Advances in integrative medicine最新文献

{"title":"Opinion piece regarding the study \"A prospective, controlled, pilot study of personalised add-on ayurveda treatment in high-risk type II diabetes COVID-19 patients\"","authors":"Aishwarya Ashish Joglekar , Meera K. Bhojani , Nikhil Mehere , Bhagyashree Dube","doi":"10.1016/j.aimed.2025.01.004","DOIUrl":"10.1016/j.aimed.2025.01.004","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100457"},"PeriodicalIF":1.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the severity of fatigue in multiple sclerosis patients have a relationship with their temperament?","authors":"Ali Jadidi ,&nbsp;Abbas Sohrabi ,&nbsp;Hooman Mohammad talebi ,&nbsp;Mehdi Salehi","doi":"10.1016/j.aimed.2025.01.002","DOIUrl":"10.1016/j.aimed.2025.01.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Multiple sclerosis (MS) is a major inflammatory demyelinating disease that causes neurological disabilities and affects approximately 2.8 million people worldwide. With a growing interest in the relationship between temperaments and disease severity, this study aims to investigate the potential correlation between temperament types and MS severity to improve the quality of life for multiple sclerosis patients.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, we evaluated the temperaments of multiple sclerosis patients and their correlation with quality of life and fatigue. Following ethical approval, 153 patients were selected from the MS Association of Arak. All participants completed four questionnaires: a validated Fatigue Severity Scale (FSS) for fatigue assessment and the MSIS-29 quality of life questionnaire. Data were analyzed using SPSS v19.</div></div><div><h3>Results</h3><div>Statistical analysis revealed no significant correlation between fatigue levels and temperament scores; however, the significance ratio was borderline. Quality of life deficit scores did not significantly correlate with temperament scores either. Comparing mean fatigue scores among different temperament types showed no significant difference (P = 0.334). Similarly, no significant difference in mean quality of life deficit scores was observed among temperament types (P = 0.152). There was also no significant correlation between patient age and fatigue scores (P = 0.773) or quality of life deficit scores (P = 0.481).</div></div><div><h3>Conclusion</h3><div>This study found no significant associations between temperaments and fatigue or quality of life scores.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100455"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing well-being at work: Qualitative insights into challenges and benefits of long-term yoga programs for desk-based workers","authors":"Poovitha Shruthi Paramashiva ,&nbsp;Annapoorna K ,&nbsp;Vaishali K ,&nbsp;Baskaran Chandrasekaran ,&nbsp;Shivashankar K.N. ,&nbsp;Suresh Sukumar ,&nbsp;Sneha Ravichandran ,&nbsp;Dilip Shettigar ,&nbsp;Sathya Sabina Muthu ,&nbsp;Koustubh Kamath ,&nbsp;Rajagopal Kadavigere","doi":"10.1016/j.aimed.2025.01.001","DOIUrl":"10.1016/j.aimed.2025.01.001","url":null,"abstract":"<div><h3>Background</h3><div>Desk-based workers face substantial health challenges due to sedentary lifestyles and work-related stress. Although yoga interventions hold promise in mitigating these issues, implementing them effectively and ensuring adherence remain significant hurdles.</div></div><div><h3>Objective</h3><div>This qualitative study explored the experiences of desk-based workers participating in a yoga programme, focusing on challenges, perceived benefits, and recommendations for future interventions.</div></div><div><h3>Methods</h3><div>Semi-structured interviews were conducted with six desk-based workers who engaged in a yoga intervention. Thematic analysis identified critical themes from the interview data.</div></div><div><h3>Results</h3><div>Participants highlighted challenges in maintaining regular yoga practice, citing time constraints, initial physical discomfort, and varying motivation levels. Despite these obstacles, they reported significant benefits, particularly in mental well-being and stress management. Improved concentration, emotional regulation, and physical flexibility were commonly cited outcomes. Participants emphasised the need for flexible scheduling, gradual intensity progression, and ongoing support to enhance adherence.</div></div><div><h3>Conclusions</h3><div>Desk-based workers encounter practical challenges in sustaining consistent yoga practice but perceive substantial mental health benefits. Future yoga interventions should prioritise flexible scheduling and adaptable practice intensity, emphasise mental health advantages, and provide ongoing support.</div></div><div><h3>Implications</h3><div>This study contributes to developing more effective workplace yoga programs, potentially improving long-term health outcomes for desk-based workers. Further research should quantitatively assess cognitive and cardiovascular impacts over extended periods.</div></div><div><h3>Limitations</h3><div>The study's small sample size limits generalisability. Future research should include more extensive and more diverse samples, integrating quantitative measures alongside qualitative insights.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100454"},"PeriodicalIF":1.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of complementary and alternative medicine use in cancer patients: A survey study in Turkey","authors":"Hulya Ertas ,&nbsp;Burcu Caner ,&nbsp;Birol Ocak ,&nbsp;Sibel Oyucu Orhan ,&nbsp;Erdem Cubukcu ,&nbsp;Ozkan Kanat","doi":"10.1016/j.aimed.2025.01.003","DOIUrl":"10.1016/j.aimed.2025.01.003","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to evaluate the characteristics of cancer patients using complementary medicine (CM) and determine possible herb-drug interactions.</div></div><div><h3>Methods</h3><div>We prepared a questionnaire about CM, that included questions about the frequency of CM use, the reasons for using CM, if there was any side effect, CM’s cost, the patient's expectations of CM, whether the following doctor was aware of the patient's CM use, and whether it should be paid for by health insurance, and asked patients to fill it out at the chemotherapy unit. Socio-demographic characteristics and medical data of patients including cancer type, stage, and current treatment protocol were also noted. The data was analyzed using SPSS Statics version 26.</div></div><div><h3>Results</h3><div>245 patients participated in the study. The prevalence of CM use was 34.7 %. The median number of herbal supplements used per patient was 3. CM users were younger [CM user group mean age 54.74 ( ± 12.17), CM non-user group mean age 58.07 ( ± 12.70), p = 0.04]. No other significant difference was found between the CM users and CM non-users. The majority of patients used Propolis (40 %), Curcuma longa (38.8 %), and Nigella sativa (32.9 %). 72.9 % of patients were using CM to complement chemotherapy's efficacy by boosting immunity; 58.8 % were using it to mitigate the side effects of chemotherapy, 34.1 % to treat cancer, and 2.4 % to prevent recurrence. 94.1 % of CM users declared that they were satisfied with CM, 7 patients (8.2 %) reported side effects such as cutaneous side effects (4), diarrhea (2), and elevated liver function tests (1). 41.2 % of CM users continued CM during chemotherapy and 64 possible CM-drug interactions were identified.</div></div><div><h3>Conclusions</h3><div>CM may be nonharmful and efficient but may also be detrimental because of drug interactions. Physicians should not ignore CM and patients should better be informed about CM by healthcare providers.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 1","pages":"Pages 99-103"},"PeriodicalIF":1.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence versus human analysis: Interpreting data in elderly fat reduction study","authors":"Piotr Sporek,&nbsp;Mariusz Konieczny","doi":"10.1016/j.aimed.2024.12.011","DOIUrl":"10.1016/j.aimed.2024.12.011","url":null,"abstract":"<div><h3>Background</h3><div>Artificial intelligence (AI) has emerged as a transformative tool in scientific research, playing an increasingly significant role in data analysis and interpretation. This study aimed to evaluate the efficiency and accuracy of AI-driven interpretations of health-related data in comparison to those provided by human experts.</div></div><div><h3>Methods</h3><div>The analysis utilized a paid version of Chat GPT-4 (AI) to interpret study results, relying solely on table titles and data extracted from the authors' previously published manuscript. The dataset encompassed body composition and health parameters within the context of a dietary intervention. Data from a prior publication by the authors were referenced, as detailed in the methods section. The evaluation focused on comparing word count and descriptive content across interpretations of three tables from the original manuscript.</div></div><div><h3>Results</h3><div>The human expert's data interpretation was succinct, comprising 160 words, while AI-generated descriptions extended to 426 words. Similarly, the AI provided a more verbose analysis of the pre/post-intervention parameter significance, with 374 words compared to the human's 108 words. Group interactions were described in 44 words by the human expert and 486 words by the AI. Notably, the AI's analysis was accurate, though more detailed.</div></div><div><h3>Conclusions</h3><div>Chat GPT-4 necessitates precise table titles and well-defined data inputs to generate comprehensive analyses, as it does not autonomously account for all parameters within the dataset. While the AI demonstrated factual accuracy and valid conclusions, its descriptions lacked precision, underscoring the importance of human oversight in ensuring interpretative clarity and relevance.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 1","pages":"Pages 13-18"},"PeriodicalIF":1.7,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143478518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of connective tissue manipulation on balance and proprioception among university students: Randomized controlled study","authors":"Çiçek Günday ,&nbsp;Feyza Şule Badıllı Hantal","doi":"10.1016/j.aimed.2024.12.010","DOIUrl":"10.1016/j.aimed.2024.12.010","url":null,"abstract":"<div><h3>Background and Purpose</h3><div>Manual therapy approaches (MTA) could stimulate the proprioceptors of the fascia. Connective tissue manipulation (CTM) is an MTA that could affect musculocutaneous and nervous systems together. Thus, it could be a more promising technique than other MTA to stimulate the fascial proprioceptors. This single-blind randomized-controlled study aimed to investigate the effects of CTM applied to the lumbar, thoracal, and cervical regions on balance and proprioception.</div></div><div><h3>Materials and Methods</h3><div>40 university students were randomly divided into exercise (16 females, 4 males; mean age: 20.87 ± 3.15) and exercise+CTM (14 females, 6 males; mean age: 22.55 ± 2.39) groups. Both groups performed home exercises to improve balance, flexibility and strength for 2 sessions a week for 6 weeks. Additionally, CTM was applied in exercise+CTM group for 6 weeks, twice-a-week. Before/after assessments were done with Biodex Balance System, Cervical Range of Motion Tester, and StabilizerTM Pressure Biofeedback Unit.</div></div><div><h3>Results</h3><div>Exercise group showed a significant improvement in proprioception only for cervical flexion to the right with (p = 0.021) and without (p = 0.002) vision while balance was improved especially on dynamic platforms (p &lt; 0.05). Exercise+CTM group showed an improvement in without-vision cervical proprioception in flexion (p = 0.001), flexion to the right (p = 0.003) and left (p = 0.010) and lumbar proprioception (p ≤ 0.001). Balance scores were improved in both static and dynamic platforms (p &lt; 0.05). Improvements in proprioception of cervical flexion with (p = 0.017) and without vision (p = 0.044), and posterior pelvic tilt (p ≤ 0.001) differed between the groups after the study. Unilateral balance scores on static platform (left foot p = 0.016, right foot p = 0.001), and right-foot-stance and bilateral-stance balance scores on dynamic platform (p = 0.008 and p = 0.048 respectively) were improved more in exercise+CTM group.</div></div><div><h3>Conclusion</h3><div>CTM with exercise improves cervical/lumbar proprioception and balance, especially static balance in comparison to exercise only. Future studies should be done with different populations such as patients with neurological conditions or athletes.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100450"},"PeriodicalIF":1.7,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical therapy treatment for facial and jaw pain associated with trigeminal neuralgia using Systemic Manual Therapy (SMT)","authors":"Adi Halili","doi":"10.1016/j.aimed.2024.12.009","DOIUrl":"10.1016/j.aimed.2024.12.009","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the effectiveness of Systemic Manual Therapy using a HOAC-APD model to treat trigeminal neuralgia-associated facial pain (TN).</div></div><div><h3>Design</h3><div>Cohort retrospective multivariate analysis using a modified adaptive platform design.</div></div><div><h3>Methods</h3><div>Overall progress across episode of care and average rate of improvement in TN symptoms and overall complaints was measured in 85 patients after using 99 different combinations of Systemic Manual Therapy protocols.</div></div><div><h3>Results</h3><div>When comparing scores from the beginning and end of the episode of care, 66 % of patients reported improvement in trigeminal neuralgia or facial pain complaints. The average improvement was 1.88/9 (<em>p</em> &lt; 0.001) and the overall improvement was 12.01/90 (<em>p</em> &lt; 0.001). Thirteen combinations containing eight distinct protocols were found to be better than the average. Five of the protocols effectively addressed central sensitization (UD, Barral, Barral-CVVT, LAUG, VTCP); one protocol was hypothesized to have a direct effect on the trigeminal system (SYMPN), and two protocols could have been effective because of either direct or desensitization effects (CCCV and DCS).</div></div><div><h3>Discussion and conclusion</h3><div>This study demonstrated that TN can be effectively treated by focusing on central sensitization, which is preserved by the continuous input of several self-reinforcing loops into the LC-NA system. This study supports the hypothesis that central sensitization can be treated by creating intermittent disruption of these self-reinforcing loops.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 2","pages":"Article 100449"},"PeriodicalIF":1.7,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary perceptions of osteopathy in the Italian hospital context","authors":"Diego Lopane ,&nbsp;Beatrice Mazzoleni ,&nbsp;Annalisa Saetta ,&nbsp;Fanny Soekeland ,&nbsp;Alessandra Dacomi ,&nbsp;Francesco Carlo Tartaglia ,&nbsp;Chiara Coldani ,&nbsp;Giuseppina Tomaiuolo ,&nbsp;Daniela Cattani ,&nbsp;Marco Sguanci ,&nbsp;Giovanni Cangelosi ,&nbsp;Sara Morales Palomares ,&nbsp;Stefano Mancin","doi":"10.1016/j.aimed.2024.12.013","DOIUrl":"10.1016/j.aimed.2024.12.013","url":null,"abstract":"<div><h3>Background</h3><div>Osteopathy was formally recognized as a healthcare profession in Italy in 2021, reflecting global trends in healthcare integration. Understanding its role within multidisciplinary hospital care is essential to fostering its integration and maximizing its clinical potential.</div></div><div><h3>Aim</h3><div>This study aimed to assess hospital healthcare professionals' perceptions of osteopathy, its role in multidisciplinary care, and its potential usefulness in Italian hospitals.</div></div><div><h3>Methods</h3><div>A cross-sectional descriptive observational study was conducted using a survey targeted at healthcare professionals. The survey was structured by experts in the field of osteopathy to investigate the perception of other healthcare professions from a multidisciplinary involvement.</div></div><div><h3>Results</h3><div>Out of 327 questionnaires received, 303 were valid for analysis. Most respondents were nurses (76 %), predominantly female (72 %), aged 25–34 (37 %), working across various hospital departments, primarily in Medicine Departments (52 %). Work experience varied, with a moderate prevalence in the 6–12 years category. Notably, 86 % held a favorable opinion of osteopathy, 50 % supported requesting osteopathic consultations, 82 % found collaboration with osteopaths advantageous, 35 % saw the inclusion of osteopaths as highly advantageous, and 47 % found it helpful. Regarding multidisciplinary teams, 49 % viewed osteopathy as beneficial, while 30 % considered it highly beneficial.</div></div><div><h3>Conclusions</h3><div>Healthcare professionals perceive osteopathy as a valuable complementary discipline that enhances multidisciplinary collaboration and patient care. The findings highlight the need for structured protocols, interdisciplinary training, and pilot projects to integrate osteopathy into hospital practice effectively. Future research should focus on standardizing practices and addressing organizational variations to further strengthen osteopathy’s role in multidisciplinary healthcare.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100453"},"PeriodicalIF":1.7,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Bozidan (Tanacetum umbelliferum Boiss.) in pain management associated with hyperuricemia: A randomized controlled trial","authors":"Nida Zakir ,&nbsp;Mohd Riyazuddin ,&nbsp;Arisha Shahid ,&nbsp;Malik Itrat","doi":"10.1016/j.aimed.2024.12.012","DOIUrl":"10.1016/j.aimed.2024.12.012","url":null,"abstract":"<div><h3>Background and Objective</h3><div>Hyperuricemia, characterized by elevated uric acid levels in the blood, is often associated with gout and other metabolic disorders. Bozidan (<em>Tanacetum umbelliferum</em> Boiss.), a plant with known anti-inflammatory and antioxidant properties, has been used in Unani medicine. This study aimed to evaluate the efficacy of Bozidan in managing hyperuricemia.</div></div><div><h3>Methods</h3><div>Twenty-six patients were enrolled, with 13 particpants in each group: intervention and control. Participants were randomly assigned in two groups. The intervention group received Bozidan 4.5 g, divided into three doses, while the control group received Habbe Suranjan (a polyherbal Unani formulation containing <em>Colchicum autumnale</em> L. as a key ingredient) three times daily for 4 weeks. Serum uric acid levels were measured at baseline and at the end of the study. Pain was assessed as a key secondary outcome weekly. Other associated symptoms and adverse effects were also monitored throughout the trial.</div></div><div><h3>Results</h3><div>Both test and control drugs demonstrated reductions in serum uric acid levels from baseline to the end of the study. However, the reduction in both groups was statistically insignificant (P &gt; 0.05). Improvements were observed in clinical symptoms related to hyperuricemia, such as joint pain, in both groups over the study period. Safety parameters remained within normal limits.</div></div><div><h3>Conclusion</h3><div>The test drugs demonstrated potential in reducing serum uric acid levels and improving clinical symptoms associated with hyperuricemia. However, further research with larger sample and extended study durations is warranted to conclusively determine its efficacy in lowering serum uric acid levels and its overall clinical benefit.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100452"},"PeriodicalIF":1.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital distraction vs. frozen relief: Battling pain and anxiety in type 2 diabetes, a randomized controlled trial","authors":"Seher Cevik Aktura ,&nbsp;Seyhan Citlik Saritas","doi":"10.1016/j.aimed.2024.12.007","DOIUrl":"10.1016/j.aimed.2024.12.007","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to examine the effects of virtual reality and ice application on pain and anxiety levels in patients with Type 2 diabetes.</div></div><div><h3>Methods</h3><div>This study was conducted as a randomized controlled clinical trial. The sample of the study consisted of 159 patients with Type 2 Diabetes in two experimental (virtual reality and ice group) and one control group (53 patients in each group). Participant Introduction Form, State Anxiety Scale and Visual Analogue Scale were used to collect the data.</div></div><div><h3>Results</h3><div>The findings of this study showed that the patients in the virtual reality and ice group had significantly lower post-application pain levels, compared to the control group (p &lt; 0.001). Also, the anxiety levels of the virtual reality group participants were found significantly lower than the ice and control group (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>As a result of the study, it was found that the use of virtual reality reduced anxiety and pain levels, while the use of ice reduced pain levels.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100447"},"PeriodicalIF":1.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}