Investigating the effects of applying low acoustic frequencies on the pain from venous and arterial blood sampling: A clinical trial study

IF 1.7 Q2 Medicine

Advances in integrative medicine Pub Date : 2025-03-28 DOI:10.1016/j.aimed.2025.100480

Saeed Mohammadi , Ebrahim Ezzati , Rooghaye Mahooti , Fatemeh Kavyannejad , Mohammad Sadegh Paran , Rasoul Kavyannejad

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Abstract

Background

The pain of the blood sampling process is an unpleasant and common experience in the treatment process. Stimulation the thalamus structure and corticothalamic pathways with at specific frequencies could play a role in modulating pain perception. The aim of this study was to investigate the use low acoustic frequencies in reducing pain during arterial and venous blood sampling.

Material and Methods

In a triple-blinded clinical trial study, 300 patients in each process were randomly divided into control and intervention groups. Patients in the intervention groups received sound frequencies of 10–200 Hz with an intensity of 50 dB during the procedures. Pain intensity, heart rate changes, number of attempts for successful sampling, and time required for each procedure were measured. Data were analyzed using Prism 10 software.

Results

Pain levels were significantly lower in the intervention groups with increasing sound frequencies in both procedures (P < 0.05). The duration of blood sampling procedures was significantly shorter with increasing sound frequency (P < 0.05), but no difference was observed in the frequency of sampling attempts (P > 0.05). By increasing the sound frequency, the intensity of tachycardia significantly decreased following the blood sampling process (P < 0.05), especially at higher frequencies.

Conclusion

Applying low sound frequencies effectively could reduce acute pain and its consequences resulting from an invasive process. Sound frequencies appear to play a role in modulating pain pathways in the central nervous system.

Implications for Clinical Practice

The study findings suggest that sound frequency ranges as a non-pharmacological analgesia intervention can be used to reduce pain and discomfort following a variety of blood sampling procedures, which performed by nurses.

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研究应用低频率对静脉和动脉采血疼痛的影响：一项临床试验研究

采血过程中的疼痛是治疗过程中令人不愉快且常见的经历。以特定频率刺激丘脑结构和皮质丘脑通路可能在调节痛觉中起作用。本研究的目的是探讨在动脉和静脉血取样时使用低声波来减轻疼痛。材料与方法采用三盲临床试验研究，每个过程300例患者随机分为对照组和干预组。干预组患者在手术过程中接受的声音频率为10-200 Hz，强度为50 dB。测量疼痛强度、心率变化、成功取样的尝试次数和每个过程所需的时间。数据分析采用Prism 10软件。结果两种手术中随着声音频率的增加，干预组的西班牙水平均显著降低（P <； 0.05）。随着声音频率的增加，血液采样过程的持续时间显著缩短（P <； 0.05），但在采样尝试的频率上没有观察到差异（P <； 0.05）。通过增加声音频率，在采血过程中心动过速的强度显著降低（P <； 0.05），特别是在较高的频率。结论低频率应用能有效减轻创伤过程中急性疼痛及其后果。声音频率似乎在调节中枢神经系统的疼痛通路中起作用。对临床实践的启示研究结果表明，声音频率范围作为一种非药物镇痛干预措施，可用于减轻由护士执行的各种血液采样程序后的疼痛和不适。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.