{"title":"Paraneoplastic Effects of Lung Adenocarcinoma Causing Persistently Elevated Lipase, Amylase, and CA 19-9.","authors":"Lily Lucerne, Saurabh Chawla","doi":"10.14309/crj.0000000000001792","DOIUrl":null,"url":null,"abstract":"<p><p>Lipase, amylase, and carbohydrate antigen 19-9 are associated with pancreatic pathology. We report a rare case of a patient with persistent elevation of these markers due to paraneoplastic effects of lung adenocarcinoma. The patient presented with right upper quadrant pain and had elevated lipase, amylase, and carbohydrate antigen 19-9. Workup was unrevealing for pancreatic pathology but found a lung nodule, later confirmed as adenocarcinoma. The patient underwent chemotherapy, radiation, and immunotherapy. All levels subsequently normalized. This case underscores the importance of considering malignancy in patients with unexplained, persistent elevation of pancreatic enzymes or tumor markers in the absence of clear pancreatic pathology.</p>","PeriodicalId":7394,"journal":{"name":"ACG Case Reports Journal","volume":"12 8","pages":"e01792"},"PeriodicalIF":0.5000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316339/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACG Case Reports Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14309/crj.0000000000001792","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Lipase, amylase, and carbohydrate antigen 19-9 are associated with pancreatic pathology. We report a rare case of a patient with persistent elevation of these markers due to paraneoplastic effects of lung adenocarcinoma. The patient presented with right upper quadrant pain and had elevated lipase, amylase, and carbohydrate antigen 19-9. Workup was unrevealing for pancreatic pathology but found a lung nodule, later confirmed as adenocarcinoma. The patient underwent chemotherapy, radiation, and immunotherapy. All levels subsequently normalized. This case underscores the importance of considering malignancy in patients with unexplained, persistent elevation of pancreatic enzymes or tumor markers in the absence of clear pancreatic pathology.
期刊介绍：
ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.
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