Semaglutide-Induced Liver Injury.

IF 0.5 Q4 GASTROENTEROLOGY & HEPATOLOGY
ACG Case Reports Journal Pub Date : 2025-08-04 eCollection Date: 2025-08-01 DOI:10.14309/crj.0000000000001776
Harsimran Kalsi, Samneet Singh Arora, Kobina Essilfie-Quaye, Raghav Bassi, Neeka Akhavan, Yaseen Perbtani, Tony S Brar
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引用次数: 0

Abstract

Semaglutide, a glucagon-like peptide-1 receptor agonist widely used for managing type 2 diabetes mellitus and obesity. Reports of semaglutide-associated hepatotoxicity are exceedingly rare. We detail a case of a 44-year-old woman who developed liver injury with elevated liver enzymes after semaglutide initiation for weight management. Liver enzyme levels normalized after discontinuing the drug and worsened upon rechallenge, confirming semaglutide's potential to cause liver injury. In addition, our case study encompasses a literature review of all reported semaglutide-related drug-induced liver injury cases, highlighting the need for diligent liver function monitoring in patients on semaglutide and offering valuable insights into its hepatotoxic potential.

Abstract Image

semaglutide诱导的肝损伤。
Semaglutide,一种胰高血糖素样肽-1受体激动剂,广泛用于治疗2型糖尿病和肥胖症。关于西马柳肽相关肝毒性的报道极为罕见。我们详细介绍了一例44岁的妇女谁发展肝损伤与肝酶升高后,西马鲁肽开始体重管理。停药后肝酶水平恢复正常,再给药后恶化,证实了西马鲁肽可能导致肝损伤。此外,我们的病例研究包括对所有报道的与西马鲁肽相关的药物性肝损伤病例的文献回顾,强调了对西马鲁肽患者进行肝功能监测的必要性,并对其肝毒性潜力提供了有价值的见解。
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来源期刊
ACG Case Reports Journal
ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-
自引率
14.30%
发文量
170
审稿时长
12 weeks
期刊介绍: ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.
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