Advances in integrative medicine最新文献

{"title":"Safety and efficacy of the anti-AGEs supplement d-Gs: A pilot study of AGEs improvement effect and safety review of anti-AGEs supplementation","authors":"Michiya Igase ,&nbsp;Yoko Okada ,&nbsp;Keiji Igase ,&nbsp;Yuuki Imai ,&nbsp;Shiroh Miura ,&nbsp;Masayuki Ochi ,&nbsp;Yasumasa Ohyagi ,&nbsp;Sho-Ichi Yamagishi","doi":"10.1016/j.aimed.2026.100638","DOIUrl":"10.1016/j.aimed.2026.100638","url":null,"abstract":"<div><div>Advanced glycation end products (AGEs) are Maillard reaction products that promote oxidative damage and thus adversely affect cellular function. Therefore, reducing harmful AGEs may reduce various age-related diseases. We designed and developed a supplement named <span>d</span>-Gs that contains four ingredients that have been shown to reduce levels of exogenous AGEs (i.e., exert an anti-AGEs effect) - <span>L</span>-carnosine, coenzyme Q10, quercetin, and phytic acid - and conducted a double-blind, randomized, placebo-controlled trial to evaluate the safety and anti-AGEs efficacy of <span>d</span>-Gs in healthy community-dwelling individuals. A total of 15 community-dwelling women aged 44–88 (mean, 67 ± 14) years participated in the study, of whom 8 were randomly assigned to receive the test supplement and 7 received the placebo. Participants received six capsules of <span>d</span>-Gs or dried brewer's yeast as placebo by oral administration with 100 ml water every day after breakfast for 12 weeks. Primary outcome was skin autofluorescence (SAF). There were no significant differences in laboratory parameters between the groups either before or after the 12-week study, with no participants showing abnormal values. There was no significant difference in skin AGEs level between the groups at baseline. At the end of the study period, a significant decrease in skin AGEs levels was observed in the test supplement group only. Between-group comparison showed no significant difference in change in skin AGEs level between the test supplement and placebo groups. These results indicate that the administration of <span>d</span>-Gs is safe and that this agent exerts an anti-AGEs effect in clinical settings.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 2","pages":"Article 100638"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147386583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate effects of cervical spine and sacroiliac joint manipulations on the autonomic nervous system and pedobarographic analysis: Randomized controlled trial","authors":"Hayriye Turgut ,&nbsp;İlker Can Büyükkırlı ,&nbsp;Sefa Haktan Hatık ,&nbsp;Emine Büşra Aydın","doi":"10.1016/j.aimed.2026.100634","DOIUrl":"10.1016/j.aimed.2026.100634","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the immediate effects of cervical and sacroiliac joint manipulations on autonomic nervous system activity and baropodometric parameters.</div></div><div><h3>Methods</h3><div>Participants were randomly assigned to three groups with equal gender distribution. The cervical manipulation group received chiropractic manipulation at the C3–C5 level, while the sacroiliac group received manipulation at the sacroiliac joint. The control group received no intervention. Pre- and post-treatment evaluations were conducted after a 30-minute interval. Plantar pressure was measured via a pedobarographic device. Autonomic nervous system activity was assessed using the Polar H10. Blood pressure and heart rate were manually recorded using a sphygmomanometer and pulse oximeter. Statistical significance was set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>No significant differences were found among groups in terms of age, gender, height, or BMI (Kruskal-Wallis, p &gt; 0.05). The cervical manipulation group showed significant decreases in systolic and diastolic blood pressure and heart rate post-intervention (Wilcoxon, p &lt; 0.05). The sacroiliac group showed a significant increase in heart rate only (Wilcoxon, p &lt; 0.05). No significant changes were observed in baropodometric parameters or autonomic activity within or between groups (Wilcoxon and Kruskal-Wallis, p &gt; 0.05). However, post-intervention comparisons showed cervical manipulation led to a greater reduction in systolic blood pressure, while sacroiliac manipulation led to a greater increase in heart rate compared to controls (Mann-Whitney U with Bonferroni correction, p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>While no significant changes were observed in baropodometric or autonomic parameters, chiropractic manipulation demonstrated short-term effects on blood pressure and heart rate. The accuracy of heart rate variability assessments should be reviewed, and further studies are needed to evaluate long-term cardiovascular and autonomic outcomes.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 2","pages":"Article 100634"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147386585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A national survey of U.S. caregivers’ perceptions of integrative health for their children","authors":"Mala Mathur ,&nbsp;Bradley R. Kerr ,&nbsp;Greta Kuphal ,&nbsp;Qianqian Zhao ,&nbsp;Jens Eickhoff ,&nbsp;Megan A. Moreno","doi":"10.1016/j.aimed.2026.100622","DOIUrl":"10.1016/j.aimed.2026.100622","url":null,"abstract":"<div><h3>Introduction</h3><div>Integrative Health (IH) is the use of conventional medical treatment alongside complementary therapies. Studies indicate the use of IH is increasing. This study aimed to update our understanding of the use of IH therapies for children.</div></div><div><h3>Methods</h3><div>A national cross-sectional survey of caregivers of children 0–17 years of age were recruited from Qualtrics panels in August 2022. Caregivers were asked abouttheir familiarity, current use, motivations and preferences for receiving IH services. Chi square analysis was used to test differences in current use of IH by age, race, gender, and level of education.</div></div><div><h3>Results</h3><div>Caregivers (n = 2151) were predominantly female (73 %), between the ages of 30–45 (60 %), white (75 %), and non-Hispanic (82 %), and most reported some college education (57 %). About 66 % of participants indicated some familiarity with IH. Caregivers (32 %, n = 680) reported using IH therapies for their child in the past 12 months to promote overall health (58 %, n = 394), to increase energy (30 %, n = 207), to address stress (25 %, n = 169), and to support mental health (25 %, n = 135). Over half of caregivers (65 %, n = 1389) indicated interest in having their health care provider use an IH approach and preferred to receive services within their health care clinic (99 %, n = 1387) and from their health care provider (75 %, n = 1048).</div></div><div><h3>Conclusion</h3><div>Findings suggest an increase in caregiver familiarity, use and interest in receiving IH services within their health care clinics. Future studies should explore opportunities to provide IH training for health care providers to support the growing number of families already engaging in IH therapies.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 2","pages":"Article 100622"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147386586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of diaphragmatic breathing on the chest pain intensity, anxiety, and physiological parameters of patients with acute coronary syndrome: A randomized controlled trial","authors":"Ali Fakhr-Movahedi ,&nbsp;Ferdous Amiri-Dastjerdi ,&nbsp;Abbasali Ebrahimian","doi":"10.1016/j.aimed.2026.100620","DOIUrl":"10.1016/j.aimed.2026.100620","url":null,"abstract":"<div><h3>Background</h3><div>Acute coronary syndrome diagnosis in patients is associated with personal challenges such as chest pain, anxiety, and changes in physiological responses. Therefore, this study aimed to examine the effect of diaphragmatic breathing on chest pain intensity, anxiety, and physiological parameters in patients with acute coronary syndrome.</div></div><div><h3>Methods</h3><div>This study was a randomized controlled trial that was conducted in the emergency department of a referral hospital in Tehran, Iran. Involving patients with acute coronary syndrome. 140 patients with acute coronary syndrome were involved and assigned to the intervention and control groups equally by permuted randomized blocks. In the intervention group, patients received diaphragmatic breathing for 10 min. Patients in the control group received routine care. Chest pain intensity, anxiety, heart rate, and systolic and diastolic blood pressure were measured before and after the procedure. Finally, the data were analyzed using descriptive and inferential statistics.</div></div><div><h3>Results</h3><div>The mean age of the patients in this study was 64.90 ± 10.45. Also, there was no significant difference in age between the two groups. Additionally, the number of male and female patients was equal in both the intervention and control groups. The difference between pre- and post-test scores of anxieties (4.72 ± 3.03) was significantly lower than that of the control group (p &lt; 0.001), as the patient’s anxiety was decreased due to diaphragmatic breathing. However, there were no differences between the groups for chest pain intensity, blood pressure, and heart rate variables (p &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Applying diaphragmatic breathing reduces the anxiety of patients. This intervention can be used as an effective and safe action in emergency settings for patients with acute coronary syndrome.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 2","pages":"Article 100620"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147386512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle profiles and the adoption of traditional, complementary and integrative medicine: Evidence from the Brazilian National Health Survey","authors":"Leticia Schmitz Nacur de Almeida ,&nbsp;Julianne Fic Alves ,&nbsp;Gislaine Terezinha Amaral Nienov ,&nbsp;Marcus Vinicius Veber Lopes ,&nbsp;Jhonatan Wélington Pereira Gaia ,&nbsp;Tuane Sarmento ,&nbsp;Renato Claudino ,&nbsp;Thiago Sousa Matias","doi":"10.1016/j.aimed.2026.100635","DOIUrl":"10.1016/j.aimed.2026.100635","url":null,"abstract":"<div><h3>Background:</h3><div>The clustering of unhealthy lifestyle behaviors is a global concern due to its association with increased morbidity and greater demand for health services. In this context, traditional, complementary and integrative medicine (TCIM) has emerged as a strategy increasingly adopted by individuals seeking broader approaches to health and well-being. This study aimed to investigate the association between lifestyle profiles and the adoption of traditional, complementary and integrative medicine.</div></div><div><h3>Method</h3><div>A secondary analysis was conducted using data from the 2019 Brazilian National Health Survey. Lifestyle behaviors (physical activity, sedentary behavior, and diet) were grouped using two-step cluster analysis to identify distinct lifestyle profiles. Traditional, complementary and integrative medicine (TCIM) adherence (e.g., acupuncture, homeopathy, medicinal plants and phytotherapy) was assessed through self-report. Logistic regression models were used to examine associations between outcomes.</div></div><div><h3>Results</h3><div>A total of 90,814 individuals aged &gt; 15 years were included in the analysis. Three lifestyle profiles were identified (Active-fruits and vegetable eatersInactive-healthy eaters, and At-risk), allhad high scores of sedentary behavior. Individuals with healthier lifestyle patterns were significantly more likely to report TCIM adoption compared to those in the least healthy profile (adjusted OR = 1.55; 95% CI = 1.34–1.81).</div></div><div><h3>Conclusion</h3><div>The lifestyle profiles were marked by a large prevalence of risk habits, such as high sedentary behaviour. Healthier lifestyle profiles were positively associated with TCIM. These findings suggest that TCIM practices may reflect broader health-oriented behavioral patterns, supporting the integration of these approaches into public health planning.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 2","pages":"Article 100635"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147386580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adopting AI-driven clinical decision support: Implications for medical education and practice","authors":"Manuel Millán-Hernández ,&nbsp;Daniela F. Albarrán-Pérez","doi":"10.1016/j.aimed.2026.100621","DOIUrl":"10.1016/j.aimed.2026.100621","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 2","pages":"Article 100621"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wellbeing in medical training: The missing role of assessment design","authors":"Manuel Millán-Hernández ,&nbsp;Daniela F. Albarrán-Pérez","doi":"10.1016/j.aimed.2026.100632","DOIUrl":"10.1016/j.aimed.2026.100632","url":null,"abstract":"<div><div>This letter responds to a recent study on mindful self-compassion among psychiatry residents by highlighting an underexplored determinant of trainee wellbeing: assessment design. While individual-level interventions are valuable, high-stakes clinical examinations may function as structural stressors that influence cognitive performance and psychological safety. Drawing on evidence from medical education and stress research, the authors argue that assessment systems should be considered environmental determinants of wellbeing. An integrative approach addressing individual, interpersonal, and structural factors may strengthen efforts to promote sustainable and humanistic medical training</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 2","pages":"Article 100632"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147386581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Mindfulness and the brain: A systematic review of neuroimaging evidence on structural and functional connectivity” [Adv. Integr. Med. 13 (2026) 100614]","authors":"Mamta Trichal","doi":"10.1016/j.aimed.2026.100631","DOIUrl":"10.1016/j.aimed.2026.100631","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 2","pages":"Article 100631"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147386582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ScarWork for post-breast surgery pain syndrome (PBSPS) in early-stage breast cancer patients: a protocol for a mixed methods feasibility study","authors":"Nicole Collaço ,&nbsp;Beverley de Valois ,&nbsp;Carole Caplin ,&nbsp;Davina Opoku-Arhin ,&nbsp;Rachel Henry ,&nbsp;John Hughes","doi":"10.1016/j.aimed.2026.100619","DOIUrl":"10.1016/j.aimed.2026.100619","url":null,"abstract":"<div><h3>Background</h3><div>Post-breast surgery pain syndrome (PBSPS) affects over 40 % of BCa survivors and can persist for years after surgery, significantly impacting quality of life, including body image, daily functioning and mental health. Treatment options are limited. ScarWork, a light touch manual therapy for scars, may help reduce pain, but there are few studies evaluating its effectiveness in people with cancer.</div></div><div><h3>Methods</h3><div>This study will employ a pragmatic, mixed-methods, randomised parallel-group exploratory design. Forty participants diagnosed with early-stage BCa who experience ongoing pain following surgery and/or radiotherapy will be randomly assigned to receive either up to five ScarWork sessions or a control group receiving usual care. The study will assess feasibility outcomes including recruitment, retention, and acceptability, as well as exploratory clinical outcomes related to pain, scar appearance and symptoms, physical function and psychosocial wellbeing. Quantitative outcomes will be measured using validated questionnaires at baseline, post-treatment, and four weeks post-treatment. Semi-structured interviews with participants and stakeholders will explore trial design, acceptability of the intervention and perceived effectiveness. Descriptive and exploratory statistical analysis will be used for quantitative data, and qualitative data will be analysed using the Framework method.</div></div><div><h3>Conclusion</h3><div>This feasibility trial will provide evidence on the acceptability and feasibility of ScarWork for PBSPS within a National Health Service setting. Should the intervention prove both feasible and effective, a subsequent full scale, pragmatic randomised controlled trial will be conducted to further evaluate its impact.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 2","pages":"Article 100619"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147386525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy of Brahmi Vati (Herbo-mineral Formulation) in premenstrual dysphoric disorder – A randomized double blind placebo controlled pilot clinical trial","authors":"Sushmita Patil ,&nbsp;Kashavva V. Hiremath ,&nbsp;Gayatri Hubli ,&nbsp;Krishika Muralidharan","doi":"10.1016/j.aimed.2026.100636","DOIUrl":"10.1016/j.aimed.2026.100636","url":null,"abstract":"<div><h3>Background</h3><div>Premenstrual Dysphoric Disorder (PMDD) is a severe disabling form of Premenstrual syndromes (PMS) affecting 3–9% of women with menstruation. It causes bodily and psychological harm with severe social and occupational dysfunction. Currently none of the medicinal systems have curative treatment for PMDD. As PMDD is a psychosomatic disorder, preparations like <em>Brahmi vati</em> which can act on both body and mind will be more effective in managing the condition.</div></div><div><h3>Objectives</h3><div>To evaluate the effect of capsule <em>Brahmi vati</em> in the management of PMDD.</div></div><div><h3>Methods</h3><div>In the present randomized double blind placebo controlled pilot clinical trial, 30 women aged between 19 and 30 years fulfilling the diagnostic criteria of Premenstrual Symptom Screening Tool (PSST-DSM V) were assigned into 2 groups. <em>Brahmi</em> Group received capsule <em>Brahmi vati</em> (CBV) 500 mg and Placebo Group received placebo 500 mg thrice a day, with lukewarm water for 60 days. Assessments were conducted through Premenstrual Symptom Screening Tool (PSST), Hamilton Anxiety Rating Scale (HAM-A) and Hamilton Depression Rating Scale (HDRS) on 0th, 30th, 60th day with intervention and on 90th day without intervention. Results were analysed using Friedman test, Mann-Whitney U test, Independent and Dependent t-tests.</div></div><div><h3>Results</h3><div>Statistically significant differences were noted among the PSST components like depressed mood (p = 0.0213) and difficulty in concentrating (p = 0.0310) on comparison between the two groups. Both the interventions were comparable in HAM-A (p = 0.3557) and HDRS (p = 0.7583), with significant outcomes within the groups.</div></div><div><h3>Conclusion</h3><div>CBV was found to be effective in managing PMDD compared to placebo assessed through PSST. Both the medications were comparable in HAM-A and HDRS parameters.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"13 2","pages":"Article 100636"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147386584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}