{"title":"补充生姜对功能性消化不良患者生活质量的影响:一项开放标签的临床试验","authors":"Lemlem Gebremariam Aregawi , Csiki Zoltan","doi":"10.1016/j.aimed.2025.100477","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and purpose</h3><div>Functional dyspepsia (FD) is a prevalent gastrointestinal disorder, often marked by persistent discomfort and negatively impacting patients' quality of life. Despite various treatment approaches, many patients continue to experience symptoms. Ginger has been suggested as a potential natural remedy for dyspepsia due to its anti-inflammatory and prokinetic properties. While previous studies have focused on ginger’s ability to alleviate dyspeptic symptoms, its impact on QoL in FD patients remains unclear. This study aimed to assess the effects of ginger supplementation on QoL in patients with FD.</div></div><div><h3>Materials and methods</h3><div>This open-label clinical trial enrolled adult FD patients who met the Rome IV criteria. A total of 62 patients were enrolled, and 51 completed the study. Participants received a standardized ginger supplement of 540 mg twice daily for eight weeks. Quality of life was assessed at baseline and post-intervention using a validated questionnaire, Nepean Dyspepsia Index (NDI). Secondary outcomes were also evaluated.</div></div><div><h3>Results</h3><div>After eight weeks of ginger supplementation, there was a significant improvement in QoL, as indicated by a decrease in NDI scores (mean change ± SD: 9.97 ± 16.20, p = 0.039). This demonstrates a notable enhancement in the participants' QoL, particularly in terms of interference, eating and improved day-to-day activity. Secondary outcomes also showed favorable changes.</div></div><div><h3>Conclusion</h3><div>Ginger supplementation may offer a beneficial adjunct therapy for patients with FD, improving both symptom management and overall QoL. Future studies with larger sample sizes and randomized controls are warranted to confirm these findings and explore the mechanisms involved.</div></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"12 4","pages":"Article 100477"},"PeriodicalIF":1.7000,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of ginger supplementation on quality of life in patients with functional dyspepsia: An open-label, clinical trial\",\"authors\":\"Lemlem Gebremariam Aregawi , Csiki Zoltan\",\"doi\":\"10.1016/j.aimed.2025.100477\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and purpose</h3><div>Functional dyspepsia (FD) is a prevalent gastrointestinal disorder, often marked by persistent discomfort and negatively impacting patients' quality of life. Despite various treatment approaches, many patients continue to experience symptoms. Ginger has been suggested as a potential natural remedy for dyspepsia due to its anti-inflammatory and prokinetic properties. While previous studies have focused on ginger’s ability to alleviate dyspeptic symptoms, its impact on QoL in FD patients remains unclear. This study aimed to assess the effects of ginger supplementation on QoL in patients with FD.</div></div><div><h3>Materials and methods</h3><div>This open-label clinical trial enrolled adult FD patients who met the Rome IV criteria. A total of 62 patients were enrolled, and 51 completed the study. Participants received a standardized ginger supplement of 540 mg twice daily for eight weeks. Quality of life was assessed at baseline and post-intervention using a validated questionnaire, Nepean Dyspepsia Index (NDI). Secondary outcomes were also evaluated.</div></div><div><h3>Results</h3><div>After eight weeks of ginger supplementation, there was a significant improvement in QoL, as indicated by a decrease in NDI scores (mean change ± SD: 9.97 ± 16.20, p = 0.039). This demonstrates a notable enhancement in the participants' QoL, particularly in terms of interference, eating and improved day-to-day activity. Secondary outcomes also showed favorable changes.</div></div><div><h3>Conclusion</h3><div>Ginger supplementation may offer a beneficial adjunct therapy for patients with FD, improving both symptom management and overall QoL. Future studies with larger sample sizes and randomized controls are warranted to confirm these findings and explore the mechanisms involved.</div></div>\",\"PeriodicalId\":7343,\"journal\":{\"name\":\"Advances in integrative medicine\",\"volume\":\"12 4\",\"pages\":\"Article 100477\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-03-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in integrative medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212958825000369\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in integrative medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212958825000369","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Effects of ginger supplementation on quality of life in patients with functional dyspepsia: An open-label, clinical trial
Background and purpose
Functional dyspepsia (FD) is a prevalent gastrointestinal disorder, often marked by persistent discomfort and negatively impacting patients' quality of life. Despite various treatment approaches, many patients continue to experience symptoms. Ginger has been suggested as a potential natural remedy for dyspepsia due to its anti-inflammatory and prokinetic properties. While previous studies have focused on ginger’s ability to alleviate dyspeptic symptoms, its impact on QoL in FD patients remains unclear. This study aimed to assess the effects of ginger supplementation on QoL in patients with FD.
Materials and methods
This open-label clinical trial enrolled adult FD patients who met the Rome IV criteria. A total of 62 patients were enrolled, and 51 completed the study. Participants received a standardized ginger supplement of 540 mg twice daily for eight weeks. Quality of life was assessed at baseline and post-intervention using a validated questionnaire, Nepean Dyspepsia Index (NDI). Secondary outcomes were also evaluated.
Results
After eight weeks of ginger supplementation, there was a significant improvement in QoL, as indicated by a decrease in NDI scores (mean change ± SD: 9.97 ± 16.20, p = 0.039). This demonstrates a notable enhancement in the participants' QoL, particularly in terms of interference, eating and improved day-to-day activity. Secondary outcomes also showed favorable changes.
Conclusion
Ginger supplementation may offer a beneficial adjunct therapy for patients with FD, improving both symptom management and overall QoL. Future studies with larger sample sizes and randomized controls are warranted to confirm these findings and explore the mechanisms involved.
期刊介绍:
Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.