绝经后妇女的炎症生物标志物调节：一项随机对照试验，共同补充姜黄素纳米胶束和黑草的优势

IF 1.7 Q2 Medicine

Advances in integrative medicine Pub Date : 2025-06-18 DOI:10.1016/j.aimed.2025.100528

Amir Mehdi Iranshahi , Mahdi Amirpour , Soraya Babaie , Azizeh Farshbaf-Khalili , Alireza Ostadrahimi

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引用次数: 0

摘要

持续的炎症，无论是由激素变化直接介导的还是由氧化应激诱导的，都对骨骼健康有显著的负面影响，可能导致绝经后骨质减少和骨质疏松症的发生。抗炎草药产品，以成本效益和安全性而闻名，支持骨骼重塑。本研究评估姜黄素纳米胶束（CUR）、黑草（NS）及其共补充物（NS-CUR）对绝经后骨质疏松或骨质疏松妇女血清炎症因子的影响。方法对120例绝经后妇女进行三盲随机对照试验。根据骨密度将患者分为四组。在6个月的干预期间，NS组每天服用NS油胶囊和CUR安慰剂胶囊。CUR组每天服用一个CUR胶囊和一个NS安慰剂胶囊。NS-CUR组每日给予1颗CUR胶囊和1颗NS油胶囊。安慰剂组每天服用两粒微晶纤维素（MCC）胶囊。测定血清中高敏c反应蛋白（hs-CRP）、白细胞介素-6 （IL-6）、肿瘤坏死因子-α (TNF-α)的浓度。ResultThe血清TNF -α、il - 6和hs-CRP NS组显著下降(p & lt; 0.001),坏蛋(p & lt; 0.001,p & lt; 0.001,p = 0.001,分别),和NS-CUR (p & lt; 0.001)组与基线相比。组间分析显示，与安慰剂组相比，NS组、CUR组和NS-CUR组IL-6和TNF-α显著降低（p <； 0.001）。尽管NS组和NS-CUR组hs-CRP显著降低（p = 0.001,p <； 0.001），但在CUR组和安慰剂组之间没有发现显著差异（p = 0.096）。结论补充CUR、NS和NS-CUR可调节IL-6、TNF-α和hs-CRP水平。此外，NS和CUR的共同补充显著影响炎症生物标志物。

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Inflammatory biomarkers modulation in postmenopausal women: A randomized controlled trial of the superiority of Co-supplementing curcumin nano-micelles and Nigella sativa

Background

Lasting inflammation, whether directly mediated by hormonal changes or induced by oxidative stress, has significant negative effects on bone health, potentially contributing to the development of postmenopausal osteopenia and osteoporosis. Anti-inflammatory herbal products, known for cost-effectiveness and safety, support bone remodeling. This study evaluates the efficacy of Curcumin Nano-micelles (CUR), Nigella sativa (NS), and their co-supplementation (NS-CUR) on serum inflammatory factors in postmenopausal women with osteopenia or osteoporosis.

Methods

A triple-blind randomized trial was conducted on 120 postmenopausal women. Patients were allocated to four groups stratified by bone density. During the 6-month intervention, the NS group took an NS oil capsule and a CUR placebo capsule daily. The CUR group consumed a CUR capsule and an NS placebo capsule daily. The NS-CUR group received a CUR capsule and an NS oil capsule daily. The placebo group received two microcrystalline cellulose (MCC) capsules daily. The serum concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were determined.

Result

The serum levels of TNF-α, IL-6, and hs-CRP significantly declined in the NS group (p < 0.001), CUR (p < 0.001, p < 0.001, p = 0.001, respectively), and NS-CUR (p < 0.001) groups compared to baseline. Between-group analyses revealed that IL-6 and TNF-α showed significant reductions in the NS, CUR, and NS-CUR groups (p < 0.001) compared to placebo. Despite significant reductions in hs-CRP in the NS and NS-CUR groups (p = 0.001, p < 0.001, respectively), no significant differences were identified between the CUR and placebo groups (p = 0.096).

Conclusion

The supplementation of CUR, NS, and NS-CUR modulated IL-6, TNF-α, and hs-CRP levels. Moreover, the co-supplementation of NS and CUR significantly influenced inflammatory biomarkers.

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来源期刊

Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.