Advances in integrative medicine最新文献

{"title":"Safety and efficacy of colchicine in Covid-19 treatment: Systematic review and meta-analysis","authors":"Ahmed Hosney Nada ,&nbsp;Ismail A. Ibrahim ,&nbsp;Nada Khalid Asar ,&nbsp;Abdulrahman Qenawy ,&nbsp;Mariam M. Mohammed ,&nbsp;Mohamed Wagdy ,&nbsp;Heidi Sherif Farouk","doi":"10.1016/j.aimed.2025.100571","DOIUrl":"10.1016/j.aimed.2025.100571","url":null,"abstract":"<div><h3>Background</h3><div>Colchicine is an anti-inflammatory drug used for the treatment of gout and other autoinflammatory conditions. Several trials reported promising results of the efficacy of colchicine in Covid-19 due to its anti-inflammatory properties. However, applying these results to clinical settings remains the subject of ongoing research.</div></div><div><h3>Methods</h3><div>We performed a systematic review and meta-analysis on the efficacy and safety of colchicine in the treatment of Covid-19. PubMed, Cochrane Library, Web of Science, and Scopus were searched for relevant studies. The primary outcomes were 28-day mortality, invasive mechanical ventilation, non-invasive mechanical ventilation, and ICU admissions. The risk ratio was used to compare effectiveness between the two groups. Subgroup analysis was done for C-reactive protein and duration of hospitalization.</div></div><div><h3>Results</h3><div>17 randomized controlled trials with a total of 25478 patients were included. The overall Risk ratio didn’t favor any of the two groups in terms of 28-day mortality (RR = 1.03, 95 % CI [0.93:1.15], P = 0.58), non-invasive mechanical ventilation (RR = 0.81, 95 % CI [0.44:1.48], P = 0.49), ICU admission (RR = 0.89, 95 % CI [0.56:1.41], P = 0.62).</div><div>The overall mean difference (MD) did not show statistical significance between both groups in terms of C- reactive protein (CRP) (mg/dl) (MD = −1.21, 95 % CI [-2.42:0.01], P = 0.05), lactate dehydrogenase (LDH) (U/L) (MD = 50.95, 95 % CI [-92.07: 193.98], Ferritin (ng/ml) (MD = 128.08, 95 % CI [51.97:204.18], P = 0.001), ICU length of stay (MD = −0.09, 95 % CI [-0.34:0.15], P = 0.45) and duration of hospitalization (MD = −0.41, 95 % CI [-1.56:0.73], P = 0.48).</div></div><div><h3>Conclusion</h3><div>In Covid-19 treatment, colchicine didn’t result in significant benefits in terms of clinical outcomes. More large-scale randomized clinical trials with standardized dosages and long-term follow-up are needed for further investigation into the colchicine effect.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100571"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of compound Wuwei ironing pack combined with ERAS management mode on the recovery of gastrointestinal function after primary hepatocellular carcinoma surgery","authors":"Jing Zou,&nbsp;Rao Fu,&nbsp;Lixia Zhang","doi":"10.1016/j.aimed.2025.100554","DOIUrl":"10.1016/j.aimed.2025.100554","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of the compound Wuwei ironing pack combined with the ERAS (Enhanced Recovery After Surgery) management protocol on postoperative gastrointestinal recovery in hepatocellular carcinoma patients.</div></div><div><h3>Methods</h3><div>A convenience sampling approach was used to recruit liver cancer patients from the hepatobiliary and pancreatic surgery ward of our hospital between June 2023 and February 2024. A total of 159 patients were randomized into three groups: (1) the control group, which received standard ERAS management; (2) the fennel ironing pack group, which used an independent fennel-based physiotherapy formula; and (3) the compound Wuwei ironing pack group, which utilized a physiotherapy pack developed by the Traditional Chinese Medicine Department. This pack contained five traditional Chinese herbs: fennel, dried tangerine peel, Fructus Aurantii Immaturus, Magnoliae Officinalis Cortex, and malt. The groups were compared based on time to first defecation, length of hospital stay, incidence of infection, and nutritional indicators.</div></div><div><h3>Results</h3><div>The compound Wuwei ironing pack group demonstrated significantly shorter time to first defecation and postoperative hospital stay compared to the fennel group and the control group (both P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The compound Wuwei traditional Chinese medicine ironing pack demonstrated better recovery outcomes compared to fennel physiotherapy and standard ERAS management. It reduced hospital stay, is simple to use, safe, and suitable for clinical application.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100554"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Lapis Judaicus compared with hydrochlorothiazide on kidney stones","authors":"Elham Akbarzadeh ,&nbsp;Mohammad Mehdi Hosseini ,&nbsp;Zohreh Abolhassanzadeh ,&nbsp;Ebrahim Fallahzadeh Abarghooei ,&nbsp;Shahrokh Ezzatzadegan Jahromi ,&nbsp;Seyed Hamed Jafari ,&nbsp;Alireza Mohamadian ,&nbsp;Amir Mohammad Jaladat","doi":"10.1016/j.aimed.2025.100583","DOIUrl":"10.1016/j.aimed.2025.100583","url":null,"abstract":"<div><h3>Introduction</h3><div>More than one million referrals to the emergency department worldwide is related to kidney stones. Lapis Judaicus (LJ) as an ancient treatment of kidney stones has been described by Dioscorides, Galen, and some famaous Iranian scholars such as Ibn Sina, Razi, and Ahvazi and currently is used in the folk medicine market of Iran, Pakistan, Afghanistan, and India. Despite its popularity in some regions, few studies have evaluated its effect on renal stones. In this study, we investigated the effect of LJ in comparison with hydrochlorothiazide (HCTZ) on renal stone.</div></div><div><h3>Methods</h3><div>Seventy–seven adult patients with a stable and opaque kidney stones equal or greater than 5 mm, who received no treatment for their kidney stone in the past month were recruited and randomized into three groups: A) HCTZ (12.5 mg capsules two each morning, N = 25), B) LJ+HCTZ (1gr capsules two each morning +12.5 mg HCTZ N = 27), and C) LJ (1gr capsules two each morning, N = 25) for 2 months. After the intervention (the end of 2 months), checking serum and urinary parameters and kidney ultrasound were performed and compared with pre-intervention findings.</div></div><div><h3>Results</h3><div>A significant decrease was found in the size of renal stones in groups B and C. LJ alone or with hydrochlorothiazide did not cause any significant change in serum and urine parameters between before and after treatment (P &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>The stone sizes changed significantly in two groups that received LJ, compared with HCTZ, without any significant effect on liver enzymes or renal function.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100583"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145323278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study on the correlation between syndrome types and Traditional Chinese Medicine constitution in 409 cases of female infertility","authors":"Gao Zhuwei ,&nbsp;Miao Xiaoling ,&nbsp;Hu Yixiao ,&nbsp;Yu Jiannan ,&nbsp;Feng Jiaxing ,&nbsp;Liu Yang ,&nbsp;Wu Xiaoke","doi":"10.1016/j.aimed.2025.100579","DOIUrl":"10.1016/j.aimed.2025.100579","url":null,"abstract":"<div><h3>Objective</h3><div>This research aims to investigate the patterns and interconnections between infertility syndrome classifications and Traditional Chinese Medicine (TCM) constitutional profiles.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted to categorize cases that fulfilled the eligibility criteria, followed by an examination of the statistical outcomes.</div></div><div><h3>Results</h3><div>The findings revealed that among the 409 infertility cases, the most prevalent TCM syndrome was Kidney Deficiency Syndrome, with 242 cases (59.2 %); Balanced Constitution accounted for 118 cases (28.9 %), while Yang Deficiency Constitution was the most common among the Biased Constitutions, with 86 cases (21 %). The influencing factors included BMI, disease duration, age, and ovarian factors. Yang Deficiency Constitution (64 cases) was more frequent in the high-incidence Kidney Deficiency Syndrome.</div></div><div><h3>Conclusion</h3><div>Kidney Deficiency Syndrome was the most common TCM syndrome in female infertility, and Yang Deficiency Constitution was more prevalent among Biased Constitutions.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100579"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between caffeine consumption and self-reported sleep quality among healthcare professionals","authors":"Sedat Arslan ,&nbsp;Kevser TARI Selcuk ,&nbsp;Kübra Betül Kirbiyik ,&nbsp;Nuh Şerbetçi̇","doi":"10.1016/j.aimed.2025.100553","DOIUrl":"10.1016/j.aimed.2025.100553","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to examine the relationship between caffeine consumption and sleep quality among healthcare professionals.</div></div><div><h3>Method</h3><div>This cross-sectional study was conducted on 98 healthcare professionals working at Balıkesir Havran State Hospital. Participants' caffeine consumption levels were assessed using the Caffeine Consumption Frequency Questionnaire, and their sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). The data were analyzed using the SPSS 22.0 statistical software package. Descriptive statistics, student’s t-test, and linear regression analyses were performed, with a significance level set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>The average daily caffeine consumption among participants was found to be 279.12 ± 168.50 mg. Although the mean caffeine intake was slightly higher among females, this difference was not statistically significant. 57.1 % of the participants were evaluated as having poor sleep quality. According to the regression analysis, daily caffeine consumption was positively associated with sleep duration (p &lt; 0.05), but no significant relationship was found with other components of sleep quality.</div></div><div><h3>Conclusion</h3><div>This study suggests that daily caffeine consumption among healthcare professionals may have a positive effect on sleep duration, but does not have a significant impact on overall sleep quality.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100553"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropometric indices correlates of temperament (Mizaj) in traditional medicine: A cross-sectional study of Iranian males","authors":"Soheil Ashouri ,&nbsp;Mohammad Mahdi Ahmadian-Attari ,&nbsp;Malihe Farid ,&nbsp;Hamid Shamsi Baghbanan ,&nbsp;Simin Mahakizadeh","doi":"10.1016/j.aimed.2025.100536","DOIUrl":"10.1016/j.aimed.2025.100536","url":null,"abstract":"<div><div>Traditional Iranian medicine classifies individuals based on temperament (Mizaj), defined by hot-cold and dry-wet attributes, which are thought to influence health and disease susceptibility. This study investigates the relationship between temperaments and anthropometric variables, aiming to provide a quantitative, evidence-based foundation for traditional medicine. A cross-sectional study conducted with 200 healthy males aged 20–30. We recorded a number of anthropometric measurements, including height, weight, skinfold thickness, and hip (HC) and waist (WC) circumferences. Body Mass Index (BMI) and body fat index (BFI) were calculated. Participants completed a validated temperament assessment questionnaire. Participants were categorized into four groups: Warm-Dry (WD) (28 %), Warm-Wet (WW) (18 %), Cold-Dry (CD) (17.3 %), and Cold-Wet (CW) (36.7 %). Significant differences were observed in weight, BMI, BFI, waist, and hip circumferences among the groups. The CW group had the highest average weight (88.35 kg), BFI (25.1 %), BMI (27.93 kg/m²), while the WD group had the lowest weight (69.39 kg), BMI (21.13 kg/m²), BFI (14.8 %), ROC curve analysis identified pelvic circumference as the optimal predictor for cold-warm temperament classification, with a cut-off value of 99.5 cm, for dry-wet temperament, BFI was the reasonable predictor, with a cut-off of 20.10 %. The findings are consistent with traditional Iranian medicine principles, which associate warm-wet temperaments with larger body sizes and greater soft tissue mass, while cold or dry temperaments correlate with a leaner physique. These findings support the using anthropometric indices as objective measures for temperament classification, offering a scientific basis for traditional Iranian medicine and enhancing personalized health interventions.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100536"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis extract in treatment of narcolepsy: A case report","authors":"Daniel Lopes ,&nbsp;Alana C. Costa ,&nbsp;Cícero A.C. Pereira ,&nbsp;Helena P.G. Joaquim","doi":"10.1016/j.aimed.2025.100561","DOIUrl":"10.1016/j.aimed.2025.100561","url":null,"abstract":"<div><div>Narcolepsy is a chronic neurological disorder that affects sleep-wake regulation and is characterized by excessive daytime sleepiness, sudden sleep episodes, cataplexy, sleep paralysis, and vivid hallucinations. While there is no cure, symptoms can be managed through pharmacological and non-pharmacological interventions. Emerging research, based on pre-clinical evidence, supports the use of cannabinoid therapies for managing narcolepsy symptoms. This case study reports on a 33-year-old Brazilian woman with narcolepsy who, after conventional treatments proved insufficient, benefited from cannabinoid therapy. Initially treated with modafinil and aripiprazole, her treatment regimen was adjusted to include a Cannabis sativa extract (CSE), allowing for a reduction in her other medications. After 5 months of treatment, she experienced significant improvements in daytime sleepiness, motivation, and ability to perform daily tasks. With the stabilization of her condition, her quality of life was enhanced. While conventional treatments are often effective, they may lose efficacy over time, necessitating dose adjustments or alternative therapies. Cannabinoid therapies have shown promise in managing sleep disorders and may represent a viable alternative for treating narcolepsy.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100561"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An altmetric analysis of the research literature about traditional, complementary, and integrative medicine","authors":"Jeremy Y. Ng ,&nbsp;Alep Judge ,&nbsp;Holger Cramer","doi":"10.1016/j.aimed.2025.100506","DOIUrl":"10.1016/j.aimed.2025.100506","url":null,"abstract":"<div><h3>Background</h3><div>The use of traditional, complementary, and integrative medicine (TCIM) is known to be popular worldwide; there have been over 200,000 research articles published on this topic as of 2024. For decades, traditional citation-based metrics have been the assumed norm when assessing the impact of research, but in the digital age, alternative metrics (altmetrics) have also become a valuable proxy. By analyzing trends associated with the altmetrics of scholarly outputs relating to TCIM, patterns of social engagement were identified to obtain a better understanding of the factors that drive social impact in this field online.</div></div><div><h3>Methods</h3><div>This study was conducted using Altmetric.com, whereby this database was searched by the subject area “Traditional, Complementary and Integrative Medicine”. The subsequent data obtained was further analyzed to discern social trends within TCIM scholarly outputs at the article level.</div></div><div><h3>Results</h3><div>62,278 research outputs, from 1925 to 2024, with +497,000 online mentions were analyzed. Outputs from the Journal of Natural Products were mentioned the most frequently online (n = 5314, 10.56 %). The highest average Altmetric attention scores were associated with news outputs (M = 203.67), and outputs published under a bronze OA type (M = 17.54). The most mentions were contributed by X (n = 350,630, 70.41 %), Facebook (n = 57,540, 11.55 %), and news outlets (n = 39,941, 8.02 %).</div></div><div><h3>Conclusions</h3><div>Using the features found in this study to be linked with higher online attention, and sharing research through well-used online platforms, may help make TCIM research more visible to the public and more relevant to policy discussions.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100506"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-driven clinical decision support systems: Revolutionizing medication selection and personalized drug therapy","authors":"Hrishikesh Khude ,&nbsp;Pravin Shende","doi":"10.1016/j.aimed.2025.100529","DOIUrl":"10.1016/j.aimed.2025.100529","url":null,"abstract":"<div><div>Artificial Intelligence (AI) analyzes complex medical data records using Machine learning (ML), Natural Language Processing (NLP), and Deep Learning (DL) algorithms. These algorithms assist physicians in the optimization of therapeutic decisions that allow for the integration and interpretation of individual biological data, including genomics, proteomics, and transcriptomics. By identifying complex patterns in these data records, AI-driven systems facilitate the development of personalized treatment strategies that align with individual patient profiles. Furthermore, AI enhances pharmacovigilance by predicting potential drug interactions and conducting in-silico toxicity risk assessments through advanced molecular composition analysis. Moreover, AI accelerates the drug discovery process by screening and identifying novel drugs, thereby facilitating the development of targeted treatment. AI empowers physicians to prescribe medications, perform real-time formulary checks, and recommend therapeutic equivalent, economically viable alternatives to patient-specific factors. AI-driven clinical decision support systems (CDSS) further assist physicians in improving drug compliance and optimizing population health strategies by identifying pharmacologically cost-effective therapies. Additionally, AI enhances real-time clinical decision-making by improving diagnostic precision, refining therapeutic choices, and patient outcomes. The evolution of AI technologies offers immense potential for seamless integration into healthcare systems despite challenges such as data bias, limited model interpretability, and regulatory complexities. This integration revolutionizes personalized medicines, accelerates the drug discovery process, and improves the safety, efficacy, and cost-effectiveness of drug therapy. In summary, AI plays a significant role in modern medicine, promoting data-based clinical decisions and enhancing the overall quality and efficiency of healthcare delivery.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100529"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yoga as a holistic intervention for primary dysmenorrhea: A pilot study on pain, mental well-being, and quality of life","authors":"Deeksha P. Shetty ,&nbsp;Neetinakumar J Patil ,&nbsp;G. Shyamala ,&nbsp;Vijetha Shenoy Belle ,&nbsp;K. Annapoorna ,&nbsp;R. Vani Lakshmi ,&nbsp;Hemant Bhargav ,&nbsp;Rajeshkrishna Bhandary ,&nbsp;Anice George","doi":"10.1016/j.aimed.2025.100558","DOIUrl":"10.1016/j.aimed.2025.100558","url":null,"abstract":"<div><h3>Aim</h3><div>This study aims to evaluate the effectiveness of a six-month yoga intervention in managing primary dysmenorrhea and its associated symptoms—including menstrual pain, psychological well-being (depression, anxiety, and stress), sleep quality, and overall quality of life—in young women.</div></div><div><h3>Methods</h3><div>A longitudinal study was conducted with 20 women aged 18–25 years diagnosed with primary dysmenorrhea. Participants were randomly assigned to either an intervention group practising yoga or a control group engaging in moderate walking. The yoga intervention was conducted for six months, with sessions held five days a week. Pain intensity (VAS), psychological outcomes (DASS-21), sleep quality (PSQI), and quality of life (WHOQOL) were assessed at baseline, 3 months, and 6 months. Statistical analyses included repeated measures ANOVA to assess changes over time and between-group differences.</div></div><div><h3>Results</h3><div>Significant improvements were observed in the intervention group compared to the control group. Pain scores were significantly lower in the yoga group at 3 months (Mean Difference = 2.30, p = 0.020) and 6 months (Mean Difference = 2.80, p &lt; 0.001). Psychological outcomes also improved, with reductions in depression (p &lt; 0.001), anxiety (p &lt; 0.001), and stress (p = 0.002). Sleep quality showed moderate improvements, but between-group differences were not statistically significant. Quality of life improved over time, particularly in the intervention group (p = 0.024).</div></div><div><h3>Conclusion</h3><div>This study highlights the potential benefits of yoga as a non-pharmacological intervention for primary dysmenorrhea. Regular yoga practice significantly reduces pain, improves mental well-being, and enhances overall quality of life. These findings support the integration of yoga into holistic treatment approaches for menstrual health management.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100558"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}