Advances in integrative medicine最新文献

{"title":"Effects of ginger supplementation on quality of life in patients with functional dyspepsia: An open-label, clinical trial","authors":"Lemlem Gebremariam Aregawi ,&nbsp;Csiki Zoltan","doi":"10.1016/j.aimed.2025.100477","DOIUrl":"10.1016/j.aimed.2025.100477","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Functional dyspepsia (FD) is a prevalent gastrointestinal disorder, often marked by persistent discomfort and negatively impacting patients' quality of life. Despite various treatment approaches, many patients continue to experience symptoms. Ginger has been suggested as a potential natural remedy for dyspepsia due to its anti-inflammatory and prokinetic properties. While previous studies have focused on ginger’s ability to alleviate dyspeptic symptoms, its impact on QoL in FD patients remains unclear. This study aimed to assess the effects of ginger supplementation on QoL in patients with FD.</div></div><div><h3>Materials and methods</h3><div>This open-label clinical trial enrolled adult FD patients who met the Rome IV criteria. A total of 62 patients were enrolled, and 51 completed the study. Participants received a standardized ginger supplement of 540 mg twice daily for eight weeks. Quality of life was assessed at baseline and post-intervention using a validated questionnaire, Nepean Dyspepsia Index (NDI). Secondary outcomes were also evaluated.</div></div><div><h3>Results</h3><div>After eight weeks of ginger supplementation, there was a significant improvement in QoL, as indicated by a decrease in NDI scores (mean change ± SD: 9.97 ± 16.20, p = 0.039). This demonstrates a notable enhancement in the participants' QoL, particularly in terms of interference, eating and improved day-to-day activity. Secondary outcomes also showed favorable changes.</div></div><div><h3>Conclusion</h3><div>Ginger supplementation may offer a beneficial adjunct therapy for patients with FD, improving both symptom management and overall QoL. Future studies with larger sample sizes and randomized controls are warranted to confirm these findings and explore the mechanisms involved.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100477"},"PeriodicalIF":1.7,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness, preference, and utilisation of Ayush in India: Evidence from National Sample Survey, 2022–23","authors":"Md. Juel Rana ,&nbsp;Manik Kumar ,&nbsp;Margubur Rahaman ,&nbsp;Mohammad Hifz Ur Rahman","doi":"10.1016/j.aimed.2025.03.006","DOIUrl":"10.1016/j.aimed.2025.03.006","url":null,"abstract":"<div><h3>Background</h3><div>Integration of Ayurveda, Yoga and Naturopathy, Unani, Siddha, Sowa-Rigpa, and Homeopathy (Ayush) for universal healthcare coverage is a key policy agenda in India. Despite growing debate on its integration with mainstream healthcare, previous studies lack exclusive data on awareness, preference, and utilisation of Ayush. This study aims to analyse Ayush awareness, preference, and utilisation in rural and urban areas of India to inform policy recommendations.</div></div><div><h3>Materials and methods</h3><div>The present study used the latest exclusive National Sample Survey (NSS) survey data on Ayush (2022–23). Descriptive, bivariate, and logistic regression analyses were applied to present the levels and patterns of awareness, preference, and utilisation of Ayush care in India.</div></div><div><h3>Results</h3><div>Over 95 % of individuals in India are aware of Ayush, while about 60 % prefer to use Ayush for their treatment and 53 % utilise Ayush. There is an insignificant difference in awareness and preference between rural and urban areas, but there is considerable gap exists in the utilisation of Ayush. A higher utilisation is noted among older individuals, females, Scheduled Tribes (STs), and urban residents as compared to their counterparts. Self-medication with Ayush is very common among the users. Predominant treatments are rejuvenation (45.4 %) and therapeutic care (27 %). Key reasons for utilisation of Ayush care include effectiveness (72.1 %), faith (58.1 %), and low side effects (50.4 %).</div></div><div><h3>Conclusions</h3><div>The preference and accessibility of Ayush services need to be enhanced particularly at the community level, to reduce reliance on self-medication and folk healers. Tailored strategies must address socio-demographic, religious, and caste-based variations to ensure equitable and broader acceptance of Ayush. Expanding rejuvenation and therapeutic care services can foster a preference for Ayush. Additionally, investment in research to understand factors influencing Ayush use and improve service infrastructure is essential for sustainable and effective integration of Ayush into the healthcare system.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 2","pages":"Article 100476"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why individuals studied naturopathy and what they hoped to contribute as naturopaths: A New Zealand study","authors":"Asmita Patel ,&nbsp;Robyn Carruthers ,&nbsp;Sandra D. Smith","doi":"10.1016/j.aimed.2025.03.005","DOIUrl":"10.1016/j.aimed.2025.03.005","url":null,"abstract":"<div><h3>Objectives</h3><div>There has been a global increase in the utilisation of traditional, complementary, and integrative medicine modalities, including that of naturopathy. Limited research exists that has explored why individuals want to study naturopathy. The present study was designed to identify and explore why individuals wanted to study naturopathy and what they hoped to contribute as practising naturopaths.</div></div><div><h3>Methods</h3><div>Participants were 15 graduates of a naturopathy degree completed in Auckland, New Zealand. Participants were individually interviewed. Interviews were analysed using an inductive thematic approach.</div></div><div><h3>Results</h3><div>Five main themes were identified: (1) Personal interest in natural medicine, (2) initial interest in nutrition, (3) family influence, (4) own health reasons, and (5) cultural factors. One main theme was identified regarding what participants hoped to contribute as practising naturopaths, and that was to help and support people on their health journey.</div></div><div><h3>Conclusions</h3><div>A personal interest in natural medicine and its holistic approach to health and healing, including the role of nutrition was prominent in influencing individuals to enrol in a naturopathy degree. Childhood exposure to naturopathy, including having a relative working in the profession, as well as positive, efficacious experiences of naturopathic care for a chronic health condition were also influencing factors. Cultural factors influenced indigenous Māori to study naturopathy so they could support family members and other Māori who had chronic health conditions through naturopathic care. There was a strong desire to help and support future clients through the utilisation of naturopathic principles of practice that centred around client education, use of natural treatments and nutritional support.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 2","pages":"Article 100475"},"PeriodicalIF":1.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of okra on metabolic parameters in Type 2 diabetes patients: Results from a double-blind clinical trial","authors":"Ali Hesamzadeh ,&nbsp;Zahra Kashi ,&nbsp;Adeleh Bahar ,&nbsp;Majid Saeidi ,&nbsp;Atena Ramzani ,&nbsp;Reza Ali Mohamadpour Tahmtan","doi":"10.1016/j.aimed.2025.03.004","DOIUrl":"10.1016/j.aimed.2025.03.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Okra (Abelmoschus esculentus), a plant with a historical background in medicinal applications, exhibits potential antidiabetic properties through mechanisms that affect sugar absorption and insulin sensitivity. This study investigates the impact of okra on glycemic control in patients with Type 2 diabetes mellitus (T2DM).</div></div><div><h3>Methods</h3><div>This double-blind, placebo-controlled, multi-center study assessed the impact of okra capsules on glycemic control in 53 patients with T2DM. Data, including demographic characteristics and metabolic parameters, were collected at baseline and after 60 days. Dietary and physical activity questionnaires were employed to control for confounding variables. Data analysis was conducted using descriptive and analytical tests, as appropriate, to compare baseline and post-intervention values both between and within groups. A statistical significance level of p &lt; 0.05 was established.</div></div><div><h3>Results</h3><div>In the intervention group, 70.04 % were female (vs. 84.6 % in the control group), with mean ages of 53.41 ± 6.36 and 52.73 ± 8.69 years, respectively. No significant demographic differences were found (p &gt; 0.05). Insulin levels increased significantly in the intervention group (5.09 ± 4.55–7.43 ± 6.78, p &lt; 0.05), as did HOMA-IR (1.94 ± 1.86–2.96 ± 2.74, p &lt; 0.05), while HbA1c remained unchanged (7.57 ± 1.23–7.94 ± 1.00, p &gt; 0.05). No significant changes were observed in BMI, FBS, BUN, creatinine, triglycerides, or liver enzymes (p &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>The results do not position okra as a primary treatment, they suggest the need for further investigation in larger, longer-term studies to explore its role in T2DM management. This highlights okra's potential as a complementary treatment and underscores the importance of a multifaceted approach in health care, focusing on patient education, research involvement, monitoring metabolic parameters, and interdisciplinary collaboration.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100474"},"PeriodicalIF":1.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sweet violet syrup reduces restlessness and improves appetite in children with fever: A double-blind randomized controlled trial","authors":"Ali Akbar Safari ,&nbsp;Meysam Shirzad ,&nbsp;Mohammad Sadegh Adel Mehraban ,&nbsp;Leila Mohammad Taghizadeh Kashani ,&nbsp;Hamid Shams-Baghbanan ,&nbsp;Kumars Pourrostami ,&nbsp;Mohammad Mahdi Ahmadian-Attari","doi":"10.1016/j.aimed.2025.03.003","DOIUrl":"10.1016/j.aimed.2025.03.003","url":null,"abstract":"<div><h3>Objectives</h3><div><em>Viola odorata</em> L. (sweet violet) has been mentioned in Iranian traditional medicine as an herb with antifebrile, antitussive, anti-headache, and sedative activities. In this study, we tried to evaluate the effect of this medicinal plant on fever, sleep, restlessness, and appetite of children with fever.</div></div><div><h3>Designs</h3><div>This double-blind randomized controlled trial was conducted on 100 febrile children (body core temperature &lt;39°C) aged between 3 and 7 years with the clinical diagnosis of a viral common cold. These children visiting a university pediatric clinic in Karaj, Iran were divided into two equal groups (sweet violet syrup vs placebo).</div></div><div><h3>Interventions</h3><div>One group received sweet violet syrup (2 ml for children&lt;15 kg; 3 ml for children&gt;15 kg TID) + acetaminophen syrup (15 mg/kg QID) and another group received placebo syrup + acetaminophen syrup with similar doses.</div></div><div><h3>Outcome measures</h3><div>To evaluate the status of fever, sleep, restlessness, and appetite, a self-reported form was filled out by one of the parents and finally submitted to the clinic.</div></div><div><h3>Results</h3><div>The results showed that sweet violet syrup can significantly reduce restlessness (P = 0.03) and improve appetite (P = 0.05). However, this syrup had no effect on sleep. Surprisingly, concomitant intake of the first dose of acetaminophen and sweet violet syrup weakened the antifebrile activity of acetaminophen (P = 0.04).</div></div><div><h3>Conclusion</h3><div>Sweet violet syrup can reduce restlessness and improve the appetite of febrile children. Due to probable chemical or physical interactions between this syrup with acetaminophen, it is suggested that these syrups be taken separately.</div></div><div><h3>Trial Registration</h3><div>This trial was registered at the Iranian Registry of Clinical Trials (IRCT20190409043215N1).</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 2","pages":"Article 100473"},"PeriodicalIF":1.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence perspectives in advancing Persian Herbal Medicine: A systematic review","authors":"Somaieh Soltani ,&nbsp;Laleh khodaie ,&nbsp;Vilas Surana","doi":"10.1016/j.aimed.2025.03.001","DOIUrl":"10.1016/j.aimed.2025.03.001","url":null,"abstract":"<div><h3>Background and aim</h3><div>In Persian Medicine (PM), herbal remedies are crucial in preventing and treating disease. The potential of AI has yet to be investigated in Persian Herbal Medicine (PHM). This study aimed to explore the potential of AI in PHM.</div></div><div><h3>Methods</h3><div>Five databases were used to collect data for this systematic review. Considering inclusion and exclusion criteria and quality assessment of the included papers led to a search strategy flowchart.</div></div><div><h3>Results and discussion</h3><div>AI, ML, and DL facilitated data analysis by prediction and pattern recognition. Predictive modeling could prognosticate herbal ingredients and chromatographic conditions, mechanism of action, toxicity, side effects, drug candidates and drug-target interactions, pharmaco-therapeutic effects, suitable drug delivery system, and interaction between drugs and herbs used in PM. Pattern recognition assists in recognizing associations among the identification of plant species, chemical ecology, optimum cultivation, harvesting conditions, and regeneration of threatened species. The mentioned facilities bring about drug discovery, standardization, and data Integration to acquire better patient outcomes, treatment, and personalized medicine. Natural medicine databases could be used to extract data for PHM. The challenges of using AI in PHM should be addressed. Since AI systems in healthcare rely on large amounts of patient data, ethical issues could be raised, and the protection of personal information necessitated. Incomplete, inaccurate data or biased algorithms and discrimination may occur.</div></div><div><h3>Conclusion</h3><div>The relationship between traditional herbal practices and cutting-edge technologies provides a more comprehensive and integrated healthcare approach, marking a transformative step towards optimized patient care and natural drug discovery.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 2","pages":"Article 100471"},"PeriodicalIF":1.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of foot bath on symptom control in cancer patients: A systematic review and meta-analysis","authors":"Neşe Uysal,&nbsp;Eylem Topbaş","doi":"10.1016/j.aimed.2025.03.002","DOIUrl":"10.1016/j.aimed.2025.03.002","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this systematic review and meta-analysis is to evaluate the effect of foot bath protocols on symptom control in cancer patients.</div></div><div><h3>Methods</h3><div>Six clinical trials databases (Embase, Web of Science, Cochrane, Scopus, Ebscho and PubMed) were searched between January and February 2024 without year limitation. The studies were analysed in accordance with PRISMA guidelines. The methodological quality of the studies was assessed using the Joanna Briggs Institute Quality Assessment Tool and the risk of bias was assessed using the Cochrane Bias Assessment Tool. The data were synthesised by meta-analysis.</div></div><div><h3>Results</h3><div>A total of 11 studies were included in the meta-analysis. The foot bath protocols included warm water, salt water and aromatherapy foot baths. It was determined that foot bath had a significant effect on the reduction of fatigue symptom in cancer patients (SMD: −0.98, 95 % CI= −1.84- −0.12, p = 0.03). Foot bath is useful as supportive care in cancer patients. However, studies with a high level of evidence are needed to demonstrate the effect of foot bath.</div></div><div><h3>Conclusions</h3><div>Health professionals evaluate the results of studies with a high level of evidence and can use complementary treatments accordingly for symptom control. Meta-analysis studies contribute to confirming the benefits of foot baths and clarifying which content and which protocol may be beneficial to which patient group.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100472"},"PeriodicalIF":1.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of yoga and naturopathy as a complementary therapy in the management of COVID-19: A mixed method study","authors":"N. Kathiresan ,&nbsp;V. Venugopal ,&nbsp;K. Arunthathi ,&nbsp;M. Abirami ,&nbsp;K. Narayanasamy ,&nbsp;N. Manavalan ,&nbsp;K. Maheshkumar","doi":"10.1016/j.aimed.2025.02.002","DOIUrl":"10.1016/j.aimed.2025.02.002","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 outbreak created a significant psychological impact on patients as a public health emergency of pandemic crisis. However, investigations on psychological therapies in COVID-19 individuals are few. This mixed methods study aimed to examine the effectiveness of Yoga and naturopathy interventions in relieving psychological distress among COVID-19 patients, as well as to explore the participants' experiences and perceptions of these interventions.</div></div><div><h3>Methodology</h3><div>Fifty-one COVID-19 patients from a single cluster were selected, and yoga and naturopathy interventions were delivered for a period of seven days under the supervision of the experts. Depression Anxiety and Stress Scale-21 (DASS-21) was used to assess psychological distress for all patients at baseline and post-intervention. Additionally, semi-structured interviews were conducted with a subset of participants to gather qualitative data on their experiences regarding the intervention<strong>.</strong></div></div><div><h3>Results</h3><div>Significant reduction in the mean score of depression (p = 0.05), anxiety (p = 0.03), and stress (p = 0.05) among the patients at post intervention. During the semi-structured interview, patients expressed that the psychological and emotional wellness greatly improved, along with their physical health following the Yoga and Naturopathy sessions. Their positivity and hope towards a possible recovery from COVID also increased following the sessions<strong>.</strong></div></div><div><h3>Conclusion</h3><div>Yoga and Naturopathy treatments have proven to be beneficial in improving the physical, emotional and psychological wellbeing of patients diagnosed with COVID-19. The positive result of which could be applied in the management of most modern psycho-somatic disorders as well, as a complementary therapy to the conventional medicine.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100464"},"PeriodicalIF":1.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cameroonian medicinal plants used in the management of oral diseases: An updated review","authors":"Emilia Bih ,&nbsp;Eyenga Manga ,&nbsp;Patricia Ebai Née Besong ,&nbsp;Evariste Fedoung Fongnzossie","doi":"10.1016/j.aimed.2025.02.006","DOIUrl":"10.1016/j.aimed.2025.02.006","url":null,"abstract":"<div><div>Oral diseases which encompass a range of diseases and conditions that affect the oral cavity continue to be a major health problem worldwide. Several studies have investigated Cameroonian medicinal plants used for dental care, but a review study measuring the progress of research in this field is lacking in the country. This study aims to provide a state of knowledge on medicinal plants used in managing oral diseases in Cameroon. Authentic information was obtained using search engines such as Google Scholar and Semantic Scholar. Several scientific databases were consulted including Research Gate, Science Direct, PubMed. Information collected included: botanical names, plant parts used, chemical content, mode of preparation, type of disease treated, and mode of administration. A total of 94 plants were recorded in this survey. The commonly used plants come from the Euphorbiaceae with 9 species followed by Asteraceae family with 8 species and Fabaceae families with 7 species. The leaves were the dominant plant parts used (25 % citations). The most frequently cited mode of preparing medicinal herbs for oral treatment was by decoction, accounting for 41 % of citations. Mouthwash, gargling, and direct applications are the prominent modes of administering medication for oral diseases with frequencies of 32 %, 27 %, and 23 % respectively. Toothache was the predominant oral disease treated by the identified plants (47 % citations). The checklist of medicinal plants recorded in the present review thus proves to be a raw material for a diversity of secondary metabolites of diverse biological properties (antioxidant, anti-inflammatory, antimicrobial, anti-ulcerogenic, antitumor, etc). For herbal dental care products development, Cameroonian medicinal plants are raw materials of great potential for innovation and development.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100468"},"PeriodicalIF":1.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of inhalation aromatherapy on patients undergoing PCI angiography: A systematic review and meta-analysis","authors":"Mohamed Elsaid ,&nbsp;Majd H. Alkhawaldeh ,&nbsp;Mariam Abdelrauf Mahmoud ,&nbsp;Ahmed Moumen ,&nbsp;Moustafa Salem ,&nbsp;Mohamed Fouad Abdrabo ,&nbsp;Saad Abuzahra ,&nbsp;Mohammed Ahmed Sadeq ,&nbsp;Mohamed Hady Ashry ,&nbsp;Abdelrahman Yousry Afify","doi":"10.1016/j.aimed.2025.02.001","DOIUrl":"10.1016/j.aimed.2025.02.001","url":null,"abstract":"<div><h3>Introduction</h3><div>It is not uncommon for patients having PCI/angiography to encounter hemodynamic instability and psychological anxiety. The potential of aromatherapy as a supplementary intervention to mitigate these sensations and decrease perioperative complications has been the subject of several research.</div></div><div><h3>Objectives</h3><div>The study aims to evaluate the efficacy of aromatherapy in patients who underwent PCI/angiography.</div></div><div><h3>Methods</h3><div>A thorough search was carried out up to February 2023 across seven electronic databases (PubMed, Cochrane Library, Scopus, clinicaltrials, CINAHL, Embase, and WHO ICTRP) in order to find pertinent research. Included were RCTs looking into how aromatherapy affected PCI/angiography patients. Anxiety, blood pressure, heart rate, respiration, pain, and sleep quality were among the outcome measurements that were collected and analyzed. We performed the meta-analysis using “meta” package in R studio (V4.1.3) employing the random effects model when heterogeneity is significant (I² &gt; 50 % or p &lt; 0.05) Additionally, the risk of bias was assessed using the revised Cochrane risk of bias tool (RoB2).</div></div><div><h3>Results</h3><div>Five RCTs enrolling 449 patients were included. Aromatherapy demonstrated a statistically significant reduction in anxiety (SMD = −0.56; 95 % CI [-0.98; −0.14], p &lt; 0.01, [I² = 66 %, p = 0.05]), heart rate (SMD= −0.42, 95 % CI [ −0.68; −0.17], p &lt; 0.01), Systolic and diastolic blood Pressure (SMD = −0.29; 95 %CI [-0.49; −0.10], p &lt; 0.01, [I² = 33 %, p = 0.20]), (SMD = −0.22; 95 % CI [-0.41; −0.03], p = 0.03, [I² = 0 %, p = 0.54]). respectively. Furthermore, inhalation aromatherapy was reportedly associated with a significant decrease in pain score compared to control in two different studies (p &lt; 0.05). However, there was no statistically significant change in pooled respiratory rate (p &gt; 0.05). Regarding the risk of bias, three studies showed low risk while only one showed high risk of bias.</div></div><div><h3>Conclusion</h3><div>Aromatherapy significantly improved anxiety, heart rate, SBP and DBP in patients underwent PCI/angiography. However, these results should be interpreted cautiously due to absence of blindness in such studies, moreover, heterogeneity of aromatherapy methods has been reported. Therefore, further RCTs are recommended to compare those methods, determine the optimal dosage, duration of treatment and to evaluate the long-term effects and safety profile of aromatherapy.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100463"},"PeriodicalIF":1.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}