Efficacy of nutraceuticals in migraine symptoms relief: A systematic review and network meta-analysis

IF 1.7 Q2 Medicine

Advances in integrative medicine Pub Date : 2025-03-23 DOI:10.1016/j.aimed.2025.100478

Imen Ketata , Emna Ellouz

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引用次数: 0

Abstract

Background

The effectiveness of nutraceuticals in alleviating migraine symptoms remains controversial, with ongoing debate among experts. This network meta-analysis (NMA) aims to compare the efficacy of various nutraceuticals on migraine symptoms relief.

Methods

A frequentist NMA was performed on double-blind randomized clinical trials involving migraine patients using NS. We searched PubMed, Europe PMC, Google Scholar, Web of Science, APA PsycInfo, gray literature, and systematic review references up to April 25, 2024. This NMA is registered in PROSPERO (CRD42024504214). Data analysis was conducted using R software, estimating the mean difference (MD) and 95 % CI for NS effects on migraine relief.

Results

twenty-five trials were reviewed. Compared to placebo, CoQ10 + L-carnitine (MD: −4.8 [95 % CI: −8.0; −1.7]), vitamin D3 (MD: −3.5 [95 %CI: −5.3; −1.6]), curcumin (MD: −6.0 [95 % CI: −10.7; −1.3]), and cinnamon (MD: −3.5 [95 % CI: −5.5; −1.1]) were ranked as the most effective NS for reducing monthly migraine frequency, migraine days duration/month, attack duration (hours), and migraine severity, respectively. Based on GRADE approach, the certainty of evidence was respectively low, moderate, low and high. The meta-regression revealed that follow-up duration significantly affected the impact of NS on MA/mo.

Conclusion

NS, particularly CoQ10 +L-carnitine, vitamin D3, curcumin, and cinnamon, may help reduce migraine symptoms. However, these findings are preliminary and require confirmation with higher-quality evidence. Additional research is needed to evaluate the combined effectiveness of these NS for migraine relief.

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营养保健品缓解偏头痛症状的疗效：系统回顾和网络荟萃分析

营养保健品在缓解偏头痛症状方面的有效性仍然存在争议，专家之间正在进行辩论。本网络荟萃分析（NMA）旨在比较各种营养保健品对缓解偏头痛症状的疗效。方法对使用NS的偏头痛患者进行双盲随机临床试验。我们检索了截止到2024年4月25日的PubMed、Europe PMC、b谷歌Scholar、Web of Science、APA PsycInfo、灰色文献和系统综述参考文献。该NMA在PROSPERO （CRD42024504214）中注册。使用R软件进行数据分析，估计NS对偏头痛缓解作用的平均差异（MD）和95% % CI。结果共回顾了25项试验。与安慰剂相比，辅酶q10 + 左旋肉碱(MD:−4.8[95 % CI:−8.0；−1.7])，维生素D3 (MD:−3.5[95 %CI:−5.3；- 1.6])，姜黄素(MD: - 6.0[95 % CI: - 10.7；−1.3])，肉桂(MD:−3.5[95 % CI:−5.5；−1.1])分别被评为减少每月偏头痛频率、偏头痛持续天数/月、发作持续时间（小时）和偏头痛严重程度的最有效的NS。基于GRADE方法，证据的确定性分别为低、中、低、高。meta回归分析显示，随访时间显著影响NS对MA/mo的影响。结论：ns，尤其是辅酶q10 +左旋肉碱、维生素D3、姜黄素和肉桂，可能有助于减轻偏头痛症状。然而，这些发现是初步的，需要更高质量的证据来证实。需要进一步的研究来评估这些NS缓解偏头痛的联合有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.