Advances in integrative medicine最新文献

{"title":"Managing iron overload through dietary modification: A case report","authors":"Alireza Asghari,&nbsp;Babak Daneshfard,&nbsp;Maryam Golzar","doi":"10.1016/j.aimed.2025.100570","DOIUrl":"10.1016/j.aimed.2025.100570","url":null,"abstract":"<div><div>Iron homeostasis is crucial for maintaining optimal health, as both iron deficiency and iron overload can result in significant clinical complications. This case report explores the therapeutic potential of dietary modification in managing iron overload through an individualized, temperament-based nutritional approach. A 35-year-old female presented with symptoms of hair loss and increased blood viscosity, with laboratory findings indicating elevated serum iron levels (48.7 µmol/L) and a high transferrin saturation (0.85). A tailored dietary intervention was initiated, focusing on reducing the intake of warming, desiccating foods and incorporating more hydrating and moistening dietary elements, including increased fluid intake and specific herbal teas. After one month, follow-up assessments revealed normalized serum iron levels (22.3 µmol/L), improved hemorheological parameters, and notable improvement in hair shedding, which coincided with the dietary changes. This case underscores the potential of personalized dietary strategies, grounded in traditional concepts of food temperament, as a non-pharmacological approach to correcting metabolic imbalances associated with iron overload. Future studies are recommended to investigate the efficacy of these dietary strategies.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100570"},"PeriodicalIF":1.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An analysis of predictors of conventional and complementary healthcare use in Yorkshire","authors":"Felicity Astin ,&nbsp;Elizabeth Goyder ,&nbsp;Richard Cooper ,&nbsp;John Stephenson ,&nbsp;Farideh A. Javid","doi":"10.1016/j.aimed.2025.100566","DOIUrl":"10.1016/j.aimed.2025.100566","url":null,"abstract":"<div><h3>Background</h3><div>Well-recognised trends in types of services used by patients exist within health service utilisation. One increasing area is complementary and alternative medicine (CAM); considered distinct from the use of health professionals working in conventional medicine. Little is known about the contribution of CAM and whether people using CAM with multiple comorbidities make correspondingly less use of conventional health services.</div></div><div><h3>Aims</h3><div>1) To describe self-reported visits to conventional health professionals and CAM practitioners, and to identify predictors of such visits; 2) To quantify the effect of demographic, health-related and CAM service take-up factors on contact with health services delivered by conventional health professionals.</div></div><div><h3>Methods</h3><div>Data from 70,836 participants in the Yorkshire Health Study, a large-scale population-based cohort study, was analysed descriptively and inferentially to test for associations between variables.</div></div><div><h3>Results</h3><div>3.5 % of the cohort reported accessing CAM services in the previous three months. Level of contact with conventional health professionals was higher in those accessing practitioner-led CAM services (incidence rate ratio [IRR]=1.28; <em>p &lt; 0.001.) Female gender, older age and increased incidence of mental and physical health conditions were also positively associated with the outcome.</em></div></div><div><h3>Conclusions</h3><div>Self-reported utilisation of CAM services was low but there were several predictors of recent CAM use based on demographic and health conditions which may be of help in understanding conventional and CAM healthcare utilisation.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100566"},"PeriodicalIF":1.7,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new era in global health: It’s time to act on the promise of integrative medicine","authors":"Susan Arentz","doi":"10.1016/j.aimed.2025.100569","DOIUrl":"10.1016/j.aimed.2025.100569","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100569"},"PeriodicalIF":1.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a yoga program for patients with hirayama disease, and feasibility testing through a case series","authors":"Vinod Kumar ,&nbsp;Nishitha Jasti ,&nbsp;Nupur Pruthi ,&nbsp;Pooja More ,&nbsp;Karthik Mallina ,&nbsp;Kankan Gulati ,&nbsp;Hemant Bhargav ,&nbsp;Shivarama Varambally ,&nbsp;Atchayaram Nalini","doi":"10.1016/j.aimed.2025.100563","DOIUrl":"10.1016/j.aimed.2025.100563","url":null,"abstract":"<div><h3>Background</h3><div>Hirayama Disease (HD), a rare flexion-induced myelopathy, is typically managed with cervical collar therapy, surgery, and lifestyle modifications. Yoga-based interventions have shown promise in managing neurological disorders such as multiple sclerosis and cervical radiculopathy. Given the pathophysiology of HD, we hypothesized yoga could benefit HD patients, especially those awaiting surgery or contraindicated for it. However, literature search revealed that no standardized yoga protocol for HD currently exists.</div></div><div><h3>Objectives</h3><div>This study aimed to develop and validate a yoga module for HD and test its feasibility in patients.</div></div><div><h3>Methods</h3><div>A tailored yoga program was developed by two yoga therapy experts and a neurosurgery consultant. The module was validated by 10 yoga experts and 5 neurologists/neurosurgeons. It was implemented in 20 HD patients to evaluate safety and feasibility. Outcomes included the Visual Analog Scale (VAS) for pain, Client Satisfaction Questionnaire (CSQ-8), hand grip strength (via dynamometer), and a Yoga Performance Assessment (YPA) scale, measured at baseline and after 3 months of practice.</div></div><div><h3>Results</h3><div>A specific yoga module was finalized for HD patients, designed for those awaiting surgery, unwilling to undergo it, or in the static phase of the disease. The program was found safe and feasible in both online and offline formats. Participants learned and independently practiced the module after 20 supervised sessions and reported a high level of satisfaction. Significant improvements were observed at 3 months in hand grip strength, tremors, and hand fatigue.</div></div><div><h3>Conclusion</h3><div>The validated yoga module offers a complementary approach to HD management, benefiting patients awaiting or unable to undergo surgery. The findings suggest yoga can address both functional and symptomatic aspects of the disease, providing a safe and effective intervention.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100563"},"PeriodicalIF":1.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy and safety of Polypodium vulgare L. in psychosomatic and behavioural symptoms and health-related quality of life in premenstrual women: A randomized placebo-controlled study","authors":"Marhaba Khanam ,&nbsp;Arshiya Sultana ,&nbsp;Taseen Banu","doi":"10.1016/j.aimed.2025.100560","DOIUrl":"10.1016/j.aimed.2025.100560","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Premenstrual syndrome (PMS) significantly affects the quality of life and disrupts personal and social relationships among women of reproductive age. This study aimed to evaluate the efficacy and safety of <em>Polypodium vulgare</em> L. (<em>Bisfayej</em>) in alleviating PMS symptoms and improving health-related quality of life (HRQoL) in affected women.</div></div><div><h3>Methods</h3><div>Sixty women diagnosed with PMS were randomly assigned to receive either two capsules of <em>P. vulgare</em> (1000 mg) or a placebo. The treatment was administered twice daily for three menstrual cycles, starting from day 16 of the cycle until day 5 of the following cycle. The primary outcomes were changes in symptom severity, measured by the Premenstrual Syndrome Scale (PMSS), and symptom duration, recorded using a premenstrual tracker sheet. The secondary outcome was assessed using the EQ-5D-5L (EuroQol 5-Dimensions 5-Levels) health questionnaire. Data were analyzed using both parametric and non-parametric tests at a 5 % significance level.</div></div><div><h3>Results</h3><div>Following the intervention, the <em>P. vulgare</em> group showed a significant reduction in PMS symptom severity and duration, along with an improvement in EQ-5D-5L scores, compared to the placebo group (<em>p</em> &lt; 0.001). The mean reduction in PMSS scores from baseline to the end of the third treatment cycle was 44.23 (95 % CI: 39.81–48.65) in the treatment group and 24.7 (95 % CI: 21.43–27.96) in the placebo group, indicating a statistically significant difference (<em>p</em> &lt; 0.001). No adverse effects were reported in either group.</div></div><div><h3>Discussion</h3><div>The findings suggest that <em>P. vulgare</em> is both effective and safe in reducing the severity and duration of PMS symptoms while enhancing HRQoL. The therapeutic effects may be attributed to its anti-inflammatory and antioxidant properties, as well as its potential to modulate serotonin levels. These results support the potential of <em>P. vulgare</em> as a promising treatment option for women suffering from PMS.</div></div><div><h3>Conclusion</h3><div><em>P. vulgare</em> was more efficacious than the placebo in reducing PMS and improving the woman’s HRQoL.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100560"},"PeriodicalIF":1.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedentary lifestyle and occupational stress: Rethinking employee wellness through culturally attuned yoga","authors":"Erma Pratiwi Nufi","doi":"10.1016/j.aimed.2025.100568","DOIUrl":"10.1016/j.aimed.2025.100568","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100568"},"PeriodicalIF":1.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the mechanism of Jiawei Xiaoyao San in treating metabolic associated fatty liver disease (MAFLD) based on the ileal microbiota-bile acid-FXR axis","authors":"Taotao Wei ,&nbsp;Gaozhong Dai ,&nbsp;Tianye Liu ,&nbsp;Yaozhou Tian","doi":"10.1016/j.aimed.2025.100567","DOIUrl":"10.1016/j.aimed.2025.100567","url":null,"abstract":"<div><div>Metabolic Associated Fatty Liver Disease (MAFLD) has become a main cause of chronic liver disease globally, necessitating the development of preventive and early therapeutic strategies. Traditional Chinese Medicine (TCM) plays a significant role in human metabolism, and Jiawei Xiaoyao San (JWXYS) has demonstrated notable ameliorative effects on liver stagnation and spleen deficiency-type liver disease. However, its potential mechanisms are still unclear. This study aimed to explore the therapeutic mechanism of JWXYS in treating chronic liver disease by establishing a rat model induced by a high-fat diet. The results revealed that JWXYS could reduce serum levels of total cholesterol (TC) triglycerides (TG) and aspartate aminotransferase (AST) in model rats, significantly improve the structure of liver lobule, reduce lipid deposition in hepatocytes, and reduce the abundance of harmful intestinal flora (such as <em>Staphylococcus</em> and <em>Enterococcus</em>). In addition, JWXYS improved gut microbiota imbalance, regulated bile acid and lipid metabolism, and maintained the overall health of rats. These findings provide a theoretical basis for using JWXYS to treat chronic fatty liver disease.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100567"},"PeriodicalIF":1.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis extract in treatment of narcolepsy: A case report","authors":"Daniel Lopes ,&nbsp;Alana C. Costa ,&nbsp;Cícero A.C. Pereira ,&nbsp;Helena P.G. Joaquim","doi":"10.1016/j.aimed.2025.100561","DOIUrl":"10.1016/j.aimed.2025.100561","url":null,"abstract":"<div><div>Narcolepsy is a chronic neurological disorder that affects sleep-wake regulation and is characterized by excessive daytime sleepiness, sudden sleep episodes, cataplexy, sleep paralysis, and vivid hallucinations. While there is no cure, symptoms can be managed through pharmacological and non-pharmacological interventions. Emerging research, based on pre-clinical evidence, supports the use of cannabinoid therapies for managing narcolepsy symptoms. This case study reports on a 33-year-old Brazilian woman with narcolepsy who, after conventional treatments proved insufficient, benefited from cannabinoid therapy. Initially treated with modafinil and aripiprazole, her treatment regimen was adjusted to include a Cannabis sativa extract (CSE), allowing for a reduction in her other medications. After 5 months of treatment, she experienced significant improvements in daytime sleepiness, motivation, and ability to perform daily tasks. With the stabilization of her condition, her quality of life was enhanced. While conventional treatments are often effective, they may lose efficacy over time, necessitating dose adjustments or alternative therapies. Cannabinoid therapies have shown promise in managing sleep disorders and may represent a viable alternative for treating narcolepsy.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100561"},"PeriodicalIF":1.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology in the Unani system of medicine: A comprehensive review and hypothesis","authors":"Md Manzar Alam ,&nbsp;Mustehasan ,&nbsp;Usama Akram ,&nbsp;Mumtaz Ahmad ,&nbsp;N. Zaheer Ahmed","doi":"10.1016/j.aimed.2025.100564","DOIUrl":"10.1016/j.aimed.2025.100564","url":null,"abstract":"<div><h3>Background</h3><div>Nanotechnology is an emerging technology which is a game changer for various fields of discipline like<!--> <!-->medicine, biotechnology, material sciences, and environmental sciences. This is about controlling materials on a nanoscale,<!--> <!-->where at least one dimension is less than 100 nm (a nanometer). Such technology may lead to smart materials that can be used in construction and other fields.</div></div><div><h3>Objective</h3><div>To investigate the relationship between nanotechnology and Unani medicine, examining knowledge of nanoscale<!--> <!-->materials in classical Unani literature and their modern applications in nanomedicine.</div></div><div><h3>Methods</h3><div>This was done by a narrative review of classical Unani medical<!--> <!-->writings, and a comprehensive search of scientific databases such as Google Scholar, PubMed, ScienceDirect, and Web of Science up to October 2023. The contributions of scholars including <em>Jābir<!--> <!-->ibn Ḥayyān</em> (Geber), <em>Zakariyyā Rāzī</em> (Rhazes), <em>Shamsuddīn Undulusī</em> and <em>Ḥakīm Ajmal Khān</em> are reviewed here, particularly their observations on the maximum particle size of a drug intended for medicinal purposes. For example, nanoparticle synthesis techniques such as photolysis, co-precipitation, sol-gel, electrochemical precipitation, and green<!--> <!-->chemistry were examined due to their implications regarding present nanotechnology.</div></div><div><h3>Results</h3><div>This study demonstrates that ancient Unani scholars had knowledge of therapeutic potential of metal-based nanoparticles specifically through the use of <em>Kushta</em> (calx) and<!--> <em>Sayyāl</em> (dissolved metals) in their medicinal formulations. Such practices are aligned with contemporary<!--> <!-->nanotechnological principles. The review further elaborates on current approaches of nanoparticles synthesis that mirror traditional Unani methods, especially in the regard of eco-friendly approaches including chemistry<!--> <!-->green.</div></div><div><h3>Conclusion</h3><div>This study provides<!--> <!-->an insight into nanotech being a part of Unani medicine far earlier than modern-day practices, with <em>Kushtasāzī</em> (calcination) and <em>Sayyāl</em> being potential forerunners to modern nanotechnology. However, the adoption of<!--> <!-->modern nanotechnological techniques into the well-established Unani system leads to tremendous innovation and establishes a link between ancient wisdom and recently developed advanced therapeutic approaches.</div></div><div><h3>Funding statement</h3><div>This work received no specific funding from any external funding agencies. The study was performed in the Regional Research Institute of Unani Medicine, Patna, using institutional resources and facilities.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100564"},"PeriodicalIF":1.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development, validation, and feasibility testing of Tele-Yoga Module for PTSD","authors":"Naresh Katla ,&nbsp;Judu Ilavarasu ,&nbsp;Ramesh Mavathur ,&nbsp;Hemant Bhargav ,&nbsp;Bharath Holla ,&nbsp;Vinod Kumar ,&nbsp;Atmika Y. Ramsahaye ,&nbsp;Arun Thulasi ,&nbsp;Syed Zaeem Haider Zaidi","doi":"10.1016/j.aimed.2025.100562","DOIUrl":"10.1016/j.aimed.2025.100562","url":null,"abstract":"<div><h3>Introduction</h3><div>Post-traumatic stress disorder (PTSD) is a growing concern worldwide. The increasing incidence of PTSD, compounded by the social stigma associated with it, often prevents individuals from seeking professional help. The objective of this study was to develop, validate, and test the feasibility of Tele-Yoga Module (TYM) for managing PTSD, within a community setting in India.</div></div><div><h3>Methods</h3><div>The TYM was developed and validated following the procedure presented in the protocol study <span><span>[1]</span></span>. The feasibility of the module was then tested in a 12-week study with sixty participants diagnosed with PTSD as per DSM-V criteria. Participants were split evenly between the TYM and a treatment-as-usual (TAU) group. We measured variables such as PTSD symptoms, social functioning, resilience, anxiety, depression, and yoga-based personality traits.</div></div><div><h3>Results</h3><div>Participants in the TYM group showed significant improvements in PTSD symptoms, anxiety, and depression, compared to the TAU group (<em>p</em> &lt; 0.001 for all). No significant between-group differences were observed in resilience and psycho-social functions (<em>p</em> = 0.11). The feasibility aspects of the TYM have been discussed under seven dimensions, including safety and acceptability. These findings suggest that the TYM can serve as a potentially useful add-on intervention in managing PTSD. This study contributes to the emerging field of tele-yoga and highlights the importance of culturally and contextually adapted mental health interventions. Such approaches are crucial for addressing the global burden of PTSD.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100562"},"PeriodicalIF":1.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}