, often causes gastrointestinal adverse effects such as delayed gastric emptying and abdominal discomfort. Current literature has not described an associated case of gastric pneumatosis with semaglutide use. We report a 61-year-old man on semaglutide for 9 months with gastric pneumatosis. Symptoms resolved on discontinuation. Clinicians should be vigilant for significant gastrointestinal adverse effects, including pneumatosis with semaglutide use.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 1","pages":"e01579"},"PeriodicalIF":0.6,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small-Bowel Metastatic Melanoma From Primary Mucosal Melanoma of the Anus: A Comprehensive Case Report.
IF 0.6
ACG Case Reports Journal Pub Date : 2024-12-27 eCollection Date: 2025-01-01 DOI: 10.14309/crj.0000000000001577
Andrea Gomez Pons, Frank J Lukens, Osayande Osagiede
{"title":"Small-Bowel Metastatic Melanoma From Primary Mucosal Melanoma of the Anus: A Comprehensive Case Report.","authors":"Andrea Gomez Pons, Frank J Lukens, Osayande Osagiede","doi":"10.14309/crj.0000000000001577","DOIUrl":"10.14309/crj.0000000000001577","url":null,"abstract":"<p><p>Anorectal mucosal melanoma (ARMM) is exceptionally rare, highly malignant, and characterized by a poor prognosis. We present the case of a 76-year-old woman with ARMM and recurrent gastrointestinal (GI) bleeding/anemia caused by small-bowel metastases, which was successfully managed with laparoscopic resection. ARMM is an aggressive type of cancer that has the potential to metastasize to the GI tract approximately 4.5 years after the primary diagnosis. Intussusception and GI bleed are potential complications. Small-bowel metastatic melanoma typically goes undiagnosed until autopsy and requires a multidisciplinary approach. Key treatment options include surgery and immunotherapy to improve patient outcomes.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 1","pages":"e01577"},"PeriodicalIF":0.6,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated and Localized Immunoglobulin 4-Related Cholecystitis Mimicking Gallbladder Carcinoma.
IF 0.6
ACG Case Reports Journal Pub Date : 2024-12-27 eCollection Date: 2025-01-01 DOI: 10.14309/crj.0000000000001576
Kenji Yorita, Sunao Uemura, Michiyo Okazaki
{"title":"Isolated and Localized Immunoglobulin 4-Related Cholecystitis Mimicking Gallbladder Carcinoma.","authors":"Kenji Yorita, Sunao Uemura, Michiyo Okazaki","doi":"10.14309/crj.0000000000001576","DOIUrl":"10.14309/crj.0000000000001576","url":null,"abstract":"","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 1","pages":"e01576"},"PeriodicalIF":0.6,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Hepatitis B Infection in a Patient With Confirmed Immunity on Long-Acting Cabotegravir/Rilpivirine.
IF 0.6
ACG Case Reports Journal Pub Date : 2024-12-27 eCollection Date: 2025-01-01 DOI: 10.14309/crj.0000000000001575
William K B Boateng, Neil Carlin, Etan Spira, Maria E Szabela, Kosisochukwu J Ezeh
{"title":"Acute Hepatitis B Infection in a Patient With Confirmed Immunity on Long-Acting Cabotegravir/Rilpivirine.","authors":"William K B Boateng, Neil Carlin, Etan Spira, Maria E Szabela, Kosisochukwu J Ezeh","doi":"10.14309/crj.0000000000001575","DOIUrl":"10.14309/crj.0000000000001575","url":null,"abstract":"<p><p>Long-acting injectable formulation of cabotegravir/rilpivirine (CAB/RPV) is a promising novel maintenance therapy for HIV infection. However, coinfection with active hepatitis B virus (HBV) infection is a contraindication to initiating this therapy. Despite guidelines, patients with HBV immunity can still contract acute HBV infection. We report a case of a 30-year-old man with HIV who transitioned from antiretroviral therapy to CAB/RPV and had confirmed HBV immunity. The patient, though asymptomatic, showed significantly elevated liver function tests (LFTs) before his monthly CAB/RPV injection. He was hospitalized and diagnosed with acute HBV infection. His LFTs improved, and he was taken off CAB/RPV and returned to antiretroviral therapy for the treatment of HIV and HBV. During subsequent follow-ups as an outpatient, the patient's LFTs normalized, and his HBV viral load significantly decreased. This case highlights the potential need for routine HBV testing in patients on CAB/RPV therapy.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 1","pages":"e01575"},"PeriodicalIF":0.6,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Double Whammy: A Case Report of Immune Checkpoint Inhibitor Colitis and Concomitant Cytomegalovirus Colitis in a Patient on Nivolumab.
IF 0.6
ACG Case Reports Journal Pub Date : 2024-12-27 eCollection Date: 2025-01-01 DOI: 10.14309/crj.0000000000001569
Misha Gautam, Vinay Jahagirdar, Himil Mahadevia, Kimberly Sanders, John P Campbell, Pamela B Sylvestre, Rajiv Chhabra, Wendell Clarkston, Sreenivasa S Jonnalagadda
{"title":"Double Whammy: A Case Report of Immune Checkpoint Inhibitor Colitis and Concomitant <i>Cytomegalovirus</i> Colitis in a Patient on Nivolumab.","authors":"Misha Gautam, Vinay Jahagirdar, Himil Mahadevia, Kimberly Sanders, John P Campbell, Pamela B Sylvestre, Rajiv Chhabra, Wendell Clarkston, Sreenivasa S Jonnalagadda","doi":"10.14309/crj.0000000000001569","DOIUrl":"10.14309/crj.0000000000001569","url":null,"abstract":"<p><p>Immune checkpoint inhibitors commonly cause gastrointestinal immune-related adverse effects. These patients also carry an increased risk of concomitant infections. This 66-year-old man with immune checkpoint inhibitor colitis was discovered to have concurrent <i>Yersinia</i> and <i>Cytomegalovirus</i> colitis. Such infections may mimic or complicate disease course. Hence, clinicians must monitor patient symptoms, have a low threshold for infectious testing and colonoscopy, and consider treatment strategies to mitigate their risk.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 1","pages":"e01569"},"PeriodicalIF":0.6,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Bile Ducts to Esophagus: A Novel Cholangioscopic Method for Foreign Body Removal.
IF 0.6
ACG Case Reports Journal Pub Date : 2024-12-27 eCollection Date: 2025-01-01 DOI: 10.14309/crj.0000000000001561
Akshaya Sathyamurthy Iyer, Vikramaditya Rawat, Saiprasad Lad, Mit Shah, Motij Kumar Dalai, Meghraj Ingle
{"title":"From Bile Ducts to Esophagus: A Novel Cholangioscopic Method for Foreign Body Removal.","authors":"Akshaya Sathyamurthy Iyer, Vikramaditya Rawat, Saiprasad Lad, Mit Shah, Motij Kumar Dalai, Meghraj Ingle","doi":"10.14309/crj.0000000000001561","DOIUrl":"10.14309/crj.0000000000001561","url":null,"abstract":"","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 1","pages":"e01561"},"PeriodicalIF":0.6,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare Presentation of Cytomegalovirus Colitis Mimicking Colonic Neoplasm.
IF 0.6
ACG Case Reports Journal Pub Date : 2024-12-21 eCollection Date: 2024-12-01 DOI: 10.14309/crj.0000000000001572
Mohammed Abusuliman, Taher Jamali, Najwa El-Nachef
{"title":"Rare Presentation of Cytomegalovirus Colitis Mimicking Colonic Neoplasm.","authors":"Mohammed Abusuliman, Taher Jamali, Najwa El-Nachef","doi":"10.14309/crj.0000000000001572","DOIUrl":"https://doi.org/10.14309/crj.0000000000001572","url":null,"abstract":"","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"11 12","pages":"e01572"},"PeriodicalIF":0.6,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Initial Experience With Safety and Efficacy of Endoscopic Full-Thickness Resection in Patients With Inflammatory Bowel Disease: A Case Series.
IF 0.6
ACG Case Reports Journal Pub Date : 2024-12-20 eCollection Date: 2024-12-01 DOI: 10.14309/crj.0000000000001571
Himsikhar Khataniar, Aakash Desai, Gursimran S Kochhar
{"title":"Initial Experience With Safety and Efficacy of Endoscopic Full-Thickness Resection in Patients With Inflammatory Bowel Disease: A Case Series.","authors":"Himsikhar Khataniar, Aakash Desai, Gursimran S Kochhar","doi":"10.14309/crj.0000000000001571","DOIUrl":"10.14309/crj.0000000000001571","url":null,"abstract":"<p><p>Endoscopic full-thickness resection (EFTR) is a novel endoscopic technique for removing complex colorectal lesions. The inflammatory bowel disease (IBD) population poses unique challenges for endoscopic resection due to an increased prevalence of fibrotic, nonlifting lesions and higher recurrence rates compared with the general population. This case series reports on the successful use of EFTR in 5 patients with IBD who had challenging colonic polyps, including fibrotic and nonlifting lesions. Technical success was achieved in all cases without any postoperative complications. Follow-up surveillance revealed no residual lesions or recurrence, and histopathological analysis confirmed full-thickness resection in all samples. This is one of the first case series suggesting that EFTR is a promising, safe, and effective alternative to surgery for managing complex colorectal polyps in patients with IBD.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"11 12","pages":"e01571"},"PeriodicalIF":0.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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