中药预防妊娠纹的有效性：一项系统回顾和荟萃分析

IF 1.7 Q2 Medicine

Advances in integrative medicine Pub Date : 2025-06-23 DOI:10.1016/j.aimed.2025.100530

Masoumeh Razavi , Mojgan Mirghafourvand , Mahnaz Shahnazi , Khadije Hajizadeh

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引用次数: 0

摘要

背景：妊娠纹是一种常见的皮肤病，影响了大约60 - 90% %的孕妇。本系统综述旨在评估草药在怀孕期间预防妊娠纹的有效性。方法在PubMed、Cochrane Library、Embase、Scopus和SID数据库中检索1972年1月至2024年5月间发表的文献。随机对照试验（rct）评估了草药（包括油、面霜和植物提取物）对孕妇的预防作用。使用RevMan软件对数据进行分析，并根据异质性程度采用固定效应或随机效应模型进行meta分析。根据草药类型对发生率（主要结局）和瘙痒和红斑（次要结局）进行亚组分析。结果共纳入12项随机对照试验，涉及孕妇1956例。与安慰剂相比，芦荟凝胶、甜杏仁油和芝麻油等草药治疗显著降低了妊娠纹的发生率(12项研究，n = 1956；OR = 0.47, 95 % CI: 0.28-0.79, p = 0.004)。此外,四子群分析从四个不同的研究(n = 601)表明,草药产品显著降低发病率的瘙痒而控制(或= 0.09,95 % CI: 0.03 - -0.30, p & lt; 0.00001),而两项研究(n = 139)显示,红斑发生率显著减少干预组(或= 0.17,95 % CI: 0.07 - -0.38, p & lt; 0.0001)。结论虽然芦荟、甜杏仁油和芝麻油等一些草药在预防和治疗妊娠纹方面具有很大的潜力，但研究设计和结果的异质性表明需要更多高质量的研究。

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The effectiveness of herbal remedies in preventing striae gravidarum: A systematic review and meta-analysis

Background

Striae gravidarum is a common skin condition that affects approximately 60–90 % of pregnant women. This systematic review aimed to evaluate the effectiveness of herbal remedies in preventing stretch marks during pregnancy.

Methods

A comprehensive literature search was conducted in PubMed, Cochrane Library, Embase, Scopus, and SID databases for studies published between January 1972 and May 2024. Randomized controlled trials (RCTs) assessing the preventive effects of herbal remedies—including oils, creams, and plant-based extracts—on pregnant women were included. Data were analyzed using RevMan software, and meta-analysis was performed using fixed-effect or random-effects models based on the degree of heterogeneity. Subgroup analysis was performed based on the type of herbal remedies on incidence (primary outcome) and itching and erythema (secondary outcomes).

Results

A total of 12 randomized controlled trials involving 1956 pregnant women were included. Herbal treatments such as Aloe vera gel, sweet almond oil, and sesame oil showed a significant reduction in the incidence of stretch marks compared to placebo (12 studies, n = 1956; OR = 0.47, 95 % CI: 0.28–0.79, p = 0.004). In addition, four subgroup analyses from four distinct studies (n = 601) demonstrated that herbal products significantly reduced the incidence of itching compared to controls (OR = 0.09, 95 % CI: 0.03–0.30, p < 0.00001), while two studies (n = 139) showed a significant reduction in erythema incidence in the intervention groups (OR = 0.17, 95 % CI: 0.07–0.38, p < 0.0001).

Conclusion

Although some herbal remedies, especially Aloe vera, Sweet Almond oil and Sesame oil have high potential for the prevention and management of stretch marks, the heterogeneity in the studies' design and results indicates the need for more high-quality research.

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来源期刊

Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.