Advances in integrative medicine最新文献

{"title":"Ethnopharmacology of Calotropis procera: Traditional knowledge and scientific insights from Dodoma Region, Tanzania","authors":"Hamisi Yunus Nchimbi","doi":"10.1016/j.aimed.2025.100535","DOIUrl":"10.1016/j.aimed.2025.100535","url":null,"abstract":"<div><h3>Introduction</h3><div>This study explored the integration of traditional knowledge and contemporary science in the ethnopharmacology of <em>Calotropis procera</em> in the Kongwa District, Dodoma region in Tanzania.</div></div><div><h3>Method</h3><div>A cross-sectional design combining qualitative interviews with 110 respondents from Lenjulu and Majawanga villages, alongside laboratory analyses, was employed. These included preliminary phytochemical screening, GC–MS complemented by LC-MS, and in vitro antimicrobial assays using the microdilution method in 96-well microtiter plates.</div></div><div><h3>Results</h3><div>Ethnobotanical data revealed that traditional knowledge of <em>C. procera</em> is predominantly held by older community members, with 41.8 % of respondents above 55 years, and is transmitted mainly through intergenerational transfer, apprenticeships, and gender-specific roles. Phytochemical screening confirmed the presence of key bioactive compounds such as phenols, flavonoids, alkaloids, tannins, saponins, terpenoids, and steroids, validating its traditional use in treating ailments. The chemical profiling of <em>C. procera</em> using LC-MS and GC-MS revealed several dominant bioactive compounds across multiple pharmacological classes. For example, LC-MS analysis identified amino acids L-Tyrosine (12.73 %) and L-Isoleucine (8.92 %) and a flavonoid Quercetin (9.65 %), indicating their abundance and potential biological significance. GC-MS results highlighted a sesquiterpene Caryophyllene (8.12 %)<strong>,</strong> a diterpene Neophytadiene (4.92 %) and a triterpenoid Squalene (3.56 %), all are known for anti-inflammatory and antimicrobial activities. These findings underscore the phytochemical richness and therapeutic potential of <em>C. procera</em>. In vitro antimicrobial assays revealed pronounced antibacterial efficacy of the <em>C. procera</em>, with B.subtilis exhibiting the highest susceptibility (MIC: 7.03 mg/L), followed by S.typhi (MIC: 14.06 mg/L), E.coli (MIC: 28.13 mg/L), and S.aureus (MIC: 56.25 mg/L). The observed activity is attributed to the presence of bioactive phytochemical constituents, underscoring the plant’s ethnopharmacological relevance as a promising source of natural antibacterial compounds.</div></div><div><h3>Conclusion</h3><div>These findings support the therapeutic potential of <em>C. procera and underscore the critical need to preserve traditional medical knowledge for future healthcare applications.</em></div></div><div><h3>Take-home message</h3><div>Preserving the traditional knowledge of <em>C. procera</em> in Kongwa District is essential for future pharmaceutical and medical breakthroughs, as scientific validation has confirmed its strong antibacterial properties.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100535"},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review exploring the role of homoeopathic drugs as a host directed therapy in the management of drug-resistant tuberculosis","authors":"Bhargav Sarma K ,&nbsp;Vaishali Vasant Dolas ,&nbsp;Vijay Nema","doi":"10.1016/j.aimed.2025.100533","DOIUrl":"10.1016/j.aimed.2025.100533","url":null,"abstract":"<div><h3>Introduction</h3><div>Host-directed therapies (HDTs) for tuberculosis are being investigated. By regulating host cell factors, especially in conditions like Drug-resistant tuberculosis, the increasing burden of Anti-Microbial Resistance (AMR) can be reduced. The role of homoeopathic drugs or CAM (complementary and alternative medicine) drugs in regulating host-directed mechanisms is largely unknown. The primary objective of this scoping review is to identify the host-directed mechanisms of homoeopathic drugs in relation to Mycobacterium tuberculosis pathophysiology. The second objective is to understand whether these host-directed mechanisms can be useful for treating sensitive and drug-resistant tuberculosis.</div></div><div><h3>Methods</h3><div>Our scoping review was drafted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) extension for scoping reviews. The following databases were searched to identify potentially relevant papers: PUBMED, COCHRANE, AYUSH RESEARCH PORTAL, and Google SCHOLAR. Forty-eight papers were screened by two people independently with blinding using Rayyan.</div></div><div><h3>Results</h3><div>The number of papers identified from databases and registers was 82. Only 15 papers were included in the final selection, while others were excluded because they did not meet the criteria for homoeopathy, host-directed mechanisms, and drug-resistant tuberculosis.</div></div><div><h3>Discussion</h3><div>To be considered host-directed, a homoeopathic drug action must act through the following mechanisms: regulation of adaptive immune responses, innate immune responses, cell death targets, and metabolism regulation. If we analyse the studies taken for review, we may find that some homoeopathic drugs regulate cytokines, matrix metalloproteinases (MMPs), Phosphofructokinase and other mechanisms. These experiments demonstrate that homoeopathic drugs act through host-directed mechanisms, but there is a lack of research papers on sensitive and drug-resistant tuberculosis.</div></div><div><h3>Conclusion</h3><div>So this concludes that in this review we were able to achieve only one objective which is the action of homoeopathic drugs through the host-directed mechanism, further research with In Vitro or In Vivo models can help us to complete our second objective.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100533"},"PeriodicalIF":1.7,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of art therapy interventions on satisfaction with life: A systematic review and meta-analysis","authors":"Javier Fernández-Sánchez ,&nbsp;Daniel Trujillo-Colmena ,&nbsp;Daniel Collado-Mateo ,&nbsp;Juan Luis Leon-Llamas ,&nbsp;Ana Myriam Lavín-Pérez ,&nbsp;Miriam Lorenzo-González","doi":"10.1016/j.aimed.2025.100532","DOIUrl":"10.1016/j.aimed.2025.100532","url":null,"abstract":"<div><div>Art therapies have emerged as a cost-effective global resource for promoting wellbeing, and quality of life and for reducing mental health problems through mind-body connection and creative expression. The aim was to systematically review the current evidence about the benefits of dance and theater-based interventions on the life satisfaction of participants. Furthermore, this study is aimed to synthesize and meta-analyze the results of the previously published randomized controlled trials. Thus, to identify the articles, a systematic search was conducted in PubMed (Medline) and Web of Science. The inclusion criteria included: being a randomized controlled trial, evaluating the effects of dance or drama interventions and providing pre-post data showing the effects on life satisfaction. A total of 12 articles were included in the Systematic Review, with 8 of them being included in the meta-analysis. Meta-analysis results showed that dance and drama interventions are effective (p = 0.01) in increasing the satisfaction with life of participants with different ages and conditions. In conclusion, dance and theater-based interventions are two forms of art therapies that may be useful to enhance the life satisfaction of people. Furthermore, further studies are needed to make stronger evidence-based recommendations or comparisons to other types of physical activity.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100532"},"PeriodicalIF":1.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of attitudes of hypertension patients toward holistic complementary and alternative medicine","authors":"Zeliha Buyukbayram Genc ,&nbsp;Seyhan Citlik Saritas","doi":"10.1016/j.aimed.2025.100534","DOIUrl":"10.1016/j.aimed.2025.100534","url":null,"abstract":"<div><h3>Background</h3><div>Hypertension is one of the most common cardiovascular diseases.</div></div><div><h3>Purpose</h3><div>This study was conducted to examine the attitudes of patients diagnosed with hypertension toward holistic complementary and alternative medicine.</div></div><div><h3>Method</h3><div>This descriptive and cross-sectional study was carried out with 230 adult patients diagnosed with hypertension who applied to the internal medicine and cardiology outpatient clinics of a Training and Research Hospital. Data were collected using the Personal Information Form and the Attitude Scale towards Holistic Complementary and Alternative Medicine. Data were analyzed with descriptive statistics, independent groups t-test, Kruskal-Wallis, and ANOVA tests. In addition, the Dunn-Bonferroni test was used to determine the difference between groups.</div></div><div><h3>Results</h3><div>The study revealed that the mean age of the patients was 54.36 ± 13.09, while 59.1 % were women, 81.3 % were married, 27.4 % were literate, and 61.3 % were unemployed. Also, it was observed that 41.3 % of the patients were diagnosed with hypertension between 1 and 5 years, 58.7 % had no other chronic illnesses, and 60.0 % had a family hypertension history. Additionally, 77.0 % of the patients used CAM, 24.9 % got information from the Internet/media via CAM, 27.1 % used CAM in addition to medical treatment, 56.5 % found CAM methods safe, 38.4 % used herbal agents, 76.3 % It has been determined that ten of them benefit from the use of CAM. The patients’ total mean score participating in the study in HCAMQ was 28.80 ± 6.73.</div></div><div><h3>Conclusion</h3><div>It was determined that the patients' attitudes toward CAM were positive and moderate. Additionally, the findings disclosed that the education level of the patients affected their use of CAM, their benefit from CAM, and their attitudes towards CAM.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100534"},"PeriodicalIF":1.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-driven clinical decision support systems: Revolutionizing medication selection and personalized drug therapy","authors":"Hrishikesh Khude ,&nbsp;Pravin Shende","doi":"10.1016/j.aimed.2025.100529","DOIUrl":"10.1016/j.aimed.2025.100529","url":null,"abstract":"<div><div>Artificial Intelligence (AI) analyzes complex medical data records using Machine learning (ML), Natural Language Processing (NLP), and Deep Learning (DL) algorithms. These algorithms assist physicians in the optimization of therapeutic decisions that allow for the integration and interpretation of individual biological data, including genomics, proteomics, and transcriptomics. By identifying complex patterns in these data records, AI-driven systems facilitate the development of personalized treatment strategies that align with individual patient profiles. Furthermore, AI enhances pharmacovigilance by predicting potential drug interactions and conducting in-silico toxicity risk assessments through advanced molecular composition analysis. Moreover, AI accelerates the drug discovery process by screening and identifying novel drugs, thereby facilitating the development of targeted treatment. AI empowers physicians to prescribe medications, perform real-time formulary checks, and recommend therapeutic equivalent, economically viable alternatives to patient-specific factors. AI-driven clinical decision support systems (CDSS) further assist physicians in improving drug compliance and optimizing population health strategies by identifying pharmacologically cost-effective therapies. Additionally, AI enhances real-time clinical decision-making by improving diagnostic precision, refining therapeutic choices, and patient outcomes. The evolution of AI technologies offers immense potential for seamless integration into healthcare systems despite challenges such as data bias, limited model interpretability, and regulatory complexities. This integration revolutionizes personalized medicines, accelerates the drug discovery process, and improves the safety, efficacy, and cost-effectiveness of drug therapy. In summary, AI plays a significant role in modern medicine, promoting data-based clinical decisions and enhancing the overall quality and efficiency of healthcare delivery.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100529"},"PeriodicalIF":1.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of herbal remedies in preventing striae gravidarum: A systematic review and meta-analysis","authors":"Masoumeh Razavi ,&nbsp;Mojgan Mirghafourvand ,&nbsp;Mahnaz Shahnazi ,&nbsp;Khadije Hajizadeh","doi":"10.1016/j.aimed.2025.100530","DOIUrl":"10.1016/j.aimed.2025.100530","url":null,"abstract":"<div><h3>Background</h3><div>Striae gravidarum is a common skin condition that affects approximately 60–90 % of pregnant women. This systematic review aimed to evaluate the effectiveness of herbal remedies in preventing stretch marks during pregnancy.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted in PubMed, Cochrane Library, Embase, Scopus, and SID databases for studies published between January 1972 and May 2024. Randomized controlled trials (RCTs) assessing the preventive effects of herbal remedies—including oils, creams, and plant-based extracts—on pregnant women were included. Data were analyzed using RevMan software, and meta-analysis was performed using fixed-effect or random-effects models based on the degree of heterogeneity. Subgroup analysis was performed based on the type of herbal remedies on incidence (primary outcome) and itching and erythema (secondary outcomes).</div></div><div><h3>Results</h3><div>A total of 12 randomized controlled trials involving 1956 pregnant women were included. Herbal treatments such as Aloe vera gel, sweet almond oil, and sesame oil showed a significant reduction in the incidence of stretch marks compared to placebo (12 studies, n = 1956; OR = 0.47, 95 % CI: 0.28–0.79, p = 0.004). In addition, four subgroup analyses from four distinct studies (n = 601) demonstrated that herbal products significantly reduced the incidence of itching compared to controls (OR = 0.09, 95 % CI: 0.03–0.30, p &lt; 0.00001), while two studies (n = 139) showed a significant reduction in erythema incidence in the intervention groups (OR = 0.17, 95 % CI: 0.07–0.38, p &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>Although some herbal remedies, especially Aloe vera, Sweet Almond oil and Sesame oil have high potential for the prevention and management of stretch marks, the heterogeneity in the studies' design and results indicates the need for more high-quality research.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100530"},"PeriodicalIF":1.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory biomarkers modulation in postmenopausal women: A randomized controlled trial of the superiority of Co-supplementing curcumin nano-micelles and Nigella sativa","authors":"Amir Mehdi Iranshahi ,&nbsp;Mahdi Amirpour ,&nbsp;Soraya Babaie ,&nbsp;Azizeh Farshbaf-Khalili ,&nbsp;Alireza Ostadrahimi","doi":"10.1016/j.aimed.2025.100528","DOIUrl":"10.1016/j.aimed.2025.100528","url":null,"abstract":"<div><h3>Background</h3><div>Lasting inflammation, whether directly mediated by hormonal changes or induced by oxidative stress, has significant negative effects on bone health, potentially contributing to the development of postmenopausal osteopenia and osteoporosis. Anti-inflammatory herbal products, known for cost-effectiveness and safety, support bone remodeling. This study evaluates the efficacy of Curcumin Nano-micelles (CUR), Nigella sativa (NS), and their co-supplementation (NS-CUR) on serum inflammatory factors in postmenopausal women with osteopenia or osteoporosis.</div></div><div><h3>Methods</h3><div>A triple-blind randomized trial was conducted on 120 postmenopausal women. Patients were allocated to four groups stratified by bone density. During the 6-month intervention, the NS group took an NS oil capsule and a CUR placebo capsule daily. The CUR group consumed a CUR capsule and an NS placebo capsule daily. The NS-CUR group received a CUR capsule and an NS oil capsule daily. The placebo group received two microcrystalline cellulose (MCC) capsules daily. The serum concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) were determined.</div></div><div><h3>Result</h3><div>The serum levels of TNF-α, IL-6, and hs-CRP significantly declined in the NS group (<em>p</em> &lt; 0.001), CUR (<em>p</em> &lt; 0.001, <em>p</em> &lt; 0.001, <em>p</em> = 0.001, res<em>p</em>ectively), and NS-CUR (<em>p</em> &lt; 0.001) groups compared to baseline. Between-group analyses revealed that IL-6 and TNF-α showed significant reductions in the NS, CUR, and NS-CUR groups (<em>p</em> &lt; 0.001) compared to placebo. Despite significant reductions in hs-CRP in the NS and NS-CUR groups (<em>p</em> = 0.001, <em>p</em> &lt; 0.001, respectively), no significant differences were identified between the CUR and placebo groups (<em>p</em> = 0.096).</div></div><div><h3>Conclusion</h3><div>The supplementation of CUR, NS, and NS-CUR modulated IL-6, TNF-α, and hs-CRP levels. Moreover, the co-supplementation of NS and CUR significantly influenced inflammatory biomarkers.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100528"},"PeriodicalIF":1.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting emotional resilience through laughter yoga in health professions education","authors":"Manuel Millán-Hernández ,&nbsp;Daniela F. Albarrán-Pérez","doi":"10.1016/j.aimed.2025.100527","DOIUrl":"10.1016/j.aimed.2025.100527","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100527"},"PeriodicalIF":1.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ending the exploitation of wild animals in traditional medicine: An urgent call for global conservation action","authors":"Emad M. Abdallah","doi":"10.1016/j.aimed.2025.100525","DOIUrl":"10.1016/j.aimed.2025.100525","url":null,"abstract":"","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100525"},"PeriodicalIF":1.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new paradigmatic framework for integrative medicine, and its implications for medicine and politics","authors":"Josef M. Schmidt","doi":"10.1016/j.aimed.2025.100526","DOIUrl":"10.1016/j.aimed.2025.100526","url":null,"abstract":"<div><h3>Introduction</h3><div>One of the major shortcomings of the discussion concerning integrative medicine is often an insufficient awareness of the peculiarity and multi-dimensionality of the object in question, on the part of critics and advocates alike.</div></div><div><h3>Methods</h3><div>Focusing on homeopathy as an example, this paper points out that the essence of this unique concept of healing cannot be wholly understood without a basic knowledge of the dimensions that constitute it.</div></div><div><h3>Results</h3><div>The three traditions of thinking on which it is based date back to antiquity, namely: <em>lógos</em>-thinking, <em>hómoion</em>-thinking and <em>iásthai</em>-thinking, i.e. thinking in terms of rationality, similarity and healing.</div></div><div><h3>Discussion</h3><div>While modern medicine is, for the most part, driven by reasoning in terms of quantification and generalisation, this at the cost of neglecting the remaining two dimensions, – homeopathy, due to its methodology, finds itself constantly searching to find a balance for all of its constituents.</div></div><div><h3>Conclusions</h3><div>This model of a three-dimensional art of healing may serve as a paradigm for integrative medicine to recollect an awareness of its own strength and multi-dimensionality, and, finally, also for medicine and politics in general.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 3","pages":"Article 100526"},"PeriodicalIF":1.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}