Bazhen Decoction, mainly containing ginseng and rehmannia for treatment of patients with type 2 diabetes: A systematic review and meta-analysis

IF 1.7 Q2 Medicine

Advances in integrative medicine Pub Date : 2024-12-01 DOI:10.1016/j.aimed.2024.08.010

Yunyi Yang , Wenjun Sha , Shufa Tan , Junyi Yang , Xiaoxiao Qu , Yanming He , Hongjie Yang

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引用次数: 0

Abstract

Introduction

BZD is a classic Chinese herbal formula consisting of eight herbs, including Panax ginseng C.A. Mey. (Rén shēn), Rehmannia glutinosa (Gaertn.) DC. (Dì (Huáng), Atractylodes macrocephala Koidz. (Bái zhú), Smilax glabra Roxb. (Fúlíng), Angelica sinensis (Oliv.) Diels (Dāngguī), Conioselinum anthriscoides 'Chuanxiong' (Chuānxiōng), Paeonia lactiflora Pall. (Sháoyào), Glycyrrhiza glabra L. (Gāncǎo). Pharmacological studies have demonstrated that the active ingredients in BZD have some hypoglycemic effect. This study aims to systematically evaluate the effectiveness and safety of BZD on T2DM.

Methods

PubMed, Cochrane Library, Embase, Web of Science, China Knowledge Infrastructure (CNKI), China Biomedical CD-ROM (Sino Med), Wanfang database, and Vipshop (VIP) were searched from its inception to August 2023. The quality of the included literature was assessed by including randomized controlled trials (RCTs) involving BZD for T2DM with no language restrictions, using the Cochrane recommended risk of bias assessment tool, and applying RevMan 5.4 software for data analysis.

Results

The final analysis covered 12 publications, showing that the combination of BZD with conventional treatment was more effective than conventional treatment alone in the levels of fasting blood glucose (WMD = −1.18; 95 % CI [-1.55, −0.82], p < 0.00001), two-hour postprandial glucose (WMD = −1.3; 95 % CI [-1.98, −0.61]; p < 0.00001), glycosylated haemoglobin ( WMD = −0.66; 95 % CI [-0.93, −0.39]; p < 0.00001), total cholesterol (WMD = −1.11; 95 % CI [-1.94, −0.28]; p < 0.00001), triglycerides (WMD = −0.55; 95 % CI [-0.63, −0.48]; p = 0.36), and total effective rate (RR = 1.21; 95 % CI [1.14, 1.28]; p < 0.00001).

Conclusion

BZD has a potential to enhance glucose and lipid metabolism among the patients with T2DM and improve clinical outcomes. However, more high-quality RCTs are required to validate these findings.

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以人参、地黄为主的八珍汤治疗2型糖尿病的系统评价与meta分析

bzd是一种经典的中药配方，由八种草药组成，包括人参。（r shēn），地黄（Gaertn.）直流。(Dì （Huáng），苍术。（Bái zhú）， Smilax glabra Roxb。（Fúlíng）、当归（Oliv.）黄芪（Dāngguī），川芎（Chuānxiōng），芍药（Chuānxiōng）。（Sháoyào），甘草（Gāncǎo）。药理研究表明，泻泻汤的有效成分具有一定的降血糖作用。本研究的目的是系统评价BZD治疗2型糖尿病的有效性和安全性。方法检索spubmed、Cochrane Library、Embase、Web of Science、中国知网（CNKI）、中国生物医学光盘（Sino Med）、万方数据库和唯品会（VIP）自建站至2023年8月的数据库。采用Cochrane推荐的偏倚风险评估工具，并应用RevMan 5.4软件进行数据分析，纳入无语言限制的T2DM患者采用BZD的随机对照试验（RCTs），评估纳入文献的质量。结果最终分析涵盖了12篇出版物，结果显示BZD联合常规治疗在空腹血糖水平上比单独常规治疗更有效(WMD = - 1.18；95 % CI [-1.55, - 0.82], p <；0.00001)，餐后2小时血糖(WMD = - 1.3；95 % ci [-1.98, - 0.61]；p & lt;0.00001)，糖化血红蛋白(WMD = - 0.66；95 % ci [-0.93, - 0.39]；p & lt;0.00001)，总胆固醇(WMD = - 1.11；95 % ci [-1.94, - 0.28]；p & lt;0.00001)，甘油三酯(WMD = - 0.55；95 % ci [-0.63, - 0.48]；p = 0.36)，总有效率(RR = 1.21；95 % ci [1.14, 1.28]；p & lt;0.00001)。结论bzd具有改善T2DM患者糖脂代谢、改善临床预后的作用。然而，需要更多高质量的随机对照试验来验证这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.