Impact of GLP-1 Receptor Agonists on Whole-Gut Gastrointestinal Motility Using Wireless Motility Capsule: A Descriptive Single-Center Case Series.

IF 0.5 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2025-08-04 eCollection Date: 2025-08-01 DOI:10.14309/crj.0000000000001789

Michael Cymbal, Zehra Naseem, Din Hoxha, Samita Garg

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引用次数: 0

Abstract

This retrospective case series investigates the impact of GLP-1 receptor agonists (GLP-1RAs) on whole-gut gastrointestinal motility using wireless motility capsule testing. We analyzed 10 patients on GLP-1RAs who underwent wireless motility capsule testing for constipation or gastroparesis to assess gastric, small bowel, and colonic transit times. Delayed gastric emptying time was observed in 80% of patients, whereas delayed whole-gut transit time was noted in 44% of patients. The 3 patients on semaglutide (1 mg) had the longest gastric emptying time, delayed whole-gut transit time, and were the only patients with delayed small bowel transit time. Although limited by retrospective observation, our findings are consistent with the effects of GLP-1RAs on gastric motility delay and suggest an impact on whole-gut motility. With the expanding use of GLP-1RAs, these findings underscore the need for prospective studies using emerging motility technologies to further characterize the motility effects both during treatment and after cessation, thereby guiding evidence-based clinical decision-making.

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使用无线运动胶囊GLP-1受体激动剂对全肠胃肠运动的影响：描述性单中心病例系列。

本回顾性病例系列研究了GLP-1受体激动剂（GLP-1RAs）对全肠胃肠运动的影响，采用无线运动胶囊试验。我们分析了10例GLP-1RAs患者，他们接受了便秘或胃轻瘫的无线运动胶囊测试，以评估胃、小肠和结肠的运输时间。80%的患者胃排空时间延迟，而44%的患者全肠转运时间延迟。服用西马鲁肽（1mg）的3例患者胃排空时间最长，全肠转运时间延迟，是唯一小肠转运时间延迟的患者。尽管受到回顾性观察的限制，我们的研究结果与GLP-1RAs对胃运动延迟的影响一致，并提示对全肠运动有影响。随着GLP-1RAs的广泛应用，这些发现强调了前瞻性研究的必要性，使用新兴的运动技术来进一步表征治疗期间和戒烟后的运动效应，从而指导循证临床决策。

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来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.