Advances in integrative medicine最新文献

{"title":"The effect of acupressure on urinary incontinence severity in older women with urinary incontinence: A randomized, single-blind, controlled trial","authors":"Sana Motalebifar ,&nbsp;Maryam Momeni ,&nbsp;Mohammad Habibi ,&nbsp;Farnoosh Rashvand","doi":"10.1016/j.aimed.2025.100499","DOIUrl":"10.1016/j.aimed.2025.100499","url":null,"abstract":"<div><h3>Background</h3><div>Urinary incontinence is one of the problems that can affect different aspects of the older ’s lives and decrease their quality of life. Acupressure is recommended as a non-invasive method in the management of genitourinary system problems.</div></div><div><h3>Objective</h3><div>The present study aims to determine the effect of acupressure on urinary incontinence severity in older women with urinary incontinence in Qazvin, Iran, in 2024.</div></div><div><h3>Method</h3><div>This randomized, single-blind, controlled clinical trial included 82 women over 65, all members of two adult daycare centers. Participants were randomly assigned to an intervention or a control group. In the intervention group, participants received acupressure 12 times, targeting ten acupoints associated with urinary incontinence symptom control. The control group did not receive any interventions except routine care. Three assessment tools were used: the ATM questionnaire for evaluating mental status, the QUID questionnaire for diagnosing urinary incontinence, and the PRAFAB questionnaire for assessing urinary incontinence severity. Data were analyzed using descriptive and analytical statistical tests and SPSS software.</div></div><div><h3>Results</h3><div>Results showed no significant differences in demographic variables or urinary incontinence severity between the two groups baseline (p-value &gt; 0.05). Immediately and one month post intervention, the total score and the scores of all items of urinary incontinence severity were lower in the intervention group than in the control group, and the difference between the two groups was statistically significant (p-value&lt;0.05).</div></div><div><h3>Conclusion</h3><div>Acupressure appears to be effective in urinary incontinence severity in older women. Further studies are recommended to confirm these findings.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100499"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ending the exploitation of wild animals in traditional medicine: An urgent call for global conservation action","authors":"Emad M. Abdallah","doi":"10.1016/j.aimed.2025.100525","DOIUrl":"10.1016/j.aimed.2025.100525","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100525"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the mechanism of Jiawei Xiaoyao San in treating metabolic associated fatty liver disease (MAFLD) based on the ileal microbiota-bile acid-FXR axis","authors":"Taotao Wei ,&nbsp;Gaozhong Dai ,&nbsp;Tianye Liu ,&nbsp;Yaozhou Tian","doi":"10.1016/j.aimed.2025.100567","DOIUrl":"10.1016/j.aimed.2025.100567","url":null,"abstract":"<div><div>Metabolic Associated Fatty Liver Disease (MAFLD) has become a main cause of chronic liver disease globally, necessitating the development of preventive and early therapeutic strategies. Traditional Chinese Medicine (TCM) plays a significant role in human metabolism, and Jiawei Xiaoyao San (JWXYS) has demonstrated notable ameliorative effects on liver stagnation and spleen deficiency-type liver disease. However, its potential mechanisms are still unclear. This study aimed to explore the therapeutic mechanism of JWXYS in treating chronic liver disease by establishing a rat model induced by a high-fat diet. The results revealed that JWXYS could reduce serum levels of total cholesterol (TC) triglycerides (TG) and aspartate aminotransferase (AST) in model rats, significantly improve the structure of liver lobule, reduce lipid deposition in hepatocytes, and reduce the abundance of harmful intestinal flora (such as <em>Staphylococcus</em> and <em>Enterococcus</em>). In addition, JWXYS improved gut microbiota imbalance, regulated bile acid and lipid metabolism, and maintained the overall health of rats. These findings provide a theoretical basis for using JWXYS to treat chronic fatty liver disease.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100567"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auricular acupuncture for chemotherapy-induced nausea and vomiting: A pilot study of a blinded randomized clinical trial","authors":"Eliza Mara das Chagas Paiva ,&nbsp;Caroline de Castro Moura ,&nbsp;Natália da Silva Martins Fonseca ,&nbsp;Ana Cláudia Mesquita Garcia","doi":"10.1016/j.aimed.2025.100559","DOIUrl":"10.1016/j.aimed.2025.100559","url":null,"abstract":"<div><h3>Objective</h3><div>Auricular acupuncture (AA) is a promising intervention for managing chemotherapy-induced nausea and vomiting (CINV). However, most randomized clinical trials (RCTs) have methodological limitations and a significant risk of bias, making the evidence inconclusive. This pilot study aimed to assess the feasibility of an AA protocol for controlling CINV in adult cancer patients.</div></div><div><h3>Methods</h3><div>This was a pilot study of a parallel, two-arm, blinded RCT with a 1:1 allocation ratio. Participants were randomized into two study arms: the AA group, which received true auricular acupuncture, or the sham AA group. The evaluated outcomes included preliminary evaluation of the effectiveness of the intervention for the occurrence of CINV, adverse effects of the intervention and study feasibility.</div></div><div><h3>Results</h3><div>Among the participants assessed for eligibility, 50 patients were randomized into the study arms, with 70 % of final evaluations completed. Thirty-five participants completed the study between January and July 2023. No serious adverse events occurred. A significant difference was observed between the AA and sham groups regarding nausea after the last chemotherapy session at follow-up (p = 0.005), suggesting a potential benefit of the intervention.</div></div><div><h3>Conclusion</h3><div>This pilot study demonstrated the feasibility of conducting an RCT on AA for CINV control, highlighting challenges in recruitment and adherence. Preliminary findings suggest that AA is safe and generally associated with few adverse events, which were transient and mild in intensity. These findings reinforce the need for a definitive RCT to confirm efficacy and support the integration of AA into clinical practice.</div></div><div><h3>Trial registration</h3><div>This study is registered in the Brazilian Registry of Clinical Trials (ReBEC): RBR-5rp37x8.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100559"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of selected acupuncture points on lung functions and inflammatory markers in patients with asthma – An interventional study","authors":"S. Sasikumar ,&nbsp;Thanalakshmi Jagadeesan ,&nbsp;Arbind Kumar Choudhary ,&nbsp;Sundareswaran Loganathan ,&nbsp;V. Venugopal ,&nbsp;K. Bincy ,&nbsp;Maheshkumar Kuppusamy","doi":"10.1016/j.aimed.2025.100573","DOIUrl":"10.1016/j.aimed.2025.100573","url":null,"abstract":"<div><h3>Background</h3><div>Acupuncture is commonly utilized as an alternative method for managing bronchial asthma and has the added benefit of being cost-effective while improving the quality of life. Although previous studies have demonstrated the effectiveness of acupuncture in treating patients with bronchial asthma, there is a lack of evidence regarding its impact on inflammatory markers associated with the condition. Therefore, the purpose of this study was to assess the effects of acupuncture treatment on pulmonary function and blood inflammatory markers in patients diagnosed with bronchial asthma.</div></div><div><h3>Methods</h3><div>n this particular study, a group of 15 patients diagnosed with mild or moderate bronchial asthma were included. These patients underwent acupuncture treatment sessions lasting 20 min each, once a day, for a duration of one month. Before and after the treatment period, patients' pulmonary functions and inflammatory markers were estimated.</div></div><div><h3>Results</h3><div>The results of the study revealed significant improvements in pulmonary function parameters following acupuncture treatment in patients with asthma. Specifically, there was a notable increase in Forced Vital Capacity (FVC) and the ratio of Forced Expiratory Volume in one second (FEV1) to FVC. Additionally, acupuncture was associated with increased levels of Interleukin-10 (IL-10) and Dehydroepiandrosterone sulfate (DHEA-S), which is a sulphated metabolite of dehydroepiandrosterone. Also, there was a significant decrease in levels of Tumor Necrosis Factor-alpha (TNF-α), cortisol, and salivary alpha amylase (sAA).</div></div><div><h3>Conclusion</h3><div>These findings suggest that acupuncture treatment in patients with asthma may lead to improvements in pulmonary function and modulation of inflammatory markers. The increase in IL-10 and DHEA-S, along with the decrease in TNF-α, cortisol, and sAA, may indicate a potential anti-inflammatory effect of acupuncture in asthma management.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100573"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnobotanical survey and anthelmintic activity of Origanum compactum and Trigonella foenum graecum extracts against Ascaris","authors":"Sana Chaoua ,&nbsp;Samia Boussaa ,&nbsp;Zuhair Dardona ,&nbsp;Ali Boumezzough ,&nbsp;Mohamed Hafidi","doi":"10.1016/j.aimed.2025.100580","DOIUrl":"10.1016/j.aimed.2025.100580","url":null,"abstract":"<div><div>Helminthiasis remains a ubiquitous parasitic disease worldwide, affecting a substantial proportion of the global population. However, the growing problem of anthelmintic resistance, combined with the high cost and limited accessibility of conventional pharmaceuticals, has intensified the search for plant-based alternatives in parasite control strategies. An ethnobotanical survey was carried out to identify medicinal plants used for treating diarrhea and parasitic infections in Morocco. Informed by ethnobotanical evidence, Origanum compactum (oregano) and Trigonella foenum-graecum (fenugreek) were selected for an <em>in vitro</em> assessment of their anthelmintic properties. The efficacy of their ethanolic extracts was systematically evaluated against Ascaris eggs across graded concentrations (1.25, 2.5, 5, and 10 mg/mL). Furthermore, distilled water and albendazole were employed as negative and positive controls, respectively. In addition, acute toxicity assays and comprehensive phytochemical screening were performed for plant extracts. The statistical significance of the observed anthelmintic activity was subsequently evaluated using analysis of variance (ANOVA test). The results revealed that the ethanolic extracts of <em>O. compactum</em> and <em>T. foenum-graecum</em> were non-toxic in acute oral toxicity assays, with LD₅₀ values exceeding 5 g/kg. At a concentration of 10 mg/mL, both extracts exhibited pronounced ovicidal activity against <em>Ascaris</em> eggs, achieving mortality rates of 97.73 % and 100 %, respectively. These findings indicate that the aerial parts of both species possess substantial anthelmintic potential, likely attributable to the bioactive secondary metabolites detected through phytochemical screening.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100580"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145216888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization of herbal medicine use: A global imperative for safety, efficacy, and public health","authors":"Emad M. Abdallah,&nbsp;Wael E. Abdalla,&nbsp;Alaa M.M. Sadeek","doi":"10.1016/j.aimed.2025.100482","DOIUrl":"10.1016/j.aimed.2025.100482","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100482"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yoga for mitigating cardiovascular risk and psychological implications of overweight and obesity: Study protocol for a randomized controlled trial","authors":"Kiriti Bhushan Ghosh ,&nbsp;Vijaya Majumdar ,&nbsp;Amit Kumar Singh ,&nbsp;Apar Avinash Saoji","doi":"10.1016/j.aimed.2025.100588","DOIUrl":"10.1016/j.aimed.2025.100588","url":null,"abstract":"<div><h3>Background</h3><div>Overweight and obesity are common risk factors for cardiovascular events. Yoga is useful in overweight, obesity, and cardiovascular diseases. However, empirical studies on yoga to mitigate cardiovascular risk factors are lacking. Therefore, the current trial aimed to evaluate the effect of yoga on cardiovascular risk in overweight and obese individuals.</div></div><div><h3>Methods</h3><div>A total of 110 overweight and obese participants will be randomized into yoga (n = 55) and waitlist control (n = 55) groups. Specific yoga interventions will be administered for a duration of three months. Soluble urokinase plasminogen activator receptor (suPAR) and high-sensitivity C-reactive protein (hsCRP) are the primary markers of cardiovascular risk. Secondary outcomes will include body weight, body mass index (BMI), anthropometric measures, lipid profile, and psychological measures. Data will be analysed using relevant statistical tests.</div></div><div><h3>Expected outcomes</h3><div>We hypothesize that yoga will attenuate cardiovascular risk in overweight and obese individuals, which may be illustrated by biomarkers such as suPAR, hsCRP, and other markers.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100588"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended reality in acupuncture-related research and practice: A bibliometric analysis","authors":"Jing He","doi":"10.1016/j.aimed.2025.100586","DOIUrl":"10.1016/j.aimed.2025.100586","url":null,"abstract":"<div><h3>Purpose</h3><div>In recent years, the application of extended reality (XR) technology in acupuncture-related research and practice has gained increasing popularity. This article aimed to conduct a bibliometric analysis in this field.</div></div><div><h3>Methods</h3><div>Publications between 1996 and 2024 in this field were searched in Web of Science Core Collection and Scopus. Software used for data preprocessing and analysis included Microsoft Excel, RStudio, CiteSpace, and VOSviewer.</div></div><div><h3>Results</h3><div>A total of 143 articles were selected. Publications in this field were increasing rapidly. The top three countries by publication volume were China, the United States and Canada. The top three most-cited countries were the United States, Belgium and China. The overall cooperation network was loose and mainly dominated by China, the United States, and the United Kingdom. The top three affiliations by publication volume were University of Toronto, Emory University, and Southern Medical University. KU Leuven had the highest total and average citations. The author with the most publications and total citations was Moseley G. The source with the most publications was Frontiers in Neurology, whereas the top cited source was Frontiers in Human Neuroscience. Hatem SM (Front Hum Neurosci, 2016) was the top cited publication with the highest average annual citation rate. The most frequent keywords included “virtual reality”, “acupuncture”, “cognitive behavioral therapy”, “stroke” and “pain”. Keyword clusters mainly focused on three aspects: neurological rehabilitation, mental health and pain management. An isolated sub-cluster existed in mental health cluster with “simulation” as its core keyword.</div></div><div><h3>Conclusion</h3><div>As a specialized domain, the field is expected to progress by forging a more direct integration of XR with acupuncture and a deeper convergence of basic science and clinical practice, indicating substantial progress in the future.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100586"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145358031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of traditional healthcare knowledge transmission and practice in rural nigeria: A case study of Egbejila community","authors":"Ahmed Ahmed Olaitan ,&nbsp;Asmawi Ibrahim ,&nbsp;Mohd Syaiful Nizam Bin Abu Hassan","doi":"10.1016/j.aimed.2025.100578","DOIUrl":"10.1016/j.aimed.2025.100578","url":null,"abstract":"<div><div>This research study examines the dynamics of traditional healthcare knowledge transmission and practice in Egbejila, a rural community in Nigeria. Traditional healthcare knowledge is deeply embedded in cultural heritage and remains essential for sustaining traditional healthcare practices across generations. Through a qualitative research approach, the collection of primary data involved interviews and focus group discussions. Besides, secondary sources were gathered to complement the primary data. The study comprised twenty-five (25) informants. The collected data were analysed using a qualitative data analysis software package known as NVivo. Findings from the study revealed that traditional practitioners in the Egbejila community established that they acquired their traditional healthcare knowledge from various sources, which significantly contributed to their specialization. The findings also shed light on the participants' knowledge regarding the aetiology of illness, common illnesses, and diagnostic methods employed by traditional healthcare practitioners in the study community. Based on the findings, it is recommended that there is a need for better healthcare knowledge acquisition; the government should establish a modality for formal sandwich training or a traditional healthcare institute that accommodates formal teaching and advanced apprenticeship, drawing inspiration from other countries.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100578"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}