{"title":"Viola odorata糖浆对更年期妇女潮热和盗汗的影响：三盲随机对照试验","authors":"Fatemeh Zahra Karimi , Nahid Nazari , Fatemeh Lotfi , Seyed Reza Mazloom , Mahdi Yousefi , Hassan Rakhshandeh","doi":"10.1016/j.aimed.2024.04.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Hot flashes and night sweats are among the most common and disruptive symptoms in menopausal women. The present study aimed to assess the effects of <em>Viola odorata</em> syrup on hot flashes and night sweats in menopausal women. V. odorata contain flavonoids, saponins, mucilage, alkaloid, vitamin C, magnesium and melatonin.</p></div><div><h3>Methods</h3><p>This triple-blind, Randomized Controlled Trial was conducted on 84 menopausal women aged 40–65 years referring to the healthcare centers in Mashhad, Iran. Eligible menopausal women received the <em>V. odorata</em> syrup (5 ml) or placebo twice daily for one month. Data were collected before, during, and after the intervention using valid and reliable daily hot flash checklists. Data analysis was performed in SPSS using independent t-test, Mann-Whitney U test, Friedman test, and Chi-square at the significance level of 0.05.</p></div><div><h3>Results</h3><p>In the first week (before the intervention), the intervention group (<em>V. odorata</em> syrup) and placebo group (control) were homogenous in terms of the frequency and intensity of hot flashes and night sweats. The Mann-Whitney U test indicated a significant difference in the duration of hot flashes between the two groups. In addition, significant differences were observed between the <em>V. odorata</em> syrup and placebo groups between the mean duration of hot flashes in the second (P = 0.044), third (P = 0.031), fourth (P < 0.001), and fifth weeks (P<0.001), mean frequency of hot flashes in the third, fourth, and fifth weeks (P < 0.001), and mean intensity of hot flashes in the third (P = 0.003), fourth, and fifth weeks (P < 0.001), as well as night sweats in the second week, the mean values of which were significantly lower in the <em>V. odorata</em> group compared to the control group.</p></div><div><h3>Conclusion</h3><p><em>V. odorata</em> syrup could reduce the frequency, intensity, and duration of hot flashes since the second week of the treatment. Therefore, the use of this plant is recommended for the reduction of hot flashes and night sweats in menopausal women.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Viola odorata syrup on hot flashes and night sweats in menopausal women: A randomized, triple-blind, controlled trial\",\"authors\":\"Fatemeh Zahra Karimi , Nahid Nazari , Fatemeh Lotfi , Seyed Reza Mazloom , Mahdi Yousefi , Hassan Rakhshandeh\",\"doi\":\"10.1016/j.aimed.2024.04.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Hot flashes and night sweats are among the most common and disruptive symptoms in menopausal women. The present study aimed to assess the effects of <em>Viola odorata</em> syrup on hot flashes and night sweats in menopausal women. V. odorata contain flavonoids, saponins, mucilage, alkaloid, vitamin C, magnesium and melatonin.</p></div><div><h3>Methods</h3><p>This triple-blind, Randomized Controlled Trial was conducted on 84 menopausal women aged 40–65 years referring to the healthcare centers in Mashhad, Iran. Eligible menopausal women received the <em>V. odorata</em> syrup (5 ml) or placebo twice daily for one month. Data were collected before, during, and after the intervention using valid and reliable daily hot flash checklists. Data analysis was performed in SPSS using independent t-test, Mann-Whitney U test, Friedman test, and Chi-square at the significance level of 0.05.</p></div><div><h3>Results</h3><p>In the first week (before the intervention), the intervention group (<em>V. odorata</em> syrup) and placebo group (control) were homogenous in terms of the frequency and intensity of hot flashes and night sweats. The Mann-Whitney U test indicated a significant difference in the duration of hot flashes between the two groups. In addition, significant differences were observed between the <em>V. odorata</em> syrup and placebo groups between the mean duration of hot flashes in the second (P = 0.044), third (P = 0.031), fourth (P < 0.001), and fifth weeks (P<0.001), mean frequency of hot flashes in the third, fourth, and fifth weeks (P < 0.001), and mean intensity of hot flashes in the third (P = 0.003), fourth, and fifth weeks (P < 0.001), as well as night sweats in the second week, the mean values of which were significantly lower in the <em>V. odorata</em> group compared to the control group.</p></div><div><h3>Conclusion</h3><p><em>V. odorata</em> syrup could reduce the frequency, intensity, and duration of hot flashes since the second week of the treatment. Therefore, the use of this plant is recommended for the reduction of hot flashes and night sweats in menopausal women.</p></div>\",\"PeriodicalId\":7343,\"journal\":{\"name\":\"Advances in integrative medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in integrative medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212958824000351\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in integrative medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212958824000351","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
背景潮热和盗汗是更年期妇女最常见、最具干扰性的症状之一。本研究旨在评估臭紫苏糖浆对更年期妇女潮热和盗汗的影响。方法这项三盲随机对照试验的对象是在伊朗马什哈德市医疗保健中心就诊的 84 名 40-65 岁绝经妇女。符合条件的更年期妇女每天两次服用 V. odorata 糖浆（5 毫升）或安慰剂，为期一个月。在干预前、干预期间和干预后，使用有效可靠的每日热潮红检查表收集数据。在 SPSS 中使用独立 t 检验、Mann-Whitney U 检验、Friedman 检验和 Chi-square 进行数据分析，显著性水平为 0.05。曼-惠特尼 U 检验表明，两组在潮热持续时间上存在显著差异。此外，在第二周（P = 0.044）、第三周（P = 0.031）、第四周（P <0.001）和第五周（P<0.001）潮热的平均持续时间，第三周、第四周和第五周潮热的平均频率（P <0.001），第三周（P = 0.003）、第四周和第五周（P <0.001）潮热的平均强度，以及第二周的盗汗，与对照组相比，V. odorata 组的平均值显著降低。因此，建议使用这种植物来减少更年期妇女的潮热和盗汗。
Effects of Viola odorata syrup on hot flashes and night sweats in menopausal women: A randomized, triple-blind, controlled trial
Background
Hot flashes and night sweats are among the most common and disruptive symptoms in menopausal women. The present study aimed to assess the effects of Viola odorata syrup on hot flashes and night sweats in menopausal women. V. odorata contain flavonoids, saponins, mucilage, alkaloid, vitamin C, magnesium and melatonin.
Methods
This triple-blind, Randomized Controlled Trial was conducted on 84 menopausal women aged 40–65 years referring to the healthcare centers in Mashhad, Iran. Eligible menopausal women received the V. odorata syrup (5 ml) or placebo twice daily for one month. Data were collected before, during, and after the intervention using valid and reliable daily hot flash checklists. Data analysis was performed in SPSS using independent t-test, Mann-Whitney U test, Friedman test, and Chi-square at the significance level of 0.05.
Results
In the first week (before the intervention), the intervention group (V. odorata syrup) and placebo group (control) were homogenous in terms of the frequency and intensity of hot flashes and night sweats. The Mann-Whitney U test indicated a significant difference in the duration of hot flashes between the two groups. In addition, significant differences were observed between the V. odorata syrup and placebo groups between the mean duration of hot flashes in the second (P = 0.044), third (P = 0.031), fourth (P < 0.001), and fifth weeks (P<0.001), mean frequency of hot flashes in the third, fourth, and fifth weeks (P < 0.001), and mean intensity of hot flashes in the third (P = 0.003), fourth, and fifth weeks (P < 0.001), as well as night sweats in the second week, the mean values of which were significantly lower in the V. odorata group compared to the control group.
Conclusion
V. odorata syrup could reduce the frequency, intensity, and duration of hot flashes since the second week of the treatment. Therefore, the use of this plant is recommended for the reduction of hot flashes and night sweats in menopausal women.
期刊介绍：
Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.
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