Advances in integrative medicine最新文献

{"title":"Exploring the role of traditional medicine in complementary management for sexually transmitted diseases (STDs)","authors":"Amit Anand , Santhepete Nanjundiah. Manjula , Mruthunjaya Kenganora , Subhajit Mandal , Himanshu Sharma , Rashmi Pathak","doi":"10.1016/j.aimed.2025.100531","DOIUrl":"10.1016/j.aimed.2025.100531","url":null,"abstract":"<div><h3>Background</h3><div>Sexually Transmitted Disease (STDs) remain a significant global health issue, particularly affecting women due to biological and sociocultural factors. Traditional medicine has been widely used in the management of sexually transmitted disease due to its accessibility, affordability and cultural acceptance. However, it has several limitations that challenge its efficacy and reliability due to absence of rigorous scientific validation and clinical trials. The study was undertaken to explore the integration of traditional medicine with modern approaches to STD management. The purpose of the review to bridge the gap in knowledge between traditional medicinal practices and modern interventions through a comparative analysis. It also aims to address the gaps in healthcare access, particularly in underprivileged regions where economic constraints limit the availability of conventional allopathic treatments.</div></div><div><h3>Methods</h3><div>The study employed systematic literature review methodology to explore the application of traditional medicine in STD management. Databases such as Pub Med, Google scholar, science direct, web of science was searched from up to January 2024. Search terms included “traditional medicine, “STDs”, “medicinal plants” and specific plant names (eg: Neem, Echinea, <em>Aloe vera</em>). A total of 381 articles were initially retrieved and duplicates were removed. Inclusion criteria focused on studies providing <em>in-vitro</em> and <em>in-vivo</em> data for STD treatment, cultural applications and integration with modern medicine. Relevant were extracted using a structural database, capturing the plant species, active compounds, mechanisms of action and therapeutic outcomes. Cross referencing with WHO and national databases ensured the inclusion of the latest prevalence and management.</div></div><div><h3>Results</h3><div>The findings suggest practice of traditional medicines including the use of specific plants and holistic approaches offers valuable benefits in the management of STDs and enhancing overall wellbeing. The integration of traditional medicine with modern health practices provides a comprehensive approach that addresses not only the physical aspects of health but also the emotional and social dimension. The limitations of the findings presented in the review primarily stem from the limited number of clinical trials included. Such studies primarily elucidate theoretical mechanisms of action and biological pathways. However, these results cannot be directly extrapolated to clinical outcomes or therapeutic benefits in human populations, highlighting the need for caution when interpreting the transitional potential of these findings.</div></div><div><h3>Discussion</h3><div>The review highlights the importance of combine approach of traditional medicine with modern clinical practices to create an inclusive and culturally sensitive approach to STD management and female health. The signi","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100531"},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-driven clinical decision support systems: Revolutionizing medication selection and personalized drug therapy","authors":"Hrishikesh Khude ,&nbsp;Pravin Shende","doi":"10.1016/j.aimed.2025.100529","DOIUrl":"10.1016/j.aimed.2025.100529","url":null,"abstract":"<div><div>Artificial Intelligence (AI) analyzes complex medical data records using Machine learning (ML), Natural Language Processing (NLP), and Deep Learning (DL) algorithms. These algorithms assist physicians in the optimization of therapeutic decisions that allow for the integration and interpretation of individual biological data, including genomics, proteomics, and transcriptomics. By identifying complex patterns in these data records, AI-driven systems facilitate the development of personalized treatment strategies that align with individual patient profiles. Furthermore, AI enhances pharmacovigilance by predicting potential drug interactions and conducting in-silico toxicity risk assessments through advanced molecular composition analysis. Moreover, AI accelerates the drug discovery process by screening and identifying novel drugs, thereby facilitating the development of targeted treatment. AI empowers physicians to prescribe medications, perform real-time formulary checks, and recommend therapeutic equivalent, economically viable alternatives to patient-specific factors. AI-driven clinical decision support systems (CDSS) further assist physicians in improving drug compliance and optimizing population health strategies by identifying pharmacologically cost-effective therapies. Additionally, AI enhances real-time clinical decision-making by improving diagnostic precision, refining therapeutic choices, and patient outcomes. The evolution of AI technologies offers immense potential for seamless integration into healthcare systems despite challenges such as data bias, limited model interpretability, and regulatory complexities. This integration revolutionizes personalized medicines, accelerates the drug discovery process, and improves the safety, efficacy, and cost-effectiveness of drug therapy. In summary, AI plays a significant role in modern medicine, promoting data-based clinical decisions and enhancing the overall quality and efficiency of healthcare delivery.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100529"},"PeriodicalIF":1.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory biomarkers modulation in postmenopausal women: A randomized controlled trial of the superiority of Co-supplementing curcumin nano-micelles and Nigella sativa","authors":"Amir Mehdi Iranshahi ,&nbsp;Mahdi Amirpour ,&nbsp;Soraya Babaie ,&nbsp;Azizeh Farshbaf-Khalili ,&nbsp;Alireza Ostadrahimi","doi":"10.1016/j.aimed.2025.100528","DOIUrl":"10.1016/j.aimed.2025.100528","url":null,"abstract":"<div><h3>Background</h3><div>Lasting inflammation, whether directly mediated by hormonal changes or induced by oxidative stress, has significant negative effects on bone health, potentially contributing to the development of postmenopausal osteopenia and osteoporosis. Anti-inflammatory herbal products, known for cost-effectiveness and safety, support bone remodeling. This study evaluates the efficacy of Curcumin Nano-micelles (CUR), Nigella sativa (NS), and their co-supplementation (NS-CUR) on serum inflammatory factors in postmenopausal women with osteopenia or osteoporosis.</div></div><div><h3>Methods</h3><div>A triple-blind randomized trial was conducted on 120 postmenopausal women. Patients were allocated to four groups stratified by bone density. During the 6-month intervention, the NS group took an NS oil capsule and a CUR placebo capsule daily. The CUR group consumed a CUR capsule and an NS placebo capsule daily. The NS-CUR group received a CUR capsule and an NS oil capsule daily. The placebo group received two microcrystalline cellulose (MCC) capsules daily. The serum concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were determined.</div></div><div><h3>Result</h3><div>The serum levels of TNF-α, IL-6, and hs-CRP significantly declined in the NS group (<em>p</em> &lt; 0.001), CUR (<em>p</em> &lt; 0.001, <em>p</em> &lt; 0.001, <em>p</em> = 0.001, res<em>p</em>ectively), and NS-CUR (<em>p</em> &lt; 0.001) groups compared to baseline. Between-group analyses revealed that IL-6 and TNF-α showed significant reductions in the NS, CUR, and NS-CUR groups (<em>p</em> &lt; 0.001) compared to placebo. Despite significant reductions in hs-CRP in the NS and NS-CUR groups (<em>p</em> = 0.001, <em>p</em> &lt; 0.001, respectively), no significant differences were identified between the CUR and placebo groups (<em>p</em> = 0.096).</div></div><div><h3>Conclusion</h3><div>The supplementation of CUR, NS, and NS-CUR modulated IL-6, TNF-α, and hs-CRP levels. Moreover, the co-supplementation of NS and CUR significantly influenced inflammatory biomarkers.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100528"},"PeriodicalIF":1.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting emotional resilience through laughter yoga in health professions education","authors":"Manuel Millán-Hernández ,&nbsp;Daniela F. Albarrán-Pérez","doi":"10.1016/j.aimed.2025.100527","DOIUrl":"10.1016/j.aimed.2025.100527","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100527"},"PeriodicalIF":1.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new paradigmatic framework for integrative medicine, and its implications for medicine and politics","authors":"Josef M. Schmidt","doi":"10.1016/j.aimed.2025.100526","DOIUrl":"10.1016/j.aimed.2025.100526","url":null,"abstract":"<div><h3>Introduction</h3><div>One of the major shortcomings of the discussion concerning integrative medicine is often an insufficient awareness of the peculiarity and multi-dimensionality of the object in question, on the part of critics and advocates alike.</div></div><div><h3>Methods</h3><div>Focusing on homeopathy as an example, this paper points out that the essence of this unique concept of healing cannot be wholly understood without a basic knowledge of the dimensions that constitute it.</div></div><div><h3>Results</h3><div>The three traditions of thinking on which it is based date back to antiquity, namely: <em>lógos</em>-thinking, <em>hómoion</em>-thinking and <em>iásthai</em>-thinking, i.e. thinking in terms of rationality, similarity and healing.</div></div><div><h3>Discussion</h3><div>While modern medicine is, for the most part, driven by reasoning in terms of quantification and generalisation, this at the cost of neglecting the remaining two dimensions, – homeopathy, due to its methodology, finds itself constantly searching to find a balance for all of its constituents.</div></div><div><h3>Conclusions</h3><div>This model of a three-dimensional art of healing may serve as a paradigm for integrative medicine to recollect an awareness of its own strength and multi-dimensionality, and, finally, also for medicine and politics in general.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100526"},"PeriodicalIF":1.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An altmetric analysis of the research literature about traditional, complementary, and integrative medicine","authors":"Jeremy Y. Ng ,&nbsp;Alep Judge ,&nbsp;Holger Cramer","doi":"10.1016/j.aimed.2025.100506","DOIUrl":"10.1016/j.aimed.2025.100506","url":null,"abstract":"<div><h3>Background</h3><div>The use of traditional, complementary, and integrative medicine (TCIM) is known to be popular worldwide; there have been over 200,000 research articles published on this topic as of 2024. For decades, traditional citation-based metrics have been the assumed norm when assessing the impact of research, but in the digital age, alternative metrics (altmetrics) have also become a valuable proxy. By analyzing trends associated with the altmetrics of scholarly outputs relating to TCIM, patterns of social engagement were identified to obtain a better understanding of the factors that drive social impact in this field online.</div></div><div><h3>Methods</h3><div>This study was conducted using Altmetric.com, whereby this database was searched by the subject area “Traditional, Complementary and Integrative Medicine”. The subsequent data obtained was further analyzed to discern social trends within TCIM scholarly outputs at the article level.</div></div><div><h3>Results</h3><div>62,278 research outputs, from 1925 to 2024, with +497,000 online mentions were analyzed. Outputs from the Journal of Natural Products were mentioned the most frequently online (n = 5314, 10.56 %). The highest average Altmetric attention scores were associated with news outputs (M = 203.67), and outputs published under a bronze OA type (M = 17.54). The most mentions were contributed by X (n = 350,630, 70.41 %), Facebook (n = 57,540, 11.55 %), and news outlets (n = 39,941, 8.02 %).</div></div><div><h3>Conclusions</h3><div>Using the features found in this study to be linked with higher online attention, and sharing research through well-used online platforms, may help make TCIM research more visible to the public and more relevant to policy discussions.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100506"},"PeriodicalIF":1.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of the pregnant woman’s mental visualization of her baby during the non-stress test on maternal anxiety and fetal parameters: A randomized controlled clinical trial","authors":"Fatma Keskin Töre ,&nbsp;Cansu Ağralı ,&nbsp;Gülçin Nacar ,&nbsp;Özlem Özel Özcan","doi":"10.1016/j.aimed.2025.100508","DOIUrl":"10.1016/j.aimed.2025.100508","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to examine the effects of pregnant women’s mental visualization of their babies during the non-stress test on maternal anxiety and fetal parameters.</div></div><div><h3>Methods</h3><div>This randomized controlled clinical trial was completed with 64 pregnant women (32 experimental, 32 control). It was conducted in a public hospital located in eastern Turkey. Data were collected using a personal information form, a non-stress test findings form, a baby picture evaluation form, and the State Anxiety Inventory.</div></div><div><h3>Results</h3><div>It was determined that during NST (Non-Stress Test), pregnant women’s visualization of their babies reduced the fetal heart rate (t = 2.083, p = 0.041) and fetal movements (t = 2.110, p = 0.039) while increasing the number of accelerations (t = 4.845, p = 0.001). There was no significant difference between the maternal anxiety levels in the experimental group and those in the control group (t = 1.184, p = 0.241). The maternal anxiety levels of the participants in the experimental increased in the posttest compared to the pretest (t = 3.371, p = 0.002).</div></div><div><h3>Conclusion</h3><div>It was determined that the pregnant woman’s mental visualization of her baby during the non-stress test reduced the fetal heart rate and fetal movements, increased the number of accelerations, and did not significantly affect maternal anxiety.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100508"},"PeriodicalIF":1.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of scalp acupuncture treatment on motor dysfunction in children with spastic cerebral palsy: A multicenter randomized controlled trial","authors":"Jun Wang ,&nbsp;Xueyan Li ,&nbsp;Wei Shi ,&nbsp;Bingpei Shi ,&nbsp;Xiaojuan Shi ,&nbsp;Dandan Luo ,&nbsp;Xiushu Shen ,&nbsp;Chun Zhai ,&nbsp;Lei Xu ,&nbsp;Meirong Li ,&nbsp;Nan Su ,&nbsp;Rencai Deng ,&nbsp;Huayu Huang ,&nbsp;Jian Li ,&nbsp;Yin Wang ,&nbsp;Hong Yang","doi":"10.1016/j.aimed.2025.100505","DOIUrl":"10.1016/j.aimed.2025.100505","url":null,"abstract":"<div><h3>Introduction</h3><div>Scalp acupuncture has been widely used as a treatment for motor dysfunction in children with cerebral palsy (CP). Previous studies have not provided high-quality evidence to demonstrate the effectiveness of this treatment in children with CP. To date, no high-quality randomized controlled trials on scalp acupuncture have been reported. The present study aims to evaluate the effectiveness of Jiao's scalp acupuncture for the treatment of motor dysfunction in children with spastic CP.</div></div><div><h3>Methods</h3><div>This was a randomized controlled trial. One hundred CP patients were randomly allocated to either the treatment or control group. The control group received conventional rehabilitation treatment, while the treatment group received both conventional rehabilitation treatment and Jiao’s scalp acupuncture. Thirty-six treatment sessions were conducted over a 12-week period. Outcomes were assessed using the Gross Motor Function Measure (GMFM)-66 and the Fine Motor Function Measure (FMFM) at baseline, week 4, 8, 12 (post-treatment) and week 24 (follow-up).</div></div><div><h3>Results</h3><div>Both groups showed significant improvements in motor function (p &lt; 0.01), as assessed by the GMFM-66 and the FMFM. Compared to the control, the treatment group demonstrated a significantly greater improvement in both gross and fine motor function (p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Acupuncture in the motor area of Jiao's scalp acupuncture significantly improved motor function in children with spastic CP. Scalp acupuncture treatment may serve as a beneficial adjunct to conventional rehabilitation for motor dysfunction in this population.</div></div><div><h3>Trial registration</h3><div>ClinicalTrials.gov, NCT03921281.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100505"},"PeriodicalIF":1.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of various hydrotherapeutic procedures on heart rate variability and blood pressure: A systematic review","authors":"S. Abinaya ,&nbsp;A. Vijay ,&nbsp;L. Nivethitha ,&nbsp;A. Mooventhan ,&nbsp;N. Manavalan","doi":"10.1016/j.aimed.2025.100500","DOIUrl":"10.1016/j.aimed.2025.100500","url":null,"abstract":"<div><h3>Background</h3><div>The autonomic nervous system (ANS) regulates involuntary physiological processes including blood pressure. Hydrotherapy uses water to treat various conditions and research on effect of different hydrotherapy modalities at varying temperatures on the heart rate variability (HRV) is increasing for the past few years. However, there is no systematic review of on it. Hence, this systematic review was performed to provide evidence-based effects of hydrotherapy on HRV.</div></div><div><h3>Materials and methods</h3><div>We have searched PubMed/Medline and google scholar electronic databases to find relevant articles using following keywords: hydrotherapy, balneotherapy, cryotherapy, sauna bath, immersion bath, foot bath, spinal bath, hip bath, arm and foot bath, ice massage and heart rate variability. Out of 121 articles found, 24 potentially eligible articles were reported in this review.</div></div><div><h3>Results</h3><div>In this systematic review 24 articles (including 6 RCTs) with 961 participants with various condition, underwent various hydrotherapy modalities with different temperatures were reported. The finding showed that majority of the hydrotherapy modalities produces improvements in parasympathetic activity and regulation of autonomic nervous system. However, only one study showed increased sympathetic activity during the session and transitioned into parasympathetic activity after 15–120 min of session.</div></div><div><h3>Conclusion</h3><div>Literature suggests that hydrotherapy is effective in reducing blood pressure and improving HRV as an adjuvant in healthy volunteers, sportspeople, and in patients with hypertension, heart failure, migraines, allergic rhinitis, and chronic fatigue syndrome. However, the quality of the studies included in this review low. Hence, we recommend high quality long-term RCTs to determine the efficacy and safety of hydrotherapy.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100500"},"PeriodicalIF":1.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Hypericum perforatum oil on prevention ecchymosis and pain associated with subcutaneous heparin injection: A self-controlled single-blind study","authors":"Hatice Demi̇rdağ ,&nbsp;Nurcan Uysal ,&nbsp;Fatma Zehra Kamber","doi":"10.1016/j.aimed.2025.100504","DOIUrl":"10.1016/j.aimed.2025.100504","url":null,"abstract":"<div><h3>Background</h3><div>Low molecular weight heparin is a drug with anticoagulant and antithrombotic effects. This drug is frequently administered subcutaneously to patients by nurses. Complications such as pain, ecchymosis and hematoma may commonly occur at the injection site. This study investigated the effect of Hypericum perforatum oil in preventing pain and ecchymosis after subcutaneous injection low molecular weight heparin.</div></div><div><h3>Methods</h3><div>This quasi-experimental and single blinded study was conducted with 160 patients in a coronary intensive care unit. The researcher nurse applied 5–6 drops of Hypericum perforatum oil to one arm of the patients 2 h before the injection. The other arm of the patient was considered as the control arm. A total of 320 injections were administered. The evaluation of the injection sites was performed by two other researchers at 48th hours. The data were analyzed using Wilcoxon and McNemar test.</div></div><div><h3>Results</h3><div>In the arm which was applied Hypericum perforatum oil the mean pain score was 0.08 ± 0.55 and the mean ecchymosis size was 2.49 ± 10.32 mm. In the control arm, the mean pain score was 1.28 ± 1.97 and the mean ecchymosis size was 13.29 ± 18.99 mm according to the measurements made at 48th h after injection. The difference between the measurements in both arms was statistically significant (p = .000).</div></div><div><h3>Conclusions</h3><div>It showed that Hypericum perforatum oil is effective in preventing pain and ecchymosis after low molecular weight heparin injection. However, the research needs to be repeated.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100504"},"PeriodicalIF":1.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}