Advances in integrative medicine最新文献

{"title":"The effects of the pregnant woman’s mental visualization of her baby during the non-stress test on maternal anxiety and fetal parameters: A randomized controlled clinical trial","authors":"Fatma Keskin Töre ,&nbsp;Cansu Ağralı ,&nbsp;Gülçin Nacar ,&nbsp;Özlem Özel Özcan","doi":"10.1016/j.aimed.2025.100508","DOIUrl":"10.1016/j.aimed.2025.100508","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to examine the effects of pregnant women’s mental visualization of their babies during the non-stress test on maternal anxiety and fetal parameters.</div></div><div><h3>Methods</h3><div>This randomized controlled clinical trial was completed with 64 pregnant women (32 experimental, 32 control). It was conducted in a public hospital located in eastern Turkey. Data were collected using a personal information form, a non-stress test findings form, a baby picture evaluation form, and the State Anxiety Inventory.</div></div><div><h3>Results</h3><div>It was determined that during NST (Non-Stress Test), pregnant women’s visualization of their babies reduced the fetal heart rate (t = 2.083, p = 0.041) and fetal movements (t = 2.110, p = 0.039) while increasing the number of accelerations (t = 4.845, p = 0.001). There was no significant difference between the maternal anxiety levels in the experimental group and those in the control group (t = 1.184, p = 0.241). The maternal anxiety levels of the participants in the experimental increased in the posttest compared to the pretest (t = 3.371, p = 0.002).</div></div><div><h3>Conclusion</h3><div>It was determined that the pregnant woman’s mental visualization of her baby during the non-stress test reduced the fetal heart rate and fetal movements, increased the number of accelerations, and did not significantly affect maternal anxiety.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100508"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opinion piece regarding the study \"A prospective, controlled, pilot study of personalised add-on ayurveda treatment in high-risk type II diabetes COVID-19 patients\"","authors":"Aishwarya Ashish Joglekar ,&nbsp;Meera K. Bhojani ,&nbsp;Nikhil Mehere ,&nbsp;Bhagyashree Dube","doi":"10.1016/j.aimed.2025.01.004","DOIUrl":"10.1016/j.aimed.2025.01.004","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100457"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of okra on metabolic parameters in Type 2 diabetes patients: Results from a double-blind clinical trial","authors":"Ali Hesamzadeh ,&nbsp;Zahra Kashi ,&nbsp;Adeleh Bahar ,&nbsp;Majid Saeidi ,&nbsp;Atena Ramzani ,&nbsp;Reza Ali Mohamadpour Tahmtan","doi":"10.1016/j.aimed.2025.03.004","DOIUrl":"10.1016/j.aimed.2025.03.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Okra (Abelmoschus esculentus), a plant with a historical background in medicinal applications, exhibits potential antidiabetic properties through mechanisms that affect sugar absorption and insulin sensitivity. This study investigates the impact of okra on glycemic control in patients with Type 2 diabetes mellitus (T2DM).</div></div><div><h3>Methods</h3><div>This double-blind, placebo-controlled, multi-center study assessed the impact of okra capsules on glycemic control in 53 patients with T2DM. Data, including demographic characteristics and metabolic parameters, were collected at baseline and after 60 days. Dietary and physical activity questionnaires were employed to control for confounding variables. Data analysis was conducted using descriptive and analytical tests, as appropriate, to compare baseline and post-intervention values both between and within groups. A statistical significance level of p &lt; 0.05 was established.</div></div><div><h3>Results</h3><div>In the intervention group, 70.04 % were female (vs. 84.6 % in the control group), with mean ages of 53.41 ± 6.36 and 52.73 ± 8.69 years, respectively. No significant demographic differences were found (p &gt; 0.05). Insulin levels increased significantly in the intervention group (5.09 ± 4.55–7.43 ± 6.78, p &lt; 0.05), as did HOMA-IR (1.94 ± 1.86–2.96 ± 2.74, p &lt; 0.05), while HbA1c remained unchanged (7.57 ± 1.23–7.94 ± 1.00, p &gt; 0.05). No significant changes were observed in BMI, FBS, BUN, creatinine, triglycerides, or liver enzymes (p &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>The results do not position okra as a primary treatment, they suggest the need for further investigation in larger, longer-term studies to explore its role in T2DM management. This highlights okra's potential as a complementary treatment and underscores the importance of a multifaceted approach in health care, focusing on patient education, research involvement, monitoring metabolic parameters, and interdisciplinary collaboration.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100474"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized homeopathic medicines in the treatment of chronic tonsillitis in adults: Randomized, double-blind, placebo-controlled trial","authors":"Ashish Sarkar ,&nbsp;Madhabananda Saha ,&nbsp;Siddharth Kumar Das ,&nbsp;Saleema Naaz Tabassum ,&nbsp;Shubhamoy Ghosh ,&nbsp;Koushik Bhar ,&nbsp;Munmun Koley ,&nbsp;Subhranil Saha","doi":"10.1016/j.aimed.2025.100495","DOIUrl":"10.1016/j.aimed.2025.100495","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Chronic tonsillitis is said to benefit from homeopathic medicines, however, evidence supporting this claim is inadequate. The objective of this trial was to compare individualized homeopathic medicines (IHMs) against placebos using the sore throat pain model (STPM) in adults with chronic tonsillitis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;In this 3-month, double-blind, randomized (1:1), placebo-controlled trial at Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India, 60 adults with chronic tonsillitis were randomized to receive either IHMs or identical-looking placebos. Included were the patients experiencing three or more episodes of medically confirmed acute tonsillitis per year for the last 2 years, and the patients presenting with 5 clinical signs and symptoms of chronic tonsillitis. Excluded were the cases with peritonsillar abscess or acute or chronic respiratory disease, occlusion of pharynx due to enlarged tonsils, or previous surgery in the past 6 months or need for surgery of the nose, and paranasal sinuses. Conventional management was advised concurrently to all individuals. The primary outcome was composite in nature, three visual analog scales (VAS) of STPM: sore throat pain intensity VAS (STPIS-VAS), difficulty swallowing scale VAS (DSS-VAS), and swollen throat scale VAS (SWOTS-VAS); secondary outcomes were the Tonsil and adenoid health status instrument (TAHSI) and Glasgow benefit inventory (GBI) – all measured monthly, up to 3 months. Blinded were the study participants, trial recruiters, investigators, outcome assessors, and the data-entry operator. Group differences were estimated on the intention-to-treat sample using two-way repeated measure analysis of variance accounting for between groups and time interactions, and additionally by unpaired &lt;em&gt;t&lt;/em&gt;-tests to examine whether the group differences were statistically significant at different time points. A Bonferroni-corrected &lt;em&gt;P&lt;/em&gt; value &lt; 0.017 two-tailed was considered statistically significant for three primary outcomes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Sixty individuals were randomized, 30 in each group, and all entered the final analysis. Group differences were non-significant in the primary outcomes – STPIS VAS: F1, 58 = 0.256, P = 0.614; DSS VAS: F1, 58 = 0.315, P = 0.577; SWOTS VAS: F1, 58 = 0.135, P = 0.715; however, the secondary outcomes demonstrated significances favoring IHMs over placebos – TAHSI total: F1, 58 = 10.103, P = 0.002; GBI total: F1, 58 = 13.013, P = 0.001. Additional analyses using unpaired t-tests revealed significances in both primary and secondary outcomes and subscales (all P &lt; 0.05). Rhus toxicodendron, Belladonna, and Bryonia alba were the most frequently indicated medicines. No adverse events or drug reactions were reported during the trial.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;While the trial failed to demonstrate a significant benefit of IHMs over placebo in","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100495"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Glycyrrhiza glabra on peptic ulcer disease: A systematic review and meta-analysis","authors":"Elham Zaeif Khorasani ,&nbsp;Tahereh Amirian ,&nbsp;Ebrahim Nasiri Formi ,&nbsp;Fatemeh Mahjoub ,&nbsp;Masoumeh Sadeghi","doi":"10.1016/j.aimed.2025.100485","DOIUrl":"10.1016/j.aimed.2025.100485","url":null,"abstract":"<div><h3>Introduction</h3><div>Peptic ulcer is a common gastrointestinal disorder, marked by lesions in the mucosal lining of the stomach and duodenum. Due to the limitations of conventional treatments, herbal medicines have gained wide popularity for treating digestive conditions. The current study aims to conduct a systematic review and meta-analysis to assess the effects of licorice on peptic ulcers.</div></div><div><h3>Methods</h3><div>A comprehensive search was performed in online databases, including PubMed, Web of Science, Scopus, Cochrane, and Embase, covering publications up to 7 August 2024, using relevant keywords. Ultimately, 9 studies, comprising a total of 618 participants, had the eligibility criteria. In the statistical analysis, binary data were analyzed using odds ratios (OR) with 95 % confidence intervals (CIs). To evaluate statistical heterogeneity across studies, the I2 statistic was calculated.</div></div><div><h3>Results</h3><div>These studies reported clinical improvement in peptic ulcer symptoms (stomach and duodenal ulcers) and radiographic and endoscopic evidence of complete healing lesion or reduction in size. Some of them demonstrated licorice’s positive effects on ulcer healing, while others found no significant difference compared to placebo. The pooled odds ratio for clinical symptom improvement in pain was calculated to be 0.52 (95 % CI: 0.42–1.45), and for complete ulcer healing, it was 0.60 (95 % CI: 0.24–1.43), indicating that these findings were not statistically significant.</div></div><div><h3>Conclusions</h3><div>While the intervention demonstrated a trend toward improved clinical symptoms and healing in peptic ulcers compared to placebo, the lack of statistical significance and the observed heterogeneity highlight the need for further research to clarify these effects</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100485"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review exploring the role of homoeopathic drugs as a host directed therapy in the management of drug-resistant tuberculosis","authors":"Bhargav Sarma K ,&nbsp;Vaishali Vasant Dolas ,&nbsp;Vijay Nema","doi":"10.1016/j.aimed.2025.100533","DOIUrl":"10.1016/j.aimed.2025.100533","url":null,"abstract":"<div><h3>Introduction</h3><div>Host-directed therapies (HDTs) for tuberculosis are being investigated. By regulating host cell factors, especially in conditions like Drug-resistant tuberculosis, the increasing burden of Anti-Microbial Resistance (AMR) can be reduced. The role of homoeopathic drugs or CAM (complementary and alternative medicine) drugs in regulating host-directed mechanisms is largely unknown. The primary objective of this scoping review is to identify the host-directed mechanisms of homoeopathic drugs in relation to Mycobacterium tuberculosis pathophysiology. The second objective is to understand whether these host-directed mechanisms can be useful for treating sensitive and drug-resistant tuberculosis.</div></div><div><h3>Methods</h3><div>Our scoping review was drafted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) extension for scoping reviews. The following databases were searched to identify potentially relevant papers: PUBMED, COCHRANE, AYUSH RESEARCH PORTAL, and Google SCHOLAR. Forty-eight papers were screened by two people independently with blinding using Rayyan.</div></div><div><h3>Results</h3><div>The number of papers identified from databases and registers was 82. Only 15 papers were included in the final selection, while others were excluded because they did not meet the criteria for homoeopathy, host-directed mechanisms, and drug-resistant tuberculosis.</div></div><div><h3>Discussion</h3><div>To be considered host-directed, a homoeopathic drug action must act through the following mechanisms: regulation of adaptive immune responses, innate immune responses, cell death targets, and metabolism regulation. If we analyse the studies taken for review, we may find that some homoeopathic drugs regulate cytokines, matrix metalloproteinases (MMPs), Phosphofructokinase and other mechanisms. These experiments demonstrate that homoeopathic drugs act through host-directed mechanisms, but there is a lack of research papers on sensitive and drug-resistant tuberculosis.</div></div><div><h3>Conclusion</h3><div>So this concludes that in this review we were able to achieve only one objective which is the action of homoeopathic drugs through the host-directed mechanism, further research with In Vitro or In Vivo models can help us to complete our second objective.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100533"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development, validation, and feasibility testing of Tele-Yoga Module for PTSD","authors":"Naresh Katla ,&nbsp;Judu Ilavarasu ,&nbsp;Ramesh Mavathur ,&nbsp;Hemant Bhargav ,&nbsp;Bharath Holla ,&nbsp;Vinod Kumar ,&nbsp;Atmika Y. Ramsahaye ,&nbsp;Arun Thulasi ,&nbsp;Syed Zaeem Haider Zaidi","doi":"10.1016/j.aimed.2025.100562","DOIUrl":"10.1016/j.aimed.2025.100562","url":null,"abstract":"<div><h3>Introduction</h3><div>Post-traumatic stress disorder (PTSD) is a growing concern worldwide. The increasing incidence of PTSD, compounded by the social stigma associated with it, often prevents individuals from seeking professional help. The objective of this study was to develop, validate, and test the feasibility of Tele-Yoga Module (TYM) for managing PTSD, within a community setting in India.</div></div><div><h3>Methods</h3><div>The TYM was developed and validated following the procedure presented in the protocol study <span><span>[1]</span></span>. The feasibility of the module was then tested in a 12-week study with sixty participants diagnosed with PTSD as per DSM-V criteria. Participants were split evenly between the TYM and a treatment-as-usual (TAU) group. We measured variables such as PTSD symptoms, social functioning, resilience, anxiety, depression, and yoga-based personality traits.</div></div><div><h3>Results</h3><div>Participants in the TYM group showed significant improvements in PTSD symptoms, anxiety, and depression, compared to the TAU group (<em>p</em> &lt; 0.001 for all). No significant between-group differences were observed in resilience and psycho-social functions (<em>p</em> = 0.11). The feasibility aspects of the TYM have been discussed under seven dimensions, including safety and acceptability. These findings suggest that the TYM can serve as a potentially useful add-on intervention in managing PTSD. This study contributes to the emerging field of tele-yoga and highlights the importance of culturally and contextually adapted mental health interventions. Such approaches are crucial for addressing the global burden of PTSD.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100562"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital distraction vs. frozen relief: Battling pain and anxiety in type 2 diabetes, a randomized controlled trial","authors":"Seher Cevik Aktura ,&nbsp;Seyhan Citlik Saritas","doi":"10.1016/j.aimed.2024.12.007","DOIUrl":"10.1016/j.aimed.2024.12.007","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to examine the effects of virtual reality and ice application on pain and anxiety levels in patients with Type 2 diabetes.</div></div><div><h3>Methods</h3><div>This study was conducted as a randomized controlled clinical trial. The sample of the study consisted of 159 patients with Type 2 Diabetes in two experimental (virtual reality and ice group) and one control group (53 patients in each group). Participant Introduction Form, State Anxiety Scale and Visual Analogue Scale were used to collect the data.</div></div><div><h3>Results</h3><div>The findings of this study showed that the patients in the virtual reality and ice group had significantly lower post-application pain levels, compared to the control group (p &lt; 0.001). Also, the anxiety levels of the virtual reality group participants were found significantly lower than the ice and control group (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>As a result of the study, it was found that the use of virtual reality reduced anxiety and pain levels, while the use of ice reduced pain levels.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100447"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of selenium administration on mean platelet volume, neutrophil-to-lymphocyte ratio, and red cell distribution width in critically ill older adults: A double-blinded randomized clinical trial","authors":"Sarvin Sanaie ,&nbsp;Elnaz Faramarzi ,&nbsp;Anita Reyhanifard ,&nbsp;Akbar Azizi ,&nbsp;Mostafa Araj-Khodaei ,&nbsp;Ali Shamekh ,&nbsp;Ata Mahmoodpoor ,&nbsp;Fateme Tahmasbi","doi":"10.1016/j.aimed.2024.10.014","DOIUrl":"10.1016/j.aimed.2024.10.014","url":null,"abstract":"<div><h3>Background</h3><div>Low serum Selenium (Se) levels in critical patients have been associated with poor clinical outcomes and higher mortality rates. The purpose of this study was to investigate the effect of Se administration on mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (N/L), and red cell distribution width (RDW) in older adults admitted to the intensive care unit (ICU).</div></div><div><h3>Method</h3><div>This study was a double-blinded randomized clinical trial. Critically ill patients were randomly divided into two groups of Se and placebo. The Se group (N=30) initially received 3000 mg of Se at once within 3 hours, followed by a dose of 1500 mg daily for 10 days as a one-hour infusion. The control group (N=30) received normal saline for 10 days. A venous blood sample was collected on the first and 10th day. Statistical analysis was performed using SPSS.26 statistical software. To analyze quantitative data in two groups, based on the estimated normality, an independent t-test was used. P value less than 0.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>On day 10, the MPV value in the Se group was significantly lower compared to the placebo group (9.32 ± 1.78 and 10.43 ± 2.06, respectively, p = 0.03). Within the Se group, contrary to the controls, the MPV value decreased significantly from day 1 to day 10 (p&lt;0.001). Further, the RDW value in the Se group was significantly lower compared to the placebo group (13.77 ± 1.57 and 15.32 ± 2.42, respectively, p = 0.005). The N/L ratio remained similar between the two groups before and after the intervention.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that Se can affect the MPV and RDW parameters in older adults hospitalized in the ICU. However, further studies with a larger population are necessary to support these findings.</div></div><div><h3>Clinical Relevancy Statement</h3><div>The effects of selenium administration on hematological parameters in older adults admitted to the ICU are not well-established. There is limited direct evidence linking serum selenium levels to erythrocyte and hemoglobin stability in humans. The current clinical trial promotes the current literature and shows that selenium holds potential in management of the older ICU patients.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100438"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurveda interventions against osteoarthritis – A structured study protocol for systematic review and network meta-analysis","authors":"Ritu Kumari ,&nbsp;Mandip Goyal ,&nbsp;Kalpesh Panara","doi":"10.1016/j.aimed.2024.08.017","DOIUrl":"10.1016/j.aimed.2024.08.017","url":null,"abstract":"<div><h3>Background</h3><div>Osteoarthritis (OA) is an age-related degenerative disease and is the second leading contributor to the global burden of musculoskeletal disorders. Ayurveda is one of the traditional systems of Indian medicine commonly practiced in Southeast Asian countries. Osteoarthritis can be compared with <em>Sandhigata Vata</em> mentioned in the Ayurveda text. Despite having diverse Ayurveda treatment options against OA, there is a lack of evidence-based treatment guidelines.</div></div><div><h3>Methods</h3><div>This review will be written following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the PRISMA extension for network meta-analyses (PRISMA-NMA). Electronic searches will be carried out in PubMed, Scopus, TRIP, INDMED, the Cochrane Register for Controlled Trials (CENTRAL), The Clinical Trials Registry- India (CTRI), AYUSH research portal, and DHARA, and other pre-print repositories since its inception till 31st July 2024. The risk of bias will be assessed with ROB-2, ROBINS-I, and other revised risk of bias tools for cross-over studies and cluster randomized studies recommended by the Cochrane collaboration. To evaluate the credibility of the findings, the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method for network meta-analysis will be implemented. A narrative approach to synthesize and report qualitative and quantitative data will be used, and where feasible, we will conduct network meta-analyses using R/STATA software.</div></div><div><h3>Conclusion</h3><div>To rationalize Ayurveda treatment modalities, there is an urgent need to develop and issue clinical practice guidelines containing recommendations for the treatment of OA. This study will facilitate the process by providing the treatment hierarchy to the policymakers and the stakeholders.</div></div><div><h3>Protocol registration</h3><div>This study has been registered prospectively in PROSPERO [CRD42023423393].</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100411"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}