Advances in integrative medicine最新文献

{"title":"Arnebia euchroma root ointment for post-hemorrhoidectomy wound care: A randomized controlled trial","authors":"Ehsan Memarbashi ,&nbsp;Ebrahim Nasiri-Formi ,&nbsp;Mohammad Etezadpour ,&nbsp;Seyed Jalal Hosseinimehr","doi":"10.1016/j.aimed.2025.100576","DOIUrl":"10.1016/j.aimed.2025.100576","url":null,"abstract":"<div><h3>Introduction</h3><div>Hemorrhoidectomy is a common surgical procedure for hemorrhoids, but postoperative complications can significantly affect recovery quality. This study investigates the effect of Arnebia euchroma root ointment on wound healing and related complications in patients undergoing hemorrhoidectomy.</div></div><div><h3>Methods</h3><div>In this randomized controlled trial, patients who underwent hemorrhoidectomy were assigned to receive either Arnebia euchroma root ointment or a placebo. The primary outcomes measured included the rate of wound healing and the incidence of postoperative complications, such as fear of defecation, over a specified follow-up period.</div></div><div><h3>Results</h3><div>The application of <em>Arnebia euchroma</em> root ointment demonstrated a significant improvement in wound healing compared to the placebo group. Additionally, the incidence of complications such as pain, bleeding, and infection was notably lower in the treatment group. The mean score of fear of defecation in the control group was 6.86 ± 2.1, and the intervention group was 4.67 ± 1.4.( P &lt; 0.001). Wound healing in the intervention group was better than in the control group, with a relative risk (RR) of 1.40.( P &lt; 0.001).</div></div><div><h3>Conclusion</h3><div><em>Arnebia euchroma</em> root ointment may be an effective adjunctive treatment for enhancing wound healing and reducing complications following Hemorrhoidectomy. The positive effects of this ointment are likely attributed to its antibacterial and anti-inflammatory properties, as well as its ability to enhance blood supply to the surgical area.</div></div><div><h3>Take-home massage</h3><div>The use of <em>Arnebia euchroma</em> root ointment in post-hemorrhoidectomy wound care has demonstrated significant improvement in wound healing and reduction of postoperative complications. This ointment effectively reduces pain, bleeding, and infection, serving as a valuable adjunctive treatment for enhancing wound recovery and decreasing the fear of defecation. Its antibacterial and anti-inflammatory properties, along with improved blood supply to the surgical site, are key factors contributing to its efficacy. These findings suggest that <em>Arnebia euchroma</em> root ointment is a promising option for improving outcomes following hemorrhoidectomy.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100576"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory biomarkers modulation in postmenopausal women: A randomized controlled trial of the superiority of Co-supplementing curcumin nano-micelles and Nigella sativa","authors":"Amir Mehdi Iranshahi ,&nbsp;Mahdi Amirpour ,&nbsp;Soraya Babaie ,&nbsp;Azizeh Farshbaf-Khalili ,&nbsp;Alireza Ostadrahimi","doi":"10.1016/j.aimed.2025.100528","DOIUrl":"10.1016/j.aimed.2025.100528","url":null,"abstract":"<div><h3>Background</h3><div>Lasting inflammation, whether directly mediated by hormonal changes or induced by oxidative stress, has significant negative effects on bone health, potentially contributing to the development of postmenopausal osteopenia and osteoporosis. Anti-inflammatory herbal products, known for cost-effectiveness and safety, support bone remodeling. This study evaluates the efficacy of Curcumin Nano-micelles (CUR), Nigella sativa (NS), and their co-supplementation (NS-CUR) on serum inflammatory factors in postmenopausal women with osteopenia or osteoporosis.</div></div><div><h3>Methods</h3><div>A triple-blind randomized trial was conducted on 120 postmenopausal women. Patients were allocated to four groups stratified by bone density. During the 6-month intervention, the NS group took an NS oil capsule and a CUR placebo capsule daily. The CUR group consumed a CUR capsule and an NS placebo capsule daily. The NS-CUR group received a CUR capsule and an NS oil capsule daily. The placebo group received two microcrystalline cellulose (MCC) capsules daily. The serum concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were determined.</div></div><div><h3>Result</h3><div>The serum levels of TNF-α, IL-6, and hs-CRP significantly declined in the NS group (<em>p</em> &lt; 0.001), CUR (<em>p</em> &lt; 0.001, <em>p</em> &lt; 0.001, <em>p</em> = 0.001, res<em>p</em>ectively), and NS-CUR (<em>p</em> &lt; 0.001) groups compared to baseline. Between-group analyses revealed that IL-6 and TNF-α showed significant reductions in the NS, CUR, and NS-CUR groups (<em>p</em> &lt; 0.001) compared to placebo. Despite significant reductions in hs-CRP in the NS and NS-CUR groups (<em>p</em> = 0.001, <em>p</em> &lt; 0.001, respectively), no significant differences were identified between the CUR and placebo groups (<em>p</em> = 0.096).</div></div><div><h3>Conclusion</h3><div>The supplementation of CUR, NS, and NS-CUR modulated IL-6, TNF-α, and hs-CRP levels. Moreover, the co-supplementation of NS and CUR significantly influenced inflammatory biomarkers.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100528"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of traditional medicine in complementary management for sexually transmitted diseases (STDs)","authors":"Amit Anand ,&nbsp;Santhepete Nanjundiah. Manjula ,&nbsp;Mruthunjaya Kenganora ,&nbsp;Subhajit Mandal ,&nbsp;Himanshu Sharma ,&nbsp;Rashmi Pathak","doi":"10.1016/j.aimed.2025.100531","DOIUrl":"10.1016/j.aimed.2025.100531","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Sexually Transmitted Disease (STDs) remain a significant global health issue, particularly affecting women due to biological and sociocultural factors. Traditional medicine has been widely used in the management of sexually transmitted disease due to its accessibility, affordability and cultural acceptance. However, it has several limitations that challenge its efficacy and reliability due to absence of rigorous scientific validation and clinical trials. The study was undertaken to explore the integration of traditional medicine with modern approaches to STD management. The purpose of the review to bridge the gap in knowledge between traditional medicinal practices and modern interventions through a comparative analysis. It also aims to address the gaps in healthcare access, particularly in underprivileged regions where economic constraints limit the availability of conventional allopathic treatments.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The study employed systematic literature review methodology to explore the application of traditional medicine in STD management. Databases such as Pub Med, Google scholar, science direct, web of science was searched from up to January 2024. Search terms included “traditional medicine, “STDs”, “medicinal plants” and specific plant names (eg: Neem, Echinea, &lt;em&gt;Aloe vera&lt;/em&gt;). A total of 381 articles were initially retrieved and duplicates were removed. Inclusion criteria focused on studies providing &lt;em&gt;in-vitro&lt;/em&gt; and &lt;em&gt;in-vivo&lt;/em&gt; data for STD treatment, cultural applications and integration with modern medicine. Relevant were extracted using a structural database, capturing the plant species, active compounds, mechanisms of action and therapeutic outcomes. Cross referencing with WHO and national databases ensured the inclusion of the latest prevalence and management.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The findings suggest practice of traditional medicines including the use of specific plants and holistic approaches offers valuable benefits in the management of STDs and enhancing overall wellbeing. The integration of traditional medicine with modern health practices provides a comprehensive approach that addresses not only the physical aspects of health but also the emotional and social dimension. The limitations of the findings presented in the review primarily stem from the limited number of clinical trials included. Such studies primarily elucidate theoretical mechanisms of action and biological pathways. However, these results cannot be directly extrapolated to clinical outcomes or therapeutic benefits in human populations, highlighting the need for caution when interpreting the transitional potential of these findings.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;div&gt;The review highlights the importance of combine approach of traditional medicine with modern clinical practices to create an inclusive and culturally sensitive approach to STD management and female health. The signi","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100531"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-aging herbal prescriptions in Hakim Shafai’s Pharmacopoeia: A review of evidence","authors":"Narges Tajik ,&nbsp;Syed Mohd Abbas Zaidi ,&nbsp;Seyedeh Mahnaz Karimi","doi":"10.1016/j.aimed.2025.100503","DOIUrl":"10.1016/j.aimed.2025.100503","url":null,"abstract":"<div><h3>Introduction</h3><div>Looking at the medical texts of the past, the fight against aging has been discussed since the beginning of history. Hakim Shafai was one of the Iranian physicians of the Safavid period who claimed to have found the medicine for longevity. The purpose of this study is to introduce and review the Hakim Shafai anti-aging prescription mentioned in his Pharmacopoeia. We also review the evidence for the use of these herbs as potential anti-aging agents.</div></div><div><h3>Methods</h3><div>The present library-documentary research relied on the parts of the book, Shifai’s Pharmacopoeia, as the primary information source, along with other traditional Persian and Unani medicine text. All relevant databases of these plants were also searched for the terms “anti-aging”, “longevity”, “stress oxidative” and “D-galactose”, “<em>Caenorhabditis elegans</em>”, “<em>Drosophila melanogaster</em>” up to 30th January 2024.</div></div><div><h3>Results</h3><div>Hakim's longevity prescription consist of some medicinal herbs including: <em>Myristica fragrans, Syzygium aromaticum, Elettaria cardamomum, Cinnamomum verum, Cinnamomum tamala, Piper nigrum, Piper longum, Zingiber officinale, Phyllanthus emblica, Terminalia chebula, Trachyspermum ammi, Carum carvi and Nigella sativa</em>. Included studies showed significant improvement in brain function (memory, cognition and anxiety), skin wrinkle and sexual disorders via targeting different pathways including anti-inflammatory, immunomodulatory, antioxidant, and hormonal regulation.</div></div><div><h3>Conclusions</h3><div>Medicinal herbs derived from this ancient prescription seem to have beneficial anti-aging effects by affecting various targets. Considering the safe and long-term history of using medicinal plants, it can be a promising option to prevent aging. However, more rigorous research is needed in the future to successfully validate these experience-based traditional herbal formulas.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100503"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the effects of yoga and exercise on vascular function: A systematic review","authors":"Poovitha Shruthi Paramashiva ,&nbsp;Suresh Sukumar ,&nbsp;Dilip Shettigar ,&nbsp;Rajagopal Kadavigere ,&nbsp;Abhimanyu Pradhan ,&nbsp;Nitika C. Panakkal ,&nbsp;Winniecia Dkhar ,&nbsp;K. Vaishali ,&nbsp;Baskaran Chandrasekaran ,&nbsp;Hari Prakash Palaniswamy ,&nbsp;Sneha Ravichandran ,&nbsp;Sathya Sabina Muthu ,&nbsp;Koustubh Kamath ,&nbsp;Haris Jose Felix ,&nbsp;Anam Shazli ,&nbsp;Leena R. David","doi":"10.1016/j.aimed.2025.100556","DOIUrl":"10.1016/j.aimed.2025.100556","url":null,"abstract":"<div><h3>Background</h3><div>Sedentary behaviour negatively impacts vascular function, increasing cardiovascular risk. While yoga and conventional exercise are proposed to counteract these effects, their relative efficacy remains unclear.</div></div><div><h3>Objective</h3><div>This review aims to compare the effects of yoga and conventional exercise interventions on ultrasound-measured vascular function in sedentary individuals.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, Scopus, and Web of Science was conducted (last updated February 15, 2025), including randomized controlled trials (RCTs), crossover trials, and non-randomized studies comparing yoga and exercise interventions in sedentary adults. Studies assessing vascular function using ultrasound techniques (e.g., flow-mediated dilation [FMD], pulse wave velocity [PWV]) were included. The review followed PRISMA guidelines and was registered in PROSPERO (CRD420250655130).</div></div><div><h3>Results</h3><div>Ten studies met the inclusion criteria. Yoga interventions showed mixed results, with some improvement in endothelial function in older adults but inconsistent effects on arterial stiffness. Exercise interventions consistently improved FMD and reduced arterial stiffness. However, micro-breaks during prolonged sitting yielded limited benefits. Most studies had small sample sizes and short durations, affecting generalizability.</div></div><div><h3>Conclusion</h3><div>Exercise interventions consistently improve vascular function more than yoga among sedentary individuals. Yoga may benefit older populations but lacks</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100556"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ledum palustre 200cH in preventing injection site pain and tenderness following COVID-19 vaccination: Interim results of a double-blind, randomized, placebo-controlled trial","authors":"Subhranil Saha ,&nbsp;Abhijit Rana ,&nbsp;Aritra Roy Chowdhury ,&nbsp;Satyajit Naskar ,&nbsp;Pulakendu Bhattacharya ,&nbsp;Subhasish Ganguly ,&nbsp;Sangita Saha ,&nbsp;Amitava Paul ,&nbsp;Shyamal Kumar Mukherjee","doi":"10.1016/j.aimed.2025.100574","DOIUrl":"10.1016/j.aimed.2025.100574","url":null,"abstract":"<div><h3>Background</h3><div><strong>T</strong>he COVID-19 vaccine frequently results in cutaneous side effects, such as redness and swelling, near the injection site. This trial was carried out to determine whether <em>Ledum palustre</em> 200cH is more effective than a placebo at preventing injection site pain and tenderness after the COVID-19 vaccination.</div></div><div><h3>Methods</h3><div>This one-month, double-blind, randomized, placebo-controlled, parallel-arm clinical trial was conducted at the vaccination department of a homeopathic hospital in West Bengal, India. Despite the desired sample size being projected at 218, only 122 participants could be enrolled because of the abrupt termination of the COVID-19 immunization campaign in India. Interventions were <em>Ledum palustre</em> 200cH (<em>n</em> = 61) or placebos with the same appearance (<em>n</em> = 61). The main outcome measure was the degree of pain and tenderness at the injection site was measured on days 1, 2, 3, 5, and 7, then once a week for a month, using a 0–100 mm visual analog scale (VAS).</div></div><div><h3>Results</h3><div>The trial was terminated prematurely. The Kaplan-Meier survival distributions revealed that the time to resolution of pain was statistically significantly earlier in the verum group (median: 2 days, 95 % confidence interval (CI) 1.7–2.3) than placebo (median: 3 days, 95 % CI 2.6–3.4); Mantel-Cox log-rank test: χ₁² = 21.632, <em>p</em> &lt; 0.001. Similar trends were revealed by earlier resolution of tenderness favoring verum (median: 2 days, 95 % CI 1.7–2.3) against placebo (median: 3 days, 95 % CI 2.5–3.4); Mantel-Cox log-rank test: χ₁² = 20.172, <em>p</em> &lt; 0.001.</div></div><div><h3>Conclusion</h3><div><em>Ledum palustre</em> 200cH produced significantly better effects than placebos by earlier resolution of pain and tenderness in injection sites following COVID-19 vaccination; however, these results should be interpreted with caution because the trial was underpowered. Conclusive and robust trials should be undertaken to validate the findings.</div></div><div><h3>Trial registration</h3><div>CTRI/2022/10/046839; UTN: U1111-1284-2437.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100574"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of nutraceuticals in migraine symptoms relief: A systematic review and network meta-analysis","authors":"Imen Ketata ,&nbsp;Emna Ellouz","doi":"10.1016/j.aimed.2025.100478","DOIUrl":"10.1016/j.aimed.2025.100478","url":null,"abstract":"<div><h3>Background</h3><div>The effectiveness of nutraceuticals in alleviating migraine symptoms remains controversial, with ongoing debate among experts. This network meta-analysis (NMA) aims to compare the efficacy of various nutraceuticals on migraine symptoms relief.</div></div><div><h3>Methods</h3><div>A frequentist NMA was performed on double-blind randomized clinical trials involving migraine patients using NS. We searched PubMed, Europe PMC, Google Scholar, Web of Science, APA PsycInfo, gray literature, and systematic review references up to April 25, 2024. This NMA is registered in PROSPERO (CRD42024504214). Data analysis was conducted using R software, estimating the mean difference (MD) and 95 % CI for NS effects on migraine relief.</div></div><div><h3>Results</h3><div>twenty-five trials were reviewed. Compared to placebo, CoQ10 + L-carnitine (MD: −4.8 [95 % CI: −8.0; −1.7]), vitamin D3 (MD: −3.5 [95 %CI: −5.3; −1.6]), curcumin (MD: −6.0 [95 % CI: −10.7; −1.3]), and cinnamon (MD: −3.5 [95 % CI: −5.5; −1.1]) were ranked as the most effective NS for reducing monthly migraine frequency, migraine days duration/month, attack duration (hours), and migraine severity, respectively. Based on GRADE approach, the certainty of evidence was respectively low, moderate, low and high. The meta-regression revealed that follow-up duration significantly affected the impact of NS on MA/mo.</div></div><div><h3>Conclusion</h3><div>NS, particularly CoQ10 +L-carnitine, vitamin D3, curcumin, and cinnamon, may help reduce migraine symptoms. However, these findings are preliminary and require confirmation with higher-quality evidence. Additional research is needed to evaluate the combined effectiveness of these NS for migraine relief.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100478"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ginger supplementation on quality of life in patients with functional dyspepsia: An open-label, clinical trial","authors":"Lemlem Gebremariam Aregawi ,&nbsp;Csiki Zoltan","doi":"10.1016/j.aimed.2025.100477","DOIUrl":"10.1016/j.aimed.2025.100477","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Functional dyspepsia (FD) is a prevalent gastrointestinal disorder, often marked by persistent discomfort and negatively impacting patients' quality of life. Despite various treatment approaches, many patients continue to experience symptoms. Ginger has been suggested as a potential natural remedy for dyspepsia due to its anti-inflammatory and prokinetic properties. While previous studies have focused on ginger’s ability to alleviate dyspeptic symptoms, its impact on QoL in FD patients remains unclear. This study aimed to assess the effects of ginger supplementation on QoL in patients with FD.</div></div><div><h3>Materials and methods</h3><div>This open-label clinical trial enrolled adult FD patients who met the Rome IV criteria. A total of 62 patients were enrolled, and 51 completed the study. Participants received a standardized ginger supplement of 540 mg twice daily for eight weeks. Quality of life was assessed at baseline and post-intervention using a validated questionnaire, Nepean Dyspepsia Index (NDI). Secondary outcomes were also evaluated.</div></div><div><h3>Results</h3><div>After eight weeks of ginger supplementation, there was a significant improvement in QoL, as indicated by a decrease in NDI scores (mean change ± SD: 9.97 ± 16.20, p = 0.039). This demonstrates a notable enhancement in the participants' QoL, particularly in terms of interference, eating and improved day-to-day activity. Secondary outcomes also showed favorable changes.</div></div><div><h3>Conclusion</h3><div>Ginger supplementation may offer a beneficial adjunct therapy for patients with FD, improving both symptom management and overall QoL. Future studies with larger sample sizes and randomized controls are warranted to confirm these findings and explore the mechanisms involved.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100477"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal remedies from Persian medicine for relieving fatigue: A systematic review","authors":"Ata Amani ,&nbsp;Bayazid Ghaderi ,&nbsp;Mehdi Pasalar ,&nbsp;Ali Kashkooe ,&nbsp;Mohammad Mehdi Zarshenas ,&nbsp;Reza Tabrizi ,&nbsp;Thomas Rampp ,&nbsp;Ghazaleh Heydarirad","doi":"10.1016/j.aimed.2025.100585","DOIUrl":"10.1016/j.aimed.2025.100585","url":null,"abstract":"<div><h3>Introduction</h3><div>Fatigue is a common issue affecting individuals from diverse backgrounds, often leading to a decrease in overall health. Numerous foods, including medicinal plants, possess properties that help combat fatigue through two main mechanisms: antioxidant and anti-inflammatory effects. We aimed to explore the knowledge and potential of herbal medicines originated from Persian medicine (PM) in relieving fatigue.</div></div><div><h3>Methods</h3><div>This systematic review used a thorough search strategy, examining various historical Persian Medicine textbooks and electronic databases in both Persian and English. Herbal remedies that met the inclusion criteria were considered, particularly those exhibiting antioxidant and anti-inflammatory properties. Data from selected studies were extracted and thematically synthesized.</div></div><div><h3>Results</h3><div>A total of 49 herbal medicines were identified from Persian Medicine, showcasing varying temperaments. Among 44 articles meeting inclusion criteria, clinical trials demonstrated the effectiveness of several herbs, including <em>Acacia arabica</em>, <em>Brassica rapa</em>, <em>Camellia sinensis</em>, and <em>Coffea arabica</em>, in alleviating fatigue in humans. Additionally, <em>Areca catechu</em> and <em>Phoenix dactylifera</em> were effective in animal studies. The included articles assessed the methods and mechanisms of action for all herbal preparations, illuminating their anti-fatigue properties and the quality of supporting evidence.</div></div><div><h3>Conclusions</h3><div>Various herbs showed potential anti-fatigue properties in humans and animals, emphasizing the role of traditional modalities like PM. While further research is essential to validate and understand these effects, the identified herbs show potential for providing relief from fatigue.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100585"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145358030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Hypericum perforatum oil on prevention ecchymosis and pain associated with subcutaneous heparin injection: A self-controlled single-blind study","authors":"Hatice Demi̇rdağ ,&nbsp;Nurcan Uysal ,&nbsp;Fatma Zehra Kamber","doi":"10.1016/j.aimed.2025.100504","DOIUrl":"10.1016/j.aimed.2025.100504","url":null,"abstract":"<div><h3>Background</h3><div>Low molecular weight heparin is a drug with anticoagulant and antithrombotic effects. This drug is frequently administered subcutaneously to patients by nurses. Complications such as pain, ecchymosis and hematoma may commonly occur at the injection site. This study investigated the effect of Hypericum perforatum oil in preventing pain and ecchymosis after subcutaneous injection low molecular weight heparin.</div></div><div><h3>Methods</h3><div>This quasi-experimental and single blinded study was conducted with 160 patients in a coronary intensive care unit. The researcher nurse applied 5–6 drops of Hypericum perforatum oil to one arm of the patients 2 h before the injection. The other arm of the patient was considered as the control arm. A total of 320 injections were administered. The evaluation of the injection sites was performed by two other researchers at 48th hours. The data were analyzed using Wilcoxon and McNemar test.</div></div><div><h3>Results</h3><div>In the arm which was applied Hypericum perforatum oil the mean pain score was 0.08 ± 0.55 and the mean ecchymosis size was 2.49 ± 10.32 mm. In the control arm, the mean pain score was 1.28 ± 1.97 and the mean ecchymosis size was 13.29 ± 18.99 mm according to the measurements made at 48th h after injection. The difference between the measurements in both arms was statistically significant (p = .000).</div></div><div><h3>Conclusions</h3><div>It showed that Hypericum perforatum oil is effective in preventing pain and ecchymosis after low molecular weight heparin injection. However, the research needs to be repeated.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100504"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}