Advances in integrative medicine最新文献

{"title":"Influence of acupuncture with three specific acu-points on quality of sleep in residents of an elderly nursing home in rural India: A pilot randomized placebo-controlled trial","authors":"Pranab Das ,&nbsp;Sriloy Mohanty ,&nbsp;Apar Avinash Saoji","doi":"10.1016/j.aimed.2022.02.001","DOIUrl":"10.1016/j.aimed.2022.02.001","url":null,"abstract":"<div><h3>Background</h3><p><span>Quality of sleep is usually compromised in the geriatric<span> population resulting in excessive daytime sleepiness, difficulty sustaining attention, slowed response time, difficulty with memory, and decreased performance. </span></span>Acupuncture<span> has been established as an alternative therapy, but methodological research still needs to verify its efficacy in sleep disturbances. Hence, a pilot placebo-controlled trial was designed to assess 3 acupuncture point's effect on sleep quality in the geriatric population staying in a nursing home.</span></p></div><div><h3>Methods</h3><p><span><span>A total of 40 elderly subjects with self-reported sleep disturbance (age with mean± SD = 69.55 ± 7.80) were recruited and allocated to two groups comprising an experimental (n = 20) and a control group (n = 20). Participants were randomly allocated with an allocation ratio of 1:1. Pittsburgh Sleep Quality Index (PSQI) and </span>Epworth Sleepiness Scale (ESS) scores were obtained at baseline and following two weeks. Subjects in the experimental group received needling of </span><em>Shenmen</em> (HT-7), <em>Baihui</em> (GV-20) and <em>Yintang</em> (EX-HN-3) acupoints for 30 min per day for two weeks, and the control group received placebo points during the respective interventions.</p></div><div><h3>Results</h3><p>After two weeks of acupuncture, the intervention result showed a significant reduction in all components of PSQI and global PSQI scores (p &lt; 0.001) and a significant increase in ESS score (p &lt; 0.001) in the experimental group compared to the control group.</p></div><div><h3>Conclusion</h3><p>The study reveals that two weeks of acupuncture intervention significantly positively affect sleep quality in older adults.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78972724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A collaborative integrative and Ayurvedic approach to cirrhosis in the setting of autoantibody negative autoimmune hepatitis: a case report","authors":"George Schatz ,&nbsp;Erica Kumala ,&nbsp;Amita Nathwani","doi":"10.1016/j.aimed.2021.10.002","DOIUrl":"https://doi.org/10.1016/j.aimed.2021.10.002","url":null,"abstract":"<div><p>Autoimmune hepatitis<span><span><span> (AIH) is a chronic and progressive inflammatory process of the liver, with standard treatments<span> including prednisone, </span></span>azathioprine<span>, and ultimately liver transplant. While there are many integrative and Ayurvedic treatment options that have been shown to be helpful for other liver diseases, there are no studies that have been performed to evaluate these therapies particularly in AIH with </span></span>cirrhosis<span>. We detail the case of a 55-year-old female with cirrhosis in the setting of AIH placed on a liver transplant list after being treated with conventional therapies. She was started on various nutritional supplements and Ayurvedic treatments which resulted in a significant decrease in her Model for End-Stage Liver Disease score, which was sustained at 7 months. This is the first case report to our knowledge detailing an integrative approach to cirrhosis in the setting of AIH showing such an improvement in liver function. This paper outlines a novel approach to Autoimmune hepatitis with cirrhosis that utilizes a collaboration between Conventional, Integrative and Ayurvedic practitioners. While the basic science supports the efficacy of the individual treatments utilized in this case, there have been no published case reports outlining the safety and efficacy of these treatments when combined in a clinical setting of cirrhosis due to Autoimmune hepatitis. Thus, we set out to detail the first such case report to our knowledge of an integrative approach to cirrhosis in the setting of AIH showing such an improvement in liver function.</span></span></p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92014809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Yoga on homocysteine level, symptomatology and quality of life in industrial workers with Chronic Venous Insufficiency: Study protocol for a randomized controlled trial","authors":"U. Yamuna,&nbsp;Vijaya Majumdar,&nbsp;Apar Avinash Saoji","doi":"10.1016/j.aimed.2022.02.002","DOIUrl":"10.1016/j.aimed.2022.02.002","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Chronic Venous Insufficiency<span> (CVI) is often associated with prolonged standing at work. CVI could lead to multiple symptoms and vascular inflammation. Yoga as therapy has helped in mitigating several occupational hazards. The current study protocol is designed to assess the effect of Yoga on CVI.</span></p></div><div><h3>Materials and methods</h3><p>One hundred industry workers with CVI will be randomly allotted to Yoga and wait-list control groups following an equal allocation ratio. Yoga group will receive a specially designed Yoga module six days a week for three months. The Control group will continue with the routine activities. Serum homocysteine<span>, Venous Clinical Severity Scale (VCSS), Ankle Brachial pressure index and psychological status will be assessed at baseline and the end of three months of intervention.</span></p></div><div><h3>Statistical analyses</h3><p>Data will be tested for normality and appropriate tests will be used to assess the differences between the groups.</p></div><div><h3>Expected outcomes</h3><p>Specifically designed Yoga module will help to reduce the vascular inflammation, symptoms of CVI and enhance psychological functioning.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89878665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An opportunity for integrative approaches: bile acid diarrhoea and bile acid malabsorption","authors":"David Sarchet, J. Bold","doi":"10.1016/j.aimed.2022.04.002","DOIUrl":"https://doi.org/10.1016/j.aimed.2022.04.002","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86329846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful use of Ma'oljobon, a Persian medicine whey product, in a patient with severe chronic cough: A case report","authors":"Amir-Mohammad Jaladat ,&nbsp;Keivan Ranjbar ,&nbsp;Reza Shahriarirad ,&nbsp;Zahra Salehi","doi":"10.1016/j.aimed.2021.05.002","DOIUrl":"10.1016/j.aimed.2021.05.002","url":null,"abstract":"<div><p><span>Persian medicine is a branch of complementary and alternative medicine that tries to offer simple and suitable approaches and methods for treating diseases and health protection. </span><em>Ma'oljobon</em><span> is known as a kind of whey protein<span>. It is a remedy with various characteristics, such as removing viscous wastes from the body without causing any dryness and moistening, while also providing nutrition. A 7-year-old boy with severe chronic cough<span><span> refers to Traditional Persian Medicine Clinic due to allergic rhinitis. Formerly he had multiple failed attempts of </span>treatment. The cough resolved with a 12-week period administration of </span></span></span><em>Ma'oljobon</em>. This is the first report evaluating the remedial effect of <em>Ma'oljobon</em> on allergic rhinitis.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.aimed.2021.05.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85457898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of saffron as adjunctive therapy in adults with attention-deficit/hyperactivity disorder: A randomized, double-blind, placebo-controlled clinical trial","authors":"Benyamin Pazoki ,&nbsp;Nadia Zandi ,&nbsp;Zeinab Assaf ,&nbsp;Hossein Sanjari Moghaddam,&nbsp;Arefeh Zeinoddini,&nbsp;Mohammad Reza Mohammadi,&nbsp;Shahin Akhondzadeh","doi":"10.1016/j.aimed.2022.01.002","DOIUrl":"10.1016/j.aimed.2022.01.002","url":null,"abstract":"<div><h3>Objective</h3><p>Around 30% of patients with Attention-Deficit/Hyperactivity Disorder (ADHD) do not respond to Ritalin or cannot tolerate its side effects, which necessitates the consideration of alternative options. Previous studies have shown the beneficial effects of <em>Crocus sativus</em> (saffron) in children with ADHD. However, its potential therapeutic effects in adults with ADHD is unknown. This study aimed to evaluate the efficacy and safety of saffron as an adjuvant to Ritalin for improving symptoms in adults with ADHD.</p></div><div><h3>Design</h3><p>This was a randomized, double-blind, placebo-controlled clinical trial.</p></div><div><h3>Methods</h3><p>Fifty-six patients diagnosed with ADHD were assigned into two parallel groups to receive Ritalin (30 mg/day) plus placebo or Ritalin plus saffron (15 mg twice daily) for six weeks. The patients were assessed with Conners' Adult ADHD Rating Scales (CAARS) and the Adult ADHD Self-Report Scale (ASRS) at baseline, week 3 and week 6.</p></div><div><h3>Results</h3><p>Forty-four patients completed the trial. GLM repeated-measure analysis demonstrated significant time × treatment interaction effect for ASRS (df=2, F=3.455, and P-value=0.036) and CAARS (df=1.584, F=3.939, and P-value=0.033) score from baseline to the study endpoint. We found a significantly greater reduction in ASRS scores in the saffron group compared with the placebo group from baseline to the study endpoint (week 6) (P-value=0.024). However, the change score from baseline to week 3 was not significantly different between trial groups (P-value=0.269). There was no significant difference in the improvement of CAARS scores between saffron and placebo from baseline to week 3 or 6 (P-value=0.564 and 0.089, respectively). There was no significant difference between the two groups in baseline parameters and frequency of side effects.</p></div><div><h3>Conclusions</h3><p>Saffron combination therapy with Ritalin can effectively improve symptoms of patients with ADHD. However, further studies with larger sample sizes and longer follow-up treatment are needed to confirm our findings.</p><p>This trial was registered with the Iranian Registry of Clinical Trials (www.irct.ir; No IRCT20090117001556N111).</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87132190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant and anticholinesterase effects of rosemary (Salvia rosmarinus) extract: A double-blind randomized controlled trial","authors":"Fatemeh Dabaghzadeh ,&nbsp;Mitra Mehrabani ,&nbsp;Homa Abdollahi ,&nbsp;Somayyeh Karami-Mohajeri","doi":"10.1016/j.aimed.2021.03.002","DOIUrl":"10.1016/j.aimed.2021.03.002","url":null,"abstract":"<div><h3>Objective</h3><p>The present study was aimed at investigating the effect of <span><em>Salvia</em><span><em> </em><em>rosmarinus</em></span></span> (syn: <em>Rosmarinus officinalis</em><span><span> L.; rosemary) extract on acetyl cholinesterase (AChE) activity and </span>oxidative stress biomarkers in healthy volunteers.</span></p></div><div><h3>Method</h3><p><span>In a double-blind randomized controlled trial<span><span>, 50 healthy participants (21–25 years old) were divided into two groups: placebo (N = 25) and rosemary (N = 25). The rosemary and placebo groups respectively received rosemary (500 mg rosemary powder) and placebo capsules (500 mg starch powder) twice a day for one month. AChE activity, total </span>antioxidant capacity<span> (TAC), lipid peroxidation, and </span></span></span>protein carbonylation were determined in blood samples before and after the trial.</p></div><div><h3>Discussion</h3><p><span>Administration of 1000 mg of rosemary for 30 days significantly decreased AChE activity compared to AChE activity before rosemary treatment (</span><em>p</em> value&lt;0.001) and also in the placebo group (p value&lt;0.01). Notably, administration of rosemary considerably improved TAC (<em>p</em> value&lt;0.01) and protein carbonylation (<em>p</em> value&lt;0.05) compared to those values before rosemary treatment and in the placebo group. After administration of rosemary, no significant changes were observed in lipid peroxidation (p value&gt;0.05) compared to that value before rosemary treatment and in the placebo group.</p></div><div><h3>Conclusion</h3><p>The findings indicated the inhibitory effect of rosemary on AChE activity and the improvement of non-enzymatic antioxidant defense system. The results may reinforce the use of rosemary as a potential antioxidant supplement. Further evaluations are recommended to find out the effectiveness of rosemary in patients with Alzheimer’s disease.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.aimed.2021.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82795932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of a buccoadhesive paste from Fenugreek seeds (Trigonella foenum graecum L.) on recurrent aphthous stomatitis: in-vitro assessment of non-toxic concentration and pilot trial","authors":"Mehdi Ansari ,&nbsp;Maryam Hashemipour ,&nbsp;Alireza Farsinejad ,&nbsp;Neda Mohamadi ,&nbsp;Sima Hajebrahimi ,&nbsp;Hamide Karimi- Afshar ,&nbsp;Ali Derakhshani ,&nbsp;Fariba Sharififar","doi":"10.1016/j.aimed.2021.06.001","DOIUrl":"10.1016/j.aimed.2021.06.001","url":null,"abstract":"<div><h3>Context</h3><p><span>Recurrent aphthous stomatitis (RAS) is a highly prevalent </span>oral lesion that is limited in many cases to symptomatic remedies.</p></div><div><h3>Objective</h3><p><span>In this work, a buccoadhesive paste was prepared from Fenugreek extract (</span><em>Trigonella foenum graecum</em> L.) and clinically evaluated on RAS patients.</p></div><div><h3>Design</h3><p>This study was a double blind randomized clinical trial.</p></div><div><h3>Setting</h3><p>The study took place at Kerman University of Medical Sciences<span>, Department of Oral Medicine<span>, School of Dentistry.</span></span></p></div><div><h3>Participants</h3><p><span>SCytotoxicity of fenugreek extract was studied on five cell lines using MTT and Neutral red assay. A buccoadhesive paste was formulated at non-toxic concentration. ixty patients randomly in two groups were treated with fenugreek buccoadhesive paste (FBP) and dexamethasone </span>mouthwash<span> respectively. The patients were followed for the intensity of pain, size of the lesion, erythema and exudate severity on 0, 4, 6, 10 days after the treatment.</span></p></div><div><h3>Results</h3><p>From the fourth day of the treatment, the size of the lesion and severity of pain was significantly improved in patients<span> treated with FBP. On the sixth day of the intervention, the erythema level and the size of the ulcer significantly decreased (p &lt; 0.05).</span></p></div><div><h3>Conclusion</h3><p>FBP could improve the most symptoms of RAS in comparison to the control due to the good adhesion of the paste to the surface of the ulcer and release the extract and forms a protective barrier against more mechanical irritations or infections.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.aimed.2021.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72412427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study protocol for a randomised controlled trial on the efficacy of yoga as an adjuvant therapy for patients with Ankylosing spondylitis amidst COVID-19 pandemic","authors":"Jyoti Singh ,&nbsp;Monika Jha ,&nbsp;Kashinath Metri ,&nbsp;Sriloy Mohanty ,&nbsp;Amit Singh ,&nbsp;Padmini Tekur","doi":"10.1016/j.aimed.2021.11.001","DOIUrl":"10.1016/j.aimed.2021.11.001","url":null,"abstract":"<div><h3>Background</h3><p>Amidst the adversities of the COVID-19 pandemic, the health care system has seen a new paradigm shift towards e-health or telehealth services. In the advent of catering to the geometrically increasing health care needs of the patients suffering from various chronic health conditions when in social isolation, the need for such shifts is paramount. Patients with Ankylosing spondylitis using immunosuppressants with variable degrees of disabilities are at higher risk from this isolated status. This study aims to assess the efficacy of e-Yoga as a treatment option for these patients.</p></div><div><h3>Methods</h3><p>The proposed study is a single-center, parallel-group prospective randomized, open-blinded end-point trial. Patients aged between 30 and 50 years will be recruited from the members of Antardhwani: A society of ankylosing spondylitis based in Ahmedabad, Gujarat. Yoga experts will administer a scientifically developed and validated Yoga module via e-Yoga modalities. A total of 135 patients will be recruited and randomly allocated to Yoga and control groups. Data will be recorded at baseline and three months on disease activity, degree of functional limitations in patients, quality of life, inflammatory biomarkers, depression, and anxiety using Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index <strong>(</strong>BASFI), AS Quality of Life index <strong>(</strong>ASQOL), C reactive protein (CRP), Erythrocyte sedimentation rate (ESR), Physical health questionnaire-4 (PHQ-4), respectively.</p></div><div><h3>Discussion</h3><p>The study will report the efficacy of e-Yoga in catering to the physical and mental insufficiencies of inpatients with Ankylosing spondylitis amidst COVID-19 pandemic. The study is prospectively registered in the Clinical Trial Registry of India (CTRI/2020/08/027215)</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10740569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Add-on Psoralea corylifolia mother tincture external application to individualized homeopathic medicines in treatment of vitiligo: Open, randomized, pragmatic, pilot trial","authors":"Anaitulah Ahmad Mir ,&nbsp;Ghulam Nabi Wani ,&nbsp;Ramkripal Prajapati ,&nbsp;Nitin Saklani ,&nbsp;Avaranjika Karuppusamy ,&nbsp;Pankaj Kanti Jha ,&nbsp;Abhijit Chattopadhyay ,&nbsp;Chintamani Nayak ,&nbsp;Swapan Paul ,&nbsp;Sk. Swaif Ali ,&nbsp;Munmun Koley ,&nbsp;Subhranil Saha","doi":"10.1016/j.aimed.2021.03.003","DOIUrl":"https://doi.org/10.1016/j.aimed.2021.03.003","url":null,"abstract":"<div><h3>Background</h3><p><span>Vitiligo<span> causes patchy hypo-pigmentation of skin and mucous membrane, with cosmetic and psychological effects. Studies suggest </span></span><span><em>Psoralea corylifolia</em></span><span> (PC) has pigmentor properties and that individualized homeopathic medicines (IH) are a promising treatment option in vitiligo. This pilot trial was aimed at testing the feasibility of a future definitive trial comparing the effects of three treatment regimens – 1. IH, 2. PC mother tincture (MT) external application, and 3. IH and PC (IHPC) in the treatment of vitiligo.</span></p></div><div><h3>Methods</h3><p><span><span>An open, randomized (1:1:1), three parallel arms, pragmatic, pilot trial was conducted on 60 patients at the dermatology and </span>Materia Medica outpatients of National Institute of Homoeopathy (NIH), India. Primary outcome was Vitiligo Area Scoring Index (VASI); and secondary outcomes were Vitiligo </span>Quality of Life (VitiQoL) and Dermatological Life Quality Index (DLQI); assessed at baseline, 3rd month and 6th month. Intention-to-treat analysis was performed; intra-group and inter-group comparisons were made by Friedman and Kruskal-Wallis tests respectively.</p></div><div><h3>Results</h3><p>Five patients dropped out (IH: 2, PC: 2, IHPC: 1). Intra-group changes over 3 and 6 months were mostly statistically significant in all 3 outcomes (<em>P</em> &lt; 0.001). No significant differences were observed in VASI and DLQI total scores among the three groups over either 3 or 6 months. Differences among groups after 3 and 6 months showed statistical significances in VitiQoL total scores (<em>P</em> = 0.038 and 0.037 respectively) favoring PC and IHPC respectively.</p></div><div><h3>Conclusion</h3><p>A definitive trial appears feasible. All three regimens appeared equally effective and safe, though a small positive direction of effect towards PC and IHPC was observed. As a pilot trial, no definite conclusions could be drawn. Trial registration: CTRI/2018/04/013446.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.aimed.2021.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91711095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}