A scoping review exploring the role of homoeopathic drugs as a host directed therapy in the management of drug-resistant tuberculosis

IF 1.7 Q2 Medicine

Advances in integrative medicine Pub Date : 2025-06-26 DOI:10.1016/j.aimed.2025.100533

Bhargav Sarma K , Vaishali Vasant Dolas , Vijay Nema

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引用次数: 0

Abstract

Introduction

Host-directed therapies (HDTs) for tuberculosis are being investigated. By regulating host cell factors, especially in conditions like Drug-resistant tuberculosis, the increasing burden of Anti-Microbial Resistance (AMR) can be reduced. The role of homoeopathic drugs or CAM (complementary and alternative medicine) drugs in regulating host-directed mechanisms is largely unknown. The primary objective of this scoping review is to identify the host-directed mechanisms of homoeopathic drugs in relation to Mycobacterium tuberculosis pathophysiology. The second objective is to understand whether these host-directed mechanisms can be useful for treating sensitive and drug-resistant tuberculosis.

Methods

Our scoping review was drafted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) extension for scoping reviews. The following databases were searched to identify potentially relevant papers: PUBMED, COCHRANE, AYUSH RESEARCH PORTAL, and Google SCHOLAR. Forty-eight papers were screened by two people independently with blinding using Rayyan.

Results

The number of papers identified from databases and registers was 82. Only 15 papers were included in the final selection, while others were excluded because they did not meet the criteria for homoeopathy, host-directed mechanisms, and drug-resistant tuberculosis.

Discussion

To be considered host-directed, a homoeopathic drug action must act through the following mechanisms: regulation of adaptive immune responses, innate immune responses, cell death targets, and metabolism regulation. If we analyse the studies taken for review, we may find that some homoeopathic drugs regulate cytokines, matrix metalloproteinases (MMPs), Phosphofructokinase and other mechanisms. These experiments demonstrate that homoeopathic drugs act through host-directed mechanisms, but there is a lack of research papers on sensitive and drug-resistant tuberculosis.

Conclusion

So this concludes that in this review we were able to achieve only one objective which is the action of homoeopathic drugs through the host-directed mechanism, further research with In Vitro or In Vivo models can help us to complete our second objective.

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一篇探讨顺势疗法药物作为宿主定向治疗在耐药结核病管理中的作用的综述

目前正在研究针对结核病的宿主导向疗法（HDTs）。通过调节宿主细胞因子，特别是在耐药结核病等情况下，可以减少抗微生物药物耐药性（AMR）日益增加的负担。顺势疗法药物或CAM（补充和替代药物）药物在调节宿主导向机制中的作用在很大程度上是未知的。本综述的主要目的是确定与结核分枝杆菌病理生理相关的顺势疗法药物的宿主定向机制。第二个目标是了解这些宿主导向机制是否可用于治疗敏感和耐药结核病。方法采用PRISMA（优选报告项目用于系统评价和荟萃分析）扩展进行范围评价。检索了以下数据库以确定可能相关的论文：PUBMED、COCHRANE、AYUSH RESEARCH PORTAL和谷歌SCHOLAR。48篇论文由两个人独立使用Rayyan进行盲法筛选。结果从数据库和注册库中检索到的论文数量为82篇。最终入选的论文只有15篇，其他论文因不符合顺势疗法、宿主导向机制和耐药结核病的标准而被排除。为了被认为是宿主导向的，顺势疗法药物的作用必须通过以下机制起作用：调节适应性免疫反应、先天免疫反应、细胞死亡靶点和代谢调节。如果我们对已有的研究进行分析，我们可能会发现一些顺势疗法药物调节细胞因子、基质金属蛋白酶（MMPs）、磷酸果糖激酶等机制。这些实验表明，顺势疗法药物通过宿主导向机制起作用，但缺乏关于敏感和耐药结核病的研究论文。综上所述，在本综述中我们只能达到顺势疗法药物通过宿主作用机制的一个目标，进一步的体外或体内模型研究可以帮助我们完成第二个目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.