Advances in integrative medicine最新文献

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Effect of Yoga on musculoskeletal pain and discomfort, perceived stress, and quality of sleep in industrial workers: Study protocol for a randomized controlled trial 瑜伽对工业工人肌肉骨骼疼痛和不适、感知压力和睡眠质量的影响:随机对照试验的研究方案
IF 1.7
Advances in integrative medicine Pub Date : 2022-12-01 DOI: 10.1016/j.aimed.2022.11.003
B. Pravalika , U. Yamuna , Apar Avinash Saoji
{"title":"Effect of Yoga on musculoskeletal pain and discomfort, perceived stress, and quality of sleep in industrial workers: Study protocol for a randomized controlled trial","authors":"B. Pravalika ,&nbsp;U. Yamuna ,&nbsp;Apar Avinash Saoji","doi":"10.1016/j.aimed.2022.11.003","DOIUrl":"10.1016/j.aimed.2022.11.003","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Musculoskeletal pain and discomfort at the workplace are closely associated with prolonged, repetitive, continuous, and unnatural movements. Yoga as mind-body medicine has been shown to reduce pain and disability. The current study aims to assess the effect of yoga on musculoskeletal pain and discomfort among industry workers.</p></div><div><h3>Materials and methods</h3><p>Ninety industrial workers with self-reported pain symptoms will be randomly assigned to Yoga and wait-list control groups following an equal allocation ratio. Yoga group will receive a specially designed Integrated Yoga module five days a week for eight weeks. The control group will be given lifestyle suggestions, and they will be offered the same Yoga module after the post-assessment. Musculoskeletal pain and discomfort scores, perceived stress, and quality of sleep will be assessed at baseline, after four and eight weeks.</p></div><div><h3>Statistical analyses</h3><p>Normality and appropriate statistical tests will be done after data collection to assess the differences between and within the groups.</p></div><div><h3>Expected outcomes</h3><p>Specifically designed Yoga module will help reduce subjective pain, stress and improve sleep quality in industrial workers.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88060589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The potential role of integrative medicine in disaster recovery needs more focus and attention 中西医结合在灾难恢复中的潜在作用需要更多的关注和关注
IF 1.7
Advances in integrative medicine Pub Date : 2022-12-01 DOI: 10.1016/j.aimed.2023.02.007
{"title":"The potential role of integrative medicine in disaster recovery needs more focus and attention","authors":"","doi":"10.1016/j.aimed.2023.02.007","DOIUrl":"10.1016/j.aimed.2023.02.007","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78016004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of yoga intervention on skeletal muscle linked glucose homeostasis in pre-diabetic individuals: Study protocol for a randomized controlled trial 瑜伽干预对糖尿病前期个体骨骼肌相关葡萄糖稳态的影响:随机对照试验的研究方案
IF 1.7
Advances in integrative medicine Pub Date : 2022-12-01 DOI: 10.1016/j.aimed.2022.11.002
Supriya Bhalerao , Jayshree Kharche , Shubhangi Harke
{"title":"Effect of yoga intervention on skeletal muscle linked glucose homeostasis in pre-diabetic individuals: Study protocol for a randomized controlled trial","authors":"Supriya Bhalerao ,&nbsp;Jayshree Kharche ,&nbsp;Shubhangi Harke","doi":"10.1016/j.aimed.2022.11.002","DOIUrl":"https://doi.org/10.1016/j.aimed.2022.11.002","url":null,"abstract":"<div><h3>Background</h3><p>The pre-diabetic stage is important in terms of identification and timely management due to its reversible nature. Along with other factors, insulin resistance in skeletal muscle<span><span> is often considered as primary defect before development of overt hyperglycemia and Diabetes Mellitus (DM). Physical exercises are beneficial in prevention of DM by improving skeletal muscle mediated </span>glucose metabolism. Evidence suggests that Yoga interventions appear to be equal and/or superior to exercise in most outcome measures. As the Yogic postures are relatable to exercises, they are considered to improve skeletal muscle function and reverse the pre-diabetic stage.</span></p></div><div><h3>Methods</h3><p><span>This open-labelled, randomized clinical study is planned to evaluate effect of Yoga interventions on muscle mass, strength, endurance and flexibility which are direct/indirect indicators of fat deposition<span> in skeletal muscles. Association between changes in muscle quality/ functionality and glycemic control will also be explored. With ethics committee permission, 120 pre-diabetic individuals of either sex between age group of 35–49 years with BMI range of 25–35 kg/m</span></span><sup>2</sup><span><span> and family history of Type 2 Diabetes Mellitus (T2DM) will be recruited after obtaining written </span>informed consent. They will be randomly allocated to either Yoga or exercise group by computer generated randomized method in a 1:1 ratio. One group will receive defined Yoga interventions, while other group will receive fixed program of physical exercises. Prior to initiating this 12-week study, both groups will undergo a training session for 4 weeks under supervision of a trained instructor. The outcome measures will be parameters related to muscle quality/functionality and glucose metabolism markers.</span></p></div><div><h3>Discussion</h3><p>Our study aims to explore practicality of Yoga in pre-diabetic stage on skeletal muscle related glycemic control, which is novel. Additionally, the study will generate awareness about pre-diabetes and provide people with active coping skills for reversing it.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137180393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breathing-based meditation (Sudarshan Kriya Yoga) increases sense of coherence. No-cost stress prevention 以呼吸为基础的冥想(苏达山克里亚瑜伽)增加了连贯性。无成本应力预防
IF 1.7
Advances in integrative medicine Pub Date : 2022-12-01 DOI: 10.1016/j.aimed.2022.11.001
Agnieszka Banaś-Ząbczyk , Paweł Jakubczyk , Barbara Pikuła , Anna Sendera , Marta Kopańska
{"title":"Breathing-based meditation (Sudarshan Kriya Yoga) increases sense of coherence. No-cost stress prevention","authors":"Agnieszka Banaś-Ząbczyk ,&nbsp;Paweł Jakubczyk ,&nbsp;Barbara Pikuła ,&nbsp;Anna Sendera ,&nbsp;Marta Kopańska","doi":"10.1016/j.aimed.2022.11.001","DOIUrl":"10.1016/j.aimed.2022.11.001","url":null,"abstract":"<div><h3>Background and aim</h3><p>Our society deals with multiple challenges such as psychological stress, anxiety, and depression, as well as disasters, crises including the pandemic crisis, and the current war. Excess stress can manifest itself in a variety of emotional, behavioral, and even physical symptoms, which strongly correlate with deterioration of health and a decrease in quality of life<span>. Sense of coherence<span> (SOC) is a central pillar of Antonovsky’s salutogenic model of health and it is focused on the relationship between health, stress, and coping. The SOC scale comprises the evaluation of the sense of comprehensibility (SC), the sense of manageability (SM), and the sense of meaningfulness (SMF), which are associated with both physical and psychological health.</span></span></p></div><div><h3>Methods</h3><p>The Mind-Body Medicine intervention breathing-based meditation (SKY-Sudarshan Kriya Yoga) was evaluated to assess its impact on the sense of coherence of practitioners in a pilot trial. The study groups consisted of 132 practitioners of SKY during the <em>Youth Empowerment Seminar</em> (YES!+) and 128 not participating/not practicing (260 in total). Both groups filled out SOC-29 questionnaire twice, on day first and sixth. Based on the SOC-29 test, SOC, SC, SM, and SMF have been evaluated in both groups.</p></div><div><h3>Results and conclusion</h3><p>Experience with the SKY breathing technique showed a statistically significant (p &lt; 0.05) increase of the sense of coherence of practitioners. Also, the senses of comprehensibility, manageability, and meaningfulness increased by 12%. The SKY exercise does not require any additional preparation, or equipment and may present a no-cost solution to help deal with stress and life demands.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80677021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Balancing promoting the public’s right to traditional, complementary and integrative health with evidence-based health care 在促进公众获得传统、补充和综合保健的权利与循证保健之间取得平衡
IF 1.7
Advances in integrative medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.07.001
Jon Wardle
{"title":"Balancing promoting the public’s right to traditional, complementary and integrative health with evidence-based health care","authors":"Jon Wardle","doi":"10.1016/j.aimed.2022.07.001","DOIUrl":"10.1016/j.aimed.2022.07.001","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83684990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Effects of antioxidant supplement on immune health and physical wellbeing: A randomized, controlled trial 抗氧化剂补充对免疫健康和身体健康的影响:一项随机对照试验
IF 1.7
Advances in integrative medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.06.007
Jessie Hawkins, Christy Hires, Elizabeth Dunne, Lindsey Keenan
{"title":"Effects of antioxidant supplement on immune health and physical wellbeing: A randomized, controlled trial","authors":"Jessie Hawkins,&nbsp;Christy Hires,&nbsp;Elizabeth Dunne,&nbsp;Lindsey Keenan","doi":"10.1016/j.aimed.2022.06.007","DOIUrl":"10.1016/j.aimed.2022.06.007","url":null,"abstract":"<div><h3>Background</h3><p>Maintaining a healthy immune system came to the forefront of people’s minds as SARS-CoV-2 (COVID-19) was introduced. Antioxidants contained in dark berries have been shown to support the physical wellbeing of otherwise healthy adults. Adding a supplement rich in dark berries and citrus essential oils contributes antioxidants to the body and serves as an aid to reduce free radicals.</p></div><div><h3>Aim</h3><p>We evaluated the effects of an antioxidant rich supplement on immune health and overall physical wellbeing compared to a control group.</p></div><div><h3>Method</h3><p>Participants were otherwise healthy adults, aged 18–60 years old, and were placed in either the antioxidant supplement group or control group using adaptive randomization. Data was collected at day 1 and 60. The Physical Health Questionnaire was used to measure the primary outcomes of this study. The immune health was reflected through the Jackson Symptom Scale.</p></div><div><h3>Results</h3><p>155 participants were analyzed. Participants who consumed the antioxidant beverage saw improvements to overall health which dramatically exceeded those of the control group. The sleep domain produced improvements which represented disturbances in sleep habits as they pertain to general health. Those in the supplement group who reported illness, had illnesses lasting 1–2 days while those in the control group had illnesses lasting from 1 to 9 days.</p></div><div><h3>Conclusion</h3><p>Length of illness was shorter and sleep duration improved in the supplement group compared to the control group. Daily consumption of 60 ml of the antioxidant drink NingXia RedⓇ showed significant improvement after 60 days.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40401948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Chronic plaque psoriasis treated with topical Unani formulation Marham Ḥina – A series of case reports 慢性斑块型银屑病治疗局部Unani制剂Marham Ḥina -一系列病例报告
IF 1.7
Advances in integrative medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.06.005
Faiza Khatoon , Arzeena Jabeen , Qamar Uddin , Nazim Husain , Mohd Azahar , Md Sanaul Moin
{"title":"Chronic plaque psoriasis treated with topical Unani formulation Marham Ḥina – A series of case reports","authors":"Faiza Khatoon ,&nbsp;Arzeena Jabeen ,&nbsp;Qamar Uddin ,&nbsp;Nazim Husain ,&nbsp;Mohd Azahar ,&nbsp;Md Sanaul Moin","doi":"10.1016/j.aimed.2022.06.005","DOIUrl":"10.1016/j.aimed.2022.06.005","url":null,"abstract":"<div><h3>Background</h3><p>Although psoriasis<span> treatment has advanced significantly in recent years, the disease remains incurable and relapsing. Alternatively, several potent systemic and topical formulations have been described in the Unani (Greco-Arab) system of medicine for conditions clinically similar to psoriasis, but there is a dearth of scientific evidence.</span></p></div><div><h3>Aim</h3><p>The purpose of this study was to investigate the efficacy and safety of the Unani formulation Marham Ḥina in chronic plaque psoriasis.</p></div><div><h3>Methods</h3><p>Seven patients with chronic plaque psoriasis, were treated with Marham Ḥina for 12 weeks.</p></div><div><h3>Results</h3><p>The mean ± SD of the psoriasis area and severity index (PASI) was significantly decreased from 24.00 ± 10.18 at baseline to 2.00 ± 1.29. One case attained PASI 100, two cases attained PASI 95, another two cases attained PASI 90, and the remaining two cases attained PASI 75.</p></div><div><h3>Conclusion</h3><p>The trial formulation appears to have a strong anti-psoriatic effect, while posing no adverse effects. However, more precise prospective clinical studies are recommended to confirm its scientific validity</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88463366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The effects of a 12-week yoga intervention on body awareness in people with multiple sclerosis: A non-controlled pilot study 12周瑜伽干预对多发性硬化症患者身体意识的影响:一项非对照的初步研究
IF 1.7
Advances in integrative medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.06.001
Signe Reitzel Gunnersen , Kirsten Hanehøj , Signe Gro , Clara Mosborg Petersen , Lasse Skovgaard
{"title":"The effects of a 12-week yoga intervention on body awareness in people with multiple sclerosis: A non-controlled pilot study","authors":"Signe Reitzel Gunnersen ,&nbsp;Kirsten Hanehøj ,&nbsp;Signe Gro ,&nbsp;Clara Mosborg Petersen ,&nbsp;Lasse Skovgaard","doi":"10.1016/j.aimed.2022.06.001","DOIUrl":"10.1016/j.aimed.2022.06.001","url":null,"abstract":"<div><h3>Introduction and objective</h3><p><span><span>Multiple sclerosis is a neurological autoimmune disease. Different disease-modifying </span>treatments exist; however, they do not control the neurodegenerative processes and often result in adverse events. Therefore, many people with multiple sclerosis turn to complementary or integrative health (CIH) practices. Yoga is one of the more popular CIH practices among people with multiple sclerosis, and evidence points to an association between yoga and improved body awareness. The objective of this study was to investigate if a 12-week yoga course can improve body awareness </span>in patients with multiple sclerosis as measured with the Multidimensional Assessment of Interoceptive Awareness (MAIA) questionnaire.</p></div><div><h3>Material and methods</h3><p>In this non-controlled pilot study, 22 patients participated in a 12-week yoga course. They attended weekly classes with the instructor and were encouraged to practice the exercises at home twice weekly. Before and after the course, all participants filled in the MAIA questionnaire, which consists of the eight dimensions: Noticing, Not-distracting, Not-Worrying, Attention regulation, Emotional awareness, Self-regulation, Body-listening and Trusting. Changes in mean scores were estimated with two-tailed paired t-tests.</p></div><div><h3>Results</h3><p>After the 12-week yoga course, participants’ total mean scores for body awareness improved significantly. Significant improvements were detected within three of the eight subscales from the MAIA, Attention regulation, Emotional awareness and Trusting.</p></div><div><h3>Conclusion</h3><p>The results of this non-controlled pilot study suggest that yoga may have a positive effect on body awareness in patients with multiple sclerosis. Improvements were found in all subscales of body awareness although only improvements in three of the eight subscales were significant.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85531523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of an on-campus herb garden in facilitating teaching and learning for students enroled in a naturopathic and herbal medicine degree 校园草药园在促进自然疗法和草药学位学生教学中的作用
IF 1.7
Advances in integrative medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.06.003
Asmita Patel, Wayne Hill, Karen Wesseling, Karen Mees, Robyn Carruthers, Clive Standen
{"title":"The role of an on-campus herb garden in facilitating teaching and learning for students enroled in a naturopathic and herbal medicine degree","authors":"Asmita Patel,&nbsp;Wayne Hill,&nbsp;Karen Wesseling,&nbsp;Karen Mees,&nbsp;Robyn Carruthers,&nbsp;Clive Standen","doi":"10.1016/j.aimed.2022.06.003","DOIUrl":"10.1016/j.aimed.2022.06.003","url":null,"abstract":"<div><h3>Objectives</h3><p>The educational role of elementary/primary school gardens for school-aged children has been well-researched and documented. Within tertiary education, limited published research exists regarding the role that on-campus gardens have as a practical teaching resource for the learning of degree curriculum. Therefore, the aim of the present study was to ascertain the role that an extensive on-campus herb garden had in facilitating teaching and learning for students enroled in a naturopathic and herbal medicine degree.</p></div><div><h3>Methods</h3><p>Twenty-one students enroled in a naturopathy and herbal medicine degree at a naturopathic college in Auckland, New Zealand were individually interviewed. Data was analysed using an inductive thematic approach.</p></div><div><h3>Results</h3><p>A number of themes and subthemes were identified. The on-campus herb garden provided students with ongoing access to a wide range of herbs and plants that are not readily accessible in the wider community. The herb garden acted as a practical resource for teaching and learning, as it aided coursework by providing students with salient opportunities for practical learning, which included the manufacturing of products for assessments. The direct physical interaction that the herb garden provided, was perceived by students as taking their learning of course material to a level beyond what a textbook could provide. The herb garden provided sensory/kinaesthetic learning opportunities, which were perceived to aid student learning. Students also utilised the herb garden for the acquisition of herbs for food and tea consumption, including the preparation of tea to provide to clients in the student clinic.</p></div><div><h3>Conclusions</h3><p>The present study provided qualitative insights from students regarding the salient role and multiple ways in which an extensive on-campus herb garden supported and aided their learning within a naturopathic and herbal medicine degree curriculum.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90152401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Safety and tolerability of Pau d′ Arco (Tabebuia avellanedae) for primary dysmenorrhea: A single-arm, open-label trial on adults ages 18–45 Pau d ' Arco (Tabebuia avellanedae)治疗原发性痛经的安全性和耐受性:一项针对18-45岁成年人的单臂、开放标签试验
IF 1.7
Advances in integrative medicine Pub Date : 2022-09-01 DOI: 10.1016/j.aimed.2022.04.003
C. McClure , M. Bollen , L. Buttolph , E. Stack , B.O. Langley , D. Hanes , K.M. Wright , D. Tibbitts , R. Bradley
{"title":"Safety and tolerability of Pau d′ Arco (Tabebuia avellanedae) for primary dysmenorrhea: A single-arm, open-label trial on adults ages 18–45","authors":"C. McClure ,&nbsp;M. Bollen ,&nbsp;L. Buttolph ,&nbsp;E. Stack ,&nbsp;B.O. Langley ,&nbsp;D. Hanes ,&nbsp;K.M. Wright ,&nbsp;D. Tibbitts ,&nbsp;R. Bradley","doi":"10.1016/j.aimed.2022.04.003","DOIUrl":"10.1016/j.aimed.2022.04.003","url":null,"abstract":"<div><h3>Objectives</h3><p><span>To evaluate the safety and tolerability of encapsulated </span><span><em>Tabebuia</em><em> avellanedae</em></span><span> in generally healthy women aged 18–45 with primary dysmenorrhea.</span></p></div><div><h3>Methods</h3><p>A single arm, open-label trial was conducted in which 1050 mg/day of encapsulated <em>Tabebuia avellanedae</em><span><span> (Pau d′Arco) was administered to twelve healthy women aged 18–45 for eight weeks. The primary outcome was safety and tolerability as measured by standardized adverse events scales and serial collection of laboratory markers to assess general health, prothrombin times, and the presence or absence of anemia. Secondary outcomes included pain intensity, </span>quality of life<span>, and pain interference measured by the Visual Analog Scale (VAS), the Patient-Reported Outcomes Measurement Information System (PROMIS) 29 survey, and the PROMIS Visual </span></span><em>Sexual Function and Satisfaction: Interfering Factors</em> survey, respectively. Exploratory outcomes included serum concentration of high-sensitivity C-reactive protein as a marker of systemic inflammation.</p></div><div><h3>Results</h3><p>Seventy-five percent of participants (n = 9/12) completed the study. Seventy-five percent of study participants (n = 9/12) reported an adverse event, most of which were characterized as mild, and none were determined to be a Food and Drug Administration (FDA) serious adverse event. Most laboratory markers stayed within normal limits throughout the study period with a few clinically mild abnormalities. There was a significant decrease in pain intensity compared to baseline after the first dose (p &lt; .01), after 4 weeks of treatment (p &lt; .01), and after 8 weeks of treatment (p &lt; .01). Over the 8-week intervention period, pain interference, quality of life, and sexual function and satisfaction scores improved nonsignificantly and hs-CRP decreased nonsignificantly.</p></div><div><h3>Conclusions</h3><p><em>Tabebuia avellanedae</em> supplementation of 1050 mg/day dose for eight weeks in generally healthy women aged 18–45 with primary dysmenorrhea was generally safe, associated with moderate tolerability, and associated with significant improvements in pain intensity scores. Future studies examining the safety and efficacy of <em>Tabebuia avellanedae</em> on primary dysmenorrhea are warranted.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9192260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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