Therapeutic efficacy and safety of traditional Thai herbal medicines for insomnia: A double-blind randomized controlled trial

IF 1.7 Q2 Medicine

Advances in integrative medicine Pub Date : 2025-01-31 DOI:10.1016/j.aimed.2025.01.006

Thanyaluck Siriyong , Hatairat Chanphool , Sarinrat Jitjum , Sirirat Laohaprapanon , Supayang Piyawan Voravuthikunchai

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引用次数: 0

Abstract

Background

Traditional Thai herbal medicine has been commonly used for insomnia therapy in Asian countries for centuries. However, there has been a limited amount of clinical efficacy and safety research on Yahom-Navakot and Suk-Sai-Yat for patients with insomnia.

Objective

This study aims to evaluate the efficacy and safety of traditional Thai herbal medicines such as Yahom-Navakot and Suk-Sai-Yat, in the treatment of insomnia.

Design setting participants and intervention

This randomised, double-blind clinical investigation was conducted at a Thai Traditional Medical Clinic. A total of 58 participants diagnosed with insomnia were randomly allocated to receive either Yahom-Navakot or Suk-Sai-Yat; the therapy consisted of a 1000 mg dosage, administered once daily at bedtime for a duration of 2 weeks. Following a 2-week therapy period, the participants were followed for an additional 2 weeks.

Main outcome measures

The primary outcome measures of sleep quality, sleepiness, and quality of life were assessed at baseline and weekly during the treatment period with the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Health-Related Quality of Life Measure (EQ-5D), respectively. Adverse drugs responses were investigated as a secondary outcome measure during a clinical study.

Results

The findings demonstrated that at weeks 1 and 2 after initiating Yahom-Navakot or Suk-Sai-Yat, all parameters, including PSQI, ESS, and EQ-5D scores, exhibited statistically significant changes (p < 0.05) in response to the Yahom-Navakot intervention, in comparison to Suk-Sai-Yat. Clinically significant changes (p < 0.05) were observed in the overall PSQI, ESS, and EQ-5D scores within Yahom-Navakot after the first follow-up, in comparison to Suk-Sai-Yat. Moreover, statistically significant changes were noted in both groups post-intervention, relative to baseline measurements. No significant adverse responses were noticed in either group.

Conclusion

The findings indicated that Yahom-Navakot was significantly more effective than Suk-Sai-Yat in enhancing sleep quality, including sleep quality, sleep latency, sleep duration, sleep efficiency, and daytime dysfunction in the treatment of insomnia. Additional research is recommended to clarify the mechanism beneath the anti-insomnia properties of Yahom-Navakot.

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泰国传统草药治疗失眠的疗效和安全性：一项双盲随机对照试验

几个世纪以来，传统的泰国草药一直被亚洲国家普遍用于治疗失眠。然而，yahoma - navakot和Suk-Sai-Yat对失眠患者的临床疗效和安全性研究有限。目的：评价泰国传统中草药雅洪那瓦可和素赛逸治疗失眠症的疗效和安全性。本随机、双盲临床研究在一家泰国传统医学诊所进行。共有58名被诊断为失眠症的参与者被随机分配接受yahoma - navakot或Suk-Sai-Yat；治疗包括1000 mg的剂量，每天一次在睡前给药，持续2周。在两周的治疗期后，参与者又被随访了两周。主要结局指标在基线和治疗期间每周分别用匹兹堡睡眠质量指数（PSQI）、Epworth嗜睡量表（ESS）和健康相关生活质量量表（EQ-5D）评估睡眠质量、嗜睡和生活质量的主要结局指标。在一项临床研究中，不良药物反应作为次要结果进行了调查。结果研究结果表明，在开始yahoma - navakot或Suk-Sai-Yat后的第1周和第2周，与Suk-Sai-Yat相比，yahoma - navakot干预后的所有参数，包括PSQI、ESS和EQ-5D评分，均表现出具有统计学意义的变化（p <； 0.05）。与Suk-Sai-Yat相比，在第一次随访后，yahoma - navakot患者的PSQI、ESS和EQ-5D总分出现了临床显著变化（p <； 0.05）。此外，与基线测量值相比，干预后两组均有统计学上的显著变化。两组均未见明显不良反应。结论在改善睡眠质量、睡眠潜伏期、睡眠时间、睡眠效率和日间功能障碍等方面，yahomn - navakot治疗失眠的效果明显优于suk - saiyat。建议进一步的研究来阐明yahomo - navakot抗失眠特性的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.