Advances in integrative medicine最新文献

{"title":"Acupuncture in palliative care for management of sequelae of head and neck cancer treatment: Scoping review","authors":"Samyra Yukiko Tazaki Dote ,&nbsp;Camila Teixeira do Nascimento ,&nbsp;Marcelo Coelho Goiato ,&nbsp;Daniela Micheline dos Santos","doi":"10.1016/j.aimed.2025.100493","DOIUrl":"10.1016/j.aimed.2025.100493","url":null,"abstract":"<div><h3>Background</h3><div>Head and neck cancer can affect the mouth, oropharynx, nasopharynx, and salivary glands. The main therapeutic options are surgery, radiotherapy, and chemotherapy, alone or in combination and acupuncture. Objective: This study aimed to assess the scientific literature on the use of acupuncture in palliative care for the management of sequelae of head and neck cancer treatment. Methods: To this end, we searched the PubMed/MEDLINE, Virtual Health Library (VHL)/LILACS, Web of Science, Embase, Scopus, Cochrane Library, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Google Scholar, and OpenGrey gray literature databases using the terms “head and neck cancer” and “acupuncture.” These searches retrieved 453 articles. Results: Articles were selected using the Rayyan platform and 407 were excluded (148 duplicates and 259 outside the scope). After reading the full text of the remaining 46 articles, 17 were included in this review. Conclusion: The main treatment-related sequelae reported in the studies were xerostomia, dysphagia, pain, and indigestion.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100493"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of attitudes of hypertension patients toward holistic complementary and alternative medicine","authors":"Zeliha Buyukbayram Genc ,&nbsp;Seyhan Citlik Saritas","doi":"10.1016/j.aimed.2025.100534","DOIUrl":"10.1016/j.aimed.2025.100534","url":null,"abstract":"<div><h3>Background</h3><div>Hypertension is one of the most common cardiovascular diseases.</div></div><div><h3>Purpose</h3><div>This study was conducted to examine the attitudes of patients diagnosed with hypertension toward holistic complementary and alternative medicine.</div></div><div><h3>Method</h3><div>This descriptive and cross-sectional study was carried out with 230 adult patients diagnosed with hypertension who applied to the internal medicine and cardiology outpatient clinics of a Training and Research Hospital. Data were collected using the Personal Information Form and the Attitude Scale towards Holistic Complementary and Alternative Medicine. Data were analyzed with descriptive statistics, independent groups t-test, Kruskal-Wallis, and ANOVA tests. In addition, the Dunn-Bonferroni test was used to determine the difference between groups.</div></div><div><h3>Results</h3><div>The study revealed that the mean age of the patients was 54.36 ± 13.09, while 59.1 % were women, 81.3 % were married, 27.4 % were literate, and 61.3 % were unemployed. Also, it was observed that 41.3 % of the patients were diagnosed with hypertension between 1 and 5 years, 58.7 % had no other chronic illnesses, and 60.0 % had a family hypertension history. Additionally, 77.0 % of the patients used CAM, 24.9 % got information from the Internet/media via CAM, 27.1 % used CAM in addition to medical treatment, 56.5 % found CAM methods safe, 38.4 % used herbal agents, 76.3 % It has been determined that ten of them benefit from the use of CAM. The patients’ total mean score participating in the study in HCAMQ was 28.80 ± 6.73.</div></div><div><h3>Conclusion</h3><div>It was determined that the patients' attitudes toward CAM were positive and moderate. Additionally, the findings disclosed that the education level of the patients affected their use of CAM, their benefit from CAM, and their attitudes towards CAM.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100534"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of thyme and ginger on gastrointestinal symptom relief: A randomized controlled trial","authors":"Mohammad Rostamkhani ,&nbsp;Masoud Etedali ,&nbsp;Azam Malek Hoseini ,&nbsp;Hooman Mohammad talebi","doi":"10.1016/j.aimed.2025.100584","DOIUrl":"10.1016/j.aimed.2025.100584","url":null,"abstract":"<div><h3>Introduction</h3><div>Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder with significant impacts on quality of life. Conventional treatments offer limited relief, prompting interest in herbal remedies. This study evaluates the efficacy of ginger (<em>Zingiber officinale</em>) and Shirazi thyme (<em>Zataria multiflora</em>) in managing IBS symptoms.</div></div><div><h3>Methods</h3><div>This double-blind, randomized clinical trial was conducted after obtaining the ethical approval. Sixty-six IBS patients, aged 20–50, were randomly assigned to three groups: ginger (1 g/day), Shirazi thyme (20 mg twice daily), or placebo (brown sugar) for four weeks. Participants completed the Gastrointestinal Symptom Rating Scale (GSRS) before and after treatment. Randomization minimized IBS subtype bias, and identical capsules ensured blinding. Data were analyzed using SPSS v22 to assess symptom changes.</div></div><div><h3>Results</h3><div>A total of 66 participants (42.4 % male, mean age 35.6 years) were enrolled and evenly allocated across the three groups. A one-way ANOVA revealed a significant group effect on post-intervention GSRS scores (F (2,63) = 85.2, p &lt; 0.001). Post hoc analyses showed that the ginger group reported significantly lower GSRS scores compared with both the control (mean difference = −12.77, p &lt; 0.001) and thyme groups (mean difference = −8.72, p &lt; 0.001). Additionally, the thyme group had significantly lower scores than the control (mean difference = −4.05, p = 0.036). Only the ginger group showed a significant pre–post reduction in GSRS scores (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Ginger significantly improved IBS symptoms, while thyme had a modest effect. Ginger appears promising as a complementary treatment, whereas thyme requires further investigation.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100584"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145262307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolotherapy for the treatment of sacroiliac joint instability in patients with Ehlers-Danlos syndrome","authors":"Philip Montana ,&nbsp;Hung M. Le ,&nbsp;Jeffrey Lo ,&nbsp;Olivia Elie ,&nbsp;Danielle L. Cook ,&nbsp;Sealy Hambright ,&nbsp;Pierre d’Hemecourt","doi":"10.1016/j.aimed.2025.100577","DOIUrl":"10.1016/j.aimed.2025.100577","url":null,"abstract":"<div><h3>Aim</h3><div>To evaluate patient response and efficacy of prolotherapy in managing sacroiliac joint (SIJ) instability and pain in patients with Ehlers-Danlos syndrome (EDS).</div></div><div><h3>Methods</h3><div>A retrospective cohort study on patients aged 13–55 years diagnosed with EDS who received prolotherapy for SIJ instability. Patient demographics, treatment characteristics, and clinical outcomes were assessed by phone follow-up. The visual analog scale (VAS) and Oswestry Low Back Disability (ODI) were utilized to measure pain and disability respectively pre- and post-intervention. Spearman correlation was used to determine correlations between injection number and VAS/ODI scores.</div></div><div><h3>Results</h3><div>Ten patients were included (median age 32 years). 60 % (6/10) had Polidocanol, 30 % (3/10) had sodium tetradecyl sulfate, and one person (10 %) had PRP. The median number of injections was 2 (range, 1–3). Median follow-up was 9 months (IQR, 6–11) after their injection(s). Median VAS score at follow-up was 2 (IQR, 0–4, p = 0.008). There was no significant correlation between the number of injections and VAS (r = 0.29; p = 0.42) or ODI scores (r = 0.21; p = 0.56). Median ODI score was 13 (IQR, 0–24) and 70 % (7/10) of the cohort resided in the “minimal disability” group. Compared to before treatment, 90 % reported moderate to significant improvement in exercise ability and activities of daily living while 100 % showed moderate to significant improvement in movement apprehension.</div></div><div><h3>Conclusions</h3><div>Prolotherapy may be a promising treatment option for SIJ instability in patients with EDS. It significantly reduced pain and improved functional outcomes. Further prospective studies with larger sample sizes are needed to confirm these findings and to optimize treatment protocols.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100577"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the health and biochemical effects of kratom (Mitragyna speciosa) consumption within the local community of Putussibau district, Borneo, Indonesia","authors":"Mery Budiarti ,&nbsp;Lusi Kristiana ,&nbsp;Pramita Andarwati ,&nbsp;Aris Yulianto ,&nbsp;Rohmat Mujahid ,&nbsp;Slamet Wahyono ,&nbsp;Zulvikar Syambani Ulhaq","doi":"10.1016/j.aimed.2025.100555","DOIUrl":"10.1016/j.aimed.2025.100555","url":null,"abstract":"<div><h3>Background</h3><div><em>Mitragyna speciosa</em> Korth, commonly known as kratom, is a native medicinal plant of Southeast Asia, including Indonesia, known for its opioid-like effects. The traditional brewing of kratom has been a longstanding folk remedy, especially within the local community in Indonesia. Our study aims to evaluate the health and biochemical impacts of kratom consumption among regular users in the local community of Putussibau District, Kapuas Hulu Regency, Borneo, Indonesia.</div></div><div><h3>Methods</h3><div>A total of 75 participants were involved in this cross-sectional study. All surveys were carried out through face-to-face interviews to gather information on participants' sociodemographic characteristics and their history of kratom use. Clinical chemistry analysis (n = 60 participants) was then performed to assess potential alterations in the biochemical parameters of kratom users.</div></div><div><h3>Results</h3><div>The majority of participants perceived that kratom consumption positively influenced their overall health status. However, these perceived benefits may not consistently supported by corresponding biochemical findings. Kratom users showed an inclination towards elevated LDL and TG levels compared to the reference levels (73 % (44/60) and 58 % (35/60) of the total participants, respectively), as well as increased hs-CRP (62 % (36/60) of the total participants). Notably, individuals consuming higher doses of kratom tended to have a higher BUN levels.</div></div><div><h3>Conclusion</h3><div>In summary, our study suggests that, in general, individuals who regularly consume brewed kratom over an extended period did not experience undesirable effects. Nevertheless, it is crucial to highlight the potential adverse effects of kratom consumption, including alterations in lipid profile, kidney function, and inflammatory response.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100555"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a yoga program for patients with hirayama disease, and feasibility testing through a case series","authors":"Vinod Kumar ,&nbsp;Nishitha Jasti ,&nbsp;Nupur Pruthi ,&nbsp;Pooja More ,&nbsp;Karthik Mallina ,&nbsp;Kankan Gulati ,&nbsp;Hemant Bhargav ,&nbsp;Shivarama Varambally ,&nbsp;Atchayaram Nalini","doi":"10.1016/j.aimed.2025.100563","DOIUrl":"10.1016/j.aimed.2025.100563","url":null,"abstract":"<div><h3>Background</h3><div>Hirayama Disease (HD), a rare flexion-induced myelopathy, is typically managed with cervical collar therapy, surgery, and lifestyle modifications. Yoga-based interventions have shown promise in managing neurological disorders such as multiple sclerosis and cervical radiculopathy. Given the pathophysiology of HD, we hypothesized yoga could benefit HD patients, especially those awaiting surgery or contraindicated for it. However, literature search revealed that no standardized yoga protocol for HD currently exists.</div></div><div><h3>Objectives</h3><div>This study aimed to develop and validate a yoga module for HD and test its feasibility in patients.</div></div><div><h3>Methods</h3><div>A tailored yoga program was developed by two yoga therapy experts and a neurosurgery consultant. The module was validated by 10 yoga experts and 5 neurologists/neurosurgeons. It was implemented in 20 HD patients to evaluate safety and feasibility. Outcomes included the Visual Analog Scale (VAS) for pain, Client Satisfaction Questionnaire (CSQ-8), hand grip strength (via dynamometer), and a Yoga Performance Assessment (YPA) scale, measured at baseline and after 3 months of practice.</div></div><div><h3>Results</h3><div>A specific yoga module was finalized for HD patients, designed for those awaiting surgery, unwilling to undergo it, or in the static phase of the disease. The program was found safe and feasible in both online and offline formats. Participants learned and independently practiced the module after 20 supervised sessions and reported a high level of satisfaction. Significant improvements were observed at 3 months in hand grip strength, tremors, and hand fatigue.</div></div><div><h3>Conclusion</h3><div>The validated yoga module offers a complementary approach to HD management, benefiting patients awaiting or unable to undergo surgery. The findings suggest yoga can address both functional and symptomatic aspects of the disease, providing a safe and effective intervention.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100563"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do name characteristics influence the career success of UK paediatric surgeons?","authors":"Marianna E. Kapsetaki","doi":"10.1016/j.aimed.2025.100557","DOIUrl":"10.1016/j.aimed.2025.100557","url":null,"abstract":"<div><h3>Background</h3><div>Career success can be influenced by many factors. Could these include name characteristics?</div></div><div><h3>Methods</h3><div>In this study, online sources were used to collect biographical information and bibliometrics of all consultant paediatric surgeons working in the United Kingdom (N = 192). Excel formulas and online name analysis tools were used to collect many forename and surname characteristics.</div></div><div><h3>Results</h3><div>Shorter forenames were associated with having graduated from a top university for their medical degree, having a higher academic age and h-index, and more citations. Those who graduated from a non-top university for their medical degree had a longer number of consequent consonants in their surname. The number of consonant sequences in the first name was higher in those currently affiliated with a top university. A higher consonant-to-vowel ratio was found in paediatric surgeons who a) are currently affiliated with a non-top university (this was found only for the forename), b) had graduated from a top university for their medical degree or started publishing early following medical school graduation (these were found only for the surname). Those with an initial plosive in the forename had more first author publications, whereas those with an initial plosive in the surname were more likely to have graduated from a non-top university for their PhD. Paediatric surgeons with more popular names were more likely to have obtained their medical degree from the United Kingdom.</div></div><div><h3>Conclusion</h3><div>This study revealed that associations exist between certain name characteristics of consultant paediatric surgeons in the United Kingdom and their career success.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100557"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aromatherapy as an antimicrobial intervention: Anecdotal promise or evidence-based therapy? A call for rigorous scientific evaluation","authors":"Emad M. Abdallah","doi":"10.1016/j.aimed.2025.100507","DOIUrl":"10.1016/j.aimed.2025.100507","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100507"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Vitamin-D deficiency and respiratory tract infections in adults: A cross-sectional study","authors":"Karin Ried ,&nbsp;Avni Sali","doi":"10.1016/j.aimed.2025.100587","DOIUrl":"10.1016/j.aimed.2025.100587","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the prevalence of Vitamin-D deficiency and respiratory illnesses in Australian adults.</div></div><div><h3>Methods</h3><div>In a cross-sectional sample of Australian adults, serum Vitamin-D levels and frequency of cold and flu symptoms were assessed. Those with sub-optimal Vitamin-D levels (&lt;75nmol/L) were supplied with 4000–10,000IU Vitamin-D3 daily for 3-months. Data was analyzed with ANOVA and Pearson-correlation.</div></div><div><h3>Results</h3><div>A total of 199 adults aged 57 ± 15 years participated in the study. A third (34 %) had optimal Vitamin-D levels at baseline, 42 % were insufficient (&lt;75nmol/L), 19 % deficient (&lt;50nmol/L) and 5 % severely-deficient (&lt;25nmol/L). About half (56 %) had regularly taken Vitamin-D supplements (1000–5000IU/day) prior to the study.</div><div>The prevalence of respiratory illnesses was slightly higher (70 %, mean=3-per-year) in the severely-deficient-group compared to other Vitamin-D-groups (50 %, mean 2.5 ± 2).</div><div>Overall, the frequency of respiratory illnesses tended to be lower with higher Vitamin-D levels (group 3: r = -0.285; p = 0.009).</div><div>A total of 66 participants (50 %) with sub-optimal Vitamin-D levels (n = 131) completed Vitamin-D3 supplementation. After 3-months, no participants were Vitamin-D deficient, only 15 % remained insufficient, while 85 % reached optimal Vitamin-D levels (mean 97 ± 4nmol/L).</div></div><div><h3>Conclusion</h3><div>Optimal Vitamin-D levels are correlated with the prevention of respiratory illnesses, and can be achieved with Vitamin-D supplementation within 3-months.</div></div><div><h3>Implications for public health</h3><div>A large proportion of Australians are Vitamin-D deficient/insufficient. Vitamin-D supplementation is key to alleviate Vitamin-D deficiency and support Vitamin-D’s role in the prevention of acute respiratory infections via the innate and adaptive immune system.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100587"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145358029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology in the Unani system of medicine: A comprehensive review and hypothesis","authors":"Md Manzar Alam ,&nbsp;Mustehasan ,&nbsp;Usama Akram ,&nbsp;Mumtaz Ahmad ,&nbsp;N. Zaheer Ahmed","doi":"10.1016/j.aimed.2025.100564","DOIUrl":"10.1016/j.aimed.2025.100564","url":null,"abstract":"<div><h3>Background</h3><div>Nanotechnology is an emerging technology which is a game changer for various fields of discipline like<!--> <!-->medicine, biotechnology, material sciences, and environmental sciences. This is about controlling materials on a nanoscale,<!--> <!-->where at least one dimension is less than 100 nm (a nanometer). Such technology may lead to smart materials that can be used in construction and other fields.</div></div><div><h3>Objective</h3><div>To investigate the relationship between nanotechnology and Unani medicine, examining knowledge of nanoscale<!--> <!-->materials in classical Unani literature and their modern applications in nanomedicine.</div></div><div><h3>Methods</h3><div>This was done by a narrative review of classical Unani medical<!--> <!-->writings, and a comprehensive search of scientific databases such as Google Scholar, PubMed, ScienceDirect, and Web of Science up to October 2023. The contributions of scholars including <em>Jābir<!--> <!-->ibn Ḥayyān</em> (Geber), <em>Zakariyyā Rāzī</em> (Rhazes), <em>Shamsuddīn Undulusī</em> and <em>Ḥakīm Ajmal Khān</em> are reviewed here, particularly their observations on the maximum particle size of a drug intended for medicinal purposes. For example, nanoparticle synthesis techniques such as photolysis, co-precipitation, sol-gel, electrochemical precipitation, and green<!--> <!-->chemistry were examined due to their implications regarding present nanotechnology.</div></div><div><h3>Results</h3><div>This study demonstrates that ancient Unani scholars had knowledge of therapeutic potential of metal-based nanoparticles specifically through the use of <em>Kushta</em> (calx) and<!--> <em>Sayyāl</em> (dissolved metals) in their medicinal formulations. Such practices are aligned with contemporary<!--> <!-->nanotechnological principles. The review further elaborates on current approaches of nanoparticles synthesis that mirror traditional Unani methods, especially in the regard of eco-friendly approaches including chemistry<!--> <!-->green.</div></div><div><h3>Conclusion</h3><div>This study provides<!--> <!-->an insight into nanotech being a part of Unani medicine far earlier than modern-day practices, with <em>Kushtasāzī</em> (calcination) and <em>Sayyāl</em> being potential forerunners to modern nanotechnology. However, the adoption of<!--> <!-->modern nanotechnological techniques into the well-established Unani system leads to tremendous innovation and establishes a link between ancient wisdom and recently developed advanced therapeutic approaches.</div></div><div><h3>Funding statement</h3><div>This work received no specific funding from any external funding agencies. The study was performed in the Regional Research Institute of Unani Medicine, Patna, using institutional resources and facilities.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100564"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}