Efficacy of Glycyrrhiza glabra on peptic ulcer disease: A systematic review and meta-analysis

IF 1.7 Q2 Medicine

Advances in integrative medicine Pub Date : 2025-04-16 DOI:10.1016/j.aimed.2025.100485

Elham Zaeif Khorasani , Tahereh Amirian , Ebrahim Nasiri Formi , Fatemeh Mahjoub , Masoumeh Sadeghi

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引用次数: 0

Abstract

Introduction

Peptic ulcer is a common gastrointestinal disorder, marked by lesions in the mucosal lining of the stomach and duodenum. Due to the limitations of conventional treatments, herbal medicines have gained wide popularity for treating digestive conditions. The current study aims to conduct a systematic review and meta-analysis to assess the effects of licorice on peptic ulcers.

Methods

A comprehensive search was performed in online databases, including PubMed, Web of Science, Scopus, Cochrane, and Embase, covering publications up to 7 August 2024, using relevant keywords. Ultimately, 9 studies, comprising a total of 618 participants, had the eligibility criteria. In the statistical analysis, binary data were analyzed using odds ratios (OR) with 95 % confidence intervals (CIs). To evaluate statistical heterogeneity across studies, the I2 statistic was calculated.

Results

These studies reported clinical improvement in peptic ulcer symptoms (stomach and duodenal ulcers) and radiographic and endoscopic evidence of complete healing lesion or reduction in size. Some of them demonstrated licorice’s positive effects on ulcer healing, while others found no significant difference compared to placebo. The pooled odds ratio for clinical symptom improvement in pain was calculated to be 0.52 (95 % CI: 0.42–1.45), and for complete ulcer healing, it was 0.60 (95 % CI: 0.24–1.43), indicating that these findings were not statistically significant.

Conclusions

While the intervention demonstrated a trend toward improved clinical symptoms and healing in peptic ulcers compared to placebo, the lack of statistical significance and the observed heterogeneity highlight the need for further research to clarify these effects

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甘草对消化性溃疡疾病的疗效：系统回顾和荟萃分析

消化性溃疡是一种常见的胃肠道疾病，以胃和十二指肠粘膜损伤为特征。由于传统治疗方法的局限性，草药在治疗消化系统疾病方面得到了广泛的普及。本研究旨在通过系统回顾和荟萃分析来评估甘草对消化性溃疡的影响。方法综合检索PubMed、Web of Science、Scopus、Cochrane、Embase等数据库，检索截止到2024年8月7日的出版物，并使用相关关键词进行检索。最终，共有618名参与者的9项研究符合资格标准。在统计分析中，二元数据采用比值比（OR）进行分析，比值比为95 %置信区间（ci）。为了评估研究间的统计异质性，计算I2统计量。结果这些研究报告了消化性溃疡症状（胃和十二指肠溃疡）的临床改善，以及x线和内镜下病变完全愈合或缩小的证据。其中一些研究表明，甘草对溃疡愈合有积极作用，而另一些研究发现，与安慰剂相比，甘草没有显著差异。计算疼痛临床症状改善的合并优势比为0.52(95 % CI: 0.42-1.45)，溃疡完全愈合的合并优势比为0.60(95 % CI: 0.24-1.43)，表明这些发现无统计学意义。结论：虽然与安慰剂相比，干预显示出改善消化性溃疡临床症状和愈合的趋势，但缺乏统计学意义和观察到的异质性突出表明需要进一步研究来阐明这些效果

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.